9. Δημοσιεύσεις:
Ι. Ερευνητικές εργασίες σε διεθνή περιοδικά :
1. Synthesis and Study of 2-(Pyrrolesulfonylmethyl)-N-arylimines: A New Class of Inhibitors for Human Glutathione Transferase A1-1. Koutsoumpli GE, Dimaki VD, Thireou TN, Eliopoulos EE, Labrou NE, Varvounis GI, Clonis YD. 2012 J Med Chem. Aug 9;55(15):6802-13. Epub 2012 Jul 31.
2. A RANKL G278R mutation causing osteopetrosis identifies a functional amino acid essential for trimer assembly in RANKL and TNF. Douni, E., Rinotas, V., Makrinou, E., Zwerina, J., Penninger, J.M., Eliopoulos, E., Schett, G., Kollias, G. 2012 Human Molecular Genetics 21 (4), art. no. ddr510 , pp. 784-798.
3. Mapping the Anopheles gambiae Odorant Binding Protein 1 (AgamOBP1) using modeling techniques, site directed mutagenesis, circular dichroism and ligand binding assays. Rusconi, B., Maranhao, A.C., Fuhrer, J.P., Krotee, P., Choi, S.H., Grun, F., Thireou, T., (...), Eliopoulos, E. 2012 Biochimica et Biophysica Acta - Proteins and Proteomics 1824 (8) , pp. 947-953
4. Anopheles gambiae odorant binding protein crystal complex with the synthetic repellent DEET: implications for structure-based design of novel mosquito repellents. K. E. Tsitsanou, T. Thireou, C. E. Drakou, K. Koussis, M. V. Keramioti, D. D. Leonidas, E. Eliopoulos, K. Iatrou and S. E. Zographos. 2011 Cellular and Molecular Life Sciences, DOI: 10.1007/s00018-011-0745-z..
5. Association of the PTPN22 R620W polymorphism with increased risk for SLE in the genetically homogeneous population of Crete. Eliopoulos E, Zervou M, Andreou A, Dimopoulou K, Cosmidis N, Voloudakis G, Mysirlaki H, Vazgiourakis V, Sidiropoulos P, Niewold T, Boumpas D, Goulielmos G. 2011 Lupus. 20(5):501-6
6. The role of the pro-apoptotic protein Siva in the pathogenesis of Familial Mediterranean fever: A structural and functional. Goulielmos GN, Petraki E, Vassou D, Eliopoulos E, Iliopoulos D, Sidiropoulos P, Aksentijevich I, Kardassis D, Boumpas DT. 2010 Biochem Biophys Res Commun. 402:141-146.
7. The Anopheles gambiae odorant binding protein 1 (AgamOBP1) mediates indolerecognition in the antennae of female mosquitoes. Biessmann H, Andronopoulou E, Biessmann MR, Douris V, Dimitratos SD, Eliopoulos E, Guerin PM, Iatrou K, Justice RW, Kröber T,Marinotti O, Tsitoura P, Woods DF, Walter MF. 2010 A PLoS One. Mar 1;5(3):e9471
8. Quantitative Prediction of Critical Amino Acid Positions for Protein Folding. Thireou T, Atlamazoglou V, Papandreou NA, Lonquety M, Chomilier J, Eliopoulos E. 2009 Protein Pept Lett. 16(11):1342-9.
9. Design and expression of human alpha7 nicotinic acetylcholine receptor extracellular domain mutants with enhanced solubility and ligand-binding properties. Zouridakis M, Zisimopoulou P, Eliopoulos E, Poulas K, Tzartos SJ. 2009 Biochim Biophys Acta. Feb;1794(2):355-66.
10. Selection at 6-PGD locus in laboratory populations of Bactrocera oleae. Cosmidis N, Goulielmos G, Eliopoulos E, Loukas M. 2008 Genet Res. Oct;90(5):379-84.
11. Model of the extracellular domain of the human a7 nAChR based on the crystal structure of the mouse a1 nAChR extracellular domain. M. Konstantakaki , S. J. Tzartos , K. Poulas , E. Eliopoulos. Journal of Molecular Graphics and Modelling 2008 26, 1333-1337.
12. Familial Mediterranean Fever in Crete: a genetic and structural biological approach in a population of 'intermediate risk'. Fragouli E, Eliopoulos E, Petraki E, Sidiropoulos P, Aksentijevich I, Galanakis E, Kritikos H, Repa A, Fragiadakis G, Boumpas D, Goulielmos GN. 2008 Clin Genet. Feb;73(2):152-9..
13. Recombinant extracellular domains of human neuronal nicotinic receptors: Preliminary studies on mutant forms for the improvement of solubility. M. Zouridakis, P. Zisimopoulou, E. Eliopoulos, L. Jacobson, K. Poulas and S.J. Tzartos. 2007 Neurophysiology (Ukr.), 39,4/5,p.302-306..
14. Circular dichroism studies of extracellular domains of human nicotinic acetylcholine receptors provide an insight into their structure. Marios Zouridakis, Kalliopi Kostelidou, Alexandros Sotiriadis, Christos Stergiou, Elias Eliopoulos, Konstantinos Poulas and Socrates J. Tzartos. 2007 Int J Biol Macromol. Oct 1;41(4):423-9.
15. Purification, crystallization, X-ray diffraction analysis and phasing of an engineered single-chain PvuII restriction endonuclease. Chrysi Meramveliotaki, Dina Kotsifaki, Maria Androulaki, Athanasios Hountas, Elias Eliopoulos and Michael Kokkinidis. 2007 Acta Cryst Part F,63.
16. CrystTwiV: a web-server for automated phase extension and refinement in X-ray crystallography. Trias Thireou, Vassilis Atlamazoglou, Manolis Levakis, Elias Eliopoulos, Athanassios Hountas, George Tsoucaris and Kostas Bethanis 2007 Nucleic Acid Research doi: 10.1093/nar/gkm225.
17. Molecular modeling of the complex between Torpedo acetylcholine receptor and anti-MIR Fab198. M. Konstantakaki , S. J. Tzartos , K. Poulas , E. Eliopoulos 2007 Biochem Biophys Res Commun., 356 (3), 569-575.
18. Using a pharmacophore representation concept to elucidate molecular similarity of dopamine antagonists. V. Atlamazoglou, T. Thireou and E. Eliopoulos 2007 J Comput Aided Mol Des. May;21(5):239-49.
19. Mutational analysis of the PRYSPRY domain of pyrin and implications for familial Mediterranean Fever (FMF). Goulielmos, G.N., Fragouli, E., Aksentijevich, I., P. Sidiropoulos, Boumpas, D.T., and Eliopoulos, E 2006 Biochem. Biophys. Res. Commun. 345(4):1326-1332.
20. Cloning and structural characterization of the 6 -phosphogluconate dehydrogenase (6Pgd) locus of the medfly Ceratitis capitata and the olive fruit fly Bactrocera oleae, Goulielmos, G.N., Eliopoulos, E., Loukas, M. and E. Zouros. 2006 Biochem. Biophys. Res. Commun.311, 341:721-727.
21. Isolation and and characterization of stress related Heat shock protein calmodulin binding gene from cultivated cotton (Gossypium hirsutum L.), Kosmas SA, Argyrokastritis A, Loukas MG, Eliopoulos E, Tsakas S, Kaltsikes PJ. 2006 Euphytica, 147,343-351.
22. Isolation and characterization of drought-related trehalose 6-phosphate-synthase gene from cultivated cotton (Gossypium hirsutum L.). Kosmas SA, Argyrokastritis A, Loukas MG, Eliopoulos E, Tsakas S, Kaltsikes PJ. 2005 Planta. Aug 6;1-11.
23. T-cell recognition of HLA-DQ2-bound gluten peptides can be influenced by an N-terminal proline at p-1’. Dariusz Stepniak, L. Willemijn Vader, Yvonne Kooy, Peter A. van Veelen, Antonis Moustakas, Nikolaos A. Papandreou, Elias Eliopoulos, Jan Wouter Drijfhout, George K. Papadopoulos and Frits Koning 2005 Immunogenetics 57(1-2):8-15.
24. Structure determination of scPvuII by crystallographic and SAXS methods. C. Meramveliotaki, E. Eliopoulos and M. Kokkinidis. 2005 Acta Cryst. A61, c226 (Αρθρο σε πρακτικά Συνεδρίου).
25. Universal positions in globular proteins: observation to simulation. Nikolaos Papandreou, Igor Berezovsky, Anne Lopes, Elias Eliopoulos, Jacques Chomilier. 2004 European Journal of Biochemistry, 271:4762-4768.
26. Functional constraints of 6-phosphogluconate dehydrogenase (6PGD) protein based on sequence and structural information. Goulielmos, G.N., Eliopoulos, E., Loukas, M. and Tsakas, S. 2004 J. Mol. Evol., 58,1-15.
27. Functional constraints of alcohol dehydrogenase (ADH) of Tephritidae and relationships with other dipteran species. Eliopoulos, E., Goulielmos, G.N. and Loukas, M. 2004 J. Mol. Evol., 58, 493-505.
28. Analysis of fragments induced by simulated lattice protein folding’. Jacques Chomilier, Marc Lamarine, Jean-Paul Mornon, Jorge Hernandez Torres, Elias Eliopoulos, Nikolaos Papandreou. 2004 C.R. Biologies 327:431-443.
29. Macroevolutionary Relationships of Species of Drosophila Melanogaster Group Based on mtDNA Sequences. P. Kastanis, E. Eliopoulos, G. Goulielmos, S. Tsakas and M. Loukas 2003 Mol. Phylogenetics and Evolution, 28,518-528.
30. Drosophila Cu,Zn superoxide dismutase gene confers resistance to paraquat in Escherichia coli. Goulielmos, G.N., Eliopoulos, E., Arhontaki, K., Tserpistali, K., Tsakas, S. and Loukas, M. 2003 Biochem. Biophys. Res. Commun. 308:433-438.
31. Functional constraints of the Cu, Zn superoxide dismutase in species of Drosophila melanogaster subgroup and phylogenetic analysis. K. Arhontaki , E. Eliopoulos, G. Goulielmos, P. Kastanis, S. Tsakas, M. Loukas and F. Ayala. 2002 J. Mol. Evolution, 55: 745-756.
32. Expression of selected drought-related genes and physiological response of Greek cotton varieties. A.E. Voloudakis, S.A. Kosmas, S. Tsakas, E. Eliopoulos, M. Loukas and K. Kosmidou. 2002 Functional. Plant. Biol., 29, 1237-1245.
33. Crystal structure of Fab198, an efficient protector of acetylcholine receptor against myasthenogenic antibodies. K. Poulas, E. Eliopoulos, E. Vatzaki, J. Navaza, M. Kontou, N. Oikonomakos, K. R. Acharya, and S. J. Tzartos. 2001 Eur.J. Biochem., 268, 1-10.
34. Structural analysis of two HLA-DR-presented autoantigenic epitopes: crucial role of peripheral but not central peptide residues for T-cell receptor recognition. De Oliveira DB, Harfouch-Hammoud E, Otto H, Papandreou NA, Stern LJ, Cohen H, Boehm BO, Bach J, Caillat-Zucman S, Walk T, Jung G, Eliopoulos E, Papadopoulos GK, van Endert PM. 2001 Mol Immunol. 37(14):813-825.
35. A novel tool for multiple protein sequence alignment. Xarkiolakis N. and Eliopoulos E. 2000 HSBMB Newsletter, 47, 224-228. (Άρθρο σε πρακτικά Συνεδρίου)
36. Finding stable conformations of polypeptide chains utilizing genetic algorithms Eliopoulos E. and Xarkiolakis N. 2000 HSBMB Newsletter, 47, 89-91. (Άρθρο σε πρακτικά Συνεδρίου)
37. Multiple nuclei intermediate states revealed by lattice Monte-Carlo simulation of protein folding. Papandreou N., Eliopoulos E., Lamarine M., Mornon J.-P., Chomilier J. 2000 HSBMB Newsletter 47, 83-87. (Αρθρο σε πρακτικά Συνεδρίου)
38. Molecular Modeling for the Design of a Biomimetic Chimeric Ligand. Application to the Purification of Bovine Heart L-Lactate Dehydrogenase. Labrou, N. E. Eliopoulos, E. Clonis, Y. D. 1999 Biotechnology and Bioengineering 63 (3)322-332.
39. Construction and characterization of a humanized single chain Fv antibody fragment against the main immunogenic region of the acetylcholine receptor. Papanastasiou, D. Mamalaki, A., Eliopoulos, E, Poulas, K., Liolitsas, C., Tzartos, S. J. 1999 J. of Neuroimmunology 94; (1-2), 182-195.
40. Cell size of various lactic acid bacteria as determined by scanning electron microscope and image analysis. Kokkinos, A. Fasseas, C. Eliopoulos, E. Kalantzopoulos, G. 1998 LAIT 78; 5, 491-500.
41. RGD sequences in several receptor proteins: novel cell adhesion function for receptors? Papadopoulos, G.K., Ouzounis, C., Eliopoulos, E.E. 1998 International Journal of Biological Macromolecules 22, 51-57.
42. “Βαριά Μυασθένεια: Ανθρωποποίηση ενός μονοκλωνικού αντισώματος και προστασία του υποδοχέα της ακετυλοχολίνης από αυτοαντισώματα.” Παπαναστασίου Δ, Μαμαλάκη Α, Πουλάς Κ, Ηλιόπουλος Η, Τζάρτος Σ. 1998 Αρχεία Ελληνικής Ιατρικής, 15(4):356-363.
Η παράνω εργασία βραβεύθηκε με το Α’ Βραβείο «Σωτήρης Παπασταμάτης», κατά το Πανελλήνιο Ιατρικό Συνέδριο 1998.
43. Molecular modelling for the design of chimeric biomimetic dye-ligands and their interaction with bovine heart mitochondrial malate dehydrogenase N.E. Labrou, E. Eliopoulos and Y.D. Clonis 1996 Biochemical Journal 315, 695-703.
Αναφορές 22
44. Dye affinity labeling of bovine heart mitochondrial malate dehydrogenase and study of the NADH-binding site. N.E. Labrou, E. Eliopoulos and Y.D. Clonis 1996 Biochemical Journal 315, 687-693.
45. Crustacyanin, the lobster carapace astaxanthin-protein: effects of modification of tyrosine residues of apocrustacyanin with tetranitromethane on the ability of the protein to reconstitute with astaxanthin. P.F. Zagalsky, R.S. Mummery, E.E. Eliopoulos and J.F. Keen. 1995 Comp.Biochem.Physiol 110B, 393-401.
Αναφορές 1
46. Synthesis, crystal structure and biological properties of a new series of lipophilic s- triazines, dihydrofolate reductase inhibitors. P. Tsitsa, E. Antoniadou-Vyza, S.J. Hamodrakas, E.E. Eliopoulos, A. Tsantili-Kakoulidou, E. Lada-Hytiroglou, C. Roussakis, I Chinou, A. Hempel, N. Camerman, F.P. Ottensmeyer, D.A. Vanden Berghe. 1993 Eur. J. Med. Chem. 28,149-158.
47. Structure of a 16kD Integral Membrane Protein that has Identity to the Putative Proton Channel of vacuolar H+ ATPase. Finbow, M.E., Eliopoulos, E.E. Jackson, P.J., Keen, J.N., Meagher, L., Thompson, P., Smith, K., McLean, P. and Findlay, J.B.C. 1992 Protein Engineering 5,1,7-15.
48. The structure of ethyl 3-[4,5-dimethoxy-2-2-pyridylsulphamoyl-phenyl]propio-[1,4-oxazine]. Eliopoulos, E., Sheldrick B. and Hamodrakas S. 1991 Acta Cryst. C47, 1212-1214.
49. Multiple Sequence Alignment of Protein Families Showing Low Sequence Homology: A Methodological Approach Using Database Pattern-Matching Discriminators for G-protein linked receptors. Attwood, T.K., Findlay, J.B.C. and Eliopoulos E.E. 1991 Gene 98,153.
Αναφορές 38
50. Complete Sequence and Model for the C1 Subunit of the Carotenoprotein, Crustacyanin, and model for the dimer, β-crustacyanin, formed from the C1 and A2 subunits with astaxanthin. Keen, J.N., Careres, I., Eliopoulos, E.E., Zagalsky, P.F. and Findlay, J.B.C. 1991 Eur. J. Biochem. 202, 31-40.
51. Complete Sequence and Model for the A2 Subunit of the Carotenoid Pigment Complex, Crustacyanin. Keen, J.N., Careres, I., Eliopoulos, E.E., Zagalsky, P.F. and Findlay, J.B.C. 1991 Eur. J. Biochem 197, 407-417.
Αναφορές 41
52. 3-Dimensional Modelling of Membrane-Bound Proteins: G Protein linked Receptors. Findlay J.B.C. and Eliopoulos E.E. 1990 Trends in Pharm. Sci.11, 492-499.
53. The Lobster Carapace Carotenoprotein, a-Crustacyanin: A Possible role for Tryptophan in the Bathochromic Spectral Shift of protein-bound astaxanthin. Zagalsky, P.F., Eliopoulos, E.E. and Findlay, J.B.C. 1990 Biochem. J. 274,79-91.
54. Alternative Ligands as probes for the carotenoid-binding site of lobster carapace crustacyanin. Clarke, J.B., Eliopoulos, E.E., Findlay, J.B.C. and Zagalsky, P.F. 1990 Biochem. J. 265, 919-921.
55. The architecture of invertebrate carotenoproteins. Zagalsky P.F., Eliopoulos E.E. and Findlay J.B.C. 1990 J. Comp. Biochem. Physiol. 97b, 1-18.
Αναφορές 43
56. The Quartenary Structure of the lobster carapace carotenoprotein Crustacyanin : Studies using Cross-linking agents. Zagalsky, P.F., Mummery, R.S., Eliopoulos, E.E. and Findlay, J.B.C. 1990 J. Comp.Physiol.Biochem. 97B, 837-848.
57. Molecular Modelling of Integral Membrane Proteins. Findlay, J.B.C., Eliopoulos, E.E. and Finbow, M. 1990 Biochem.Trans. 18 ,838-839. (Αρθρο σε πρακτικά Συνεδρίου)
58. The structure of G-protein Linked Receptors. Findlay, J.B.C., Eliopoulos, E.E. and Attwood, T.K. 1990 Biochem.Soc. Symb. 56, 1-8. (Αρθρο σε πρακτικά Συνεδρίου)
59. Complete amino-acid sequence of Pyrazine Binding Protein from Cow nasal mucosa. Tirindelli, R., Keen, J.N., Cavaggioni, A., Eliopoulos, E.E. and Findlay, J.B.C. 1989 Eur. J. Biochem. 185,569-574.
60. The structure of Mouse L1210 Dihydrofolate Reductase- drug complexes and the contruction of a model of human enzyme. Stammers, D.K.,Champness, J.N., Beddell, C.R.,Dann J.G., Eliopoulos, E., Geddes, A.J., Ogg D., North, A.C.T 1987 FEBS 218, 1,178-184.
61. The Primary structure, Chemistry and Molecular Modelling of Rhodopsin. Findlay, J.B.C., Pappin, D.J.C., Eliopoulos,E.E. 1987 Progress in Retinal Research 7,3,63-87.
62. Crystal structure of the Trigonal Form of Bovine Beta- lactoglobulin and of its complex with retinol at 2.5Ĺ resolution. Monaco, H.L., Zanotti, G., Spadon, P., Bolognesi, M., Sawyer, L. and Eliopoulos, E.E. 1987 J. Mol. Biol. 197,695-706.
63. The structure of beta-lactoglobulin and its similarity to plasma retinol-binding protein. Papiz, M.Z., Sawyer, L., Eliopoulos, E., North, A.C.T., Findlay, J.B.C., Sivaprasadarao, R., Jones, T.A., Newcomer, M.E. and Kraulis, P.J. 1986 Nature 324 ,6095, 383-385.
64. Beta-Lactoglobulin - A Function from a Structure. Papiz MZ, Hambling SG, Sawyer L, Eliopoulos EE, Yewdall S, North ACT, Sivaprasadarao R, Findlay JBC 1986 J. of Mol. Graphics 4: (4) 237-238.
Αναφορές
65. Posttranslational processing of Concanavalin A precursors in Jackbean cotyledons. Bowles, D.J., Marcus, S.E., Pappin, D.J.C., Findlay, J.B.C., Eliopoulos, E. and Burgess, J. 1986 J.Cell.Biol. 102,1285-1297.
66. The structure and function of bovine beta-lactoglobulin. Sawyer, L., Papiz, M.Z., North, A.C.T. and Eliopoulos, E. 1985 Biochemical Society Transactions, 13, 265-266.
67. Divergent protein coding in otherwise closely related androgen regulated mRNAs. McDonald, C.J., Eliopoulos, E. and Higgins, S.J. 1984 The EMBO Journal 3, 11, 2517-21.
Αναφορές 22
68. A structural model for ovine rhodopsin. Pappin D.J.C., Eliopoulos E., Brett M. and Findlay J.B.C. 1984 Int.J.Biol.Macromol. 6,73-76.
69. The structure of ethyl 3-[4,5-dimethoxy-2-3-methyl-2-pyridylsulphamoyl-phenyl] propionate. Eliopoulos, E., Sheldrick B. and Hamodrakas S. 1983 Acta Cryst. C39, 1693-95.
70. The structure of ethyl 3-[4,5-dimethoxy-2-4-methyl-2-pyridyl sulphamoyl-phenyl]propionate Eliopoulos, E., Sheldrick B. and Hamodrakas S. 1983 Acta Cryst. C39, 743-745.
71. Rat relaxin: Insulin-like fold predicts a likely receptor binding region. Dodson G., Eliopoulos E.E., Isaacs, N.W., McCall, M.J.,Niall, H.D. & North A.C.T. 1982 Int.J.Biol.Macromol. 4, 399-405.
72. A structural model for the chromophore-binding domain of ovine rhodopsin. Eliopoulos E., Geddes A.J., Brett M., Pappin D.J.C. and Findlay J.B.C. 1982 Int.J.Biol Macromol. 4, 263-268.
Σύνολο αναφορών των δημοσιεύσεων 1989