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JOURNAL OF PHARMACEUTICAL & BIOMEDICAL ANALYSIS, 1994, VOL. 12, PP. 635-641
Automated Flow-injection Technique for Use in Dissolution Studies of Sustained-release Formulations: Application to Iron(II) Formulations
Constantinos A. Georgioua, Georgia N. Valsamib, Panayotis E. Macherasb and Michael A. Koupparis*,b
aLaboratory of Analytical Chemistry, Department of Chemistry, and bLaboratory of Biopharmaceutics and Pharmacokinetics, Department of Pharmacy, University of Athens, Panepistimiopolis, Kouponia, Athens 157 71, Greece
The application of flow-injection analysis (FIA) to automated dissolution studies of sustained-release formulations is described. The long-term stability of the dissolution-FIA analyser was checked during unattended operation for 42 h. The construction of multiple calibration curves with the so-called electronic dilution FIA procedure was used to extend the linear range of the determination. The computer-controlled FIA system and the principles of associated software are described and applied to dissolution studies of sustained-release formulations of iron(II) using its sensitive reaction with the colour reagent, ferrozine. The extended linear range of the determination is 1-130 ppm iron(II) and the precision (RSD) better than 3% (n = 3).
Keywords: Iron determination in drug formulations; flow-injection analysis; ferrozine; dissolution testing automation; sustained-release formulations
*Corresponding author.
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