Γεωπονικό Πανεπιστήμιο Αθηνών

Εργαστήριο Γενετικής

Ηλεκτρονικές Βιολογικές και Γεωπονικές Βάσεις Δεδομένων

Σημειώσεις του εργαστηρίου Βιολογικές Βάσεις Δεδομένων

Άσκηση 5η

ΗΛΙΑΣ ΗΛΙΟΠΟΥΛΟΣ

ΑΘΗΝΑ 2001

Άσκηση 5

Ανάλυση γενομικής πληροφορίας χρησιμοποιώντας το Internet

(Genomic information analysis using Internet functions)

Η χρήση των γενετικών βάσεων δεδομένων για την δημιουργία χαρτών περιοριστικών ενζύμων, μετάφραση και εύρεση ομολόγων ακολουθιών (με το BLAST).

Οι περισσότερες ασκήσεις που αναπτύσσονται παρακάτω χρησιμοποιούν την μέθοδο της αντιγραφής μιάς νουκλεοτιδικής ή πρωτεϊνικής ακολουθίας από παράθυρο (Netscape ή Explorer) σε παράθυρο. Γι’αυτό είναι χρήσιμο να χρησιμοποιούνται δύο παράθυρα ταυτόχρονα με το ίδιο πρόγραμμα δικτύου (Netscape ή Explorer) και την μεταφορά της πληροφορίας με «Αποκοπή-Επικόλληση» (Cut-Paste).

Διαδικτυακά κέντρα (Internet Sites) που θα χρησιμοποιηθούν:

• NCBI Entrez (http://www.ncbi.nlm.nih.gov/Entrez)
• SRS (Sequence retrieval system) ( http://srs.ebi.ac.uk/ )
• (http://www.firstmarket.com/cutter/cut2.html) Webcutter (για τον εντοπισμό θέσεων περιοριστικών ενζύμων)
• Sequence translator at ebi (http://www2.ebi.ac.uk/translate )
• BLAST για αναζήτηση ακολουθιών (www2.ebi.ac..uk/blastall)
• CLUSTALW για ευθυγράμμιση ακολουθιών (www2.ebi.ac.uk/clustalw/)
• bio.lundberg.gu.se/edu/translat.html για μετάφραση νουκλεοτιδικών σε αμινοξικές ακολουθίες
• bio.lundberg.gu.se/edu/msf2.html για ευθυγράμμιση δύο ακολουθιών
• bio.lundberg.gu.se/edu/msf1.html για πολλαπλή ευθυγράμιση ακολουθιών

Δ. Ανάλυση της γενομικής πληροφορίας.

Οι παρακάτω ασκήσεις περιέχουν την ευθυγράμμιση 2-4 διαφορετικών ακολουθιών. Χρήσιμες περιοχές του διαδικτύου για την ευθυγράμμιση 2 ακολουθιών είναι:

· bio.lundberg.gu.se/edu/msf2.html (select global alignment!)

· www2.ebi.ac.uk/clustalw

Για πολλαπλή ευθυγράμμιση:

· bio.lundberg.gu.se/edu/msf1.html

1. Επαναλήψεις Alu .

Χρησιμοποιείστε την SRS για να ανακαλέσετε την νουκλεοτιδική ακολουθία Z82206, μία ακολουθία από το ανθρώπινο χρωμόσωμα 22 (Στην SRS επιλέξτε EMBL ως βάση δεδομένων και εισάγετε τον κωδικό στο πεδίο "AccNumber" . Η περιοχή επεξηγήσεων της ακολουθίας μπορεί να χρησιμοποιηθεί για την αναγνώριση των επαναλήψεων Alu ("repeat region .. Alu.."). Μέρος του πίνακα στοιχείων της περιοχής επεξηγήσεων θα είναι όπως παρακάτω:

FT repeat_region 1495..1797

FT /note="AluSp repeat: matches 1..303 of consensus"

FT repeat_region 2171..2375

FT /note="AluJo repeat: matches 100..302 of consensus"

FT /note="incomplete repeat"

FT repeat_region 2443..2519

FT /note="MIR repeat: matches 191..260 of consensus"

FT repeat_region 2664..2966

FT /note="AluSp repeat: matches 1..303 of consensus"

FT repeat_region 3146..4279

FT /note="TIGGER1 repeat: matches 2418..1298 of consensus"

FT repeat_region 4273..5430

FT /note="TIGGER1 repeat: matches 1172..1 of consensus"

FT repeat_region 6761..7062

FT /note="AluSx repeat: matches 1..302 of consensus"

FT repeat_region 7771..8069

FT /note="AluSc repeat: matches 1..299 of consensus"

FT repeat_region 8289..8692

FT /note="MLT1A1 repeat: matches 3..365 of consen

Χρησιμοποιήστε πολλαπλή ευθυγράμμιση για να συγκρίνετε τέσσερεις διαφορετικές επαναλήψεις Alu. Επιλέξτε για παράδειγμα τις περιοχές 1495..1797, 2171..2375, 6761..7062 and 7771..8069. Είναι ομόλογες;

2. Δομή εξονίων - ιντρονίων.

1. Αναγνώριση γονιδίου με το BLAST. Χρησιμοποιείστε την ίδια ακολουθία με κωδικό Z82206 όπως και παραπάνω. Στην περιοχή επεξήγησης υπάρχει πληροφορία για ένα τμήμα της το (<20809..21617). Χρησιμοποιείστε το ακολουθιών BLAST (www2.ebi.ac.uk/blastall/) για να συγκρίνετε την ακολουθία αυτού του τμήματος με την βάση δεδομένων. Επιλέξτε ως βάση την nr). Ποιά είναι η πρωτείνη που κωδικοποιείται από το εξόνιο;

2. Ευθυγράμμιση γενομικής ακολουθίας με mRNA. Ανακαλέστε τις ακολουθίες DNA με κωδικούς V00594 (Human mRNA για την metallothionein) και J00271 (αντίστοιχη γενομική ακολουθία). Συγκρίνετε αυτές τις ακολουθίες με ευθυγράμμιση ακολουθιών. Χρησιμοποιείστε το bio.lundberg.gu.se/edu/msf2.html. Βασιστείτε στην ευθυγράμμιση για να πείτε πόσα εξόνια υπάρχουν στο γονίδιο. Συγκρίνετε τα αποτελέσματα σας με την επεξήγηση που δίνεται στην περιγραφή του J00271.

3. Ψευδογονίδια.

Επιλέξτε τις παρακάτω ακολουθίες ανθρώπινης beta-tubulin :

Κανονική γενομική ακολουθία : DNA

mRNA της beta-tubulin

Ενα ψευδογονίδιο : DNA

Κανονική beta-tubulin : πρωτείνη

Εξετάστε αυτές τις ακολουθίες για να βρείτε γιατί τα ψευτογονίδια δεν δίνουν λειτουργικές πρωτείνες.

Μεθοδολογία:

1. Ευθυγραμμίστε τις νουκλεοτιδικές ακολουθίες hum_beta_tub_DNA, hum_beta_tub_mRNA, και hum_beta_tub_pseudoDNA. Για την ευκολία σας και οι τρείς ακολουθίες βρίσκονται στο αρχείο beta_tub_nuclseq.htm . Απο το αποτέλεσμα της ευθυγράμμισης εντοπίστε και επιλέξτε τις κοινές περιοχές των τριών ακολουθιών.
2. Μεταφράστε το ψευτογονίδιο και στα τρία αναγνωστικά πλαίσια. Συγκρίνατε κάθε ένα από τα προϊόντα της μετάφρασης με την αμινοξική ακολουθία της betatubulin (betatub). Αφού εντοπίσετε το σωστό αναγνωστικό πλαίσιο, ευθυγραμμίστε την αμινοξική ακολουθία που προκύπτει από την μετάφραση του ψευδογονιδίου και την κανονική beta-tubulin. Ποιά είναι η κύρια διαφορά; Ποιές είναι οι σημαντικές διαφορές σε επίπεδο νουκλεοτιδίων;

 
ΠΑΡΑΡΤΗΜΑ
Δ.1.a
 
ID HS370M22 standard; DNA; HUM; 143747 BP.
XX
AC Z82206;
XX
SV Z82206.1
XX
DT 08-NOV-1996 (Rel. 49, Created)
DT 26-FEB-1998 (Rel. 54, Last updated, Version 7)
XX
DE Human DNA sequence from PAC 370M22 on chromosome 22q12-qter.
DE contains GRB2 ADAPTOR LIKE PROTEIN, UBIQUINOL-CYTOCHROME C
DE REDUCTASE IRON-SULFUR SUBUNIT PRECURSOR (UQCRFS1) exon,
DE  ESTs, STS, CA repeat and CpG island.
XX
KW 22q12-qter; CpG island; GRB2; repeat polymorphism; UQCRFS1.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria;
OC Primates; Catarrhini; Hominidae; Homo.
XX
RN [1]
RP 1-143747
RA Burgess J., Whiteley M.;
RT ;
RL Submitted (09-DEC-1997) to the EMBL/GenBank/DDBJ databases.
RL Chromosome 22 Project Group (http://www.sanger.ac.uk/HGP/Chr22/) Sanger
RL Centre, Hinxton, Cambridgeshire, CB10 1SA, UK. E-mail enquires:
RL humquery@sanger.ac.uk Clone requests: clonerequest@sanger.ac.uk
XX
DR RZPD; RPCIP704M22370; 16-Jul-1999.
DR SPTREMBL; O43726; O43726.
XX
CC IMPORTANT: This sequence is not the entire insert of clone
CC 370M22. It may be shorter because we only sequence overlapping
CC sections once, or longer because we arrange for a small
CC overlap between neighbouring submissions.
XX
CC During sequence assembly data is compared from overlapping clones.
CC Where differences are found these are annotated as variations together
CC with a note of the overlapping clone name. Note that the variations
CC annotated may not be found in the sequence submission corresponding to
CC the overlapping clone as we submit sequences with only a small overlap
CC as described above.
XX
CC This sequence was generated from part of bacterial clone contigs of
CC human chromosome 22, constructed by the Sanger Centre chromosome 22
CC mapping group. Further information can be found at
CC http://www.sanger.ac.uk/HGP/Chr22/
XX
CC This sequence has been finished according to sequence map criteria
CC as follows. An attempt is made to resolve all sequencing problems,
CC such as compressions and repeats, but not necessarily within known
CC annotated human repeat sequence elements (e.g. Alu). Where the
CC sequence is ambiguous, there is an annotation using the "unsure"
CC feature key.
XX
CC The true left end of clone 370M22 is at 1 in this sequence.
CC The true left end of clone 140N12 is at 69666.
CC The true left end of clone 496C20 is at 143644.
XX
CC 370M22 is from the library RPCI3 constructed at the Roswell Park Cancer
CC Institute by the group of Pieter de Jong.
CC For further details see http://bacpac.med.buffalo.edu/
XX
FH Key Location/Qualifiers
FH
FT source 1..143747
FT /chromosome="22"
FT /db_xref="taxon:9606"
FT /db_xref="RZPD:RPCIP704M22370"
FT /organism="Homo sapiens"
FT /map="22q12-qter"
FT /clone="370M22"
FT /clone_lib="RPCI3"
FT exon <20814..21617
FT  /note="match: P47985"
FT /product="UQCRFS1"
FT 5'UTR join(46642..46832,92595..92608)
FT /note="GRB2L"
FT CDS join(92609..92686,101321..101412,105557..105676,
FT 111492..111660,116407..116586)
FT  /db_xref="SPTREMBL:O43726"
FT /product="dJ370M22.1 (growth factor receptor bound-protein
FT 2 like"
FT  /gene="GRB2L"
FT /protein_id="CAB05103.1"
FT /translation="MEAVAKFDFTASGEDELSFHTGDVLKILSNQEEWFKAELGSQEGY
FT VPKNFIDIQFPKWFHEGLSRHQAENLLMGKEVGFFIIRASQSSPGDFSISVRHEDDVQH
FT FKVMRDNKGNYFLWTEKFPSLNKLVDYYRTNSISRQKQIFLRDRTREDQRVRWARALYD
FT FEALEDDELGFHSGEVVEVLDSSNPSWWTGRLHNKLGLFPANYVAPMTR"
FT 3'UTR  116581..116730
FT /note="GRB2L"
FT prim_transcript <118442..>118798
FT /note="match: EST F21127"
FT misc_feature 21614..21904
FT /note="match: STS G13234"
FT misc_feature 66394..66519
FT /note="match: Z16533 STS containing (CA) repeat"
FT repeat_region 66446..66491
FT /note="26 copies of copies of AC 100% conserved"
FT /note="differs from Z23853"
FT misc_feature 82463..82669
FT /note="match: STS G04359"
FT misc_feature 109482..109984
FT /note="match: STS G33279"
FT misc_feature 124959..125267
FT /note="match: STS L18079"
FT misc_feature 129677..129859
FT /note="match: exon trap H55317 clone C22_318"
FT misc_feature 131684..132022
FT /note="match: Z23853 STS containing (CA) repeat"
FT repeat_region 131855..131904
FT /note="25 copies of AC 100% conserved"
FT /note="differs from Z23853"
FT misc_feature 139983..140988
FT /note="Putative CpG island"
FT repeat_region 1093..1122
FT /note="15 copies of 2 mer 90 % conserved"
FT repeat_region 15486..15509
FT /note="6 copies of 4 mer 100 % conserved"
FT repeat_region 16693..16724
FT /note="8 copies of 4 mer 97 % conserved"
FT repeat_region 35620..35667
FT /note="12 copies of 4 mer 88 % conserved"
FT repeat_region 74763..74794
FT /note="16 copies of 2 mer 88 % conserved"
FT repeat_region 80677..80720
FT /note="11 copies of 4 mer 82 % conserved"
FT repeat_region 82166..82211
FT  /note="23 copies of 2 mer 83 % conserved"
FT repeat_region 85868..85901
FT /note="17 copies of 2 mer 88 % conserved"
FT repeat_region 93459..93527
FT /note="3 copies of 23 mer 100 % conserved"
FT repeat_region 112483..112516
FT /note="17 copies of 2 mer 91 % conserved"
FT repeat_region 113961..114026
FT /note="33 copies of 2 mer 88 % conserved"
FT repeat_region 117873..118004
FT /note="3 copies of 44 mer 80 % conserved"
FT repeat_region 120615..120656
FT  /note="21 copies of 2 mer 83 % conserved"
FT repeat_region 125089..125144
FT /note="14 copies of 4 mer 91 % conserved"
FT repeat_region 128261..128288
FT /note="14 copies of 2 mer 100 % conserved"
FT repeat_region 132903..132948
FT /note="23 copies of 2 mer 94 % conserved"
FT repeat_region 1495..1797
FT /note="AluSp repeat: matches 1..303 of consensus"
FT repeat_region 2171..2375
FT /note="AluJo repeat: matches 100..302 of consensus"
FT /note="incomplete repeat"
FT repeat_region 2443..2519
FT /note="MIR repeat: matches 191..260 of consensus"
FT repeat_region 2664..2966
FT /note="AluSp repeat: matches 1..303 of consensus"
FT repeat_region 3146..4279
FT /note="TIGGER1 repeat: matches 2418..1298 of consensus"
FT repeat_region 4273..5430
FT /note="TIGGER1 repeat: matches 1172..1 of consensus"
FT repeat_region 6761..7062
FT /note="AluSx repeat: matches 1..302 of consensus"
FT repeat_region 7771..8069
FT /note="AluSc repeat: matches 1..299 of consensus"
FT repeat_region 8289..8692
FT /note="MLT1A1 repeat: matches 3..365 of consensus"
FT repeat_region 8919..8993
FT /note="MIR repeat: matches 64..139 of consensus"
FT repeat_region 10022..10149
FT  /note="MIR2 repeat: matches 1..131 of consensus"
FT repeat_region 10152..10411
FT /note="AluSx repeat: matches 40..299 of consensus"
FT /note="incomplete repeat"
FT repeat_region 11784..11920
FT /note="MIR2 repeat: matches 146..5 of consensus"
FT repeat_region 12411..12704
FT /note="AluY repeat: matches 293..1 of consensus"
FT  repeat_region 13230..13305
FT /note="AluSp repeat: matches 218..293 of consensus"
FT /note="incomplete repeat"
FT repeat_region 14003..14383
FT /note="L1 repeat: matches 5005..5390 of consensus"
FT repeat_region 14238..15135
FT /note="L1PA15 repeat: matches 1..904 of consensus"
FT repeat_region 15511..15810
FT /note="AluSx repeat: matches 302..1 of consensus"
FT repeat_region 16405..16692
FT /note="AluJo repeat: matches 13..302 of consensus"
FT repeat_region 16879..16980
FT /note="MIR repeat: matches 188..74 of consensus"
FT repeat_region 18353..18613
FT /note="AluJo repeat: matches 299..1 of consensus"
FT repeat_region 19394..19747
FT /note="THE1B repeat: matches 364..1 of consensus"
FT repeat_region 19832..19904
FT /note="7SK repeat: matches 193..121 of consensus"
FT repeat_region 19942..20004
FT /note="7SK repeat: matches 124..62 of consensus"
FT repeat_region 20085..20281
FT /note="L1 repeat: matches 5190..5387 of consensus"
FT repeat_region 20137..20812
FT /note="L1MB8 repeat: matches 1..729 of consensus"
FT repeat_region 22036..22213
FT /note="L1ME2 repeat: matches 710..902 of consensus"
FT repeat_region 22368..22434
FT /note="MIR2 repeat: matches 144..76 of consensus"
FT repeat_region 24469..24679
FT /note="L1 repeat: matches 5137..5350 of consensus"
FT repeat_region 24576..24682
FT /note="L1MC1 repeat: matches 5..113 of consensus"
FT repeat_region 24683..24984
FT /note="AluY repeat: matches 1..301 of consensus"
FT repeat_region 24986..25447
FT /note="L1MC3 repeat: matches 100..572 of consensus"
FT repeat_region 25448..25719
FT /note="AluJo repeat: matches 1..267 of consensus"
FT /note="incomplete repeat"
FT repeat_region 25728..26165
FT /note="L1MC2 repeat: matches 639..1077 of consensus"
FT repeat_region 26374..26597
FT /note="MIR repeat: matches 1..234 of consensus"
FT repeat_region 27032..27165
FT  /note="MIR2 repeat: matches 128..2 of consensus"
FT repeat_region 28225..28525
FT /note="AluSg repeat: matches 1..300 of consensus"
FT repeat_region 29230..29375
FT /note="AluY repeat: matches 155..301 of consensus"
FT  /note="incomplete repeat"
FT repeat_region 29383..29450
FT /note="L1 repeat: matches 4369..4440 of consensus"
FT repeat_region 29493..29659
FT /note="L1 repeat: matches 4425..4590 of consensus"
FT repeat_region 29682..29981
FT /note="AluSx repeat: matches 299..1 of consensus"
FT repeat_region 30073..30758
FT /note="L1 repeat: matches 4687..5390 of consensus"
FT repeat_region 30616..31458
FT /note="L1MB5 repeat: matches 1..896 of consensus"
FT repeat_region 31493..31559
FT  /note="L1ME1 repeat: matches 844..910 of consensus"
FT repeat_region 31583..32083
FT /note="L1MC2 repeat: matches 561..1077 of consensus"
FT repeat_region 32716..32876
FT /note="FAM repeat: matches 161..1 of consensus"
FT repeat_region 33765..33935
FT /note="AluJo repeat: matches 302..135 of consensus"
FT /note="incomplete repeat"
FT repeat_region 33936..34227
FT /note="AluSg repeat: matches 292..1 of consensus"
FT repeat_region 34229..34354
FT /note="AluJb repeat: matches 143..19 of consensus"
FT /note="incomplete repeat"
FT repeat_region 35317..35619
FT /note="AluSx repeat: matches 1..302 of consensus"
FT repeat_region 36768..36899
FT /note="MIR2 repeat: matches 1..135 of consensus"
FT repeat_region 36978..37103
FT /note="FLAM_A repeat: matches 130..5 of consensus"
FT repeat_region 37123..37421
FT /note="AluSx repeat: matches 298..1 of consensus"
FT repeat_region 37432..37484
FT /note="FLAM repeat: matches 126..72 of consensus"
FT repeat_region 38450..38534
FT /note="MIR2 repeat: matches 146..60 of consensus"
FT repeat_region 39764..40023
FT /note="L1PA2 repeat: matches 584..843 of consensus"
FT repeat_region 41080..41162
FT /note="MIR repeat: matches 206..119 of consensus"
FT repeat_region 41173..41227
FT /note="MIR2 repeat: matches 146..87 of consensus"
FT repeat_region 43019..43321
FT /note="AluSp repeat: matches 303..1 of consensus"
FT repeat_region  43807..43939
FT /note="MIR2 repeat: matches 11..145 of consensus"
FT repeat_region 44033..44334
FT /note="AluSx repeat: matches 1..302 of consensus"
FT repeat_region 45203..45499
FT /note="AluSq repeat: matches 1..294 of consensus"
FT repeat_region 48291..48350
FT /note="MIR repeat: matches 159..216 of consensus"
FT repeat_region 48870..48934
FT /note="AluSx repeat: matches 1..65 of consensus"
FT /note="incomplete repeat"
FT repeat_region 48978..49278
FT /note="AluJb repeat: matches 302..1 of consensus"
FT repeat_region 49337..49391
FT /note="MIR2 repeat: matches 139..85 of consensus"
FT repeat_region 49611..49909
FT /note="AluSx repeat: matches 2..302 of consensus"
FT repeat_region 50022..50650
FT /note="MER42c repeat: matches 1409..774 of consensus"
FT repeat_region 50893..51101
FT  /note="MIR repeat: matches 12..225 of consensus"
FT repeat_region 51108..51321
FT /note="MIR repeat: matches 236..21 of consensus"
FT repeat_region 52992..53261
FT /note="AluJb repeat: matches 36..300 of consensus"
FT  /note="incomplete repeat"
FT repeat_region 53518..53605
FT /note="MIR repeat: matches 56..144 of consensus"
FT repeat_region 55909..56208
FT /note="AluSg repeat: matches 300..1 of consensus"
FT repeat_region 57291..57440
FT /note="MER5A repeat: matches 11..183 of consensus"
FT repeat_region 57641..57933
FT /note="AluJo repeat: matches 1..292 of consensus"
FT repeat_region 57982..58157
FT /note="MER20 repeat: matches 29..214 of consensus"
FT repeat_region 58413..58713
FT /note="AluSx repeat: matches 1..301 of consensus"
FT repeat_region 60409..60710
FT /note="AluSx repeat: matches 1..302 of consensus"
FT repeat_region 64499..64657
FT /note="AluJo repeat: matches 137..302 of consensus"
FT /note="incomplete repeat"
FT repeat_region 65359..65466
FT /note="MIR repeat: matches 220..105 of consensus"
FT repeat_region 66706..66905
FT /note="MIR repeat: matches 37..225 of consensus"
FT repeat_region 67304..67432
FT /note="AluJo repeat: matches 302..176 of consensus"
FT /note="incomplete repeat"
FT repeat_region 68263..68558
FT /note="AluSx repeat: matches 1..298 of consensus"
FT repeat_region 69006..69104
FT /note="MIR2 repeat: matches 1..95 of consensus"
FT repeat_region 69921..70217
FT /note="AluSx repeat: matches 1..296 of consensus"
FT repeat_region 71545..71681
FT /note="MIR2 repeat: matches 2..144 of consensus"
FT repeat_region 74632..74758
FT  /note="MER42B repeat: matches 1143..1273 of consensus"
FT repeat_region 75455..75724
FT /note="MER33 repeat: matches 45..322 of consensus"
FT repeat_region 75823..75989
FT /note="MIR repeat: matches 43..213 of consensus"
FT repeat_region 76591..76671
FT /note="MIR2 repeat: matches 59..142 of consensus"
FT repeat_region 77931..78235
FT /note="AluJb repeat: matches 1..299 of consensus"
FT repeat_region 78247..78492
FT /note="MIR repeat: matches 260..14 of consensus"
FT repeat_region 79061..79361
FT /note="AluSq repeat: matches 1..302 of consensus"
FT repeat_region 80218..80390
FT /note="AluJb repeat: matches 128..300 of consensus"
FT /note="incomplete repeat"
FT repeat_region 83187..83304
FT /note="MIR repeat: matches 153..28 of consensus"
FT repeat_region 84783..85083
FT /note="AluY repeat: matches 1..301 of consensus"
FT repeat_region 85166..85424
FT /note="AluSx repeat: matches 37..298 of consensus"
FT /note="incomplete repeat"
FT repeat_region 86665..86720
FT /note="MIR2 repeat: matches 145..94 of consensus"
FT repeat_region 88004..88295
FT /note="AluJo repeat: matches 1..286 of consensus"
FT repeat_region 89221..89506
FT /note="AluSc repeat: matches 299..1 of consensus"
FT repeat_region 91361..91662
FT /note="AluSx repeat: matches 302..1 of consensus"
FT repeat_region 91663..91808
FT /note="MIR repeat: matches 204..51 of consensus"
FT repeat_region 94779..94999
FT /note="MIR repeat: matches 259..30 of consensus"
FT repeat_region 97527..97828
FT  /note="AluSx repeat: matches 302..1 of consensus"
FT repeat_region 98339..98435
FT /note="MIR repeat: matches 221..130 of consensus"
FT repeat_region 99117..99414
FT /note="AluJo repeat: matches 295..1 of consensus"
FT repeat_region 99908..100196
FT /note="AluSx repeat: matches 292..1 of consensus"
FT repeat_region 100581..100878
FT /note="AluSc repeat: matches 3..299 of consensus"
FT repeat_region 101659..101958
FT /note="AluJb repeat: matches 301..1 of consensus"
FT repeat_region 102001..102270
FT /note="AluSx repeat: matches 294..1 of consensus"
FT repeat_region 103166..103451
FT /note="AluJo repeat: matches 12..296 of consensus"
FT repeat_region 103915..104060
FT /note="MIR2 repeat: matches 1..146 of consensus"
FT repeat_region 106167..106445
FT /note="MER39 repeat: matches 16..298 of consensus"
FT repeat_region 106456..106715
FT /note="AluJo repeat: matches 301..41 of consensus"
FT /note="incomplete repeat"
FT repeat_region 106791..106861
FT /note="MER39 repeat: matches 434..511 of consensus"
FT repeat_region 107643..107938
FT /note="AluJo repeat: matches 1..294 of consensus"
FT repeat_region 108163..108468
FT /note="AluSx repeat: matches 297..3 of consensus"
FT repeat_region 109238..109526
FT /note="AluY repeat: matches 1..290 of consensus"
FT repeat_region 110452..110563
FT /note="MIR repeat: matches 33..152 of consensus"
FT repeat_region 110614..110894
FT /note="AluSx repeat: matches 5..302 of consensus"
FT repeat_region 111789..111931
FT /note="MIR repeat: matches 48..201 of consensus"
FT repeat_region 112249..112463
FT /note="MIR repeat: matches 38..256 of consensus"
FT repeat_region 112884..112934
FT /note="MIR repeat: matches 181..231 of consensus"
FT repeat_region 112909..112973
FT /note="MIR2 repeat: matches 84..141 of consensus"
FT repeat_region 114588..114706
FT /note="MIR2 repeat: matches 17..146 of consensus"
FT repeat_region 115134..115436
FT /note="AluSq repeat: matches 1..303 of consensus"
FT repeat_region 115619..115882
FT /note="AluJo repeat: matches 299..1 of consensus"
FT repeat_region 116142..116265
FT  /note="AluJo repeat: matches 2..125 of consensus"
FT /note="incomplete repeat"
FT repeat_region 117479..117543
FT /note="L1 repeat: matches 3836..3777 of consensus"
FT repeat_region 120657..120958
FT /note="AluSx repeat: matches 302..1 of consensus"
FT repeat_region 121085..121146
FT /note="AluSc repeat: matches 258..194 of consensus"
FT /note="incomplete repeat"
FT repeat_region 121156..121268
FT /note="MIR2 repeat: matches 30..146 of consensus"
FT repeat_region 122626..122759
FT /note="MER3 repeat: matches 2..132 of consensus"
FT repeat_region 123266..123564
FT /note="AluSg repeat: matches 1..299 of consensus"
FT repeat_region 123607..124175
FT /note="L1MC1 repeat: matches 30..621 of consensus"
FT repeat_region 124185..124490
FT /note="AluSx repeat: matches 302..1 of consensus"
FT repeat_region 124491..124962
FT /note="L1MC1 repeat: matches 604..1079 of consensus"
FT repeat_region 126470..126596
FT /note="MIR repeat: matches 9..142 of consensus"
FT repeat_region 126741..126779
FT /note="FLAM repeat: matches 86..124 of consensus"
FT repeat_region 126782..127076
FT /note="AluSx repeat: matches 296..1 of consensus"
FT repeat_region 127094..127271
FT /note="AluJo repeat: matches 131..302 of consensus"
FT /note="incomplete repeat"
FT repeat_region 127284..127582
FT /note="AluSg repeat: matches 1..299 of consensus"
FT repeat_region 127650..127784
FT /note="AluSq repeat: matches 1..135 of consensus"
FT /note="incomplete repeat"
FT  repeat_region 127785..128084
FT /note="AluSq repeat: matches 1..301 of consensus"
FT repeat_region 128086..128260
FT /note="AluSg repeat: matches 126..300 of consensus"
FT /note="incomplete repeat"
FT repeat_region 128291..128587
FT /note="AluSx repeat: matches 1..297 of consensus"
FT repeat_region 129700..129813
FT /note="MIR repeat: matches 25..151 of consensus"
FT repeat_region 129961..130296
FT /note="AluSc repeat: matches 2..299 of consensus"
FT repeat_region 132088..132357
FT /note="AluSq repeat: matches 33..303 of consensus"
FT /note="incomplete repeat"
FT repeat_region 132662..132851
FT /note="AluJo repeat: matches 111..296 of consensus"
FT /note="incomplete repeat"
FT repeat_region 133113..133404
FT /note="AluSc repeat: matches 1..289 of consensus"
FT repeat_region 133407..133704
FT /note="AluSq repeat: matches 4..303 of consensus"
FT repeat_region 135744..136040
FT  /note="AluSq repeat: matches 1..298 of consensus"
FT repeat_region 136951..137099
FT /note="MIR repeat: matches 2..151 of consensus"
FT repeat_region 137100..137262
FT /note="AluJo repeat: matches 300..126 of consensus"
FT  /note="incomplete repeat"
FT repeat_region 137557..137680
FT /note="FLAM_A repeat: matches 126..1 of consensus"
FT repeat_region 137692..137832
FT /note="MIR repeat: matches 152..11 of consensus"
FT repeat_region 137852..137950
FT /note="MER5A repeat: matches 11..109 of consensus"
FT repeat_region 138055..138159
FT /note="MIR repeat: matches 192..98 of consensus"
FT repeat_region 138428..138467
FT /note="MIR2 repeat: matches 97..136 of consensus"
FT repeat_region 138516..138799
FT /note="AluSg repeat: matches 13..298 of consensus"
FT repeat_region 139351..139430
FT  /note="MIR repeat: matches 60..145 of consensus"
FT repeat_region 141614..141666
FT /note="MIR2 repeat: matches 124..71 of consensus"
FT repeat_region 142475..142694
FT /note="MIR repeat: matches 249..2 of consensus"
FT repeat_region 143445..143510
FT /note="MIR repeat: matches 149..85 of consensus"
XX
SQ Sequence 143747 BP; 41994 A; 31978 C; 30808 G; 38967 T; 0 other;
 gatcattttt gtaataactg ttgcctctac aaaaatggcc tgatgcttag agctgagtta 60
 taattgtcct ttttgtattg ttctgtcttg ccatcaagca gcaatgatcc ttcagtccat 120
 ctcttccttc aaacttcaaa agcatcgaaa caaaaaccac ccaggctatc tactagaatt  180
 aaaacttggg aaaacatcca agaaaagaaa aaaaaaaaga agtagaagtg gtgatgtgta 240
 tataacacct tctttaaagt gcctcttttc ccttgctgat tcaccataaa gaagggaagc 300
 acagctgttt cagctctagg tcctaaaggc tggaaatcac atttcctgca ttcaatttta 360
  catttcactg taactaaata acttagagac atctttagac tccttctaat gaaaatttac 420
 ctgtatgata tcatcacttg cctccatttt ctctaatgca aatgttagtc aatttcaatt 480
 tctctcttct ccagtacatc atccacttac ccccattgcc tctctacagt ctatctttaa 540
 acactactgt ttcctcattt ctataaccct aggagcaggt cctggatgcc tggattgaaa 600
 caactgtctc ttacaagctt cgttcaattt gtatctcctt catttctaca caaagcaata 660
 agaattatct tccacaaata gctgttttca gtaataagga agctcagttc tgtgactaag 720
 ctaaacattc cttctgttct ccaaggccta caatggttcc tagttgctac tcatatcaaa 780
 ctgagtttat tagctcattt atgaattgct ctgagtactc tcagctatct acccctactg 840
 ttttacatat tcaaatttat atttttattc catttagtca gacaactctg tattaccatg 900
 cttaatctgt gtcttgcttg tattctttac cattattgta gaaatgattt gtggtcccga 960
 gcatttattc tctccatctt ccttaataac agaatctctt aactttcatc tgggcacatg 1020
 atatttctca acctcctttg tagctaggag tgtcagtggg actaagtact aaacaataat 1080
 atgtgacttg ttaaaaaaaa aaaaaagaag aaagaaaaaa aagggaagag acattcatat 1140
 tttcaatctc ccttcctttc tcctggctag aaggcagatg tgatggctgg agctcaagca 1200
 gcaatgaatc aaaaagtgga agtggatcat gaagtggaac ttaaacgctg agtttggtgg 1260
 agcaatgaga ctcaaaaata gccctgaagc caacagtgta gagagccata tcagtcatag 1320
 aacacctaca agagagtatt tcagaagaga gaaataaatt tgtatgttta agctgctagc 1380
 atttttgtgg cctctactat cataacttgt ggatgcacct ccttctaact aatctaccta 1440
 tctttgagtt ttaatttgct acttctcctg tcccattaag aatgtccccc tcgtggccgg 1500
 gcgcggtggc tcaacgcctg taatcccagc actttgggag gctgaggcgg gcagatcacc 1560
 tgaggtcggg agttcaagac tagtctgacc aacatggaga aaccccgtct ctactaaaaa 1620
 tacaaaatta gccgggtatg gtggcatgtg cctgtaatcc cagatactgg ggaggctgag 1680
 gcaggagaac cacttgaacc tgggaggcag aggttgcggt gagccaagat tgcaccattg 1740
 cactccagcc tgggcaacaa gagtgaaact tcatctcaaa aaaaaaaaaa aaaaaaaaag 1800
 aatgtcccct caatttctta ttttttccca ccccaactcc aaactgtcag ttttctttct 1860
 tcctttaaaa tacagcttca gattcaaatg cctacatgga attggttagt attgccaagt 1920
 ttacttaatc caattactct tttttgaaca caaacacaga catctgtata tctaggatgt 1980
 actcatatag aaagcagata aatgaaataa aaataacaga tttaaaacaa atttactata 2040
 gattttacat ccaaacattc actgttcgct ttaaatggta ctcttactat agatatacaa 2100
 taatgatgcc atcattgact aaagcttttt tagaacatct tttttgtgaa acatacttaa 2160
 aagcacatgg tagcaagatc ttgtctcgaa aaaatatttt ttcaagtcag ctgggtgtgg 2220
 cggtgtgtgc ctgtagtccc agctagttgg taggctaagc caggaggatt acttgagtcc 2280
 agtagttcaa ggctgcagtg agtcattatc acaccactgc gctcctgccg gggtgacaga 2340
 gcaagaccct gtctcaaaaa aaaaaaaaaa agaaagaaag aaaaggaaaa gaaaaagcac 2400
 acagtacatc acaagctata gcctccaata gagcagaaat acagtcaatt tacttaacag 2460
 gcttagaaca atgtctggca ttatagtgag gagacactca atatgtgttt gtcgtattaa 2520
 aaaataataa attgtagcaa aacttcattt gaaagtggat tcactttttt aaaatagtca 2580
 agtcattcat agctcagtgt agtgaatgag acatgtcata aagatggaga atatcatttt 2640
 aggtttaaaa acgcaatctg tggggctggg cgcagtggct catgactgta atcccagcac 2700
 tttgggaggc tgaggcaggc agatcatctg aggtcaggag ttcgagacca ccctgaccaa 2760
 catgaaggaa ccccgtctct acttaaaata caaaattagc caggcgtgat ggcgtatgcc 2820
 tgtaatccca gctactctgg aaggctgagg caggagaatc gcctgaaccc tggaggcaga 2880
 ggttgcagtg agccgagatg gtgccattgc tctccagcct ggacagcaag agtgaaactc 2940
 cgtctcaaaa aaaaaaaaaa aaaaaaaaaa aaaagcaatc tgtgactaca aaacaataaa 3000
 ctagaatttc ttgcatgaat cataaaatca gagttgggtt acttctgtat caatttaggg 3060
 attcatttct taagcttacg attcaccagg ccaagtttgc tccagtttca gagcatctac 3120
 cctgctgttc cctctgcctg atatacaggc acaccttgaa gatactgcgg tgggctgggt 3180
 tccagattac tgcaataaag caaatattcc aataaagcca ctcacacaaa catttttgtt 3240
 tcccagtgca tataaaagtt atgtttacat tagactgcag tctacttagt agactaagta 3300
 tgcaatacca tgctgcctaa aaaatatata tacataatta aataatactt tattgctaat 3360
 ttaaaaaggc taacaatcat ctgagccttc agcgagtctt catctttttg ctggtggagg 3420
 gtcttgtctc catgttgagg gctgctgata gatcagggtg gttgctgctg aaggttggga 3480
 aagctgtggc aattttttaa agtaagacaa caataaagcc tgcaacatca actgactctt 3540
 cctttcacaa aagatttatc tgtagcatgt gatgctgttt gatagcattt tacccacagt 3600
 agaacttctt tcaaaattgg agtcaatcct ctctaatcct gccactggtt tatttactaa 3660
 gtttatgtaa tattctgaat tctttgttgg cattgcaaca atgttcacag cttcttcaca 3720
 ggagtagatt tcaactcaag aaaccatttt ctttgctcat ccataagaag tatctcctca  3780
 tctgttcaag tttgatcatg agattgcagc aatccagtca catcttcagg ctccacttct 3840
 aattctagtt ctcttgctat ttccgccaca tctgcagttc cttcctccac tgaagtcttg 3900
 aacccctcaa agtcatccat aagggttgga atccacttct ttcaaactcc tgttaatgtt 3960
 gaaattttgg cttcctccca tgaatcacaa atgttcttaa tggcatctag agtggtgaat 4020
 cttttccaga aggtttttaa tttactttgc tcagatccat cagaggaatc actatctatg 4080
 gaagatatag ctttatgaaa tgtatttctt cagtaataag acttgaaagt tgaaatcact 4140
 ccttgatcca tgggctgaag aataaacact gtgttttagc aggcacgaaa acaatattaa 4200
 tctccttgta catctccatc agagctcttg ggtgaccagg tgcactgtca atgagcagta 4260
 atatttttaa agaaatctta agggcactag gattttggga atggtaaagg agcagttggc 4320
 ttcaacttaa agtcaccagt tgcattagtc cctaacaaga gagtcagcct gtcctttgaa 4380
 gctttgaagc caggcattga cttctcctct ctagctatga gagtcctaga tggcatcttt 4440
 ttccaacaaa aggctatttc acccacattg aaaatctatt tagtgtagcc cccttcatca 4500
 attaccttag ctagatcttc tggataactt gctacagctt ctccatcagt acttgctgct 4560
 tcactttgta cttgtgtgtt atggtgacag ttgctttcct tgaacctcat gaacccacct 4620
 ctgctagctt caagattttc ttctgcagtt tcctcttctc tctcagtctt tgcagaatta 4680
 aagacagtta gaaccttgct ctggattagg ctttggctta agtgataatg gggctagttg 4740
 gatcttctat ccagaccatg caacctttct ctataacagc aataaagctg tttcccattc 4800
 ttatcattcc cgtattcatt ggagcagcac ttctaatttc cttccagaac ttttccttta 4860
 cattcataac ttagctaact gtttggcaca agaggcctac ctttcagcct gtttcggctt  4920
 tcaacatgcc tttctcacta agtttaacca tttctagctt ttgaattaaa gtgagaaacc 4980
 tgcgactctt ccttacactt gaacacttag aggccattgt agggttatta attggcttaa 5040
 tttcaatatt gttgaccctc agggactagg gagacccaag gagagagaga gagatcggga 5100
  tcagtgaagc agtcagaaca cacatgacat ctatcagtaa gttcactggt cttctacagc 5160
 catggtttgt ggtaccccaa aacaattaca acagtaacat ctaagatcac tgatcataga 5220
 tcaccatgac acatataata ataaggaaaa agttaaaaat attgcaagaa ctaccaaaat 5280
 gtgacacaga cacaaagtat gcacatgcta tcagaaaaat ggtgccaata aacttcttgg 5340
 gtacaggatt gccacaaacc ttcaatttgt aaaatatacg ttatctgtga agtgtaatta 5400
 agcaaagtgc aatcgatcga ggtatgcctg tatgtgggtt gctccctcac ttcattcagg 5460
 tctgtttgaa gattcacttc ctccaaaagg ccctctctca ttacgtgacc taaaataaac 5520
 ccacccctgt cactctgttc cctgaccctg ctttcctttt ctttacagga cttgttatta 5580
 tctgacatat tttatgcttg tgacagagac atcccagtct ctaccactag aatgttagtt 5640
 ccatgataaa agaaaactta ttttactcac tcctatagtt ccaaatttct gctgaatatc 5700
 caaattttaa ataaattcaa taattatgtg tttacaatga aagaagaaag aactgacaaa 5760
 agaaaggaag aaggaagagt aagaaaggta acatcgaaga agcaaaagtg gggaagaaac 5820
 tctggatgag tcataattgg ttattcttct ctgttactct gtttttagca tcagtttgat 5880
 ttaaaggctc ccatgagaaa atttcagaat gagtggctgt ctctttcgga gatttatttc 5940
 aaaagaatca gatcccctaa agatcccacc acttttagaa gccggtaggt agtatttgct 6000
 actataatta caatggctac cctcttataa tgtctctctc caatcccaag tgtggatgtt 6060
 cactctatgt ctcactgggt gaacgtttga aactcttgat taagacagaa aagtacctga 6120
 atgattttta gcaagcttaa cttgtgttgg tattactagt aacattgtta catttttgca 6180
 cttaactgac agttggaatt atctatttgt actgaataca aagggacagt tctctaagtc 6240
  acatttcact aatgtttttg cttcctcaag ctgtccattt ctcatacaca acttatcaac 6300
 agggtttcta ctggagaagt tagagcaaaa tgacattttt taaagtttta gcaaatttgg 6360
 tagaaaagat gatagcattt ttctactcat gtctattata acattataaa taaatccctc 6420
 tgttataaaa gttcagtagt ccatatttaa agttttaagc aaaggaaagg gtaaaaggta 6480
 ttgtcctaga ataattttag agcactttta ggattctgaa gcatacttta gaaaatttca 6540
 attacttgat ttatgttaca ggatcaaaga gacctcatac gcacataact agacacctag 6600
 tcttagaaaa ctgtactcct tcactttcca gttaaggata aaaaacttaa aattgaatca 6660
 cgatgccaaa tagggtagtc actagtttaa taccttaaaa gctcaaaaac attttatttg 6720
 aatcaaagat aactgcattc agaaaacagt cataaaactg ggctgggcac agtggctcac 6780
 gcctataatc ccagcacttt cggaggccaa ggcaggagga tcacttgagg tcatgagttc 6840
 gagaccagcc tgggcaacat gctgaaaccc tgtctctact aaaaatacaa aaattagctg 6900
 ggcatggtga tgggtgcctg taatcccagc tactcaggag gctgagtcag gagaattgct 6960
 tgaacccagg agacagaggt tgcagtgagc tgagatagtg ccactacact ccagcctagg 7020
 agacagagca agattccgtc tcaaaaataa ataaataaat aaataaagca aacaaataaa 7080
 ctttaaaaag gtcataaaat cttctattga atattcttcg ttgttgtttt ctatagtatg 7140
 aagcctaata tggtaatagt aatactaaat aatattaata atttagtact aaaacataat 7200
 attttatatt tttaaatcat ttttaatgat acctgttgca ttttaggcca atgttcatta 7260
 tacgtacttt tattatgtaa ccttccaaac ttaggaagct tatacttctt ctctgaagca 7320
 gaaatatccg gtgtgggggc agaagtgcac gctgtcagtg agttacttga accaagttgt 7380
 cttttagaaa acaatataga gtgggaggta cgctgtctag tccgacatgc cacttccctc 7440
 tctttacaca gcaatggttc atccatcagc aatgtgatga cttgcttaga tttttcccgg 7500
 atataataac ctgaaaaata cattgactct gcttagaaaa ggaaatacta gttaaggcta 7560
 taattaattt tttttctaca gaaatttttt taaaaataaa aatctcagca gtgaaaaaac 7620
 ctgcagcaaa taaagaacta ctgataagta tattcctttt cttatacttt aaaaggtaaa 7680
 taagtcatta atatatgata aaattatata ctggcattac atttttcact ttaaatacat 7740
 tattggattt tccttttaaa agcaatatat ggctgggtgc ggtggctcat ggctgtaatc 7800
 tcagcacttt gggaggctga agtgggcaga tcacgaggtc aggaaatcaa gaccatcctg 7860
 gccaatatgg tgaaaccttg tctctactaa aatacaaaaa actagctggg catggtggca 7920
 tgtgcctgta gtcccagcta ctcaggaagc tgagacaggg gaatcacttg aactcaagag 7980
 gtagaggttg cagtgagctg agattgcacc actgcactcc agcttggcaa gagagcgaga 8040
 ctctgtctca aaaaaaaaaa aaaaaagaaa gaaaaagcaa taatactttg caataatcaa 8100
 acaatatagg catacaaaga aggggtatga attagatcta gatatactga cctagatgta 8160
 tgaccaggac acatggttaa agatttagag taacatacac aataggattt gaagctgtaa 8220
 catatagagg aaaagaaatc accatatatg tacacggaag agagaagcag ataaagaaat 8280
 acatacaact gtggtttgaa tgtatcccct ccaaaattca agtactgcca atgtgatagc 8340
 attaagaggt ggagccttta agaggtgatt atgccatgag gtcacctcct ttgtgaacag 8400
 actaaaggtc cttataaaag aggcttccca cagcatttgt ctcttgcttg ccttccacca 8460
 tcgcctttcg gaccttctgt cacatgagga cacagcattc ctcccttcca gaggatgcag 8520
 catcaaggcg ccatcttgga agcagacagc agccctcact agacaactga acctgccagt 8580
 gccctgaacc tggactctcc agcctccaga accatgagaa aataaatttc tcttctttct 8640
 aaattaccca gtctgtgata ctctgttata gcagcacaag cagactaaga cagatagaca 8700
 gacaggcaag aatataggaa ggcaggcagg caggcaaaca gatggcatac tcagaatatt 8760
 gttaacatct gttaccttac aggggtacag ttggggtggg acaagaaaag ggagagcaat 8820
 tggcttttct ctgacgtaac atcctatcaa aacaatttgc tgctttttaa cagagtgaca 8880
 gagcacagtc aaagacaaga attctagtga gagtgatagc tctgtcctta accatctgtg 8940
 tgactttcag tcagtcaggt ggtctatctg ggcctgagtc ttctatctga aaagcagcac 9000
 aagcagtatc tgtatggttg aattcccaga tacaaaggta cactgtaacc tataactcac 9060
 tcgaatataa ggtattacta ttttttcaac cttcttccta gaaaaacgat aaaggaaatc 9120
 acttaccttt ctccatcttg ggatgaactc acaaacatgg cttcccaagc cacctttcaa 9180
 aaataaactg aaaagtccct aatgatccac ttgtatgttc attttgggct ctaggtgtga 9240
 tgaattaaag tattaatgtt ttctaactat aatttactag cagtggaagt gatgagaaat 9300
 ggtcaaattt ggggtatatt tagatgacag tggccaacga tgttctctca ctgcgggtca 9360
 cttcattaag gactggtgtg gacagtgtca gcaacctttg ctcaagttgc catcttttcc 9420
 aagattattt tatctaatct cacttcttag ttatttcttc cttccaaatc tactttataa 9480
 ctgcttcaaa tcatatcatt ctaaacactc ttagcttcct atgatcagtt tgcattccat 9540
 aacccgaatt tccacaatgt tttgggtaac cattcagtgt cgtgtgataa acagaagtcg 9600
 gctgtgaatt ttagcctttg ggaacaatat gtcagacact tatctttccc ctgaaaaatg  9660
 gacaaagatt ggttttggag gcacaaagaa catgttttcc catttttaac atcaggaact 9720
 catctccttc caccttcccc ctcattcctt ctactctagc taccctggtg ctttattctg 9780
 caatcccacc aagctcttca tctacttaga gccatgtttt ggctgttgct tctgccagga 9840
 actctttgtg tggctctatc cctgattcat tcaggtctca agtgtcacct cctcagagaa 9900
 tctcccttct gcctaccctt tctaaaatag ccccaccctc atcactctct attcctttat 9960
 cctgctttat ttttcacatt cgcatttatc attacctaat attatatatt tattggttta 10020
 cttatttatt gtttgtttcc tcaccaaaaa tataagctcc atgaggggca gagaagtctc 10080
 attttagaca ctgatatctt cagtgtctgc aagagtgact ggcacacagt agatgctcag 10140
 taaatattta ctgagtgacc aaggtggata gatcacttga ggccaggagt ttgagaccag 10200
 cctgggcaac atggtgaaac cctgtctcta ctacaaacac aaaagttagc tgggcacggt 10260
 ggtgcacacc tgtaatccca actactcagg tggctgaggg atgataatcg cttgaaccca 10320
 ggaggcagag gttgcagtga gctgagattg ggccacagca ctccagcctg ggtgacagcg 10380
 tgagactcag tttcaaaaac aaaacaaaaa atttaccgag tgaattaatc ataaaggaat 10440
 aaattaccaa aaagctgcta attttcttct tgacatagtg taactggaac cagattgatg 10500
 aaaaatacta agtcaattta caacttagct gcctaagaca gttgcttggc ctgaaataat 10560
 ttcttgtaac actgctctca ttaagttaga actagaaatt atagaataga tatgaaatat 10620
 tctccttgga gtctgtgtgg attggtggga tttgaggaca gctgcaatag ttctaagaga 10680
 caagcaatta caccaagcaa agagccagtt gcaatagtgg aggacttctc cccagatcat 10740
 cagagcccct ccctgaggta ggactcagca gcaccaggaa gatcaggcca cagcagttca 10800
 ccaaacatag ggaataaatc acccagaagt gagcttctgc ccactaccct agcttgctat 10860
 catcctagag aaggtactag agatactaga tactagcctg gctgttcaaa agcatcaaag 10920
 ttgaaagtga gaaaatctaa gaagaacgta ataaacctgc ttcaaggatg agttaaataa 10980
  caacaacagt aataattagc accttcttac tactaaacaa tatgtttctg aaaagaaagg 11040
 gaggacagca taccaacaaa gaatagtact ggaagtagaa aacttaggca gcaaaattaa 11100
 gaaatggagt tggaagtaga aaacatggat tctctgaaat cagaaattaa actagtccaa 11160
 cagatcaata cccaaggata ttacataaaa cacatcaaga taaaaaggtt gttagatgag 11220
 gtgcaggtta aagtgaaaat aaagctatat acagttttaa ttgggaatct tttggctcta 11280
 agtgacagaa actccatttg aactgggtaa tgcaaaagct agggaaaacc aggggttgca 11340
 actgagcctc aggtacaaag gaagccaaga ctggaaaact accaggacat ctctcccctg 11400
 ccatctctgc ttctctagga aatgcttgca ttttctcttc ttgcaagttg gcttctttta 11460
 tctggatggt tatggccacc aacagctcta gattcacact gccacctgag aagtctccct 11520
 cttcaaattt ggagtatcag gagaaggact ccaagtgacc cagcttgaaa cagtcacatg 11580
 cccatcacca tggccatagg gtgtgatgcc acgattggca acctcagtta gagcacaacg 11640
 ggggcgtgag ggtagggtcc aggtgacaga aaaatgaaca agtagacagc caacttgagg 11700
 agtcctccca aacaaacaaa aaaaggacaa ggaaatcaaa ttagtagagc aactatgcaa 11760
 gagatcaagg cccaaggaca ttcatttatg cagtccatta ataatttctg gaatacttat 11820
 gtttcaggaa gtattctaag caatgggggt gcaagtcaga aaaagacaag gtccctgcac 11880
 ttgtgacact tacattgtag ttggttgaaa cagccaataa tcataaacaa gataatttca 11940
 gataaatgct ctaaaggaaa taaagaaggg tgatgtgcca gactttaatt ttgggtgtgg 12000
 tcacggaaag tcttgcagaa gaggtaacat ggctgagtct tgaatagtaa gaagcagcca 12060
 gctctgcaca gacattaggg cagagtgcgc cagacaggga acagctccaa tttcttcagg 12120
 aaagccttcc acggacagtg aacaccctct cccgctgtgc cctatgcaga catgggcctc 12180
 tgacttggcc aggccctgct ttcaaacact gtcacagtac cttacccttg tccttcacag 12240
 cacttccaca gttagtcatt gcccatttgg taactgtctt ttccctccaa ttaactgtga 12300
 catccacgag tccagactat gcttgtttaa gagacactta agaaaagttt atgaaatgaa 12360
 tgaatatgct gaggaaaagt tttccaaatg ctgaggagaa atctacatac tttttttttt 12420
 ttgagacgga gtctcgctct gttgcccagg ctggaatgca gtggcacgat ctcggcccac 12480
 cgccagctct gcctcctggg ttcaagcgat tctcctgcct cagcctccgg agtagctggg 12540
 actacaggcg cccgccacca ggcccggcta atttttttgc atttttagta gagacggggt 12600
 ttcaccgtgt tagccaggat ggtcttgatc tcctgacctc acgatccacc cacctcagcc 12660
 tcccaaagtg ctgggattac aggcgtgagc caccgcgccc ggcccgagaa atctatatac 12720
 atttacagct gaccatcgtg taaagagatt gcaaatatgg taaattcaaa gatctttggc 12780
 attgagatgc accactagga aaaatatgta tcagaagatc tttatactaa aacacgtgct 12840
 aggcttcaaa caatcgtaaa aatcttaata ctcctgtctc tattcctgac ctactgccct 12900
 accaaaatct actcttcttc ccatattcct ttctcggtga cttttatctc tactctaagt 12960
 tagaaatatg aacatatacc tcccaaattc agttatccac gtctattgac tatacccact 13020
 aattatcttc caaatccatt ctctcctctt catcttgatt cagaccttga tcatttgttg 13080
 cctgtggtgt cctaaattac ttacttagct ttagtctccc ttccaatcta ccctccacaa 13140
 tgccttcagg taacgcggtg ggggtagaaa gggaggggag aagtatctaa aatatctgat 13200
 caagtttcca ggatagaaaa ccttcagttg gttgcagtga gccgagatcg cgccattgca 13260
 ctccagcctg ggcgatgaga gcacaactcc gtctcaaaaa aaaaatccct ccagtcaagt 13320
 tgacacagta agttcatgct tcaaagtatc cccctgttct attccaaata cacagcaata 13380
 atagacactg ccagtctcaa aaacaagata aaaaccccca cgaagcagaa atataacaga 13440
 aatgaaaaag cagtgagcga ggctgaagcc aagggctgct gggctcttga tctgccagcc 13500
 cagagttcag ctcctcaggt gttaggaaac cacagctggt ctcactcttt aatgttatgg 13560
 gggcagtgtt tgtgagagaa gcctgggaag aaaaggagaa gaaaaaaaaa aaatagccat 13620
 caactgcttc ccgggataca acttatttgt ggctgtggat ctaaaagcag gaggatacac 13680
 atgcagtctt aatacttgga actaaatgaa gccacctgct tgctcagccc ctgggtctag 13740
 gacattctag tattatcaca gggcatgtgc cccaagccaa ctttataagg cctgtacagg 13800
 agggagtcta gaagacctgg gtagagggaa ctggagaaac ctttatttta ttaaaaaaaa 13860
 aaaaaaaaag gaaggaaatg aacatgagtg gttgtgggaa aaaatctccc actcaaaata 13920
 gcctaaacac taaaattcta aaatacacat ttttaaaatc taacgctaag aaagtcagcc 13980
 aatgaaatca gcaatctatg taagacctca aactataaga atcccagaag aaaagctaga 14040
 aaacaccacg ctggacattg aacttgggaa ataatttatg agtaagtcct caaaagcaac 14100
 tgcaataaaa cccaaaaatt gaccagtggc acctaattca gctaacgagc ttctgcacaa 14160
 caaaagaaac tatcagtgta aagagacagc ctatagaatg ggagaaaata ttcataaact 14220
 atgcatctga caaaggtctg atattcagaa tctataagga acttaaacaa ttaaacaagc 14280
 aaaaaacaaa taacccaact aaaaaatggg caaaacatgc acagatactt ctcaaaagac 14340
 atacaattgg ccaaaaaaca cacagaaaaa atgctccaca tcactaacca tcagagaaat  14400
 gcaaagcaaa accacaatga gataccatct cacaccagtc agaatggcta ttatcaaaaa 14460
 gccaaaaaac aacagatgct ggtaaggctg tggagaaaag gggacacttg tatactactg 14520
 gtgggaatgt aaattcgttc aaccatggta gaaaacagtc tggagatttc tcaaataact 14580
 gagaactgga ttcaacccag caatcccatt actaggtata tatccaaaag gaaatacata 14640
 attctgccaa aaatacacat gcacttgtat gttcactgca gcactgttca caatagcaaa 14700
 gacgtggaat caatctaggt gcccatcaat ggtggattga atgaagagag tgtggtacat 14760
 ataccacgaa atactatgca gccataaaaa agaatgaaat catgtccttt gcagcaacat 14820
 gggtgcagct ggaggccatt atcctaagca aattcatgca ggaacagaaa accaaatact 14880
 ggatgttctc acttataaat gggagaatgg gagctaaaca ttgggtaccc atagacataa 14940
 agatggcaac accagaaaca ggactactgg aagtgggagg agagaaggga ggcaagggct 15000
 gaaaaatgca ctattgagta ctatgattag tacacgggtg atgggatcaa tcatacccca 15060
 aacctcagca tcacacagtg tatccaggta acaaacctgc acatgtaccc cttgaatcta 15120
 aaataaaagt taaaattgta aaaaaaaaaa aaaaaccagc aatcacaata taaatccaca 15180
 ccaaatgaaa tcaatgtttc tataggatct tctatggaat ctatattcta tgatttgaaa 15240
 accctctaac aaagattttt aaataaagag attaatacat gactcatatt gacaacaagg 15300
 aatataaaag tataaaacaa aacaaaggca gatatgaaac aggaacagat ggatatgaaa 15360
 aaaatcaatt aaaatcctag aaatgaaaac tacagtcatt gagatttttt taaaaaaatt 15420
 caacatccaa ggtaaaaacc agactagaac agctgaagat agatttggta attggagaac 15480
 agtactttat ttatttattt atttatttat ttatttattt atttattttt gagacagtct  15540
 caatgtctca acctgccacc taggctggag tgtagtggca caatctcagc tcactgcaaa 15600
 ctccgcctcc tgggttcaag caattctcat gcctcagcct cccgagtggc tgggattaca 15660
 ggcagacacc accaggcctg gctaattttt gtatgtttaa tatctttgcc atgtcggcca 15720
  ggctggtctt caactcctgg cctcaagtga tccacctgcc ttgacctccc aaagtgatgg 15780
 gattacaggt atgagccacc gtgtccagcc aacaggagaa cagtactaag gaattctccc 15840
 aaaatacagc acagagaggc aacaagatta aaaagattaa ttaaaagtca taaagaacag 15900
 attataggcc ctaatattcc tctagaggaa gtttcaaaag aaaattaagg taatagaaaa 15960
 aaagcaatat tcagagacaa gagttgagaa ttttacagaa aagacataaa ttttcatgtc 16020
 aaaaatgatc tccaaagacg aagtaagata aataaaaata aatctatacc agaaacactt 16080
 cagaaaaata gaagaatatt taggataaag agaaaatatt aaacctacaa attccttctt 16140
 tgggtttata atagcatact tgccattcag tcggcccatc agccattgtc agcaaatgct 16200
 gatttcccac ttccaccaca gaaagagaag aaactgagat acaaataaag tatcctcagc 16260
 cctccaaacc tagtaaggga ggccaatgtg tgaatcaata attatggcag tgtgacaggg 16320
 ctacaatgta tacgtggaca aggtgctagg gacaagtaga gggtgaccac tttacagaac 16380
 agtagaaaag acctcctttt ctactggctc atatctgtaa ttctaacatt ttgggaggcc 16440
 gaggtgggag gatcacttga ggccaggagt ttgagaccag cctgggcaac atacagagat 16500
 cccttctcta cattaaaaag aaagaaagaa agaaaattag ctagtcatgg tggcaaacac 16560
 ttgtagtccc cactactcag gagacaactt gagcccagga gttggaagct gcagtgagct 16620
 gtgatcacac cattacactc caaccggggc aatggagtga gagcccatct tctaaaataa 16680
 ataaataaat aaataaataa ataaataaat aaataaataa atacggacct tcctagtgag 16740
 tatctgaatg gagctttatt tgaacatgaa tatctgttct aggaaatgaa aataataaaa 16800
 gttaaaatct atcaagagct gatagtagta actaatatcg acaggtaact tactatgtga 16860
 ctaactctca gacatatctc taatcctcac aaccatcctc agagttaagt ccattttacc 16920
 aaagagaaaa gtaaggttta gggtgatgaa gtaactttcc tgaagtcata aagctaataa 16980
 actagaaagt ggaggttggc tttaatttct ttgactgacc ttagcatata cttaccagtg 17040
 atttcatttg atgagaacct taagagagaa tagttctgtt gacacagcac tgaaagggct 17100
 aaactggttg ctttcccttt tttgtttact gtgctttgtc gtccatctga gtacaataaa 17160
 taaagagctc cgtgggaaga ctagccagct gggtaaaagt cacatttaag cttaaaagaa 17220
 ttcatgcttt gcttcttgct atcatgatta ccaacaggat tacatttgtt gaaaaggaac 17280
 acaaggctaa atattcaact attttaaata aaagtttttg gtttaaattc acaatgatac 17340
 aacttctaac aacaaggctt atgatgacct aaagcctgta acatatgttt gttaaaggaa 17400
 actatttgtt catcaaaaat atttgttaca ggaaattaca tttgctcact taagctataa 17460
 atgaactcag aagcctgtgt taattaaccc accaaccatg agtgcattga aattgcacta 17520
 atttattaat ctaatccacc atcatatatt aggtgggttc accgattaga gaattctgac 17580
 tctcgatgtc tgacactagt ctgaaaatta aatctgatcc acttttaagc tagaatgttt 17640
 cctataatgc ttggcccctg tatcatacta ctaggaactg cctcatatac cccaaatcca 17700
 tcccttctgt gagtgtatta atgcccccaa attttagtta tttggcttta tagccttgac 17760
 atggctaatc aacatctaga gcaatttaaa aaatatttcc tattttattt ttcttgaatg 17820
 tattttttcc agatatcttg gctttattca attcattata attgccttga aaaggaagac 17880
 ctcagacatt gctttttcct tctattccta gggttcccgc tttgtctaaa cctttttcaa 17940
 gggccaaata cttgatgttt tctctctttc tatgagaatc taaactcaaa aaacaacctc 18000
 cccccactgc ccaacaaaac ctagtgtaaa tataaataaa tgtattatgt cttccacagt 18060
 atttgccttt catattttaa tttatatctc atctatagct taaaggctta gttcttagtc 18120
 taagatattc aaaatctggt gagcaaatag gtaggcaact ggtatgagca catccctgag 18180
 tgttggagga tacaatggga gaggatacaa tggggagtat tatactaata cagaaatcgg 18240
 tcattagtat aaatgtgaag cacctcattc ctaaattagg tgactgaaaa tgaaaatgaa 18300
 aagctacaat ggcaagaata tcaccaatga atgctacttc tagtaaaatc actttttttt 18360
 ttttttttag agacagggta gagtgcagtg gcacaatcat agctcactgc aacctcaaac 18420
 tcttgggctc aagctatctt tccacctcag ccccccatca gccatgccta gctaattttc 18480
 ttttctttct ttttcttttt ttttaatgta gagacagggt ctcactatgt tgcccaggct 18540
 ggtcttgaac tcctgacctc aggaaatcct cccacagtgc tgggattaca ggagtgagcc 18600
 accacactca gcctaacata acttttaata acaacattga aatctgtctc tttaaaatgt 18660
 ggccctgttt ttaaaattat acctttaatt gaaatgtatg tgtgtatgtg tatatgaaat 18720
 agtttattta aataaaatta attgcagttt catgacttag ctaattgaga attaaaaaaa 18780
 cacacaaatc tataatccat acaattccta gaatctgaat tggttttaaa agaatactgt 18840
 aatttgtgta aataatttga tgatatttta aaactttcat atttgattag atatttttca 18900
 gataatttta attaagttca cactagtatt tcagtgaaac cccatttgga tatttttaag 18960
 actcaactag gagaggctgt ttagtatact aatagcatat gactaaatat caggatatat 19020
 tatttagatg agttctaatt gtgttcagcc ataaattgga tatgtaacct tacctaaata 19080
 acttaatatc tctgagcttt gcctccaagt ctctgtaaga gagaaaatac ctgctcttca 19140
 tttttcataa gatgctttaa ggagatcaaa caagatcatg catatggaaa tactctatta 19200
 ttaaaatcta atacttctca agcaattgga taccatacag ataagaatga actctatctc 19260
 acaatataca caaaagctaa ttctagatgg atcacagacc tagttaaaac tataaatatc 19320
 tggaagaaaa catagaacat attccttggg ataggcaagt ttctctgaca aggtaaaaaa 19380
 ggcattaacc atatgtatta gtccactttc acactgctga taaagacata tcaaagactc 19440
 ggcaatttac aaaagaaaga ggtttaatgg acttacagtt ccacatggct agggaggcct 19500
 cacaatcatg gcagaaggca aggaagagca agtcacatct tatgtggatg gtggcaggca 19560
 aagaaagaga gcttgtgcag ggaaactccc ccttataaaa ccaccagatc ttatgagact 19620
 tattcactat catgagaaca gcacacaaaa gacctgcccc catgattcaa ttcctcccac 19680
 agagtccctc ccacaagaca tggaattcac gatgagatat gggtggggac acagctaaac 19740
 tatatcacca taaaagaaaa acagattgaa cttcatgaaa attaccaact taaaactatt 19800
 tttaccccat gttctcctac aaatagatct tgagagcttg tttggaggtc ctaaaaaggg 19860
 agtgcagcta ctcctatacc cttgaccaaa gaaaaatcct cttctatcag caaaggtcat 19920
 cctctttgac caagaatcca actttaggag agacacacat acagcggtga ggaaggaaaa 19980
 ggactcctgc ctagccagcc agattgccct cacatccaaa atgacaaact tctactcatc 20040
 ataagacaac attagaaatg gaaaagacaa gctacagaat ttttgtagct tgtaggatgg 20100
 cagaaaatat ctataatatg tctatctgac aaagaactca tatccaaaat atgtaaaaat 20160
 tcctagaaat caataataaa aagataaaat gttaaaaata ggcaaaatat ttgagcaggc 20220
 aatacttgaa caggcaaaag atgtccttgt gggcaaaaat catatgaaaa ggcacttaac  20280
 aacttttcag ggaaatgcaa attaaaacca aattgaaaca acattatact cccaacaaaa 20340
 tggctaaatt gaaaataata acattcctaa gtgttgataa ggatgtgaac aacaaattct 20400
 catatattgg tagtgaaatc acttaagaaa actttagttt ctagtcatat ttaatggttt 20460
  ctacaaccca gaaatttcac tcttcaggat ataccaaaga gaaccgaatg catatcgcac 20520
 aggaatgttc ataagagttt tattcacaat aactcaaagc tataagcatc ccaaatatta 20580
 tccatcagca aaagatggat aaactgtggt atgcacatac aattgaatac aactcagcaa 20640
 taaaaacaaa tgatattctg atatacataa caatatggat gactctcaga aacattatgt 20700
 tgagagaagc cagaaactga agaacacata cggtatgctt ccatttatat aaattttaag 20760
 aacaaatgca acaaatctat acagttaaag aaattcggtc ggtcgcagcc cgctcgggcc 20820
 cgttcgcgcc cgtcctgtcg gccacgtccc gcggggtggc gggcgcgctg cggcccttgg 20880
 tgcaggccac ggtgcccgcc accccggagc agcctgtgtt ggacctgaag cggcccttcc 20940
 tcagccggga gtcgctgagc ggccaggccg tgcgccggcc tttggtcgcc tccgtgggcc 21000
 tcaatgtccc tgcttctgtt tgttattccc acacagacgt caaggtgcct gacttctctg 21060
 aataccgccg ccttgaagtt ttagatagta cgaagtcttc aagagaaagc accgaggcta 21120
 ggaaaggttt ctcctatttg gtaactggag taactactgt gggtgtcgca tatgctgcca 21180
 agaatgccgt cacccagttc gtttccagca tgagtgcttc tgctgatgtg ttggccctgg 21240
 cgaaaatcga aatcaagtta tccgatattc cagaaggcaa gaacatggct ttcaaatgga 21300
 gaggcaaacc cctgtttgta cgtcatagaa cccagaagga aattaagcag gaagctgcag 21360
 ttgaattatc acagttgagg gacccacagc atgatctaga tcgagtaaag aaacctgaat 21420
 gggttatcct gataggtgtt tgcactcatc ttggttgtgt acccattgca aatgcaggag 21480
 attttggtgg ttattactgc ccttgccatg ggtcacacta tgatgcatct ggcaggatca 21540
 gattgggtcc tgctactctc aaccttgaag tccccacgta tgagttcacc agtgacgata 21600
  tggtgattgt tggttagaga cttggactca agtcataggc ttctttcagt ctttatgtca 21660
 cctcaggaga cttatttgag aggaagcctt ctgtacttga agttgatttg aaatatgtaa 21720
 gaattgatga tgtatttgca aacattaatg tgaaataaat tgaatttaat gttgaatact 21780
 ttcaggcatt cacttaataa agccactgtt aagcactgtt atgctcagtc atacacgcga 21840
 aaggtacaac gtcttttagc taattctaat taaaaattac agactggtgt acaagatact 21900
 tgtgaaatct gtaactgact ttattttctt gcccaaatat ttgcttcctg ctttgcgtca 21960
 gggacgcaga ttctgcaagg tcattgttgg gatgaagtaa aattaacggg tcatctaaaa 22020
 aaaaaaaaaa aaaaaagaaa ttcaaaaagt agttgcctct ggagaggagg gaaagcaagc 22080
 agggatgaag gaactggatg aggtgattaa aatgttcttt attgtgctat gggtgatggt 22140
 tccactcatc caaattcatc caactgtata cttaagattt aagtatgtca taatatgtaa 22200
 attatatttc aataaagtgg ttagcataaa actattttaa aaagtaattt gtagtgaaga 22260
 aagggaaatt tttgtattag tcaactctga catttctatt ttttatcttt ctaaaaaaag 22320
 tcaattgctt taaatttgct aaaggtataa aaatatcaag gtattaatca ttcattcatc 22380
 aaatatatat tgagtgatcc taccccaagg caaggtacta agtgctagga acactgttct 22440
 tgcccttgaa aaattcagag ttttgcaagg gataaagatg tgtacataaa tggactgtga 22500
 cagaggcata cagacattgt aggcataaaa gagagaatgt cagactacct gcgaatgtta 22560
 acgagattca ggacgatcac ttgggaacct tgaatcacct gtggtaacta tggtgcccac 22620
 tcctgtgagg ttgagcctaa attgtaatgg gtcttaacct aagataaaag agactgaccc 22680
 agccttgcca actgtttcta gctgtccacc caagaccttc aaattagtga aggattttta 22740
 aagcctcaag agccacaata aagagcacat ggtgcatgct tcttgccatc cttgacctaa 22800
 acaacttaga aacggataaa aaaaaggata aacctgactt ctgatccaaa atgtaaaaag 22860
 ttggagtcgc cactccatcc taacaagtaa aaagctgaac atacagaaaa atcaactctt 22920
 cttggatccg tcagagaggt gtagtcacag ggcaaaccac ttagccccac actgagactg 22980
 acaggcaaat acagtacaga gaatcatggc ttgctggagc agaaacctcc aaggaaacaa 23040
 gtgctgaggt cgggaagcct gaactataac tgagagataa aaactccagg ggaagtcttc 23100
 agggcctccc tcacttttgt tttacctcaa ggatctcgac caagttctcg cagtaaatac 23160
 tggagaaaaa tcccctggtg cttctagcag gggaaggaaa aaaaggaacc attcagaatt 23220
 ttccagagca ctctgttctt aacaagttct gcccttagga gaagctagtt aaccaaagcc 23280
 taacctgatg gggtcttaac agagcctaac tgatctggaa gatcagtaag cctaacttac 23340
 tgccacatca ctaaaggctt atttacctga gatcctctta ctgtatctca tgcccagcta 23400
 tcaagaaaaa atcataagac atactaaaag gaaaaaatca cagtttgagg agacagaaca 23460
 agtaacaaaa cccggtgcag atagggccga gatattagaa ttattagact aggaatttaa 23520
 aataactatg attaatatgt aagggctcta acagataatg tggacagcat gcagcataga 23580
 tgggtgatgt aagcatgaga cagaaattct aagaaggaat caaaaagaaa tgctagcgat 23640
 caaaaatatt gtaacagaaa tgaagaatgc ctttggcagg ctttctggga gactggacac 23700
 agctgaggaa agaatctttg agctggagga catctcaata gaaaccacta aaactgaaaa 23760
 gcaaagagaa aaaccgaatg acaacaacaa taacaagaac agaatatcca agaactatgg 23820
 gacaactata aaaggtgtaa catatgtgta atggaaatta acaaagaaga gagacacagt 23880
 aacaggagaa atatgtgaaa cagtcactga taatttcccc aaattagtgt tatacactaa 23940
 ccacacatca aggaagctca gagaacatta agcaggataa atggaaattt ttttttcaaa 24000
 aaaaaaaaaa tactcctgaa agaaaccaga ggcaaaaaac accttacgta tagaggaaca 24060
 aagataagaa ttacattcaa cttctcagaa accaaaacta agaaagtgaa ggagaaataa 24120
 agacttttta gccaaacaaa aattgaggga atttgtggcc agtaacctac cttgcaaaaa 24180
 atattcaaag aaattcttta gagaaacaga aaatgataaa gttcagaaac tcagatctgc 24240
 ataaagaaat gaactgcatc agaaaaggaa taagtgaaaa taaaaacttt cttattattt 24300
 attaataaaa taatagcaac aatgtatttg attatacatg cttacacata tgcttatgta 24360
 taagcaaaat aagtaacagc aatgatacaa gggacaggaa gaagaaatca gaattatttt 24420
 attattataa ggtactagca ctacccatga ggcaatatag tgttattcat taaaattaaa 24480
 atttctgatc tgcaaaagac acggtcaaga aaatgaaaat atgagccaca gactgggaga 24540
 aaatatttgc aaaaaaaaat gagacgaagg agtgttatct gaaatataca cagaattctt 24600
 aaaactcaac agtaaaaaca aacaacctga cttaagaaag ggcctaaaac cttaacagac 24660
 acctcattaa agaagatata caggccgggc acggtggctc actcctgtaa tcccagcact 24720
 ttgggaggct gaggcgggcg gatcacgagg tcaggagatc gagaccatcc tggctaacat 24780
 ggtgaaaccc catctctact aaaaaataaa aaaaattagc tcggtgtggt ggtgggtacc 24840
 tgtagtccca gctacttggg aggctgaggc aggagaatgg tgggaaccca ggaggcagag 24900
 cttgcggtga gccaagattg caccactgca ctccagcctg ggtgacagag tgagactctg 24960
 tctcaaaaaa aaaaaaaaaa aaaaaaaaaa agatatacag atggcaagta agcatatgaa  25020
 agatcctcca catcatacat catcagagac atgcacacta aaataacaat aagagatgct 25080
 acatacatac ctattaggat gaccaaaatc cagaacactg acaacaccaa atgctggtaa 25140
 agatgcagag catcaggaac tctcattatt gctggtggga atgcaaaatg gggctgccac 25200
 tttaaaagac agtttggcag tttcttataa aactaaacac tcttgccata caattgagta 25260
 catcatgctc cttggtattt actccaagga gttgaaaatt attgtccaca taaaaaactt 25320
 catacagttg tttatttgta attgtcaaaa cttggaagca atcaaggtaa cgttcagtag 25380
 gtgaatggat aaatttactg tgattcatcc caacaatggg ctactattaa gtgctaaaag 25440
 gaaatgaggc tgggcgcaat ggctcatgcc tataattcca acaatttggg aagccaagac 25500
 aggaggattg cttgaggcca caaattcaag accagcctgg gcaatgtagt gagactctgt 25560
 ctccacaaaa aattttaaaa tgagctgggc atggtggtgt gcacctacag tcccagctac 25620
 tctggaagct gattctcctc tgagaggatt gcttaagcca aggagttcaa ggcttcagtg 25680
 acttctgata atgccactgc actccagccc agtgacagaa acctacttaa aaagggtaca 25740
 tgttaaatga ttccaactaa atgacatttt ggaaaaggaa aaattatgga gacagtgaaa 25800
 agatcaatgc ttgcaggggc tgaaggaggg aggaaaaaat aagcacagca cagaaaaatt 25860
 ttagggcagt gaaaccactc tgtgtgatat tataatgatg aatacatgtc attgtacatt 25920
 tgtccaaacc tataaaatgt acaacaccaa gagtgcacct taaagtaagc tatggacttt 25980
 gggtaaaaat gatacataac tgtacgttca tcgattgtaa caaatgtacc actttggttg 26040
 gggatgttta taatggggga ggctacgcat gtacagggga agagggtatt tgggaacact 26100
 cagtattttc ctctcagttt tgctgtgaat ctgaaactgc tctaaaaaac gaagtttatt 26160
 tttaaaaaac tttttaataa aaaggataca tttctgaatt cttgtcccag gatagtgatc 26220
 agtattagtt cagtctcagt cccttccatc ctgctatatg taactggtta aatgtttggt 26280
 caaagctgga aacatgacac atgctgacag gatggagtaa aggagtgaac agaatgatca 26340
  ggatgaggat cacatcctta attccttcat tcaacaatat actgtagttg ttgagaacat 26400
 gtattctgga gccaaaatgc ttagattgca atcttgactc tgctaactag ctgtgtggag 26460
 agttattcaa cctctgtgca ccttggtttc cccatcagca aaaaggagcc aacaacattt 26520
 cccatctcaa agggttgttg tgaagattaa atgaattcat acatgccaag tgttgagaat 26580
 gccacttgtt acaaagtgca gtaaacatgc ttgctaataa aagagcccaa aagttagcaa 26640
 atatagaaca aatttatttt taaacgctac gttagttaca ttttcaaaca atatgctcaa 26700
 tatgtccttc tatagcctag acactgtttc ctgtgaagta cctctaactt taaagcaatg 26760
 tatccaactg gtgactcttt taaaactaca ataagtacaa tatagaatat caccaaagtc 26820
 tggaaacaca gggaaaatca tgaatttatt ttttcagatt aacaattaga ctcactgctt 26880
 aaattcagag atatatcacc tgaaaagctg tctagagatt aaggaaaaat gcgttgagaa 26940
 attatttgaa aaagtaactt attattctcc gatgtttccc aatttttctg atttgttttc 27000
 ccaatgtttt tcctactagt ataactatta ttaattactg agcatgtgcc atgtgacagg 27060
 cactgctgag gatactggag atggggcata gacaaagcgg atataaaagg caaaatgtcc 27120
 ctgctgtcgt gaaatttaca ctttagtagg gatagacaat aaacacatcc taaaatagaa 27180
 tatacactat gtcagatgag aagcgctatg gggaaaaacg aaacagaagg tggccagggc 27240
 atatcagtac aacaaggagg ccaggctgct tttttataac tagggtagac ctagaaggcc 27300
 tctaataaga ctttctgaga agagatccaa aggaggtgga agagccatgc aggtttctgg 27360
 aaaacagcat tccaggcaaa ggcaacgcaa gtgtaaagac caaataagag agccaagaaa 27420
 gccttttttt ctatagtatc ttcttttgtc ttcatctctc ttgataacct gtaactaggg 27480
 cagactccag atatagatta ctcggaccaa ataatttctc tttcattcat ttctcagtac 27540
 agacttgaca ctgccttctt tcttctctga gacaacaaaa tcatttttat ctagcagttt 27600
 ttctttcttg tttttttcta tgacttccat ttgataaaaa tttactgtct actctgtgca 27660
 ggcctgatgg tgaaaggatg attaacatat ggtacatgcc ctcacaatct agttaaaatg 27720
 agacatataa aatcaataaa atataccata aaaagcactg ctttgatatt atgaataaag 27780
 tactacagca attaattctg cccattgagg gaaagagtag ttggggatag agggaaaaag 27840
 gattctgagc taggatttgg agactaagta ggagttcaaa acatggacag cgataaaaaa 27900
 atattccaag gggaaagaca aatcttaagc ataagcacag aaatgtctaa gcatacaata 27960
 tattaggaat gattgttaat gcaatgtgct acattgaaga ttagggaaat aagagcagaa 28020
 aagtagattg gaaacatgtt aaggggcctg actttatcct gagagccagt ggtttgcaaa 28080
 ctattttgac tgtacacctc agcagtaaca aattgttgtg catgcatata tcctcaataa 28140
 atgcacattt atttaagtat gagtgaaatt atgccaagag ctactcttct agtatatcac 28200
 attcattaga aaatacacaa agagggctgg gcacggtggc tcacacctgt aatcccagca 28260
 ctttgggagg ctgaggtggg tgaatcacta ggtcaggagt tcaagaccag cctgcccaag 28320
 atggtgaaac cctgtctcta ctaaaaatac gaaaattagc agggcatggt ggcaggtgcc 28380
 tgtagtccca gctacttggg aggctgaggc aggagaatca cttgaacctg gtggggcaga 28440
 ggttgcagtg agcctagata gcgccactgc actccagcct gggtgacaga gtaagacttc 28500
 atctcaaaaa aaaaaaaaaa aaaaaagaaa gaaagaaaag aaaatacaca aagagaaata 28560
 tgtaaaagat aatattttcc cctaatggaa tctttttcat taatttttat tagtgaataa 28620
 tgtgtacaat gttatcaatc aattgctaat gtaccttcca taatcaacaa atgaatgcac 28680
 tatgcttctg ttgacatttc agttctaact tgtatttttc ttgctctctt ggtggtcata 28740
 aatcatcaag agtactcata aagtctagca tagtgtactt gtacttactt ttttggtgct 28800
 aagatcaatt gttagggaat ctgaaagatc tttatgatag tcaatttaaa cacattcatg 28860
 tataccttat cttatacata taaaaggtac aaatgcataa aaagacaact tctttcatga 28920
 taaaaacact cgacaactag gaatagaaga gaacttcccc accctgataa aggacatcta 28980
 tgaaaaaacc catagctaac atcatacttg atgacgggaa gctttcctcc aaagagcagg 29040
 aacaagacag gatgtctgct ctcaacactt ctttctagcc aaggaatcta gattggagag 29100
 gaagaagtga aactatttgt atatgacagg atctagtata tagatcaata tacaaaaatc 29160
 atttaatcag gtttatttct atacaccagc catgaacaat ctgaaaatga aattaagaag 29220
 acaattccag cctgtagtcc cagctactcg ggaggctgag gcaggagaat ggcgtgaacc 29280
 tgggaggcgg agcttgcagt ggctgagatc atgccactgc actccagcct ggatgacaga 29340
 gcaaggctct gtcccacaaa aaaaaaaaaa aaaaaaagac aattccattt actagagctt 29400
 caaaaagaat aaaatgctta gaaataactt tcagaaatgc aagaacttct gaaattaatt 29460
 ggaaaataat ctttaaaatg aaaaaaactt aagacatgaa agacttgtac cctgaaaact 29520
 acacagcact gttgaaagaa atggaaaaaa gatctaaata aaaagaaaga catcctgtgt 29580
 acaaagattg gagaaattag tattgttaaa atgacaatat accccaaatt gatctacaga 29640
 ttcaatgtaa gcccatcaaa attctagcca aattctagcc atcttctttt ttttttctga 29700
 gacagagtct cactctgttg cccaggctgg agtgcagtgg tgtgatcttg gctcactgca  29760
 accttcacct cctaggttca agcaattctc gtgcctcagc ctcccgggta gctgggatta 29820
 caagtgcacg ccaccatacc tggctaattt ttggcatttt tagtaaagat ggggtttcac 29880
 catgttggcc aggctggtct tgacctcctg gcctcaagtg atctgcctgc ctccacctcc 29940
 caaagggctg ggattatagg cgtgagtcac cgcgcctggc cctagccatc tttttaacaa 30000
 aattcgtaag ctggtactaa acttcaaatg aaaatgcaag agactcagaa tagaaaaaaa 30060
 aaaaagctta tgaaagaaca atgttggaga ctcacactcc ttaattttaa aacttactac 30120
 aaagctactg taatcaaaac agtacagtac tagcataagg cctgacatac agatcaatga 30180
 aacaactggg agtacagaaa taagcccata catcttattt ggttgattga tttttgcaag 30240
 gatgccaata taactcaaca gggaaaaaat ggtcttttcg ataaatggta gcagggcatc 30300
 ttcatgaaaa agaatgaagt taaacttcac agcacataca caaattaatt caaaaaggac 30360
 ccaggatctg aatctacaag ctaaaactat aaatgtctta gaaaagatag gtataaatct 30420
 tcatgttctt gtattggaca atggagccca tagtttctta tatatgacac ctaaagcaca 30480
 agtaaccaag gggaaaaata gatacattgc acttcaaaat ttaaaaattt agtgcatcaa 30540
 aagacacctc caacaaaatt aaaggaatct acagaatcgg agaagatact tgcatatcac 30600
 ctttctgata agggtcttgt atccagaata tataaagaac ttttaatact caaacagttg 30660
 ttttaaaaag ttaataatgg gcaaaggatt ggaatagatg ttacaccaaa gaagacatac 30720
 aaattgccaa caacgacatg aaaagatgtt cagcatcatt agtctttagg gaaatgtaaa 30780
 tcaaaaccac aatgagatac caattcacaa ccagtaggat agctataatc aacaacaaca 30840
 aaaaaggata ataacaagtg ttggcaggaa tacagaaaaa ctgggacatt tttaaactgc  30900
 cagtggagat gtaaaatggt acagccacta tggaaaaact tagcagctcc tcaaaaagct 30960
 aaacactgac ttatcatatg atccaacaat tccactccta agtatacacc caaataaacc 31020
 gaaagccaga acttgatact tacactccca tgttcagtgc aatagctaaa agaaacaacc 31080
  caagagtcca tcaacagatg agtaaatttt ttaaaatgtg taatgtacat acaatagaat 31140
 attattcaga cataaaagga ataaagttct gatacatcct acaacatgac aacgctgagg 31200
 acattatggt aagtgaaata agcgacacaa aataacaaat actgtatgat tccacttata 31260
 agagatacct agaacaggaa aatttagaga cagatagggc cttggtggaa cgggaatggg 31320
 gagctattgc ttaatgctta cggggtttct gtttggggtg atgaaagaat tttacaaata 31380
 gtggtgatgg ccgcacaaca ctgtgaatgt aattaatgca actgaattgc acacttacaa 31440
 aggcaaattt tatgttatag ttacaattct aaaaaattat actgtaatac accaaaatcc 31500
 atataactgt acaccttaaa tgggtgaatt gtgtggtatg tgaattatat ctcaataaag 31560
 tttttttttt taaaaaaagg gaagaaaaaa ataaactctc aagctatgaa agaacatgga 31620
 ggaatcttaa gtacatattg ccaagtgaaa gaaaccagtc tgaaaaagct acatacttta 31680
 agattccaac tatacgacat ctgaaaagac aaaactatag agatgataaa aagaccagtg 31740
 gtagccaggg attcaagagg agaggaaaag gatgaatagg tggaacacag gacatatcta 31800
 ctctgtatga tagtggaatg gtggacacat gacaccatgc atttttcaaa acccacagaa 31860
 ctgtagaaca caaagagtga ctcctaatgt aagatatgaa ctttcattaa caataatgta 31920
 tcagcatttg ttgataaact gtaacaaatg gaccacacta atgcaagatg ttattaagag 31980
 aaattgtgtc tgagtgggga agggtatgtg ggaactctgc gtaactttct gcataatttt 32040
 cctgtaaacc taaaactgcc cttaaaaaaa ggtctatttt taaaatgcat gcttcccaga 32100
 gagaatgctc tgaattttat cctcttctca tgattcataa gactattcat tttgaacaca 32160
 aattataatt ctacagtagc tagagaggaa gcactgagcc ttttgtcact gtagaatatc 32220
 aggcactact gaatcatctc aggatcctat cctttcccta ctgcacctcc tcttccgccc 32280
 ccgaaagaat tattttatga tctaaatttt tgtattcata taactgcttc catctagata 32340
 gtctttgaag attccagcct gtggaaatat ttccttaatt tatgactaaa ttccagttta 32400
 attataatta taaattacag tgacattatt acaccaaatt gccatgcctc ctattttatt 32460
 cacttttttc attttctatg aggtatcatt ttatcagaaa cctaagtgtg ttcacttttt 32520
 ttttcctttt gaaaaaagta ttgttctcta aggcactgaa gactcaatac agaggattaa 32580
 attggaaact ataaccgtcc cagaggaaag acagctagta catttaagta caactcttcc 32640
 ccacctcctg gtataaaatg atcccccaaa actcctaatc tttattggca catgctataa 32700
 actttttaaa aaaactttag agatcggggt ctctctatgt tgcccaggcc ggagtacagt 32760
 ggctattcac aggtgcaatc tttcctcact acagcatcaa atgcctgggc tcatgcagtc 32820
 ctcccacctc agcctcccat gcaccaggat taccggtgta caccaccaca cccagcttat 32880
 ataaacttct ttaaccatta ccttggtctt ttccagcttc atctatgtgc tgaaaatctt 32940
 ttagtgtttg aaggttacag aacccctctc tgcaatgctg aataactttc tttgatccat 33000
 tcttgatgag ataatccatt agggtaaggg atttatacac gtggcgccag ttcttcccat 33060
 ggtcattgag tctgtgccac agcatattca taatctctga gagagaaatt gtgttgaaag 33120
 tcaagtcact gatatctaac atcagagaac tagagggacc ccaagggtcg ttagaagttg 33180
 cttccctgac ttttatttca gcatctgagt aatttttcac aaagtttttc acttgtctcc 33240
 tgaacgccat aagtaataca agttccaagg tgagatggag gatgaaagca atggaataac 33300
 agtttatgtc acgggtttat aaaactcttg acaggtaatt ggtccccagt tctgctgctc 33360
 ccaaatacaa ataattaatc tctatgttga taaagtatca atttcctgca aggaaagcac 33420
 aaaaaaattt acattaaact tttttttaag tctatagaag accaaatcaa tctgaaaatc 33480
 taggttttgt ttctaaatca gcccctcact tacagcagcc agaattgagg gtaccatata 33540
 actgttccta ggataggcat gggaaaatcc ctcatgagaa attggcctat attatttaaa 33600
 gaaatatagg ttgtctttct agtcataaaa gttcctggag aaaatatcat tcaacctctt 33660
 tggccagaaa tataatggct ataaagcatt acatggacag cagacaagca acattttaaa 33720
 aaacagaact tgcactctga catctctttc tttctttctt tctttttttt tttttttttt 33780
 ttttccaaag acagggtatt gccctgcttc ccaggctgaa gtacagtggt gcaatcatag 33840
 ctcactgcag ccttgaactc ctaggttcat gcaattctcc tgcctccgcc tcccaagcag 33900
 ctggaactat aggtgtgcgc caccatgcct ggctattttt ttttttggag atagagtctc 33960
 cctctgttgc ccaggctgga gtgcagtggt gcgatcttgg ctcactgcaa cctctgccac 34020
 ccgggttcaa gcgattatcc tgcctcagcc tcctgagtag ctgggattac agatgcacgc 34080
 caccacacct ggctaatttt tgtattttta gtagagacgg ggtttcacca tgttggcgag 34140
 gctggtctca aactcctgac cttgtgatcc ttccacctca gcctcccaaa gtgctgggat 34200
 tatagccgtg agccaccgct tccggcctgc ctggctaatt tttaaatatt gtgtagagat 34260
 gggggtctca atatgttgca caggctgttc aaaaattcct ggcctcaagt gatcctccca 34320
 cttcagcctt ctgaagtgct aggatttcag gcatctcttt atattgtcac atataaaaat 34380
 attatattct gagagtaatt aaaatggggg taaaattgag tcttagaatc acccactgac 34440
 cctatgactg tattcttttt agaactacaa gtcccgagaa tcagatctaa atatagtctg 34500
 ctttcttgct aaacctaaaa gaaaggagga tcaactatga agacaaacag ctgtatatca 34560
 gtggactcca cagctaattc atggtaccct aaaacctcta ttttagtcca gataagcctg 34620
 gtaaattaga gggaaaggtt aaattacttt atttgttcac ctttggaaaa agaagaatga 34680
 gtttaggatt aaacagtgtc aacagtaaga ctcaaataat gcaaggattt ctctaaatcc 34740
 tgcagtgatc agcctgtgtc tatcagatct caaaacaagg acacacagag aggcccatat 34800
 actaaaactt aaaagggaaa tgcagccccc aaactttaca taatgcttgt gaatgatcaa 34860
 ttcagtttat aggaaaccat tccctttctc tttttcatta ttttgtatta aggagggtca 34920
 gtcagtttgc aatttctcta gtgattcacc actgctggct gccaagacag tgtaccaaat 34980
 tgatttcaag ccctgacgaa catccagacc caacgaaacc tagaagatct ataatcagat 35040
 tttactagag aaactgcaca catacaaaag aaaaaatgtt aaaatccata acaaatgtgt 35100
 tcactgcttt tagttttgct tccctttctt gaccttctca ggtaactagc tcagccttga 35160
 ttaatttctg tatgtgtatt aaaggaagac ataaattttt agaagcatcc caaataaact 35220
 atcacttctt ttttttaaaa aaatgagata acctcttttt ggtaaaaata caacacactc 35280
 ttaactaagc aagacagaaa atgtacctgt ataagtggtt gggcgtggtg gctcacacct 35340
 gtaatcctag cactttggga ggctgccgcg ggcagatcac ctgagctcag gagttcaaca 35400
 ccagcctgga caacatggtg aaaccctatc tctactaaaa acacaaaaaa ttagccaggc 35460
 ttggtggcac acacctgtaa tcccagctac ttgggagact gaggcataag aatcactgga 35520
 acctgggagg cagaggttgc actgagccga gattaggcca ctgcgctata gcctgggaga 35580
 tagagtgaga ctctgtctca aaaataaata aataaataaa taaataaata aataaataaa  35640
 taaataaata aaaaagaaaa tgtattaaat atctgtttaa ttaagatttc tcagaaagac 35700
 actatcatta accctaggaa gaaaaagaga agttgtgttt ctacaacttt ctgattttct 35760
 ctttttcgta cttcaaacac agtcattttt atttggcacc ttcctgcagt gaaaaactga 35820
  tttataatat ttcagcaaag ctattaaaat tgtcaagcag gagggttttt ttttctattg 35880
 tccttttttt ccttctacca aactcactca atgcagagat gcactatgac attggcttag 35940
 agcaacaaat atcgatctgt ttcttcacga ttctattttc ttttaaagcc ctgttagaat 36000
 cataacttgc tggaattgaa caacaaatgt taattttttt ttcttttttg gatagctatc 36060
 tatctatatt ttggaagaac aatcgtaatt tttaggtttt tctacattct ctaacctata 36120
 ttttaaactt ttaaaaactg ttttcttaaa tgaattttct aacccagaaa aatatcaaaa 36180
 taatagcctt ctaatccaat agagtagttt aaaatgaatt tacatgacac catatcagaa 36240
 ttaaatacaa ccccaaccat tagaaaaatc gcaaggaaaa aggtctagag aagtgaattc 36300
 ttatcactta ctaatgtaca atgacttgaa ctttaccttg tgatatgaac gtagaatatg 36360
 taaaacacca ttctactact gctgtctttt caaattgaca aggagctcaa ttaattggtg 36420
 ttagttgtaa attatatgtt ggtttattat gtgttttaga cacctgacta catgaaaatg 36480
 ctgtttacat acagcatcaa ataactgtga gattgtaact acagtgatgt gacaaaaatt 36540
 gacatgagac aaaattagtg cccaagaggg taaatttcca catttgaatc ttggttgtct 36600
 ggctacccaa ctcactataa tatttagaaa tagagggaag aagttaggta tttcatgtca 36660
 caaatctgag aggtcttcac cgacctcact aactacttag gtctccccag aacctggtta 36720
 atttccttca ttgcacttgt aacaatctgt acttacctat ttgtcatttg ctcagtgcct 36780
 ttcttcacca ccaaactgga agctccttgg gggcagggac cttgacggtc ttatttacca 36840
 ctgtaatcct atccctaaca gctaattagc aacagtagat actcaagaaa catgtgttgt 36900
 gcaaataaca caatgattga atgattctgc cttgggataa acctgcactg attctatagc 36960
  tttataatta taatcacttt tttttttttt ttgagataaa gcctcactat gtagcccagg 37020
 ctgcttgcaa actcctgggc tcaagcaatc cccctgcctc agcctcccaa gtagctggga 37080
 ctacaggtgc ataccaccaa gcctaactaa ttaaaaaaaa aattttattt ttttttttga 37140
 gatagggtct tgctctgtca cccaggctgg agtgaagtgg cacgatcttg gctcattgca 37200
 acctccacct cccaggttca agcaattctc ctgcctcagc ctcccaagta gctgggactg 37260
 cagccatgag ccaccaagcc cagctaattt tttgtatttt tagtagagac ggggtttcac 37320
 catattgacc agggtggtct tgaactcctg acctcaagtg atccgcctgc ctcggcctcc 37380
 cagagtgctg ggattacagg tgtgagccac cgtgcttggc ctcaaaaaaa attttttttt 37440
 tagacacgag ttcttattgg ttgcccagat ggtcacaaac tcctataaag catgatatta 37500
 aaaaaataaa taaataaaat ctagctctca taattgtcaa gtaaaattct atagttttga 37560
 gcaaatattt tcaaatcatc aacagatatt tcttgagtac ctaccatttg tatagctttg 37620
 tggagaaata taaaacatga acctcacatt aaaacttacc attcagttaa ggagctttct 37680
 ctcctaaata attcccagca aaacaaatga ttacgtagaa aaggtctttt agtgttattt 37740
 ttagatctgc ccactttcac aatgctgttt ccttcccccc atttcatctg aattctaaca 37800
 ggaaatgatt tatcagctgg cattaaacta ttggtccacg atcttttatc ccaatccttt 37860
 gaggccagat gatttgtgga aattctcttt tgggtgcggt ggtaggggtg gaattttcaa 37920
 gagtagtgcc atgtctatac catatattac atgataccca cagtaaggtg tggagctgct 37980
 ctgaacaatt aaacacatta acatgtctgc aataaaaaca tgtaaatatt tggaataaag 38040
 actacaaatg gcctcaggcc aagttttacc accaaatgag ttggaggaaa agttgatttc 38100
 caaaagtttt tggatttcag gattgagaat aaggaacaga ggagctgaac tgactttatc 38160
 caaagacttg ggacaataat gacaatagca tctaagaggc tgagtgtcca gagctatctc 38220
 tgaaaagatg catttaaggt ggaactatga gaaaagaaca gctcttgtgt ttgtacaggt 38280
 tctgcctata gacatgagtt tgactcgtaa ggaaatgagc tctggccaag aatgctacgg 38340
 gaaaatggtt atagagacta ccatgccatt aggaggtgtt actgttttga tgaaaagaat 38400
 actgtcagag gcagagaatc taatcttttc cagccctaag tgtgtgttca ttaatttatt 38460
 caactaataa tcttccagag cttaccatgt ggcaggctcc attctaggaa atggagaaac 38520
 aggtgcacaa gacacagtcc tcacaccctg gagtaaacag ctactcttca ttgaacgctc 38580
 acaatgtgct cacacctggg ccttcacatg cctcatctct ctcctttaat taggattcaa 38640
 agccatgatt tgaggtcctg ctttgccatt tcctaactaa gacttaacaa cttctctaag 38700
 tctcagttcc ctcatccgca acacaaagaa taatcgccag acagggccgt gggggaggaa 38760
 gaaacgagat gctttggaaa gaattttgaa aatggcgggt ggaggctgag caagaatcaa 38820
 ctttctgtgg gcagggcctt tcctcggcat cctcgtcttc attcatacaa cccccacttc 38880
 agatgacgac tgtgtaccag atgagccagg tgctgggcgt tcggccacac agagaatcag 38940
 accagcaatt accctaggag aaccggcagt ggaggggaag gctggacctc aggaaagcct 39000
 ctagaaggag agagggacgt gatggcgtca cgtcacgcca cagggatttc acctcctgcg 39060
 gatggtaatg gcctcgccgc cctcccgccc ccacctggac tccgacggtg ccggcaagaa 39120
 acgggaggag ggaaggcaac cgatgtttcc agacccgcct tgagccccac caccactccc 39180
 aagcagaggc tgttacctga gaggaaagtc ggccgctgcc caacgaccaa acttcctctc 39240
 cccaggatat tccacctact ccagccaggc tcaagggccc aggccggtcc ccacttccgc 39300
 ttcctcactt tctggcctgg tgcagttcct gtcagggcgt caagcaagat ggttgcagat 39360
 acctgagctg gagggtacca aggggaatga aggtaagtgt cttcgtttca caggctgccg 39420
 ggctgtgaca ctgccctaat cctcctttca aagaataaat tttttttttt ttttgagatc 39480
 tgggaaatag tttaatcaga cactagcatt tattcttagc tgctttctta attaaataaa 39540
 aatgagtata aattaattta ctaaatgttc acaacgtaaa aacggacatt aaaaaaagaa 39600
 aaaaaatgcc aaggtaagct gataatgttt ttaaaaagta gacaataaaa taatgtatgt 39660
 aacttaaaat ttgccatgat aatttattct taaaatggaa aatcagtaaa atactcagac 39720
 ttctagcata atatctcttt ttttttattt attattattt aagttttaag gacatggatg 39780
 aaattggaaa tcatcattct cagtaaacta tcgcaagaac aaaaaaccaa acaccgcata 39840
 ttctcactca taggtgggaa ttgaacaatg agaacacatg gacacaggaa ggggaacatc 39900
 acactctggg gactgttgtg gggtgggggg aggggggagg gatagcattg ggagatatac 39960
 ctaatgctag atgacgagtt agtgggtgca gcgcaccagc atggcacatg aatacatttt 40020
 taaaagtgtg ttactactgt catttcaact gactagaaat accaccagca cgtgattgcc 40080
 acctcaaagg actgagaatg taatagtagt ctatgaagag cagtgtgtgt gatggacaat 40140
 gatggggtag ctccagtgac tgatggcttc aggtgccact gacgggtaat tgttgatgta 40200
 ttcaactgat tttccgtgag cacccacttt gtgccagaca gtaaggactc ggagataaaa 40260
 agcagccctc tgctggatac gtttacaggc tagtggaggt gacaggcacc gtcagagaag 40320
 attgtaacaa gatatgtatg gcatagtaag agagaagaga tcatctaatt ctgccactga  40380
 gtatttaagg gcaggtttca cagaagagtt tacatctgaa ttgaatctta aaggatgaca 40440
 gggagttcac tggatagaca aagtagagga ggacgtaaga ggcaaaggac acatcatgtg 40500
 taaaggcatg aaagctgagc cagcctatta tcttggaaaa actacatgta ctgtagttac 40560
 tacaactgtc acaaaggcta ttagtggagc agcagaggaa ggttaaataa cagagggaag 40620
 ttggatcatg aagaacctta tccatactac aaggtgattt tatccagtag gcattgaaaa 40680
 atgtaatcga acctgtgttt taatggaata ttgactagga tgaggggaaa agacagagga 40740
 taacaaaaca cttagtagac aaaagcaaca tttgtttcta tctcctacta cttcagtcat 40800
 aattataata ataatagccc acattattga tactgacatg tagataggtg aatccaatat 40860
 aaaatgatag gaggtatgaa agaagttggt gagtttggaa tattatttga ctggctataa 40920
 tatagagtaa tggggtggga gccagaggga aatcgaaaag gtgacctgga aaacattgtt 40980
 cagggccttg aatgctatgt tgaggtattt tgactttata aaatagtggg ggacaaacta 41040
 caagtatttt atacattgag gtatagttta tgaagttttt ttatatgtat agcttatgta 41100
 aatctcaaag gaatgctgag aagtaggcgt tattatccca ttgtacaggt gagaaagctg 41160
 agtttgtgga atatgcatac attctacatt attgagcacc tgctatttgc caagcactat 41220
 gctgagctat gagactagaa ggaagttgta gtttaatact ctaatagagg aaacaggaat 41280
 aaatcagcaa ttgtaagtag ttgctataat aaaggcaaac aatgttacgg gagtgaaagg 41340
 gggacttgtc tatatttgca tagtcaggga aggcttcctg gaggaggtga gcttaaactg 41400
 agtttggaga aacaaataga ttacagtaat tgcccagaga tatttaacta ggaagcagtt 41460
 tacctgaaac ttgaacccaa atctcctgtg tctagctctt tcccctactc caaggaccaa 41520
 tctttggtcc ttgattttaa gctctatcag caactcagtc acaagtggac ttgttatgtt 41580
 tggagaaggt cagagattcc aattttttat ttttaaattc attcattttc tccttttaaa 41640
 atctctgtgt gtgctcaaag agtagattgg aagcagagga actggaagaa gaacagaatg 41700
  ttctgatagt tcaggcaata agtgatgaag gccataacta aggcagaggt catgggcata 41760
 gtgtgaatct ccactctgtt cactctcctc acacatatac ttttacatgt aatgttaaag 41820
 tgtagcagtt atgggatcgg gctctgaata tatgtggcaa tgagagagaa ggaggagtct 41880
 acagggacta agtttctttt tggggtgacc aagtaaatga ctgttgctgt tcaccaagat 41940
 gaacatgatc cgaggggtca gtttggcagg aaagctgggg aattctgctt cggacatttt 42000
 gaatctgagc aacaggtggg agatgttcag gggacagttg aatagagata actgaaagaa 42060
 gagggtttgg ggctaggttc atagacttca gagtagtcag catatagaag gtgattgagg 42120
 aggcagatgg gaagtaggag acagggtaag attaaagact gaagtcccaa taaacagtga 42180
 gggagttggt taggcttggc aaaagtgtca agtgttacca gcttagtgga attaaccctg 42240
 ttcaagtgac aatatgtaag gggtccttct tatctgcttt cctccatttg ggggcacaat 42300
 ttagttgcaa taccgtaaca tccactaaat acaaatattg ctctatggta gcttggttgg 42360
 ttttctcctt taattttttg aacttgaggt tctataaaag tgaacacagt ttgcttcacc 42420
 tgacttcccg gacaccattt ctccttctca tctccttgac tcatccgttc tcaattctat 42480
 gacctctcaa ctttgaagga gcccattctc taacctcttg tcttctctat ctatattcac 42540
 tccacaggta gtgttatcca cttgcaaagc ggtaaatact cttcgattct gacaactctc 42600
 aaggttttct cttcagcttc tcctgacctc caaactcgtg tatctaacta ccttgacctc 42660
 tactcctggt cttgccttcc aaaccttctc tcccacggtc tctcctgtct cagtaaatga 42720
 cacatccttg cttctaggtt ctcaggccat gaacctggga gtcaccttaa ctcctgtgtt 42780
 tgtctcttat agctctcatg atatccatga gcttaccttt gaaatacaag gtggctaccc 42840
 agtctagata ataaatgatt tattgatgct acattctaat acaagataca ataacattat 42900
 ctatgtttct agactttatg atcaccctgt atattcaaaa tccaaccact tcccaccact 42960
 cacatcatcc tgttttaagc cacaaccatc tctggtctgg actatgaaag tagcctcttt 43020
 tttttttttt ttttttttga gatggagttt tgctcttatt gcccaggctg gagtgcaatg 43080
 gcgcaatctc ggctcactgc aacctccgcc tcccgggttc aagcgattct tctgcctcag 43140
 cctccctagt agctgggatt acaggcatgc gccaccatgc ctggctaatt ttgtattttt 43200
 agtagaaatt gggtttctcc atgttgatca ggatggtctc aaactcccga cctcaggtga 43260
 tccatccgcc tcagtctccc aaagtgctgg gattacaggc atgagccaac catgcctggc 43320
 caacagtagg ctcctaactg gtctctcttc ttctgttctt gctcccttgc tatctaattt 43380
 cagcacaaca gccagagcta cccttttaaa acttaaaacc caagtcagat catactactc 43440
 cccagttcaa aatcttccat tggcttccat ctcactcaga gtaaaatcca aaggcctcgc 43500
 catggcaaca aggccctaca tgttctgctc tctctctgat ctccatccca actcctctcc 43560
 acctcactca cagtgttaaa catgtctcca cctgaagtct ttgcacttgc tagtccctat 43620
 acctgcaaaa gctatttccc cagatgtcca tccaggaagt actggcttct tcactttgtt 43680
 ctagactttg ctcaaatgtc ctttgatttc ccaacgtaaa atcgcaaccc ccatctcagc 43740
 cacactccct gtggctcttg catcatttta tttttctccc taacagtagg accatctgat 43800
 gtaccttctg tttctccctt taccagaatg taagatccag gagggcagag attatgtttt 43860
 gttcactgat agttttccag cacctagaac aggactaaca cagagtaggt gttcaaactt 43920
 tatttattga ataaatgaaa cgagaatgtc tgaatgcaca ctattaaata agaagtacat 43980
 attttaccat aaagttaaat tgagcataat tatggcaaga agttcagata ttggccaggc 44040
 gcagtggctc atgcctgtaa tcccagcact ttggggggcc aaggtgggca gatcacctga 44100
 ggtcaggagt tcgagaccag cctgaccaac atggcgaaac ctcagctgtc ctaaaaatat 44160
 acaaattagc tgggtgtggt ggcaggtgcc tgcaatccca gctactcggg aggctgaggc 44220
 aggagaatca tttgaactta ggaggtggag gttgcagtga gccaagattg cgtcactgta 44280
 ctctagcctg ggcaaccgag cgagactcag tctccaaaaa acaaaataaa acaaaaaaca 44340
 aaacaaaaca gaagttcaga tataaacaaa tgacccctca aaaggaattg attaaaaaaa 44400
 ttttaaacaa agtatggttt aaaaaagaaa cttctccact gtggctaagt ccatatttca 44460
 catgttactg tatcctcctc atcttgctgc tatttttctg agtatctcat gatagtgagt 44520
 actgaaatgc tggcattctc acattagggt ctttattctt aggatctgcc tttgcactcg 44580
 ttcagttaca gagctgttat gaaataaacc actcaagtgg ccttgcttcc ctcccactat 44640
 gctctacata acatgtctgt caatcagtac ttactaccaa aataacttgc ctttgagatt 44700
 tttctgttct gcaatctgtc ccatgcttgt aaggggaagg attatattct gctccctggg 44760
 gagtagtgcc tggtgcaaaa ttagcttcct cattagggta caagctgaaa acaccatgat 44820
 actttccatg taacaccatt caacattttc ccttcgctcc cactccccaa ccatagaatt 44880
 ttagggactc ctttaaccat ttcaaaacca tcgacttggg agctatcaaa gaataaggac 44940
 tgtagccaga ggatttcagc atttaaaaac ttggcaatag agctgttcag tgtaatgatc 45000
 caagaaggtc cttagaaggc tgaataattc tgaggtcaag gttgagacgt tattattttt 45060
 aaagtagcaa gatgttgtta tttttaaatt ttatctttat aatgtggaaa tagcagagat  45120
 ccttttcaga tataaccagg atttaagaaa atttgacaaa gttgcattaa taaaaagaaa 45180
 gcctgttatt aaggagctac agggccgggt gcggtggctc atgcctgtaa tcccagcact 45240
 ttgggaggtt gaggcgggcg gatcatctga gttcaggagt tcaagaccag cctggccgac 45300
 atggtgaaac cccatctcta ctaaaaatac aaaaaaaatt agccaggcat ggtggcaggt 45360
 acctgtaatc ccagctactt gggaggctga agcaagagaa tcacttgtac tcgggagacg 45420
 gaggttgcag tgagccaaga tcatgccatt gcactccagc ctgggcaaga agagtgaaac 45480
 tccgtctcaa aaaaaaaaag gagttatgga tagaaaatta cttcctttaa ctcattcgac 45540
 aaatatttac tgagcatttt ctgtcacctt gacactttgc tgattcttct tttctatttc 45600
 aataaaaatg ttgggcaatt ataaccaagg aaaaggtttt aagaaagtaa attttaagca 45660
 aggtttagat ataaagaagc aaagagatgg aaaaggatgc cgtttcacat tgcagaaaaa 45720
 gtttaaattt tagaacccca aattgaatct ctccttgaca ctctcctctt ggtattccag 45780
 ggattaatgc taggaacatc ccagtgagcc aacatttccc tcctcatctt ggatccagtc 45840
 cccaaactct gaatggtgcc acttagcaag tagcaatgtc tctaattttc tgtaaaagat 45900
 gcaacgttgg caatccattt tctagcaaga gcaaagagaa aggaagaggc cttcacaagt 45960
 tgcagttgat atagggggaa gggtgagtgg tacatttaaa ggtaagaact aaggaagttg 46020
 aaggtaacaa aactcaaggt caatggaaag tcttaaatcc cagaaagcct tcagtctaag 46080
 actcaacaga aattgaagtc ccagaaattg aaggaactgg ttccacctca tgctggactg 46140
 tggcaaacct ggggtgagaa tgcatcccag ctcagaatgt ttcttctttt tttgtcaaga 46200
 gtaatattag aggctgagtg tatgaacaaa gcatctttcc tgggatttta acattgtgag  46260
 tgatcgaggg tgctcttaaa taagttcccc caagaagccc taatgttcct ctggatgcat 46320
 gattatacta agagaataag agttttcctt aagatcagct tgctgatgga ccatatcaag 46380
 aactataaat tttcttatgt gaacacaagt gttcaggggg gatattgtta aaactgaaac 46440
  caagcataaa gaagcaaaag tgtttcagtg aacctcctgc attttagttc aactctggca 46500
 gcaagaaaac aaaaccacat aatctaaggc tcacgcccaa ctctccgaag ccccatatgt 46560
 gctagttcct gtgtggtttg cctacagact gcagggctga ctagggttag tttggaggag 46620
 ggagtaagag gtggggagga ggaggcacag ttaatggatc tgtaaacttg caccctcttt 46680
 cagagtggta catggaagac agcacaaagt ggatccatac tctgaaatgc agtaactctg 46740
 atgcttgaat ttgtctccct tcttgccaga aaggattcta ataactcggt gtcaaagcca 46800
 agacataaac tcaacccctt ctcttccaaa aggtatgtca ttatacaaca tctgtacata 46860
 tactctagaa actttgaaca gttttataat ttgcagaatg ttctgtatga gttaattaaa 46920
 atgaatctca ctagttctct aaatattgct tttaagtccc atcagctaag gtctctaaac 46980
 cttttgctgt gacaatgttt gtggtgatgg gatttgactt ctatcaaatg aactgggaga 47040
 acacttgttc cttacccagt ccataacaca aaaatctcca caaactggct tcagaagcat 47100
 ctcagggaaa gattttcgac cttgggatca tggaggtaaa attccacttc accatggtca 47160
 gaatttaatc caaattggaa gggattggag ggggtggtag agggctgagc agtgatgaat 47220
 gaacactagc actctgaggt caggatttct ctctttgctt gaatttctag ttctgttcgc 47280
 atttttgtta cctgtacaaa ggacaccagt tttcattcct ttacgaaaag aaaactttat 47340
 gttgaagtgt attttggaag ggtattgtct ctcttcgtac tagccgttag gctccatccc 47400
 tatgactgtc tctggtttag gcgtccagtc tgaagatagc tgctttgtgt tctttgtccc 47460
 aactcttcct gaacgtgagg attgaacata ccaaccaaag gtttcactaa tttaaaatgt 47520
 actgtattgc cctgacaggt atactgtcaa aaaaaattta ccgtatttat ctacctggaa 47580
 ttaggccttc ttaataaagt gtatgcagca taatttgcac actattgaac atacacatcc 47640
 ctagataaac taggagtggg aagtgtttta gatctaaaca tccaatggga aaaatttcgt 47700
 gtgttctcgt tatgttatct gaggatggga aacttcaggt cgcagaatct tttgttctat 47760
 gcagcaatgt ttgtcataaa cggtttagtt ctttagtggc tcctttttgt ttcttatttt 47820
 tggtttcgga aagagtattt agcagaagtt actctccttt aacaatccag tattttatgt 47880
 aaaactttat agaataattt tatagtgatt ctctttacaa aaccatctgc tattaaataa 47940
 ggaacactgt gtaaatagag gaccacctaa gtatatttaa ttttcaaata cgaaaaaaat 48000
 ctgactcata cccttttttg tttttttgta aaagagaggt ggccctatat tattgaataa 48060
 aactgctttt ttagattgaa cttggagtgt ctcccatgtg gtaaactgaa atcttattct 48120
 ccccaaattg taatagattt tatcttttta aaaatgactt tactgaagca gaggagaagg 48180
 agatgatcaa tctattcaat atgaagaaat atctctgttg ctaatacaat atccttttga 48240
 atatctccca catcttaggc cctggtgaaa atccctttca attgttctgt ctacctcgta 48300
 gggatgttgt aagaataaat gagttaacat agatatgaag tgccttagga aaaaggctct 48360
 ataaaaatgc aaggcgatat catgattagt tgtttctttg actcttgatc attttcttcc 48420
 cacttcttat acaaaatgtc tctcacttat ttcctgaagc catctctttt agaactattg 48480
 cttcctagaa gagctgaaaa tgatcctagt tccaacatat ttattgattc ccagataata 48540
 acacccactg gtgttgatga ctgacagggt tcatgcctaa gcttgagtag aacttgccct 48600
 tttttcctgg gtcaagaaaa gtctgcaatt gttcgaaaat gtgtcagtaa gtgtgattcc 48660
 atcacgattt cttaaataag taacagttgc tgctggataa tcctgggggc agatgattca 48720
 tttttgtgcc cctatcaaac aaactcaaaa cttgttaaag aatctttata agttgtttga 48780
 atcaaacaat agggtcgcta ggtccccatt ttgtccattt gaggtatttg cccagcatac 48840
 cttggtctgt aaagaaatag cacagccttg gctgggcgcg gtggctcatg cttataatcc 48900
 tagcactttg ggaggccgag gtgggcagat ctccaaaaat aaataataat aatgataata 48960
 acacagcctc atgagtcttt tttttttttt tttttttgag acagggtctc actctgtcac 49020
 tcaggctgga gtacagtggc acaatcacag ctcactgcag cctcaactac cctgggttta 49080
 gtgatcctcc cacctcagcc tctcaagtag ctgagactac aggtacacac caccacacct 49140
 ggctaatatt gtatttttag tagagacagg gttttgccat gtttcccagg ctggtcttga 49200
 actcctgaac tcaagcgatt cgcctgcctc agcctcccaa agtgttggga ttacaggtgt 49260
 gaaccactac acctggcctg ccctttcttt tctcttaaaa attcttaaga aagcatggtc 49320
 ctgtttaaca aataagcatt ttacaaacat ttatcgatca attactatat gccaggcctg 49380
 gcactaggca ccaagtcctc ttcaacagtg ttaacattaa gtttcaataa acttgagtca 49440
 gtaggaattc agtaaataat ttttaaagat tgttttcttt ttaaatatgt atttataaac 49500
 aaaaatttta gagaattaaa agaaactatc acgaagtgca tgatgataaa agtcttatat 49560
 actctccaaa gaaaatgtta agacatacct taaggagata gtgaagaaca gccgggcaca 49620
 gtggctcaca cctgtaatcc cagcacttgg gcggccaaag caggcagatc atctgaggtc 49680
 aggagttgga gacaagcctg gccaacatgt tgaaaccctg tctctaccaa aatacaaaaa 49740
 ttagccgggc atgatggcag gcgcctgtaa tcccagctac ttgggagact gaggcacgag 49800
 aattgcttga acccgggagg cagatgtttc agcgagctga gatcgtgcca ctgcactcca 49860
 gcctggtcga cagagcaaga tcctgtctca aaaagaggaa aaaagaaaag aaaagaaaag 49920
 atagtgagaa aataactgaa cataaaacat aaagaaaagt tgaaatatta gtactcacta 49980
 cctaggttca acaattgcta actctttgcc gtatttgctc catctatacc tatttctttc 50040
 tgaattactt gtaagttgca gataaaataa tacttcactc ctaaataatt cagtactcat 50100
 ctaagaataa aggcattcct ctatctaacc acaattccat cattaggcct aagaggataa 50160
 acagtaagtc cttaatatca tctgatagct agtgcagatt taaccttccc catttgtccc 50220
 ccaaatgtct tctataccat tttttaaaaa aagaatctaa tttttaaaaa taagaacata 50280
 ttttgcagtt gggtctcatg cttctttctt caacattgga tgtttttaaa gattacgcca 50340
 gttctcttgt accaggtccc actttctgaa ttcgttgttg cctcatggtt aatttgttcc 50400
 tctacccact ttatttctca taagctccaa gttaggacta aaagcatgat ttgattttga 50460
 ttgaacgttt tttgcaaggt gccactgggt gctccatatt gcatcttatc aggaggtaca 50520
 gaatgccagg ttgttccact gtgcatgatg ccaagtttga tcagggcttg aggtagtgat 50580
 cttgctcaga ggatctcttg ttgtacaggc actttttcac cctttgcaat tagcgagtac 50640
 tctcaggggg tatctcaaag tgtatctcat aaacactttg gcatggtggc aatatcctat 50700
 ttcccaacaa actctcaccc ggtgacttta ggtaataatc tttgcctaaa ttgattattt 50760
 cattggagtt catatatatt tttaatacgc tttgaagatg gactcgacat gcaaattcat 50820
 cattatcagc agcaatagtg gctggaaata tttattgagt gcataagttc aggtaataat 50880
 aataatagta ggtaatgttt attgagtgct tgctgtggag ccaagacagc ctcggtgtga 50940
 gcccagtctt tcacttacta agcgaatgaa ctgggacgag ttattctttt tgtgcttcag  51000
 tttcttaagc tataaaatgg gattactaat ggtgcctatc tcgtgggatt gttctgaaga 51060
 gtaaacgatt tatacattta aggttcctaa aacagtgcct gttattattg ttatttgcca 51120
 agcattgttc taatactttg taggtactaa ctcgtctact tcttctaatg gtgcaatgaa 51180
  gaaagtgcta ataataccct tttttcacaa tgaggaaact gaggtacgga gaggtctagt 51240
 acgttgcaca aggtcactta actagtacct ggtggagcca ggatttgaac ccaggctgtc 51300
 tggttcctga gcactctctc tgatgatggg cacatgcagt gaggagtgat acaagtggag 51360
 ctgagtggaa gtagccctca cacacactca gacttgaagt tattgaaaat ccgggaggtt 51420
 gccacccaaa cacatttaag gtttaattca tctgaataag aacagcattc cactaagccc 51480
 agataagtac tcttattaca tttacatagc ttaaggctct gtacaagaaa ccttgaacat 51540
 aaaatacttg gaacagaaaa gagtaggaga actatgaagt aatgggggga aaaaatccct 51600
 gaaaggaaca atacaagcgg ggagttatga gacctgggac ctcagagcct cggggtggaa 51660
 gatgatattt tgatataatc aggagggaga aatttcctct catttttcac atttctgtac 51720
 tatataagat tttaccataa aacgcaagag tataagccat tgtcagattt ataaaaggcc 51780
 atggtggatt tccttaagag acgatggatg actgttgtta gtaggtaaat tccctggttg 51840
 gttatctcat acactcagat attccataag tcagcctgtg gcttctgaaa ctgtattgag 51900
 aaaaagctgt ataaactagg tgttggtcca tgctccttca ttagcattac aaaagggttc 51960
 gactgctgag ttgaatctta tccactcctt cagtggccat tacagaaagc tctcaagtgt 52020
 aattttctaa agagaactaa aaataaataa gaaaaaaaaa atccagcatt aataatggtt 52080
 ctttttgcat ttccaacaca gtcattgcca aattggttct gcctttttat gttttttaat 52140
 gaaaagcagc ctaattgatc aattggtcat gaataatact tcttcgtttg tttttctcca 52200
 caccccccag ccttctagaa ccacgggctt aatgtgtcgg cctacaaatg gttcatgatt 52260
 tgtgtttttt gtctagtgct ttatgggaaa atattagaaa caaactgctg agaactcagt 52320
  aggaactcag taaataataa gtagatagtt ctcttgttaa atatgatttt aaagaaactc 52380
 tttctaaata actaggaaat attacaaggg aagtacaaag tggggtggaa agcctggctg 52440
 acttgtaatt tgaaatttct cttcatcatt ttataggtca cacagtttaa ccctttataa 52500
 aacaaaatgt aaagtctgat agctgaaaag gctctcctcc gctaaataga tttgtttgaa 52560
 aatatagatc attaaatcgg taagaataac aggagaatct caaccaaaca ttgagacaac 52620
 taagaaaatt gtctaaatct aataccttat atcagtactt taagttgacc ataaatacgc 52680
 tgatatccat agcacatagg ttcttactgg cagtggtggg gtgggtgggg gaaggggagt 52740
 gtcacagaca cattcaagat gtcaacgaaa actatgaaaa ctctccccaa tggggaaaaa 52800
 aaaccaacga tgcctagcac ttatcctacg caactttgta cagaatttcc gtgggaaatt 52860
 ctggtgtcca tccatcataa atcacctggt gtccacccat atatcctgaa taggaaaaat 52920
 tgtctttctc tagagttatt gtacactgat cctgatggag ctttaaaaag agttgtcgta 52980
 caggctcatt gactttggga ggacaaggtg ggaggattgc ttgagcgcag gagattgaga 53040
 ccagcctggg caacatggtg aggccccatc tctacaagat attcttttaa aaaattagcc 53100
 aggcccagtg gcccgcacct gtagtccaag ttactccaga ggctgaggca ggaggatccc 53160
 ttgagcccaa gagatcaagg ctgcagtaag ccgtgttcac accgctacac tccagcctgg 53220
 gcaacagagt gagatcctgt ctcaaaaaat aaataagtaa ataaaaagag ttgccattat 53280
 cttgtttgat ctggctatga tctttgaggt agacagacca cagattttac ctctcattct 53340
 gcagagtggg aaaagcaagg cttggagagt ttccgggact tgctcaaggt aatttgctaa 53400
 tgtctgccgg gacgtagcac caagcctgtc acgctgtagg ctgggcccct tccacaacac 53460
 tggtccaaac acaggattct ggagatgcag gagccctcga tgggcttctg gaaagctgaa 53520
 ttctggctct accagagcta cccacgtgat cttaaacaag tcacctaact tccctgagct 53580
 tcagtttctt ccttagtcaa gtgagaggtt agactgtgtg ttctctgaag ccctttgatt 53640
 ttctgcagaa aaccacctaa tcccactggg tctgggaaca gagggaaatg accttttctg 53700
 ccatagatgg caagaccctt cacccttccc tgtagggcat aagagctggc atccaattct 53760
 taacggattc ccttgcaatg tccaaatccc attagaaact acaaacatct caatagtgcc 53820
 tttgtgggct gcttgggtgt catgccgctg gctgcctcac ttgctgcagg gctgactgtc 53880
 cacatcaatt atactccaac cctgtgctct gcaatgggca gacatcccat gagattttat 53940
 tacccctctt gggtagttca gggagtcata tggaagtaaa taatgctgat gggcttattt 54000
 tgggctgata gatccttatc cttctaaaga ggttatgcct ttcaaagggt acaaaacctt 54060
 ctccttgatt ttttattacg aacagttata tcctttaatg tcccagaatt gttcttggaa 54120
 gttggagact cacaagaggg cctgcagctg tgaatgcaga agtcctgaga ctaggggagg 54180
 acatcaccac tctcccttgg cctttggagt catccaagct aagtgctaat atttgtgatt 54240
 aacaggtgtt gataggaaat tgggcccctg tgtctcagtc tttttgtgct tcaaattttc 54300
 taagtgaact tcaggctggc aagtggagtt agatcaactt gttgcagaca gtatcatctg 54360
 ctcggtaccg tgtcaggtca ctggactgtg ggaggttata ctgaccagtg atgagagtga 54420
 cagagcatga gcttggctcc cgtatcctgt gttctgtgct cagcctcaca gatgactcac 54480
 tgtgcctcat cgactcctct gtcctcgagt gaaattatgc cattctttaa cccactatac 54540
 aagagacttt tgaagattca tgtgtggcta cccccaacaa tatctcattt gtacaatgca 54600
 gaacatggtg ctttcttgtg taaacaaact cattttgtgg aatttttatt ttctagatca 54660
 atatttttaa atagactact aattcatttt ataaaccggg tactataaga ttttatgagt 54720
 tgacacttgg taccctgtaa gtatccaaat aatcaaagaa ggagaaagtg tgaagtcaag 54780
 gaatccccta gctgaaaaga aattcccaat acctggaaca aaaaagatgg agcttttaga 54840
 gagcagactt tttctccagc aaagatccac aacttccatt tttaaatgta agacgtaagg 54900
 gagatttatg atacagccta ctttgtcaga tcatattatt tcataaagtg aagggtcaat 54960
 taggtgttat tattatcaag aaagcatgct gtaatgcttc gtcttgtaga tgctgtaaaa 55020
 attacctgtc tgattacttt aattcatctt ttggctactg tctgcagaaa ttcactcagt 55080
 ccctagctca caggtatgca gacgtactga gaacactttg ggaaataaaa gcaaaaaaaa 55140
 cattgggtcc tttcccctaa ggaatgaaca gtgtatttgg gaaactagga aaaacaaaca 55200
 aacaaaaaaa tggtaccaca atgcaaaact gatgaggaga ttaaaaaaca gctcaagatg 55260
 gagattttta gaaagaactt cttgaaggag gtgcatctgt aggctgagag agatggttta 55320
 gcaagcaggc atcaatgcat ccacaaagct ttacacttca aggaaatcat aggagaaaca 55380
 gggtcttctt tgctgaagat ctgtttattt tgcaaacaac aaagagtcag aagagccatg 55440
 tgaagtttcc atggggaatc cagaaactaa acttctgcca ctggaaatta cctcaagatc 55500
 ttttcccaga tagcctgctc ttcccctgct tccaatcatg tccctcaaag tcttcttttt 55560
 caagcataaa tatccttagt tcttgtaacc actcctccta tgaggcagtt ttgcgtgctg 55620
 ccattatttt aagcacccgc ctctgattgg actctagctt agggcctccc ctaagtcacg 55680
 ggactcagaa cggagcaacg ctctccagga gtgatctgag gatgcagaac accatggggt  55740
 agttgcctcc cttgatctgt agcctatact tctattaata tggcccatga ttgcatgagc 55800
 ccttttggca cccatgtcac actgctgact catatcgaaa ttgtggtcaa ctaaaaccca 55860
 tgagttccca tgcactacta ctaagccaga tctttctttc tttttctttt ctttttttct 55920
 ttttttttga gaccaagtct cgctctgtcg cccaggctgg agtgcagtgg cgcaatctcg 55980
 gctcactgca acctctgcct cgtgagttca agtgattctc ctgcctcagc ctcccgagta 56040
 gctgggatta caggcgcccg ccaccacgcc cggctaattt ttgtattttt agtagagacg 56100
 gggtttcacc atgttggtca ggctggtctt gaactcctga cattgtgatc cgcctgcctc 56160
 ggcctcgcaa agtgctggga ttacaggcat gagccaccat gcccagccag atctttctta 56220
 ttctgtactt acactgttga tttaaaaaaa aaaaaaaacc ctaggacaga ggtttaaatg 56280
 taaagacatt tatttctatt tcactcgatc attttgataa caacttgtcc aaatctttca 56340
 gagctagggt attagcttcc cctccctgca ggtgagtact tacctgctgg tgcagctaat 56400
 ctcatgatgg atctctggcc tctaaagggc cagaacttca ttgtctcttt cctatccata 56460
 aattctctgc aaccgtggat gaatctgcat ccttagacaa actagtgggc ctcaatcttc 56520
 ctaagtaaga taggaataag tgtgaatggc catttcctcc ttgcggtgag gatatgcgac 56580
 aatgagttcg atgtctgcaa aaccctaagg aaatgtcact cagaggcagc attagatgag 56640
 gagagaaaaa gtttatttca ggctctcagc agctttcaga agacttgatt atcctgatca 56700
 ctacgtgtga aagttaatga cttcattttt gcagttattt taaaaatata actggtttat 56760
 ctgatttttg gttgtagtaa catcacgtga tggtcagtat cattttacac attatttgta 56820
 atgtgagcaa gtgccataaa gcatatctgc aagactcatt taaaatgact ctcttccctc 56880
 catcacctcc cccagcccca tcctcaactc taccctcttc tgtttgtaat acgggactac 56940
 aaagatctta tagtttaggt ttccgtcaga cttttggaaa cctttaaaag acttaccaag 57000
 ctagcttaga agttcataga ttttcatccc tggccagcgc agagagctca caggtaactt 57060
  gtataatatt tatcatttca agctcataga aatgtcatat ttcaaaacac atccctgaga 57120
 gcagtttttt tgttccttat agacaggtgc agggaacatc caaatttttc tagtctgcca 57180
 ttctaatgca cattgtgatg ttgctcttgt gaccctataa ttattaattt tccagtagcc 57240
 cctccccaac ctttcacgtg atttttaatc cagggcctgg gcactcgtag cagagtgtga 57300
 tcctaggacc agcagcaacg gcaccgccgg ggagcctgtt agaagtgagg atctcagacc 57360
 ctgcctcaaa cctattgaat cagaatctaa actgtgaaaa aattcccctg gtgattctta 57420
 tgcacagtaa aatctgagaa gaacagatct agagtgaagg gattttcact cccattttac 57480
 ccgctgtaga ccttatgttg taatacaaaa cttacaaact tccatttggt gtttattaaa 57540
 aggttagagt ccttagttaa aatgttacca gattcaaatg ttctgtttat atattcagct 57600
 atttctcagt gtatgtaact ggctttaaaa tactcttgtt gaccaggcat ggtggctcac 57660
 gcctgtaatc ccaacccttt gggaggccag ggtgggagga ttgcttgagc tcaggagttt 57720
 gaggccagcc tgggcaacat agcgagatca catctctaca aaaaattaaa aattagccag 57780
 ggatggtgat gcatgcctgt agtcctagct acaggaggct gaggcaggag gatcacttga 57840
 gcccaggagt ttgaagttgt aatgagatat gactgagata ctgtactcca tccagcctgg 57900
 gtgacatagt gagaccttgt ctctggaaaa aaagtactct tgcctttctg ggttcttgtg 57960
 gagcaggggt tctcccccac tcccaccagg gacatttggc aatgccagga aacatttttt 58020
 gtcacagttt gcagggagag gtcctactgg tgggtagaag ctagggatgc tgctgagaat 58080
 cctacaatgc acaggatggg cccccacaac aaggacttaa ctggccccaa atgtcaatag 58140
 tgacaaggtt ggaaaacacc agtatatgat ttataaagac tcagatgtgc gaccataaac 58200
 catagaatgc cacaggaaaa tagagtcacg tggcatgtca ctatatgacc aggcaaagaa 58260
 caaatagacc agcagtggcc ggagtgatgg tggtggggtt gtgagtggca gggaatggaa 58320
 aatccagcca cagatgaaag gagacatcta ggaccaatgc taactggtac tccgtgcaca 58380
 aaggcagtga gctctagagg acagggctaa aaggccggtc acggtggctc acacctgtaa 58440
 tcccagcact ttgggtgtcc gaggcgggtg gatcatctga ggtcaggagt tcgagaccag 58500
 cctggccaac atggtgaaac cccgtctcta ctaaaaatac aaaaattagc taggcatggt 58560
 ggcgggcgcc tgtaatccca gctactcggg tggctgaggt gggagaatcg cttataccta 58620
 ggagctggag gttgcagtga gcagagattg caccactgca ctacagcctg ggtgacagag 58680
 caagactcca tctcaaaaaa aaaaaaaaaa aaagaggaca gggctgatgt tcagggactg 58740
 gacaccaggt atgagcccca ggaggggtgg aaggaggtgt gggagaaata gagagagaga 58800
 aggcttcagt tctagagtgg ataccaggta tgatctcaaa atcgtgttag acatggaaaa 58860
 caagaaagga tttcaagtat tagcatagga gtacacaggc agatttcagg taaatccagt 58920
 aagatgaaga ctcaggaaca aggcagaatc ctgcttgcta gaactggggc gcctcagagc 58980
 caggccagca gcaggcatga ccgatgctga gtcagccaag tgttcaacta gagtgagctt 59040
 cttaaatccc tcccaactga gaaggggctt agtgctgagt ctacagcatg gttgacttgc 59100
 aagaaggggt caagggctcc cagctatgga gaaaggtaga ccagaagtaa gccagaagta 59160
 ggccagtgac agtggccact gaaaaatcac gggataagaa atggaacaga actcgagagg 59220
 tcctctgggt cattccccta ctgcagcgtg cacctaaatc atttcagaaa gattatctac 59280
 gcttcaactt taacattttc agagaaagat ttcttaaaga ccagtgggtg ccttataatc 59340
 catcgaagtc acagcttctt ccccatttct aaccctaaac acctcttcct gggatgtaaa 59400
 gcgagtgtct ttcatcccac cctgcacaca gtgtgatttc tatcattcag taatgataaa 59460
 gaacacaaac tgccgtctgc aactgccaag cacagccacc ccttttccag gctaaagcat 59520
 ctcaattcca ttagtctgtt gccctgagag tctctccctg accttttaat cccctcatta 59580
 tcctctggac ctgctccaag ccttgcctgc ttgaaatagt taccaccaag tatgtatttg 59640
 ttaaataaaa gctgtgtgca gactgccctt ttgccatgga acacaaagga ggaggaatat 59700
 aaaagaatat acacagtttt gttggttttt attagtctct ctcctctctc tccaaggagt 59760
 tgtcaatctt ctctgcactt atagtctagt tggagcacta gtccttaggc taaattccac 59820
 caaaacattt tggttgttca gcaaacgctt tcactgtgac cctcacctaa gaacaataga 59880
 gtacaccatc aaatgggata gctctaatgt gaatttagct ctaaataaaa ctaggataaa 59940
 tgcatttgtt cagttctaga gaaggcatca tactgtcctg tggatttttc atttcgaatg 60000
 agctgcaaaa caaagttctt ttccatggaa aggatttact caactgaatt cactcacttt 60060
 gctgtagctg gattaatctc atttcacatc atgtctctaa gtagaaaagt aaactgattt 60120
 acagcaggct aagtggatat gttgatgcat ccaacatcag tgagatttat tccaactaga 60180
 ttgcaaccag aaaatggtgt cctggttgtt tttgcttcta taaagtagtc gcaaaagtgc 60240
 accactttcg tactcgatct gaaaaacagt ttatcaaagt tacaacagat gaggtattgt 60300
 gggatgcgac agaacgtacg tacgtcaaat gaaatgagca tttctgcctt cccagatctt 60360
 gaaatggtct tttgccccac aaccttataa aaaaaaatat tcattttagg ccaggcacgg 60420
 tggctcacac ctgtaatccc agcactctgg gaggctgagg caggtggatc actcgaagtc  60480
 tggagttgaa gaccagcctg gccaacatgg tgaaacccca tctctactaa aaatacaaaa 60540
 attagctgga tgtggtggtg ggtgcctgta atcccagcta ctcaggaggc cgaggtggga 60600
 gaatcacttg aacccgggag gcagaggctg cagtgagcca agatcacacc actacactcc 60660
 agcctgggcg acagagtcag actccatctc aaaaaaaaaa aaaaaaagaa aagaaaaaaa 60720
 agaaataaat aaataaaatc attttattct atccccatgt tctgaaagcc accctttttt 60780
 atttttgagt tgtgtttcac ggggcactgc tcaaggtaaa cacccagccc cacttgtggt 60840
 tgagcaggca ttgaccccac actggctccc tgccctggag ccagccacca ccctgttcct 60900
 tgctccacct tctgctttct gcagcacact ctttcttctt tttcttctgc atcactctgc 60960
 atttccaaag ccacaatcgt gtcatcctct cgggactctc agtctctgtc tatgctggtg 61020
 ccctctcctt tgtctctccc agattgctga ctttattcca gcttctgctt ctaacacaat 61080
 aagactgcta ttggaaatgt ttttctgact tctatagctg gcagtttcta taagcagaag 61140
 ttactttcaa aggaaagaac ttgtggagat gagcctgggg tgtcacaggg ctgttacatg 61200
 ggtcaaatgt aataacgtgt atcaaaaagc aatttgtaaa ctgtaacatg ctcttcaaaa 61260
 gtaaattatt actgtattat atgactttag ggtttaaaaa gcagctggat gatatgtaaa 61320
 aattcaaggc tcagtagcat cattggaaaa gaaaattaga aaatggggag gggcacggac 61380
 gcttccatca acaagctagg ggcctctcaa cattttttcc agccaaagca cacccattta 61440
 gctgagagca tacactctct tctgaggact gcctgctcac cattctggac ctaaggcctt 61500
 ccctcttgct taagctcccc catccctctc atcgccacct tcccaaatcc tagctgaccc 61560
 caagggctaa cccccaatcc accctccctt cccagctctg ccccagatta agtgaatctc  61620
 tttctctcca gcactcagtc ttatgttaga attatttatg tgggcattga tcttcctgga 61680
 ttgactgtga cctgctgaag gcagcggtgg tcctggcatc tgccacagcc ccctccccca 61740
 acagcacttc atcacctccg tgaacggaag tgaatggaag gaacagctca attaggatgg 61800
  cagaggatca aggagagaat tccacggacc caaaacatcc tgcaaaaagg ctttgtcccc 61860
 agaggttggt cttcaatttg gaaaaattcc tacctgagca actgtaggac ccctctgaaa 61920
 tggaacaggg tctattagac tcataaaaag cctcagtgat gagttggtta ttattattct 61980
 ctttactttt ctgtacattt aaagtgtttt atattttaaa ttgaatgtaa aaagatccca 62040
 tcctatttaa aagttagtga gttgaataag tttcattata acttgatttt cttcctaaag 62100
 gttttcctat agttcaaatt ataaaagtca ttcttagatt cccagcttag ttcccccatg 62160
 aaatcacgag ttcttagact gtgtttcaca caatgccagg tcacattgca cccttactga 62220
 aaggaacttc ttgtgcagag tgcggggctc ttggagaaag aaaagtacca cttttttagc 62280
 acattaaaaa caaatccttg agctgtttta ttattttaat actttacctt tagtggagca 62340
 gaaatgattt atttgatggt tttggcaggt gatttttttt ttcggaatct tctttaacac 62400
 tattagccat gtaactattg ccaagtacat aataagtact caataattat tattatcttt 62460
 taattaaaat gtgatgcact tctaaactaa aggtaacttc agtcatgtag aatagaaagc 62520
 aatgggtgga gcttccaatt gcttctcttt ggtattcatt agaaatcatt tttgaaactg 62580
 agaagttggg ggaaagatca gacattttta tggaaactgc attgatgaca gcagagtgta 62640
 attttgttgg tagtgatttg atacacaatt atttgaggga tttactgtgc tcatggatta 62700
 gcgctgtgtt gttactgtaa cagaggattg gcgcagagcc ctggcccagt gcaaagctct 62760
 ctaacatcgt ttctcttcct tcatcagcag cccaaagccc ccctctctac aactccatgc 62820
 agcacagtcc tggcacaaac ccctaacctg aaattccagc caatttcact aacaacacgc 62880
 ctctcccctt cacctgccag atgcttctcg ttctcagaca ctgcaccctg aaattgggag 62940
 ctttcactga gttaaaaagg caaatataga attacctagc tgtatcagta ttttaagtgc 63000
 acttgtagac ttaaatgaga gctcttgtac aaaaccactt gtattctttc ttaagatatg 63060
 ctaatttttt tctctctttg attgaactgt tgaccttctg gatatatgac tagttattac 63120
 ttcaagtatg tttggaacta ttcttgccct aactgttcta aaatgtaatt agcattgaga 63180
 cattattgta gaagcacagc acctggggct gggatctcat tagatggcaa aaattgagca 63240
 gaattgtgca tgctccatgc tcaaaatatc tctaagaaaa attaatggca ttagggggaa 63300
 agttaaaatt ggtgatttcg taggcccttt cttgctcaca tatttgattc gtataaggat 63360
 ccaaacagaa aggagattgt ggttcttctg tttaaaaaat gaagacaact ctgctttctt 63420
 agaactcttc ttatgtaatg tggctgctgt cacatctctg ggtcaaccaa aaccaaaata 63480
 atacattttc tggctctagc tttttccccc ctcaagaaat gcatagcatt tttaggcatt 63540
 atctgatttt tccttgcaac aacagatgtt acagagaatg aatattctgt aagaggtagt 63600
 taacaaagtg tggaaaaact gaggcccaaa gaggtactat aactcacggg tttttcacgc 63660
 tcctccctga acattcccgc atctcttcta ctggggaggg agctctttat tttctgaatt 63720
 gaaaaccatt tcatgcctcc tgctcagcta tttcagtact ggctcctaag tttggcacca 63780
 atcccaactg ttatgaaatc gcagacgaat aataacgaag ttcttcattg ctgggatccc 63840
 aaaaggttat catttcgagt tcattgcagg gcactttaga cgtccatatt gggccctaaa 63900
 tgattggaac catcaggaga gggcttgcct gactctgcca ttcacctcat ttgtaagtct 63960
 ctgccgtgtt tcgacactga gttgtgtctt gttgtttaaa aataacttct cattataata 64020
 acattttccc ttaattgaaa aaatatttct gacctgaatt tattattgtc atagctgtgt 64080
 gagcaagcag agtcttgttt gcctctacaa tatattaata atgtattaat tagcttccca 64140
 gtgctgccca aacaaggaac aaaaaggatt tatctaaatc atgaaaactg aagtgaagcg 64200
 aacactttgg taattatatt ttaagggcag tctcagcatt tgatagtgtg gcaaattttt 64260
 gtcctgcctt ttgagagaag ataaccaaaa acaccactca attaacaaaa cgttgtttag 64320
 tacctactat gcacaaagtc tgagaggtaa aagaggttaa gacaaataaa attgtccaat 64380
 ttatttttat ggccatagtt aaaaggcaat aaaggcaaga cactgtgagt attttgattt 64440
 agctacaatt agctgaaata tactacatca aatcatatga aattgacaat atctgggggc 64500
 tggctgccgt gactcatgcc tgtaatccca gcacttttgg ggcccaggat aatcacttga 64560
 ggccaggagt tcaaggctac agtgagccag ggttgtacca cggcactcca gcctgggcca 64620
 cagtgtgacc ctgtctctaa agaaataaaa ataaaaataa atagaagata ttgacaatag 64680
 ctgaccctat tttttacccc aaaagtggtg attttatata atttaatcta atattaaggt 64740
 attcttgtca tactgtacca gctcctaaac attatacttt tcattttact tctatttcta 64800
 agctatcatt attacaacaa ccaagagaag gtaaatacag gtcagagatt tgactcctgt 64860
 tttttgtatg tatttatttt tgtagattca caaataactt atattttgca gttttaaggt 64920
 ttctaattat attagaccct gttttttatt ttatttagag tcattgtcct tgctgcctgt 64980
 ccttcacatg tgacaagtca attcttcatg ccatttcctt cacaatcttc atgcaaactc 65040
 atcatctcca tttccatcta ttcttcagag atgtatgatt gcagaaaact cccctttttt 65100
 gaaatattgc tcaatagaga ttaaatctaa cacccagttt tacctgtcta tccttgaatt 65160
 acaggttact gagaagtcag aacagatagc catagaagta ccccactaaa tccattcttc 65220
 tatctccttc aatatttgac aaatatttac taagcatcta tcttgagcaa gcattggagt 65280
 aagtcctccc ataaatatga agttgtgtaa ataaggatgc atgcattcat gtaaatacaa 65340
 gtttaatgct ggatatatat tgttttaagt gcctgatatg tattagtcta tttattccta 65400
 tctaagggga taagtgccat tgttgtttcc atcttaaaga tgaggaaact gaggccagag 65460
 agattatacg aactcctaaa accctaactc ttaaccacag cattcagaat ctatctggtt 65520
 gtagtggagg acccaatgtc aaaaaagcaa gtgcttttcc cagaccatga acacaatgtg 65580
 tgacaaatta gcagttcttc cccttgccct aagatagtaa atatccaccc aggccaactt 65640
 gtgtctgtca gagaacaaag agtgggcttg tcacactgtt ttctcccaag agggtccatc 65700
 tgcctccgct cctttggtac acgctagggg acacacactg tccagcatat tcttgcagag 65760
 tcatatctta ccccacatct tatcacaacc ctgctgaatg tcaggcacta tcaagaaaat 65820
 gttcactcat cttcttcccg ttatgcccaa tgtgtgaact gataacacat ctaaattcaa 65880
 agaaaatcaa cagacatcac ctcaatcaac ctgaaaagtc tggtgactca ttcccaccct 65940
 tctcacgggg ctcctgctgg gctgcctggt tctccggaac cagcctccag gcctcctgca 66000
 gccggggtgc agctcagtgt tcgagccccc tctctgctgc ccatcagatg agtgttgact 66060
 ttctttggca caggcatttg agttgcattt gaattgcaga acatgctgcc cccattctgt 66120
 gctgactgtg accccacttc atgtgcccca gaggcaggct aaacaagctt gccttggaaa 66180
 aaataacagg gaagaagatg ctgactctcc aacccccaga gtaagttccg tcactctgga 66240
 ggtaaagtca taatatctaa atatggctcg attcatgtca ggtcttataa atacacacac 66300
 acacgtggat gctgaaaccg tgcatgccct gacagccaaa aaaaaagtca aaacgactta  66360
 ctgtctcatt agcaggacaa gacctgatag gccagctcac cagaataaag aatacaaaaa 66420
 atgggtattt aacttctcta cacagacaca cacacacaca cacacacaca cacacacaca 66480
 cacacacaca caatctgatg taacgacctc aagagagctg gttgccctgg caatgaagaa 66540
  tcgtttgtat attcaaggat tttcttgttt aaatttaagc tagccacttg aacttctcga 66600
 gctttcttga gcttagcttc aggcctccat ccccagacag aggtctgaca tctatgtcag 66660
 cctctagcaa ggcaggaagc ttagaagtcg gaccaaaacc tcacaagcca gccagcctgg 66720
 atttgaattt cagctctatg gtttctcagc tgtgtgacct gggttagctg cttaaccacc 66780
 ttgaacctct atttcctcac ctgtacaatg ggaataataa aattaaaaca aacttgcatg 66840
 ggttcattat gaaaattaga ttgattgatg acataataca tagcaagcat ttagagctgt 66900
 gcctgattcc gaatgtgagt tatctgtaat agtgacttga aatgggttta cactgcctgg 66960
 caggaaacca ttcaattcct ttttgttttt gactttaatc tttgaagcgc tttcatctca 67020
 tttcttctta ttttgtgttt gtggagaagg aggatgttta gccatccttg gagtacaatc 67080
 ttttattaaa aaccattatt aagtctcttc aagtttctct tttgtagtaa atgatctaga 67140
 ttacttaatg gttctgtttt acatgtttta atcatttatt tgaaccatct ccagatgtag 67200
 tacacacaga aatattgtct aggaaaatgt gttactgaaa ttccttatca tctgtggtcc 67260
 attagctcaa atgtttaaaa cccattgttt ttatttttat tatttattta tttagttatt 67320
 tttgcaagac agggtctcac tcttttgccc aggctagagt gcagtggcac aattatagtt 67380
 cattgcaggc tcgaactcct gggctcaagc aatcctccag cctaagcctc cccaaaactt 67440
 cttattctta agagcaaagt tgagttccat catattgtca gttggtttca ctccatcata 67500
 ttgccaaaac cacctaattc tcagatgcat agtttagcac aagccaaacc agaagagacc 67560
 ataggtcatt cattcattat tcattcaaca tttactaagt gactgctgta tgccagaggc 67620
 tgggctatgc tgtaaagtca caaagaagat acttctcagt tgggagagct tacagcttga 67680
  gagagaagac acacaagcaa acaaatcatt acaaatgcct ttccattggg tgccatactt 67740
 gaaatgagaa gatgaggcca gggtaccctt ggggcagaag ggagggagga ttaagctcag 67800
 ggaacagctt tacagagaag gtaacatttg caccatatta aaggatggca agaattgagg 67860
 agtacaaaaa ggagaatagt ccaagaagaa acactcaggg atgatttgca cattgtaaat 67920
 ttaggtaacc ttacatgcct tacatggggc tgctgtgact gaggcacagg gtcaaggaag 67980
 ggagcagagt cataaagcta cccaggtcag ccaaggccag gctaggaggc ctgagcttta 68040
 tcctgcaggt gtgcagagcc agaggagagt gcaagaagag acatggcaca gtctgatctg 68100
 ttttgcacaa atcactctgg aagcaatgag gaggggagaa tggaggtatt tgagcctaga 68160
 gtcaggaagg agaagtagga tgccagggtt gtggggaaag acgataaagc ccacacaaag 68220
 gagggctgat ggaaagatgg aaatcaattt caggtatatt taggccaggt gcggtggctc 68280
 gcgcctgtaa tccccacact ttgggacgcc gaggcaggtg gattgcctga gctcaggagc 68340
 tcacaaccag cctgggcaac atggtgaaac cccgttctac taaaatacaa aaaattagct 68400
 gggcatggcg gcatgcgcct gtagtcccag ctattcggga ggctgaggca ggagaattgc 68460
 ttgaacctag gaggcggagg ttgcagtgag ccgagattgc tccactgtac tccagcctgg 68520
 gcgacagagt gagattcagt taaaaaaaaa aaaaaaaatt caggtatatt taaaatatag 68580
 tgtttagaga cccattagtg gaagatacca gatttgagaa aggggaggaa aagacacgga 68640
 ggagtccaga agaaatttcc agatttctgg cctggataac tgtgagggca gtggtgccag 68700
 atagtgccag aatgaaatat atagattggc acaaatccat ctctcagaaa tgcacctctg 68760
 agacatctgt tctgctgaag gtcagtaggg aaggccaact tcatgtgcaa agagcaatat 68820
 gtgtgtattt cttactagct attcttttta aaatacttct taatatatgg gacatacatg 68880
 agctaagata gtattcatgc aggaggtttc atttttcatt ttctggcaat tgtgttttca 68940
 aatatgagat gctagcatta tttcagttat ctatgcctag catagtatat atctacggtt 69000
 caagattatt aattgtctcc cctgcctccc cactagaagg taagctttct gaagccaggg 69060
 attttgtctc ttttgtcctc atctccattc ctagccctta aaactaagtt tgactcccaa 69120
 ttatcgagta aatgattgaa tttccatctg agtaaaaaga aacagtcatt tcctttacta 69180
 atgaggaaag aaaaggaaaa caacaaacaa atctggactt aaaacagttt ttacaaaaag 69240
 atccaatttg caaaaatgga actgaagttt aaaagctact tttctccctg cagctctact 69300
 tctgggaaag tcacagctgc cagcttagat ggtggttttc actgcccggt tacaaattct 69360
 gcacagttgt acatattggc agggctcagc ttccttaaat gccattggat cagtagggaa 69420
 atggtgattt tccttattga tttaatgcca gttcctcttt tatgaaaaat cccacgtgct 69480
 gctcactggc gtatgtacca taaaaactga acgtaggggg ccagaaatta agtaagtcac 69540
 tcatgttctt ctccagccat gtgacgttaa accatctcta ctttcaggct ggagtgttca 69600
 atcattctcc ctttaaattt agcagagtga ttattcctcc tggtggattg cacatatgct 69660
 cctttgatct atgaaatact cattctggat gaactttaag ctcccaggaa atgcatgtaa 69720
 aatactgttt ataaatcgcg ggagaaatgt ttcacattct tattactccc aagtaatcat 69780
 accaagcctc tctctccaag attcgctttt tttcctagaa gagggaaaaa gaacttcggg 69840
 cagtagcact gtgacaatca tcaccacggt cgtactttcc atgagtttta cgcagtaggc 69900
 tcacggaagt gacaatgcat ggtcgggcgc ggtggctcat gcctgtaatc ccaacacttc 69960
 gggaggccga agtgggtgga tcaactgagg tcaggagttc aagaccaccc tggccaacat 70020
 agtgaaaccc tatctctact aaaaatacaa aagattagcc ggacgtggtg gtgggcgcct 70080
 gcaatcctag ctactcggga ggctgaggca ggataatcac ttcaacccgg gcggcggagg 70140
 ttgcagtgag ccaagattat accactacac tctagcctgg gtgacaaaac gagactccgt 70200
 ctcaaaaaaa aaaagaagtg acaatgtagg atacccattc atcagcaaat atttaatgtg 70260
 agcaggacaa tgtgctaagt ccatagactg caaagaggag tgaggctggg ttcccatcct 70320
 ctggggctta caaggtagct ggagaagtaa aactcaaacc acaaagtgaa gttaatagtc 70380
 accaatgaac aacatagtaa gctctgcact ggttcagaag aggacaggag taacaagaca 70440
 gtaatcctaa aggagatgga cttgaatttg agctggacct gaagagtcag gagctagagt 70500
 gagtaaaggc agagtggtgg gaacatttgt gaatcaaagc tcaggtgggg gttacggcag 70560
 gcagggtggg gatagactga ggatgacttt gaatgccatg ccactctaag gactttggac 70620
 ttgactctac aagcaaggtg gaattattaa gagattttga gtagaaatga tgtgagctga 70680
 acagtgcttt tgagaaacta aatctagcag ggatcagtgc tccaaattaa ttggacatgt 70740
 ttcagacttg agatcatgag accctgaccc aggctgggga caatgggatg tctccatcat 70800
 acattacatt cctgtgaata cttcttacag attcatatga aattctgcct caatgtgcct 70860
 actgtctctg cactgtaaga cagtgatatt gtgatcctgt gtgctgcttg gaaccagcct 70920
 cattccttta gcaccccagt ttggacttgg agtgggccca agtgcagcct gtacacaaac 70980
 ctcaaagaat ccaggcagca tagatgtaaa agcttggagc cctccaagtc cacctcctca 71040
 acttaccaag aaataagcta actcttgctc atctccctaa tgacggattc agcatgtggc  71100
 ctcagatctt cctgtgctcc agcagtgctt ctgaggccag tccaaattct gctttgaggt 71160
 gtgcgtgtgc caattgtggt gcaatccaga agcattttgg acgaatgaag gagctgtttg 71220
 tgttttcttg ccctaattga gatagttgaa gctcctctcc cttactctac accaagcccc 71280
 ccagatccgg tacctccctg agtccccgac ttcatctctg ccttgcttct tttccacaac 71340
 accctatcag ttcttgcatc ctgccattgg ttgtgctgtc ctcattatct gaagccttta 71400
 cctcccctct taggcctcat cacctccagg agactctcca tggcctcagc ccctccctta 71460
 ggtggaccaa gcttcctcct tggagctcca tgctaccctg catagggctc agtcactttg 71520
 cctccatgat gtcttgcaat tgtctattta tatgtctgcc tcctgtcctt caactgtgag 71580
 ctccctgagg aaaggaactg tgggtatgca tcattgaata ctcagcatct agcacggtgc 71640
 ctggtacaca ctaggtattg aaatgtctga taaatgaatg acagttgcat atttgtcttt 71700
 ttggtatatt cattcatttg gtaaatattt attgagtaat tacttataat tgaattggcg 71760
 ctgtgtagtt acacttaaac atcaaaatga gcctatcctc tcaagctcca aattatgcat 71820
 gcataaatta tacatgtgaa gtgttaacat gcacacgcag cagagagtgt gcgtatctac 71880
 aaataccaga gctagcaaat gaaataaact gtgtgccaga tgtccctgaa atttacaaag 71940
 aaccaagaac caaaaatgac agttagctcc gtaagcccaa caaaagaaaa aaaaaaaaaa 72000
 aaggaaaaga gcaaaaaagc aaaagaacaa aagaaccttg agcataagga agtggctatg 72060
 gttttttcta catgctctag ctgggggtgg ggaaaagtca taaaagcatt ctatgctgga 72120
 ccggttcgtg ttaagtctga gttcctcaat cgctggctct caggagctgt ttggaaaatt 72180
 cgttgccatg catgagtcgg gggattggtt ttttttccac tggaaattgt taatggggac 72240
 tgcattagcg gccccttatc gctttgcctg atagagagac agcaggttcg cccaaacaat 72300
 tctggaaccc tgatcactgc caattagggg agtattgtct ggctgacata atcaagtaag 72360
 tataaatata tttatcgtga ttggaatggg gaagggagac tgcagaaaga ttgaggcaga 72420
  agctgccacc cactgcctgg ctccagcctg gatccagccc agtttgtcac cctgtgctca 72480
 gcagaggcgg tcactggctt tctgaggtgg aatgcacagt tgagaattca ggactagaat 72540
 tgcttctccc agagagaaac ttgtctcttc tcatttttcc tcccctcttc ttctcttttt 72600
 ttcatgctca cttctgtgag agctgaaaag agaagaaaaa gcagatgcca cgttgatcac 72660
 gttttaattc tgcccccccg gccatgctat ccccacttac cttctctgta gtggaaagtg 72720
 atggtgaggc acagtgccct gactggacct cccatcctct cggcccgccg gcatgtgcaa 72780
 gttggtctgg cattgggttt atttcattgt tgatttgtgg agctttttgg gaatacctgt 72840
 gatgtgaatc agccctggga ttgaaagacc ctgaaaaaac agtcccttgc agtgggctag 72900
 tgacgggagg aattgctcac atttaaacag ctgaaaagca gacatgttta agtcacatct 72960
 ggtggcattc ctgttgtctg aatggagagc aaggtctttt taagcatctg cccagatttc 73020
 aaaatgcagg ctgcatcttt tcttcctcaa acaaatggtc aggatcggat atgaatggcc 73080
 taatcgcatc gggagaggta aacaaaactg atctcatggc tggatttcaa ccttggtcca 73140
 tccaggccca atcgatctaa ggcatgactt ttttttttcc tctcacccat gactacttga 73200
 taatggccat ttccggggcc aagttcattt cggctctttt ccaccatccc ccgtgtgctg 73260
 ccctgtctca ccacttgagg gctgaggccc cttcccaatg gctacaacag ggtaagggga 73320
 ccctgtcctt ctgtctcctt catcctatag tttgtcttca cagctgcaaa ttgctctcag 73380
 gcctgccttc ctggatttga caaaaactat tttcttactg gtactatgga taccacaagt 73440
 ggagatgtaa gtaggaaggt gcaggtccac aaataaatag ggagcccaga tgggagaaat 73500
 gtcattagag agatcactgt ccctaaaggc atctgaccac ccatgttcct gcctctttct 73560
 gcgaccattt tcctccttcg gctgctcaga aattgtcgag gccaaactcc tttcacccag 73620
 attccagaaa tacacttatt tcctttgctt tccaaatctt aatggatgaa acacctcttt 73680
 ttttttgtct tctatctctt gccagaaata ttgttttttg agaaccagag ctcatttatc 73740
 tccaagggag aaagaaattc attccatgtt tacccattaa caaattacca cttacatgaa 73800
 aatactggga cttctctcat tctttgctaa taaatgggtt attcaccttg gttgaaccat 73860
 ggcagaggca gatggatagc cactattccc ttcaagttgg cttaatattc tctcgttggc 73920
 ttttgtctcc ttgaagcaca gagatttctc agagctttct ttgcttgatt ctgcttttaa 73980
 ggaacgtgcc caacttattt gagtctgttt gtttagtaag ctgaattgat taaatccctg 74040
 gcatttatgg aggagcctac tgtgttgggt gctatgggtt cctccccact tgaaagttga 74100
 attggagtca cccatctgaa tactaactcc ctcctaatcc attggttttc ctgctgtgta 74160
 gacaggggta tgaagtagcc atttaccaag agatagtgcg atgtcataaa ccgaacatga 74220
 gttctaaagt tagcaagacc tggtttgtac agtagtgcag gcttgggcac gttgctgctc 74280
 tcttttgagt cacacattcc tcattataga tgctgatggg aacaacagag ctgtctgttc 74340
 atctttgctc ttctccataa tgagataaag ccaaacagac agtgaagagc ctggtctaac 74400
 cacataacgt tggtgcaaat tatatatggt cataagaagg taatttttac ctgagcattt 74460
 aggtggcatt tggtgtggta tttgatgcat gtcatttagt tacagagata aaacctcctg 74520
 aacacacata aagctcttgg cctggttgaa cattacatct cacagatttt tatgtttttt 74580
 actaaggata cttcctgcta ggaagttgta aaagagaaga tggaagtctt tttaatggta 74640
 ttgtagcaat atcagtttcc tagctttgat actgtactat ggtgatgtaa gatgtcccca 74700
 ttaggggaag tggggtgaag agtacagggg acctctgtac tatttttgca atttcctgag 74760
 agacagaggg aaagagagaa agagagagag agaggaggga atgagtggag tgacatgaaa 74820
 aaggagtgtt catcttggct tatgtccctg gctggacaaa tatttacatt ttgtttgcct 74880
 ctttgtatag attttgtgaa tagtcatggt taaaagctag cattcccttt tctgtggaag 74940
 agaagaaaga taatagaatg agctgagaat ccctgccaac attatattag aaagccacct 75000
 acttcctgcc tctcctcacc ctccttacct atacaaactt accttctgca tctttgtcct 75060
 ccttctttcc cattcaaagg ggagatgcgt ctcctgctga acaaatgaac tcctccgcat 75120
 gaccaaggtg tcccatccct ccctgctgtc tccaaaggtt cagtcctgct acataatctc 75180
 tctaggtgaa ttccttctta ctcagggttt tcacaatcat ctatattgga atagcaccca 75240
 aattaatagc tctacccaga cttttttatt gagttctata cctgcatagc caatccttga 75300
 ctgggagtct ctacatagat cattcacaag catttcaaac acccctttaa ttatctcctc 75360
 tttctgtatt cccttatctc agaaaatgct accaacatct accctaatgc ccccagcagg 75420
 aactcaagag tcgttctaga cctatgctgt cccaagtact tcaatgtggc ttgtccaaat 75480
 tgaaatgtgc tgtaagtgta aaatacacac cagatttcaa agacttagtt tggaaaaaat 75540
 aatgcaaagt atctcaataa tattttatat tgatttcaaa ttgaaatgat aatattttgg 75600
 acatattggg ttaaataagt tattaaaaat aattttcttt tactttttaa agtgccacca 75660
 aaatatttaa aatggcataa tggctggcat ttgtgacttg cattctattt ctattggata 75720
 acaccattct agactctttt ctgtctttta gcccccttcc aactggtcat aattcacagt 75780
 gattcccttg agttaagaca agggagaata ctgtttaagt gcacaggctg agtttgaatc  75840
 ctggctccac cattttttga tacatatgaa cttgggtgat tatttaaccc ctttgagctt 75900
 cactttcctc atctgtcagc tggatacaat agcagttctt attttgagat tcttgcatgc 75960
 tttaaatgag ataatgtgta aagtacttac tatggagata aaaacatgtg gaaagaccca 76020
 gtgtcaaaag aaagagcatg atctgtcact gttgtagttc aggccctcat cattactagc 76080
 caagactact gcgatgcttt ctccatcttc ggttcaccct gccctccatt ccttcatact 76140
 gccatctgat taaacattcc tgaatgcaaa tgttttcaaa tgtccaatga cttcccatca 76200
 tccttggtat gaagtcctaa gtccctggca tgctttcaat gtcctccatg atctgccccc 76260
 agtccaatca ctgatcccat ctcctgccag tccatgattg aaccagttgg gtccccaact 76320
 cctatttgca cacaccattc tctctgtgtg tcatatatga gctctctact ctgcctagct 76380
 acttgtctgc aagactcagt tcaattgtca cctcatttgg gaagcttcca ctaatccctc 76440
 ctgcacctgt ctccgtccta ggctagatta ggagcctgcc ctttgggttc ctgaaccact 76500
 tgaggtgtgg ttcctttatc atgctgatct cactggtttg gctgacttgt ttttcctaca 76560
 agactgaact gtctgaggtc ttaagatggg ctgtctagtc cacactggat cttcatgctc 76620
 tacacagggc ttgacacaga gtggggcaca ggaaatgttt gttgaacgaa tacacaaagc 76680
 atatggatac tcctgagaga gagaaggtgg gcaagacagc cttgtgaagt taagcagcag 76740
 aaaatctgaa aacgaacctg gatagaaatc accaattcct ggaagtacag agagaggaag 76800
 gagagagaag aatctgtgca aggagtcagt aatggaggac ttgaaatgaa aggctattaa 76860
 agagagaaga tcattcaaac aacagaacca catttggtac tgttggtggt tttgtaactt 76920
 cctctgaaat ggttccagga agagacaagg ttctaggatg gtgcaaatca tataaagaaa  76980
 ggatggggta ttataagcca attcaaggat tatttgtcat caggactaga tacatgggtg 77040
 gtacaagtaa atgtcaacct gatgactaca cgatgggact agtaataatt tactggggct 77100
 ggtgcccagg aaattttttg ctgtggtgca gatgccaagc atggaaaaat ttgacgagtt 77160
  ataggcatga gaaagtagat ggcgaatttg agagtaacaa tgtaaaatgc cagagtaatc 77220
 acaagagaaa tgtctgaata tgtaagagag tttagaagat ttctgcttta ccacaaatac 77280
 ggacttcaag aaaaattccc ttataagaac agaaattcca atatataaaa cttatttatc 77340
 aaaacacaca gtattccata atatataatg gtaaaagcat gccttttgac ccacacaata 77400
 ttaaaagcag caaataacac aagaaaggta gagaaaacag aaggtacaac attttgtggc 77460
 tcacaggata tatgagtgag attatatact tctattccaa accacaacct tcactagaac 77520
 atctaaaggc ttcattctag aaccttcata ctgcttatcc caaaggctag cccactcccc 77580
 ggttttcatg taagaaatct tgtgggacag gcgttgcatg aggtgagggg cagcagggaa 77640
 attcgagatg aaagggtgaa aagatcaaac gagtccttgc tattcttctt aacaatgctt 77700
 cagtccacca ctttgagatt tctgtggaga aagtaaagat ttgggatata catatactaa 77760
 aacaactatt ggttgcttat ctgaaaatta actttagctg ggcattctgt attttatctg 77820
 acaaccctac ttggtgaggt gtacattttc ttattcatac ttcctgcgag ccacaacatg 77880
 tcttaatagt tgttagctat taaggactat gcataaaagt gacaatagct ggctgggcac 77940
 agtggctcat gcctttaatc ccagcacttt gggaggctga ggcaggagga tcacttgagg 78000
 ccaggagttc aagatcagcc tgagcaacat agggagaccc ctgtctctac aaaaaaaaaa 78060
 aaaaaaaaaa aaagctggat gtggtggcat gcacctgtag tcccagctat ttgggaggct 78120
 gagacaggag aatcacttga acctgggagt tggaggctgc agtgagccct gattgcctca 78180
 ctgcactcca gcctgggcca cagaatgata cctgtctcaa aaaaaaaaaa aaaaagtagc 78240
 aatagctaac aactattgaa ttattgagtg cctactatgt gccagacacc atactaagtg 78300
 gattagatgg atattccaca tattcttccc aagaacatta tgaggcaggc actattatca 78360
 tccctgtttt taaaatgagg aaactgaggc tcagagatgt taaataactt gctaagggtc 78420
 actcagaaaa ctagtagtag agaagggttt gaatgctggc agcctgactc caaggctcat 78480
 gtgcttgcct accttaccca gatggcggca gcactgagca aggggtagat aacttcaagt 78540
 cccctggaag aataagagaa agtgagacca tggggtatga ggggggcagg ccctgagtaa 78600
 agctttaaag gagcagttga aattagaccc ggtgcctttg tttaagtaag aagaatgtgc 78660
 tagttctaaa cagatgcagc cccatactgg gactcacagc ttgatgagaa gcgcactgga 78720
 tgcatttcag cccttactgc aacctcagcc tgaggccttt atgcagtgag caacctgcac 78780
 aaccatacat agcaatgtga gtttgatggg agaaggaaga ccagtgcaga gacaaggatg 78840
 tcgatggagt gcttagagaa caaagggaag ctatttacta aagcatgttt gcatggtgca 78900
 ggtgattttc taaagttaat tttgacagac aggatgggga aagattgttg aaggcctgaa 78960
 atgacaagag agacttgagt ggatctggga ggtcatgtga caaacatgac attaacaaat 79020
 tctaaatgga aaaaatgacc ctcagaaagt tgtgtgtcaa ggccgggtat ggtggctcac 79080
 gtctgtaatt ccagcacttt cggaggccaa ggcaggtgga tcattagagg tcaggaattc 79140
 aagatgagcc tggccaacat ggtgaaactc catctctagt aaaaatacaa aaattagcca 79200
 ggcgtggtgg cgggcacctg taatcccagc tcctcaggag gctgaggcag gagaatctct 79260
 tgagcctggg aggcgaatgt ttcagtgagc caagattgcg ccactgcact ccaacctgag 79320
 caacagagcg agaccctgtc tcgaaaaaaa aaaaaagaaa agaaagaaag ttgtgtgtca 79380
 aaagcttcaa cacacagggg cctttgctct gtcaagcaag gagaataggg tggaggagga 79440
 acaggaacac agtagctaag gtgacagctg cctcacaaaa ggaaagtcta tggcttgcaa 79500
 aagaggtcga ggaaagcgga aaagcaattg ccgaagaggg acagtaagtg aaaagatgag 79560
 tttcttccac ttggcatctc cccaaatatg gccctgaagg aagagttgac cctgttacgg 79620
 tttctttctt tttcctgtgg ggttattaga gtgacatata agaaaagggc cacaggcacg 79680
 gcacagcttg atttcagcca ggctttgcat gacaccctac agagcagaat gaggacagat 79740
 aggctgaagg ataactactt aactgggtag gtttcaagtt gatactcaga gtgttgatta 79800
 aagggtggtc aatgacaacc tggaggaggt ctttaggtaa agaaactgag ttcaaagata 79860
 accaacttgc atgaatgaag gagccaggat ttgaacccag ccctacctga ttcaaaagtc 79920
 cattttccat ttattataaa acaaaaacca aaaaggcatg aagttcactt atgaaagaag 79980
 agttgaaaga tataaccaga gggttaggag tacaaatcca tgcccgaatg aattgtgata 80040
 ggctgagaaa ttggccaaag ggggagaaca aaaacacagt gaaagtcaga aaggttaaat 80100
 gtgaagccct gcattttggt ttcaagaaac ccgttgcaga ggtggagagg tccagcttga 80160
 ccatcttcat gttgggaagc acccgggctt ttgttgtagt tattgttgct taattcccaa 80220
 acagcagcgg ggtgtggggg cacacgattg tagccccagc tactcgggaa gctgaggcag 80280
 gaggatgcct aaagccccgg aggtcaaggc tacagtgacc catgatcacg ccactgcact 80340
 ccagcctggg caacagaaca agaccctatc taaaaaaaaa caaaagaaaa caaaaaacca 80400
 gccaacagtg taacacaatt acaaaatctt catgtacaaa tgaagtgatt aaatcatcct 80460
 attctactca gcccagctca gaccatatct tgaatactgg gttcaagtct agataatgta 80520
 ttttgtattt tgagaaaaat attgaataac tgacaggaga cctgaggaaa atgaccagga 80580
 gatcaagagt tggaaccttg tcacatgaag ggtggtcaag gactctgggg ttatttcagc 80640
 ttagaaatgg gaatttggga tttgtgattc tcattttctg tttcttttgt tcgttcattc 80700
 tttctttcat tctttctttt tctttcttgt tgtggttctt agcacagaat tcagatgaaa 80760
 gagcttttga ttcaacgtaa acaattcacc aagctgtcag ctcactccaa tcccagccgt 80820
 ccccgatgcc cattgtctat catctcaatg aattagggaa aaagactgac tttctgggcc 80880
 acttccaact ttgagaatct aggatagggg cactatttaa tcaaaactgg caagtaaaaa 80940
 gaaagagaac tattttaaac aagacaaata caagaggtgt tgaaccaaac tcaaattaga 81000
 aagaacaaaa tttcccaaaa ataagaatat tataattcat ttgatgaaag gaatttgcca 81060
 tattatccct tttactggca tttttttagt acctttactt gtaaaaatgt caggccctcc 81120
 cacttttctg ggatagactt atcgaatgaa gcaaggggag cttctctatg gatagatgat 81180
 cacttttgca agctttgaga tcagtgagct gaaaaaatga ccagcattcc aacaacaaat 81240
 gagggcttgg gagcgtaagt aaaagtgaca gcaagattaa agtaattgtg gtcatgccgt 81300
 cctctgctga cacttttgtg ttttgcccag atgagaatta aggtagccca gggcacaggc 81360
 agtgaggaaa aggagagggg cgctgagcgt atttgcagca tttgtgaacc atgtcacagc 81420
 cctggcgaaa acagagcaag aagatggagg ctttcaaatc catgataaat aagccatgct 81480
 ttcagagccc aaatcagtaa aaacaaacat taagtgaaca gaagggaaga gggaaaaaaa 81540
 gagaacatga ggccaccata aaatcctggt gatatattcc aggggaaatc atgatgtgaa 81600
 tagaaaatga gaagtaaaag aaaatgaagc ctggagattt gtaaaatgtc tgtctgtctg 81660
 tctgtctctc tcgactgtca ttcccatcta cccctgccac ccccaccccg ccctccaccc  81720
 ttctgatggg gttcattaga tgatttctga ttcaggggtg gggggcggta tttttaatgc 81780
 ttcacttatg tttgggtttt gccagcagga tccgaggtgt ttctgtagac aattgttatt 81840
 gctttaggaa acaataagaa taaaatgagg aaacatcaag tgatacatca gtctagcagc 81900
  agagtgaggc tcgaagtagc atttccagcg aggttggtgg tctctttttg ccttattttt 81960
 gttgttttgg attgatgttt tcatggtgtc attttaataa gaaaagtgtc agagaattaa 82020
 aagtggaagt atgcgagata cactttctct aactggattc atggtaagtt attaatgttt 82080
 caaggagaaa gaaaagaact tggaaaaagc agaatatatt gtggggaaag ttgatgaagg 82140
 gaaaggtaag agaactgtga caaatgagac acagacagaa ggagagagag agaaagagga 82200
 agagagagag acagggtggt gggggggacc ggcagaagaa aaggaaaaga gcgacagttt 82260
 gtaagtctat tagctgagat tgtttccatt tctgcaattg ccttaaagcg catgattgct 82320
 tggtctgagg tctgccaggt cgattgcagt ctttacctct ttgaccaaga agtaatgggc 82380
 ttgaatttcc tgggtatgtg aaaattgctc ttgaatgttt tggctaaagg acagccaccc 82440
 aggaaggttg agagggccta agctagtgag cagtcatcct gaccaagtag gagggatttg 82500
 gttatgttgc tcgtagcagg agaggcagag cagcaaagtg aagagaacac acagccttag 82560
 gtgccaacag acatgtactg aaatctcttg cctccatttc ccacctctaa aatgcaaagg 82620
 atgatagtaa caataataaa tgttgcaacg ggtgaccgat tataaagttc ttgtcacctg 82680
 atagaccata tcaatccatg gtaacttatt cttagctggt tcacgtttct aggcattggc 82740
 acagtctggg tggtgtgtgt cccctcaaag gtagcatcac agtgactgag ctctgcatag 82800
 atggcaaagt gtagaagcct ggtcagtttt ctgtttctcc atccaccatt tctccccact 82860
 tccccttggt tagtgctgtc ttctctcttt cctcactgaa ttgtcttgat tagtgtcata 82920
 ctttctgata acactgcagc taggactcca caggcaatag ggagaagcta gcgcctgccc 82980
 agggaaagtg aggaaaaata ggtgcttgag aggctgaaaa gtagtatacg cttggtggcc 83040
  ttacactttg tagaaacagt tttggatttg tctctacaag aaaggattgt agataaccag 83100
 aatgcaaaaa tgctttgaag aaagagacat tgagcattgg aaccaagtat tctacgtcct 83160
 cttccctgca acactgggga ctaaggatta ttatctgcat ttctggtgaa gaaactgagg 83220
 cacagagaag ataaactatg gttctccggc tacaaagtaa gcagcagagc ctagagtttg 83280
 aagccaggtc tgacacctaa gtcccgtagt aaacctccca ctgaggtagg caagcctcgc 83340
 cttgcagaga gtggcaaatt agggaaaaaa gaatcaaatg tgcttgagtt taacagaaca 83400
 tatacattat acttaaagag aaagatactt ttcttacaaa aagtttgagg acaaatgaga 83460
 cttcatgtga tgcgtcttgc actaaaaaaa aaaagttaga ttatataagc cagactggcg 83520
 ttgattaaag aagagcaagg taataaatac gcataagaag aaggaagtgg ctggctctac 83580
 cttgggcatc acccaagtta caggcagggg aggggatagg ccctgcatgg ggacagtctc 83640
 ctgacttgtc ttcttccttc tctacttccc tcccttcact acccctccct ccaaaaccca 83700
 aaaaacctta agcaggaaaa aagggagcta attaaaaaag agaaaaacat ccttgagacc 83760
 aatgaagtct ccataatcca cagtgacaga cagggacctg cagaacagca atttgattaa 83820
 ataaggatat aagggattta aaaggactct ccagttgtgt aaagtgtgtc catacgtctg 83880
 aaaaataccg tatttatttg gctcccaaac ctgaaaacct tctgacgggg gagattgttc 83940
 ccatttggaa actaggaaga aatcacaagg caaggccatg gggttctggc agggctgggg 84000
 atcccatgtt gggtggaaac cccaagaagc cagccaaggg tctgcaggag gggccctggc 84060
 agagagaagc attagaatgc aagggcaggt aaagccaccc tcacagaagg tgactgtggg 84120
 ctgagcctga ggcccttccc agatggggaa gagagaacag cacacctctc ctgcccacgc 84180
 ctcggtatct cactcaagaa tcagctgccc gttagtcacc tgtcatcgga gacagctctg 84240
 ttggcggctt tcagaaaaag cgaagcagcc agaggatgaa tcgttattcg gggaacacac 84300
 ctgcacacag gacaggaatg gatgggagtg gggagcgccc tggggctact gttcaaacgc 84360
 catcctcatg gtctccaaga cttgcatcag cagctcagcc gctgatgaat tataattctc 84420
 ggacaagctg cagaggcccc cctcgttcca tgtgttcacc cctgccgctc atactggggg 84480
 atttatgctt cctggggcta ggaggagaaa ataatgagtc actggggaca agagaaaaac 84540
 aaaaatgccc tgtatgtgca aaaccaccta aaatggaggc ttttagagga cactcaaatc 84600
 ccagccaact agccagaaag ggttttgctg ggggtatatt ttatgtgtct ttgctatctt 84660
 tggatgcagt aaagccagaa atgtttatat ctcttggagg gatcacctgt gcaaacagga 84720
 caggtcctct tgagaaggct gtttgttctc ctgggatctc gaacctgaga agaaatggtc 84780
 ctggcctggc gcggtggctc gcgcctgtaa tcccagcact ttgggaggcc gaggcaggca 84840
 gatcacaagg tcaggagatc gagaccatcc tggccaacac ggtgaaaccc catctctact 84900
 aaaaatacaa aaaattagcc gggcgtggtg gcaggcgcct gtagtcccag ctactcagga 84960
 ggctgaggca ggagaatagc atgaacccgg gagctggagc ttgcagtgag tggagatctt 85020
 gccactgcac tccagcctgg gggacagagt gagactccgt ctcaaaaaaa aaaaaaaaaa 85080
 aaaagaaatg gtcctgcatc tctgacttgg gaggtccaat taagcagagg aactgttggc 85140
 tgtaaacctt ctaaagcaga ggatcctttg ggaggctgag gcaggtgatc atctgaggtc 85200
 aggagttcaa gaccagcctg gccagcatgg cgaaacccca tctctactaa aaatataaaa 85260
 attagcggac cgtggtgggc tgtacctgta atctcagcta ctcgggaagc tgaggcatga 85320
 gaattgcttg agcctgggag gtggaggttg cagtgagctg agattgtgcc actgccctcc 85380
 agcctgggtg acagggcaac tccatctcaa agtaaataag taaagcagag gaccctgatg 85440
 gccaccccca agttcatagc tacctgcaca ctttatgtgg tgaagcactg gtggggggcc 85500
 caggaagccc tgcatgagtt ggttgtagct gccatgattc caactcccac gccaccctct 85560
 gcacctagcc acagagccgc atctccagag aaaaccagaa gcaagacccc accaaaaaag 85620
 aatgtgagag tctattttaa aggctccgga agatgagtta gaagtgattc aagagcaggc 85680
 acagtaaagg aatatgtaag ccttggtaga cattcagtaa gaagggtaac atttccaaca 85740
 tgaccagctg attaacaggt attctctaag cagggtgtct gctggtttag aatagagcaa 85800
 aaatattgtc atctgagagc ccaaaatggg gaaaggctac tccttggtct cttggtgagg 85860
 cccagcctgt tttgtttttt gtttgttttt tttttttttt tcactttccc actttatttt 85920
 cagaatagat tgatttgggt ctctagaaga atatttaagc agtggcttac aggcgagcca 85980
 taaggtagtt gtccgttcta tgcttacaaa ttttcaagaa gggccatctg taacctttct 86040
 cagtttcctg ttcctatgtc caatgcccaa taagaggtaa taaactaagg cagaaaggcc 86100
 ccaaacacag atgtaagatg cagagcaaag aataacacac agtaggggtt tcaatacagg 86160
 atcattaacc cagaatccaa gcaggagtga gggaagtcca ctcaggagga atgggaacca 86220
 cctctccagg ctgctcagga ggaatttaag catcagacag tgtgtaggag aagatgacca 86280
 cgaattcttt gacatctaag caattctgta ttttaaaggt ttgagtcttt gaaatgttaa 86340
 aattgatgcg ccttaaaact catgagagac aatgaagaca atcaccgaac ctgtctagtt 86400
 aaaggttacc gggactcaag atgcaaagaa aagttacgag atggaattga tggtttgggg  86460
 tgcaccattg ccctctattg gattttaaat aaatcagacc tcttagtgta ggtatgttgc 86520
 actatctctg gctgagtttg ctgagaagtc agggcacctc tgagtgggaa gttaattgat 86580
 ccttttaaat ggctccttct gtctcctgct ccttccctga ggaaatcaac cagagtaatg 86640
 ctgagggcag gtcatttgca tgtcttcatt catccaacaa acatttcctg gctgcctgct 86700
 aagcccgggc taggcattgt agagaatcta agaaaaaata acaactgcca ttcgttggac 86760
 acctactgtg tatcagagtc tacgcattaa tacagaacaa ccccacggag taactctggt 86820
 gactcccatc ccacggatgt ggaaatagga cactcaggaa gtggcacatt ttggattcaa 86880
 atccaggttc gtctactact aggcctatat tctgtccact aaactacaac ttttcccctt 86940
 aagaagttta taaactatta gggggagata ggatatagat ataaatgtat atatcagggt 87000
 ttgacaaact acagccagtg ggccaaattc agcccatcat gtgtttttga ccttgagcta 87060
 atttacattt ttacatggtt gaaaaaaata tcaaaagaat aataatactt cctgtcatgt 87120
 aaaaatgcta tgaaattcaa atctcagggt ccacaaataa agttttatgg gaaccctgct 87180
 atgcccattc atttaccatc atctaaggcc accttcctgg ctacaaaaac acggcgagtc 87240
 attgtgacag agactagatg gccaacaaag ccaaaatatt tactctctgg ctctgcacag 87300
 aaaaggtctg acaattccac atctgtactc caaggtgaaa tgttctatat caacaggaga 87360
 ggtgtttttt ttttttgtct gtttgttttg ttaagtgctt gaggagttca gaggagggga 87420
 aacaaatgtt tatttggccc acagtgtgca gagctggagg ggataggcag gtgtgctctg 87480
 ttttaagact caatgcatga aaaccctgac tttaaaacag ataaattaaa aggtagttat 87540
 ttgcataaca aattttcctt tcattttata aagcgattca ccacagggtt cctttataga 87600
 gtgagcctcc ataatacatg ctaatatgat tccatttaca aatactctat tcattataac 87660
 ttttcaagaa tatacctatt gtgtacagtg aggcttaact gtaatcattt ttcctggcag 87720
 tataaggttt cctacttctg aaaagtgatt aagctgacct tgtcaattcg actgggggag 87780
  gcggcactct cctctactgt ctccgagagg ggctttacct gtcgaacaac aaggctgtgg 87840
 attctgtctc tgcattgtgt gatgttgagt agctggtata attttacatt ttcactaagc 87900
 tcctctcagt agtagcagca gccaaagtcc taaagtgtaa actactctca ctattctctt 87960
 acttcatttc gtatacaaga tacactaata aaaattattt gttggctgga ccacggtggc 88020
 tcatgcctct aatcccagaa ctccaggaag ctgaggcagg tggatcactt gagcccagga 88080
 gttcgagacc agcctgggca acatagtgag accccgatct ctaccaaaaa aaaaaaaaaa 88140
 aattagccgg atgtgatgac acacatctgt ggtcccagct actcaggagg ctgaagtggg 88200
 agaatcctgt gagctaaaga gttcaaagcg gcagtgagct atgatcacac cactgcacat 88260
 cagcctggtc aacagaggaa aactttgtct ctaaattaat gaactaatta attaattttg 88320
 ttgctgatgt cctgacaaat atgtgacaag caattcttgt aaaaagcaat gtttccctct 88380
 ctttttaaaa aatttcaaga cattatctta tctgaattac aacataaact ggggcaagta 88440
 ttcagattag agctctcccc agcaaaatag gaagtgatag caatttagga cctgtctcct 88500
 tctctcactg ggtcctgagc ctgaatcttc acatagcttt gtggtgttat gcaattgccc 88560
 tttgtaagag atacataaaa tggaaacctt agctattcat agccaactta ggaggagctg 88620
 aatttgatca agaagtttct tgccgggtgc cattttgatg gtaactacgt gtttctgaac 88680
 aaatccactt ataatctggg tttccaatgg aggttatttt aaagagctgt agcatggctt 88740
 ttgttttcat cctctgtggt ggctatattt tagaagtaga caagcattcc tggtatatag 88800
 cctgaatatt ttttaagatt tttttggtag taaaagaagc tcacatggaa aggcaagggt 88860
 agaaaaaatc atgttcaggg cagtcctgtg tggcattacc ctctggtgaa gcagatccac 88920
 actgcatgct gctaatggct attgcgtgac agctcttaaa ggggtaagcg agagaggtgc 88980
 agagggctgg tgagaagcag agctagcact gaggccctac aaatggcatc accatctatc 89040
 aggttggcgg ggtgggggtt gggggctgct gctggaggtg gtttggctgc ccctagaggc 89100
 tgcagcgtct cacactgtat gggcaggtag catttcagcc atttctaaag cccatcactg 89160
 gcagggaaag cacatttaat ccgtctgtga ggttctctaa aaaggggcct ctcttttctt 89220
 tctttttttt tttttttttt aagatggagt ctcactctgt cgctagactg gagtgcagtg 89280
 gtgcaatctc ggctcactgc aacctccacc tcccgggttc aagtgattct cctgcctcag 89340
 cctcccaagt agctgggact acaggcacac accaccatgc ccagctaatt tctgtatttt 89400
 tagtagagat ggggttttca ccatgttggc caggatggtc tccatctctt gacctcatga 89460
 tccgcccgcc tcctgggatt acaggcgtga gccactgtgc ctggccgagg ggtctctctt 89520
 ttcagaagtc agaagcgctg aaattgaaaa cagcagcaag aaggcttcat tgcattcttg 89580
 aattcaggct gttgcactcc gccccccaca actctgtcta aattgttgct acccagttta 89640
 tatctgcatc atattttttg ttgttgtttc tccaatgcag tatgtagtgg tggcaggtac 89700
 agatcataaa acaaatggat aatcagattc ctttttccct ggtggtaatt tttaaacttt 89760
 tcaaaattaa tgctaatgga tatagaggaa tgggatatac atttccatgc atttttatga 89820
 ccaaacagaa aaccgacccc tgagggtgac atatttacta ttctctacta ctaggggtgc 89880
 ttcaagggaa gagtttttga agccctgtgg tttaaacaaa aagagaacat accccacccc 89940
 accctgaaca aacagcagct gggcagattt catctcacaa atggaaatgg gagcaaacaa 90000
 attttttcaa agcgatttta taaagagtgg gcctgtttag ttgggttttt tgagccagga 90060
 ttaatattac aagctgggga gctctgtgac atggctgtgt cgttggcttt gccataccgc 90120
 ctacctcctg ggggaaggca gaggaaagtg ctgctattca gaagcaattt tacttctgcc 90180
 tcggccttct cacttctcac tgaagtgatt tacagccagc ctggacccag tgcccaagcc 90240
 tgagctgagt tacatgtcat gttggaaaga tcttccccaa atcaaggtct tatctagagc 90300
 ttgcctggga tattttttca tttctaattt atgtaacttt ctaatatgtt tagcatttgc 90360
 ccttcccttg tctccatcct gcttattaag gtgaatttgc atacaaatgg gaccttggtc 90420
 ttcaggacca ttcacctgac acttgatccc acgaggcgac cactgtctac tgttgatacc 90480
 atgaggatga cccacagaag tcatgtctct ctgcaaacta gaggcaaggc cttaattaga 90540
 agaagccttg tgtgttaaaa tgatggggtg aatcaaatca gcaaaggcat ttagcattaa 90600
 cttaggaggg cagaatactc cttcctgttg agtgggtcgt cctaggtcac aacaatttta 90660
 atttgccttc gatagatgga tcttgaagaa agtgtacaaa aagtatattt gtgatggtgt 90720
 tgtttgggag tacgttttga ctcaaagagt taactgtgac attttacttt ggctcctggt 90780
 ctattttttg cttaacatct acctttgaat gggtaatagt catctctata aattaccttc 90840
 gaaagattga acaattgtgg agaatcagag aaatgagccc cttgctatca ccctgttgca 90900
 gtcggcttta atcctctgat ctcctggcgt ttcaccctct cactggcagc caccttcctt 90960
 atttacccaa atcttgttaa cttgggtagg aattcccact gagaggacaa atgtggtccc 91020
 agttgactgg tcgctgaaag tctattaggt tggagagtat ttattttcta ccctaaaggg 91080
 tttgaaactt agggaaattt tgatcaacaa gaaaataaca gctttcaaga ttgtcctgac 91140
 agttaagctg tcttagcaga gaatcacagg atttgatagt catggagatt agttctcaaa  91200
 tttcaatgag aaaagttcat aggagatgga gtgaggaaag aaaacttgtg ctgattttgg 91260
 tcaggctacc tttgctgggg aaaaattcat tccataaaat tattttaaaa cgtaaatact 91320
 atttagcttt atctggtgta atactttgca tctataattt ttttgttttg ttttgttttt 91380
 gagacagagt cttgctctgt cacccaggct ggagtacagt ggcatgatct tggctcactg 91440
 caacctctgc ctcccaggtt caagcgatta tcctgcctca gcctcccaag tagctgggat 91500
 tacaggcacg tgccacggca cccagctaat ttttgtattt ttagtagaga cagggttttg 91560
 ccatgttggc caggatggtc ttgaactcct gacctcaggt gatctgcccg cctcgacctc 91620
 ccaaagtgct gggattacag gcatgagcca cagcgcccgg cctgcatcta taatttgatt 91680
 taaccttgca actttattaa ttgaatatta tgatcaccat tttatagatg aggaaatgga 91740
 gactccaagg gtttaattac ttgcccaaga gtctacagct atctaccaac aaaactggga 91800
 ttggagccag ctgtcttacc attacatccc cgctgcctcc taaagcacag ctctagttca 91860
 tactaaatgt attacatagg ccgactcatt tatctttaca tgggtctcat gcattacaag 91920
 aagggggcca ctattttaac tcaattcaaa aatgttaaaa tcaaaattcc caaaatgtac 91980
 ttggtttata atatatcata aaataagtaa tctgaccaat tgagcctccc aactcgaaga 92040
 ccaagaactt ctttctactc ccaaaccatg cagaaggaag ctgagttccc cactggccaa 92100
 tgctgtctaa ttctcttaaa tgattcagat gtaaaagagg aaatggcatc cgtctaatta 92160
 acactgcctg gttaaatata gctgccaagg gacagccttg ggacagtgtt tacagaatag 92220
 tctttccagc ccctcaggcc tcaagttaca gatgatagca agccttccct ccttatcagc 92280
 tgcaaacaga gatgccccca aaagtggtgt caggccagga tgatgaaagg agaagggaaa  92340
 ggctgcggat ggccttcatt tcctgctcct ggcatctggg gattccgaga atgatcccag 92400
 gacctagatc ctatagattc cggcagctct tcctgcaaac acaagccctt gttgtgtgcc 92460
 tgagccttgc tctccggcct ggagacatcc atctgcccac tctcctagga actgctgatt 92520
  accaggaagc accatcggct ctgctgccct ccccctggca gagaggcaca atgaccacat 92580
 tatttctctt ccagcttcac gttacagcat ggaagctgtt gccaagtttg atttcactgc 92640
 ttcaggtgag gatgaactga gctttcacac tggagatgtt ttgaaggtag gtgacctggg 92700
 gccccagggg agcagtaggg agtttcagtt actcagtaat ctgacagtcc ctgcctttgt 92760
 ctcttaagaa ctgcatgtgg ttccttttaa aaagagaagt tcaccttgat tccctttgtg 92820
 cacccttata ccagacacca accaggccgg gtgatggaaa tacagtcggc ataagccacc 92880
 atccttgtcc tgggaggttc gtagtctgga gaggggaaca catccaccca aagggctgtt 92940
 acagatgttc ttggctaagt tctcagggag cacaggtgag ggaacaagtg attccatctt 93000
 gaaagatggg ggttgtagga gtgtgtgcaa tgtgaacgtc aggaatgcac tgaaggtgac 93060
 ttgggctttt agctaaagct cagagatgtg caagcccatg ctgaatgcag ggagcagcgc 93120
 caggctcagc agagctggaa ctcaggagga gaggttgtgg gtggagacag cttgggaaag 93180
 gcagccacag aggacatggc tcaacaaagg ccatgcacac ctggccactc aggggctttt 93240
 taaagcttgt cctcatcctg cacttgagtt gtagtggcca cttgctgagc tgaagtggcc 93300
 ttggacttct cccacattca tgcaccatac tttcagactc tgcatcttag cccttgggtt 93360
 tttgttttgt tttgtttgtt tgcaaaagag cataagccct tcaaaagggc atttgggagt 93420
 gtgtggagcc agaccccctc tgcctgacct cagagcaccc tcagatagcc tgatccctgg 93480
 tcctcagata gcctgatccc tggtcctcag atagcctgat ccctggtcct cagcagtccc 93540
 aatgagcctt ctcggacgcc cagcaacact gaggccatta gtgtctcacc accgagaatt 93600
 aggtttgtta tacaaagaac cttgtcagca tgtgagaggg tgacattgaa agtgtctgag 93660
 gagcacaaaa caccacagaa tggcttcttt tggaatatga acatgcccat taggtagcct 93720
 tctaactgct ctcaactttc aagatctagt aacatagtgg caaagcatag gccttcacaa 93780
 acttaaaata tgagttgggc ctcctgaccc aggaaaacct gtctgtcact gctttggggt 93840
 cttacgaagc tcctggaggg acttgccaag cagcgagaag ttcctgcctt ctctgtgggg 93900
 cactgtgatc atgtgactgt catccactgg agaccatcct tgtaccaact tccaccctcg 93960
 tcttccatta caaagagaac ctggtatctt aagttttctc tattcctcag aaaaggaaaa 94020
 aggaaagaaa aaaaaaaaaa actttgctca actctgcttc ccaatccagc tcctgatttc 94080
 tttcctcccc tttgttgcta atactgggaa gaattctcta cactgggcgt gcttcacttc 94140
 ctcacttccc actcattcca caactctctg gaatctgcct tttaccctcc ctgcaacatt 94200
 ctcttgaagt tcaccagtga tctccttaat gtgtagtata atgaccctat ggaaatgtct 94260
 gtgggattga cactgctaac tggccctctc ctggaagccc ctttctccct ggctttggca 94320
 gcaccaccct ctccgggttc ttctcctccc ttcctgacca ctcctacagg tctcatttcc 94380
 aagcattctt tttcctctct tgatcctgaa atatacactt ccctgaaggt gctgcctttg 94440
 gctttctgat ttttcttctc actctgagcc acctcatcca cttcttcagc tgcaactatc 94500
 acctctgtgc caaagaccct caagtctgtg gctcgtgttc tagctctggc cttgctcttg 94560
 aactccagac ccagacttcc aattgtctgc tggatgtccc cacatgaact ccagccccta 94620
 actcaggatg ccgagaatca ctcaaacccc catgcccatc tcacccccat ttccacccaa 94680
 gccactcttc tttccatgtt ctaattatta tcctaggtca gtcacaagct agaagcccca 94740
 attatcatca atgcctcctt taccaaatcc tggtgaccag taaccaacgt ctcctgagct 94800
 cctgttcagg gccaggatct agctaagtgg tttgcaggca tgatttcatc atctcagcaa 94860
 acctgtgagg taggcattca tttcccctcc atttcataga tgagaaactg aggctaggga 94920
 ttaaatcaca tgtccacagt cacacagcta gcatgtgacc aatccaggac ctggacagaa 94980
 ctctgtctga ctcctaagca ctaaactctg ctctgaatgt atttttttcc tcatatctct 95040
 caagcaagtc tcttcttcac cagaaaggag tgtgaggcag taaaaaggag catagacttt 95100
 gagtcagatg gatctgagtt tgaatcccag cttactaacc atggagactg gggcccagtc 95160
 atctgccccc tttgagcttt agtgtcttcc tcagcaagtg gaggtagtat ccatcttgcc 95220
 gggttgtgga gaggattcga ggtgatgacc ctgtcccaac gtagacgccc aataaatggt 95280
 ggcccgcatt atcgggatca tccatccccg ctgcttctga ctgctcagat cattgccaca 95340
 gctccttgac tgacctcatt acctcttgtc tttttcctcc ttcactcatt cttcttacta 95400
 gtcccagagg gatctttcca gacaaatcag atcatatcat ttccttgctc aaaagcattc 95460
 aggggtttcc aattaccaat tgattgagac tgaaaacatc tggccccaaa ccactgtcca 95520
 gtgtcattat gcacatgtac acatgtgtgc acacacccac acagagacat ctttgtagat 95580
 gtaacgcccc caggttgcac tgcaatgtat acaccgccct ttctcagcct ctcccctata 95640
 tactctgatt gcccctctcc tacacacaca tacttgacct cctctaccat ggaaacctcg 95700
 ctggtcctct ccactcccta ccatcccagg gaaacaaatc actccctctt cagctcctcc 95760
 ccaacatttc acataaactt cactcatttc caggcactta tgactttgcc tcacatggca 95820
 gctatttata ggcaggccat gaccctgtgg tctcatgcac cctctatttc tacctctcat 95880
 tgctgccttt gccccgtggg atcctaattg ctcgtttatg tgttgtctac tccactagca 95940
 aaagctgtgc aagggcaggg gctgtttctg cctcaatgtc tagaagagct gtgcctagaa 96000
 ctccctgaca cttgacgaat gaatgaactt tcaattcctc tccattccct gagagcaatg 96060
 tcatgcacgt gtgcacacaa tgccaggttc gtctttgtgt cttcacagca tctaacacaa 96120
 gtcatggccc aaaatagatg cccagtacat atttcttgaa ttgctaaatt gcatttcttc 96180
 ctgttcattt agaattccat tggaaagcca accccctccc tcttttcaaa ttctgtccat 96240
 tgcaggtaaa gagcaaaatg gggagggctt gttgactgag ccccacagaa tgtctacagg 96300
 atggtgattg gttcccatgg ctgggactcc ccacatgtga ttgcaatgtc tgccccccac 96360
 cttcctcaat gggtaacaca cccaggatcc tcacaaatac tttcaaagcc agctcctgac 96420
 taccccagca attcgcttct gggattctct gacttgtttg gccttttgtg ctaaagacta 96480
 aacagaggtt ttcattagaa aggtacaaaa aagtctgagc agccacccac cctcaacaga 96540
 ccatcagttt cctggggcag aggccccagc ttatttatct ccatatttca tgcacctaag 96600
 tgcaatcagc aggtgctcac tagatggtga tctacacggc atgtagatca agatggtgga 96660
 caggaaaacg ctgccaaatg acttgatcct gcttctccta tgacggaaac atttggaaac 96720
 tcaggaatca gatttttttc ctattcatgc cacaaaccac catacctgca gctacacaca 96780
 gcaccagcct cacatttgaa tttgccatta aatttgccag tagctttgaa aaatatctct 96840
 tgacccagtc catttctgtc tccttctgta atgcagctaa tgcgacctca tttcttcctg 96900
 ctaaaatagc aacctaaaag cactaagagt taattccaca taattcattt cttcaatact 96960
 tcagattttt gctatgtttc taaaagctac aatttcatcc aatttaaaaa ttcttccagc 97020
 cgtaatttgg cccttctctt cccacgtcta acttattcac aggccatgta acccaaaaaa  97080
 tcatctctta gggaacatta taagaattaa gaaacagtca agagtaaaac ttcaagtgtt 97140
 caggctgaac gccttgctca ggtttacacg atgggtacac gagatagggg gaaccgaaca 97200
 gatggagaga tgagaagaac aggaagtgtg gggccctggg cccacaacgg caggaggaaa 97260
  ccatctcccc tcccctcaaa tacttttctt tgcagaaaat gagaattttt tttaaaaaaa 97320
 aacctcacct tctatacatg gtaaagagcc tgcaaattca cctctctaga aacacagtgt 97380
 taggcagacc aagcaccagg tggcggagag aaatggctgg cattgtggga taatctttca 97440
 gtttctagag gaggtctgag gcatgataac taaaattaca gagctgcttt caggtcagaa 97500
 aatgaagtac aaagtgtgtg gttttttttt tttttttttt ctttttgaga cagagtcttg 97560
 ctctgttgcc caggctggag tgcaatggcg caatctcggc tcactgcaac ctccgcctcc 97620
 tgggttcaag caattctcgt ggctcagcct cccaagtagc tgagattaca ggcatgcacc 97680
 accatgcctg gctaattttt gtctttatgg tagagatcag gttttgccat gttggccagg 97740
 ctggtctcaa actcctgacc ttaggtgatc cacccgcctc agcctcccaa agtgctggga 97800
 ttataagcgt gagccatggc acccggcctc aacgtgtggt tcttacggtg acaaggtagt 97860
 ttccaaatgg cctcttttac ccctttctgt gtgacatttg ctaccctggc caaacaccac 97920
 attcccatgt gacgggagaa aggaattcca atgccatgaa ttcagaagcg atggatggag 97980
 tgcagtgtgc tcttgtgttt ttacgtggct acgaggcgct gctgctgggt ttcctagttc 98040
 ttttgaccta gattttctgc ttcctccctt gccccctcag cacacacata cccacatgtc 98100
 cttagtgaca ccagcagtca catttgatgt tagaaactat aaagttttct gttctcagca 98160
 atctcaaact caaatatggg acacactttt attccttcag aataaatgac taaattcaaa 98220
 acatacacac ataatgcttt aaagaacgta taaacccttc catgtcctat tcagagctgg 98280
 aggcctccct cataagaata ccacatttga tggaattgta ttttttgaaa agagtctaca 98340
 ctttctgaag gactttcagg taccagggct catttgatcc tcacatcagc tctgtgaggt 98400
  gctaggtggc tattattatc tccatttttc aaatggctga ttgacttggc caagatcaca 98460
 tatctagtga tggagccaag ctagaaacca ggtcttctcg ttcccaactc acaacactgt 98520
 ccccttcctt ccaccttgga gtgatgttag aaataggtca tcatctccac tcaagcactt 98580
 agttctttcc attatcttcc catcttcttt tctgggagaa agaagcccaa gggccctgtg 98640
 acttcaactc cacccacttt ctgatgactc tgaaacccca agccccaacc ttagcctctc 98700
 tcctgggtcc agactgacat atccagctgc tccctgagct tttcttctta gttgaagaat 98760
 tcaactcaca gtcacccgca tgcaatctga agcccatgag ccctttctca gccctgcctc 98820
 ctctcatgta tcttctattt ctgtaaagcc gtcaccacct actcagtctc ccaagccaga 98880
 aatccagtgg catcccagag tcctcctctc ccttagcttc caagattggt caagaaatcc 98940
 tgcctgtttg cttcctgaat ttctctaaaa tatatcctca cctcctctta gcctaggccc 99000
 tatcatctct tgactggagg cctgcgctca tcttcctgca gtttttctgc cgactttagc 99060
 cttgcaatct atcttcacat tctgatctct gatacagagc tctgtcgctc tctcgctctc 99120
 tcttaattag agacagagtc tctctctgtt gtccaggctg tagtacagtg gtacaatcag 99180
 agctcactac agcctttaac tcctgggctc acaccctcct cccgcttcag cctcctgagt 99240
 agctgggact acaggtgcgc ttccaccacg ccttgctaag ttttattttt attttcatag 99300
 agacaaggtc tcgctttgtt gcccaggctg gtctcaaact cctgggctca agcgatcgtc 99360
 cacttgggcc tcccaaagtg ctgggattac aggcatgagc catcgcaccc agccagagct 99420
 ctttctgaac tctaattctt actgttactt ccctgctcaa aatcctttaa gggctccccc 99480
 tacatttcaa gatattcaca gtctacattc cagccacctg gaggcatttc attcccagaa 99540
 cacaccacac ctcctcagag ctgaaggagg aagtccattg ccatctgact tggcctcagt 99600
 aactcctttc gttgccaagg caagtggtct ctcctctaca tatggatgcc ttttctatct 99660
 atttctgctt tcttctttat catcacactt ctatcagtta agatattttc aggagcaaga 99720
 aacataaact aaaaatggct taaacaataa caaagacttg taatttctca aagtccagaa 99780
 gtaggaaggc tcctgggtat catctaattc agcggttcag tgacattatc agagttcttt 99840
 ccatcttttg ctctgctatc cttatttaga attattgttc tagtctatat caaagactta 99900
 aaaaaaattt tttttttgag agaggcttgc tctgttgccc aggctggagt ccagtggcaa 99960
 gatcacggtt cactgcaacc ttgcctcctg ggttcaagca attctcctgc ctcagcctcc 100020
 cgagtagctg ggattacagg catgtgccac caggcccggc tcctttttgt atttttagta 100080
 gagatggcat ttcaccatga tggacaggct ggtctcgaac tcctggcctc aagtgatcta 100140
 tgtgccttgg cctctcaaag tgctgggatt acaggcgcga gccaccacac ctggcctcag 100200
 actttcaaaa cattctcagt ggcggtgtca aatattttgt cttttaatgg tgaatctcat 100260
 tttttgagaa accagaagcc acatacagtc aagtctggtg agtaatatga gtaactgagg 100320
 tagacaataa catttggggt cacagtcaaa gtcaggccac agagtaacaa gacagaactt 100380
 ttggttttgt ttgggatctg gctttaaaag caagtttaga aaaggcatcc caagtatctt 100440
 gggttccagc caaatatctg tgaaatacac agcatgtgaa cacaaagagt tactgtttcc 100500
 aaagctggcc ccactgggat gtttaagttt taatctgcct gtttaaaaaa caataacaaa 100560
 ttgaattttt gaaaagtttc ctgggcctgg tggctcacgc ctgtaatccc agcactttgg 100620
 gaggccaagg caggtggatc actaggtcaa aggatcaaga cagtcccggc caatatggta 100680
 aaaccccgtc tctcctaaaa atatgaaaaa ttagccaggt gtagtggcgc atgcctgtaa 100740
 tcccagctac tcaggaggct gaggcagggg gatcgcttga acccaggagg tggaggttgc 100800
 agtgagctga gatcccgcca ctgcactcca gcctggcgac agagcaagac tctgtctcaa 100860
 aaaaacgaaa aacaacaaca aaaaaaagag aaaagtttcc tggttacctg gaagagaaaa 100920
 aaaaaaatac accgtggagt aaccattctt ccttctcacc atctgctgag atgaggaact 100980
 taaggtgcta actgggacaa atgaatttcc aaaatagaaa aagggattca gggaagtcct 101040
 tgagtgctga atttgggagg ccaagccaca gtggggtgac atgagtggac ggcacaagtg 101100
 gacagaaata acctggggtc aggagaagct gactccaaag gtaaacccac ggctcctcca 101160
 caggcctggg gtaaatccta gaacagctgt tgagttcttt caacttatta acatattttc 101220
 ctctaagtcc aaaagggcct tctttgcctg gcagcccctt tctcttgttt ttttggtgtc 101280
 ctccctccaa tgtctttgtc tttccttttc ttccatgtag attttaagta accaagagga 101340
 gtggtttaag gcggagcttg ggagccagga aggatatgtg cccaagaatt tcatagacat 101400
 ccagtttccc aagtaagtat ctgcagcctg ctgagatggg cctagccaca cacactcctc 101460
 ttacatttcc agcagtcact acagttatcc atgggaaccc aagacattgt caaaaatggc 101520
 tgcctctgga gctctctccg gagagcctcc agagcatgca gctgaaggcc agggcaggag 101580
 ggagactttg catttcattt cattcccttt tgatgtttac accatgtgca tgtattgcta 101640
 ttttaagttg ttcttaactt tttttttttt tttttgggag ttggggtctc cctctgtcac 101700
 ccaggctgga gtgcggtgac tccatcacca ctcactgcag cctaaaactc ctgggctcaa 101760
 gccatcctct cacctcagcc tcccaagtag ctgggattac aggcacatgc caccacgcca  101820
 ggctagtttt tgtattttta gtagagacag ggttttacca tgttggccag gctggtccca 101880
 aactcctgac ctcaagtgat ctgccgcctc agcctcccaa agtgctggga ttacaggcgt 101940
 gaaccaccat gcctggccta ttttaagttt tgggtttttt tgggtttttt tattcatgtg 102000
 tttatttgtt ttgagacaga accttgctct gttgcccagg ctggagtgca gtggcatgat 102060
 ctcggctcat tgcaattctc ctgcctcagc ctccctagta gctgggatta caggtgcatg 102120
 ccaccacacc cagctaactt ttgtattttt agtagagatg gggtttcacc atgatggaca 102180
 ggctggtctc aaactcttga cctcaggtga tccacccgcc tcggcctccc aaagtgctgg 102240
 gattacaggt gtgagccact gcacccggcc tattttaagt ttttataaaa tgagtttgta 102300
 aactcaaatt atctatagtg atttcaatca cggcgttccc cagaattcca aaggggacgc 102360
 tattggccac cccacttcgg gagctgctct cctaagcgct tctctgtgac ctcctaatcc 102420
 taaccatcct caccaggctc tcacccttca ctcagtgggt ggacagacac tccctgcctt 102480
 cagtaaagca tgctcacccc aatgagagaa gtcagcgggg ggaaggggaa attctcttcc 102540
 taaagaggaa atgaaaaatt gagattgggc ttcgtttgtc tcaagaattg accacaaggg 102600
 ttagatagaa atctaatctt gcctcagaac cagggtctag ctcaaagagc aaaagcttgt 102660
 tagaaaacca cagtagtatt ggtgactcca gcaaggtgca agagcaccag tcttggtaaa 102720
 cctgaactga ccaccaaacc aagagaatga ccactgacct tgacggaacc cttgatgctg 102780
 cccaggaatc tgctaggtga cctctgcata ccccacgtgc tcctcaaacc ttcagcccct 102840
 ccgtgcatca ctcttagccc gtgaccttga ttccaggttc tctggaacaa tgaaagccac 102900
 cagaagtgaa gctcccagac ccccctcccc caccgcatcc acctgcctcc tgcaagtgtg 102960
 ctcaaacagt cggcctttcc tgcagctggc tggaaggaac tgtcactgct tctagcagaa 103020
 attctcctct ctctctcttc cacgtcaacc tcctttccct ctctgctgga tcattcctgt 103080
 cagcaaacac acacgctgca atttctccca acttaccaaa acacaaacaa acaaaaccaa 103140
  acccagaggc caggtgggtt ttgttgtggc tgatgcctgt aatcccagtc ctttgagagg 103200
 ctgagggagg aggatcactt gtggctagga gtttgagacc agcctgggca acatagcgag 103260
 ccccatctct acaaaaaatt tttaaaaatt agctggtcgt ggtggcatgc gcctatagtc 103320
 ccagctgctt gggaggctga ggcaggagga tcgcttgagc ctgggagttc aaggctgtgg 103380
 tggaccatga ttatatcact gcactccagc ctgggcagca gagagagact ctgtttcaaa 103440
 gaaaaaaaaa atttaaataa ataaataaat caagaaaatt cttaatccca aatccccttc 103500
 cacttgccac tccatctctt caaaaggagt gtgtgcattt gctacttcca actcctcatc 103560
 tcccgaccct tcccaccagg ctccccatgg gctgtagctc ccaggggtca tctcagcatg 103620
 acctgccctg gggatccccc ctcccactgg aacacctctt tcattttggc tccaggacgt 103680
 ccttcctccg gttgtcctcc cactgccctg gcttctcctc ctcagtctct tgtgttggtt 103740
 cctcccactc cccagtcccc tataggttta gaatgtctcc ttttcagtga ggtctttctc 103800
 atcaccatac cttacattaa tctcccaccc acagcgcccc atctctcctc tcagttttca 103860
 tgttctccac agcacttacc atcatctggc acgcttcaga tcttaattat tttgttcttt 103920
 tgtgtgtgtc cccctcgact agaatgtaag ctccctgagg gcaggggtgt gtgtctgttc 103980
 tgcccactac tgtgtcccca gtgcccagga ggggcccagc acagtactag atgttcagta 104040
 aagctgttga atgaatgaat gaatgaatga acgaacgaat atgtattatt gaaaccatga 104100
 ccactcatgt ctaatatgca atgtgtggtg atttttacaa atctttaaag aagcccccta 104160
 tcagattgca gtcagaggac aaatgtgtat ttcctaaatc cccttcactt ctgaaatgtt 104220
 tcctttgcga tatggctgct gtggtgcata ctccattcct cttcccatcc ccattacatt 104280
 tcccacacgt ggcagtggtg tgtgtggtgg cctcttgttt agccctgtag aattgtgtgg 104340
 caaatactca ggcagaatct ccaggccacc agaaactgct gctttcagcc ctctcagagc 104400
 acagccaaac ttccccctca gtcccagtgg gggactcagt ctccagtaag tacatccttc 104460
 ctgctaccta tgtctcagtt tcccaaattc tagaaagcac agagaattgc tcacaaagga 104520
 atccaaagcc aaggcctgac gggcttttat cttaaaggaa catgcgtatg agccttctgg 104580
 tgacagcaat tagagcagcc accttgaagc aatgtgacac agtcccacct ttggccgctg 104640
 agtgattgca gacactcatt ttgcttgtct gtggtggaga gaggtctctg gcctcctgct 104700
 ttgaggctgc agccacagct tgcctggccc tgtgtaagtg tttgacctat ttcatacatg 104760
 ccacgctgta tgcagctgta cctccagggg ctgccaccct gaccattctg ctaaaagagt 104820
 aatttctcct gtttcttctt ttccacagta aagattattt cccagcctgg atttttgggg 104880
 caggcccagg atctggttgt atagacgccg ctctctggcg gctgccagcc tcgctgattt 104940
 ccaagcatgt acactggact ccctaggaac actgcagcct ctgctaggca cactgagcaa 105000
 agcccccttg tgctccatgc cagcctaggt aacgtgacgc cctgggctgt aactttcctt 105060
 taatacccag ggaggaacct ctaggccact gagacctcag ggcaggcatg agcaccccag 105120
 gccctgctca gccggctgca cctggttggc tccagtgcct gaagccttcc cttccctccc 105180
 cagtgcatcc tctgtcctcg cagctctggt ctatctcttc cgcagctgcc ggcaggcggc 105240
 tgcttcctgc agtgagtcac tcccacactg ccccattttg gtgcagcgac acatttccat 105300
 gattcgtttc ccaggctgga gagagacttc tcctggagag aaggaacaaa gagggtgaat 105360
 caaggggaat gctccctcgc ctttcctgaa agctgcctgg agcactggtt tgatttcaaa 105420
 cagcacctgg tctctctctg ctccctactg tacagagtcc ccagcctctt tccctctggg 105480
 tcacctcttc tccacgtctc cctcttgtca ctcctgtgtc tcatcctgat ccttttgttt 105540
 gatctcgccc ccacagatgg tttcacgaag gcctctctcg acaccaggca gagaacttac 105600
 tcatgggcaa ggaggttggc ttcttcatca tccgggccag ccagagctcc ccaggggact 105660
 tctccatctc tgtcaggtac tgaccattcc tgacactgcc ttggcccttc tcggcctgtt 105720
 aacctcacag aatgctgaag ccatgaaggg acctctggaa tatgacccaa tggtcagaag 105780
 catggtggcc taggggccaa gcatggcagc agcttcacaa cctgctgctc ccagtgcctt 105840
 cccaaaacat gcacacacca ctctttagaa cactggtgtg tgtttgaaat tatttctacg 105900
 cccatctgcc tccccttcta gcccaggtgc ttctggaagg gcaggatttt cctctacttc 105960
 atctttatgc ctttaacagt gtcttgcata aaagagagac actcagtgag tatttgtgga 106020
 aggaaggagg gataggagga ggagaactcc cacttgtcca gatccatctg ggggtttaaa 106080
 tcttaacctt ttcttttatg attgatgcat atctgaagaa gagtcagaga aaaatagaaa 106140
 tctcaagtca ctgctgtagg atatacaggg gcggaaaagt tgtggcacct ttctttgccc 106200
 atcagaggag tcacagctga cactcctaca agacaggtta acaagaggag agtggacaca 106260
 tttatttaat caaagacttg tgtgacacag aagccttcag aaatgaagac ccaagaccca 106320
 gggaaagccg tctattttta tgcttaggtt tgtcaaagga cagacagccc tgtagaaatg 106380
 ggattggaca aagggggttt gatctaaggt aacagactga ggtaggaaac tgaacaaggc 106440
 ctgtcccaag tcttcttttt tttttttttt tttggagaca gctgttgccc aggctggagt 106500
 gcagtgacgc aatcattgct caccacagcc tctgtgtccc aggctcaagc catcttccca 106560
 cctcagcctc tcaagtagct ggggatacag gtgcacacca ccacacctgg ctaatatttt 106620
 tttaacttat ttctttgtag agactaggtc ttactgtgtt gcctgggctg atctcaaact 106680
 cctggcctcg agtaatcctc ctgccttggc ctcccccata gtgacccttc tagtctctct 106740
 gacccactgt ggggaagagg aattctaatt tctatgactc actcaggggg agaaagagga 106800
 gcgggagaca ggagggcagg agaaggccaa aggaagactt tgcttccaag gctgcttctg 106860
 aaaccttccc atctcctttg gttcgaagca ctcagcatgc caaggggtgt cgttttctga 106920
 gccccaacaa atacatgtat agttgtaggc agctgaacaa aaagaaaggc tacttcaaca 106980
 cagtacagta cagcaagacc gaaaaccaca gaacagaggg ccaggagtgg gggaggactg 107040
 taacagcgaa atctcactaa ggtgcagcaa cccataggaa gtgactcagt ccacgcgtag 107100
 acattacaca gccccaaact cagaagccca gttcggaaca cactgtgtgt ggtcagcatg 107160
 ttgaggatcg caagtcacgt atcagacttc accacatgtg aaactgcaag aatataatgc 107220
 tgttagcaga tcaggagaag tacagcaaaa ccttactgtc aagttattgg caggaaatac 107280
 cgatctggtt tattcaatat attttgaaag gcataaagct ttgttttaag gacagaaatc 107340
 caatctcaag taataaactg tggccacttt gctgtttaga aagaatggat atttgaaagg 107400
 ataggtagga aggacttaaa aataacaggt caacaatttg tatgcataca tacctttaaa 107460
 gtggtctctt tagcattgcc cttgcaatct tgcttaaact cttttcttca gtaaaaactt 107520
 tattttcata gcttggagaa tggttaactt tagttcaggc caatattgat gtatcacaaa 107580
 ttctaatctt gttaggtctt aattaatgaa atttcgctcc attaacatat attacaagtc 107640
 agggtcgggc gccgtggctc atgcctctaa tcccagcact ttgggaggct gagttgggag  107700
 gaatgcttta agccaaggag ttggagacca gccggggcaa ctagtgagac ctcatctcta 107760
 ctaaaaataa aaaattaacc cagtgcagtg gcgcatgcct gtggtcccaa ctacttggga 107820
 ggctgaagtt aaaggattgt tggagctggg cggttgaggt tgcagtgagc caagatcgat 107880
  cgcaccactg cactctagcc tgggtgacag agcaagaccc tgtctcaaga gaaaaaaatt 107940
 atttacatat attatataca tatattatta gaaaaaacaa ttatacatat atttaacatg 108000
 cgtgtatata tattacaagt caaatctatt tcttaagcct cccctcttta ccccatcata 108060
 aacttgacca agtaatttgt tagactgagg ggtatctctt gggcctttgg tttgcatgaa 108120
 gatgactctg gctttttcag ctagaaacta tggtttttgt ggtttcgttg gttttttgag 108180
 acagactctc gctctgtcgc ccaggctgga gtgcagtggc gcaatctcgg ctccctgcaa 108240
 cctccgcctc ccaggttcaa agcaattctc gtgccttggc ctcctgagta gctgggacca 108300
 tgggttcgca ccaccacgcc tggctaattt gtgtgtgtgt ggtttttttc agtagagacg 108360
 gggtttcgtc atgttggcca ggctggtctt gaactcctgg cctcatgtaa tccacccgcc 108420
 tcagcctccc aaagtgctag gattacaggc gcgacccact gtgcccggac ccagaactat 108480
 ggtttatatt tccttaatta aagtgagttc tacaaaacag taggccttga cttctaccga 108540
 agtcttcccc tgatattcag gcgatgaagc ttctagttat ggtgacaatt accgtaatcc 108600
 ttatcacgtc tttgcagaaa tgtagtataa tattttccaa agcaaaatca ttattaatta 108660
 tttttacatc tgtcatgggc acagataatt aagagctaat tgtagttcta tcactcagca 108720
 tttgttaagg gcctgaaaca ccagattttg gagtccagcg ccctgagtcg catcctttcc 108780
 tttgttcctc ttcaggcttg agacaatggt caggccatcc tctccttgta gacccagata 108840
 accagctgca accctcacac ccatccttac agcttatgag agtaaaaggg tcaatgtttc 108900
 acactctgag ttctttgagg tggtggatga aaaattataa tatcacaaga atattttctc 108960
 ctcctcacct ggatgtgaag gataatgact ttgagttgat ccatgttgtc ttagaatgaa 109020
 gaaagtatct gttggtggcc aaaaccaagg ggaagaccac aaagtgattg caatatgttg 109080
 attaccaccc gaaatcagtc aagcaagagg ccacttgtac aacctgtggc ttcacccagc 109140
 tatgagcaaa tcccagcaca taagatgaga ttgagggtca gaatttccat ctccttctta 109200
 acacaggtcc ctaaatccat ccctaagaaa cctccatggt caggcgcagt ggctcacgcc 109260
 tgtaatccca gcactttggg aggctgaggt gggcggatca tgaggtcagg agatcgagac 109320
 catcctgtct aacacgatga aaccccgtct ctactaaaaa tacaaaactt agccgggcgt 109380
 ggtggcgggc gcctgtagtc ccagctactt gggaggctga ggcaggagaa tggcatgaac 109440
 ctgggaggtg gtgcttgcag tgagcagaga tcacgccact gcactccagc ctgggcgaca 109500
 gagcgagact ctgactcaaa aagaaacctc cacttactct cagaggtatc tttactctcc 109560
 gagacccttt aaaattcttg acctttcttt tacatcaggc aattggcatc actagtgcca 109620
 gtttattttt agatataaat gtatgtctgt ttgaaaaata aactttacat ccaaaagaga 109680
 atgacttggc aatgaagtaa aactggatct aatggtaaag gctcagccca cccttcctag 109740
 atggataaaa tccattttct ctagccctgg ttcgaatgtg tcccatcact tgtgagtcca 109800
 gactggcaac aaaaggtgct gatctaaaag aagttatcgt ccagtggcag ggtctgggga 109860
 aggggcggca ggcgccatgt ccagccacga aggtggcaag aagaaggcac tgaaacagcc 109920
 caagaagcag gccaaggaga tggacgagga agagaaggct ttcaagcaga aacaaaaaga 109980
 ggagcagaag aaactcgagg tgctaaaagc gaaggtcgtg gggaaggggc ctctggccac 110040
 aggtggaatt aagaaatctg gcaaaaaata agctgttcct tgtgcctaag gagacggtga 110100
 ccctttattt catccgtatt taaacctctc tattccctcc tataatatct tttgccacct 110160
 atagttggaa ttaagtgtcg tcttggagct gttgtacatt taagaataaa cttttgtaaa 110220
 aaaaaaaaaa aaaaaatctt ccagtggctc atcatctctt tagttgtttt cactaagtca 110280
 ttcctaccat aactgtgaat ttaaagtaaa accagctcag aatcttgcca gaatctgctc 110340
 tttggtcgtt gttctaccct aaactttgta tcacctgaaa ttaaaccaac tcatttgaaa 110400
 gaaaaaagaa gttatcatgt ttaggtggcg tgacaggcca agctcactag actggagtca 110460
 gagactcagg gttctggcct cagcccttac tcagcagtga ccttgaccaa gcccctgcac 110520
 ctctgtgagc ctcagtgtcc tcatctgtaa aatggagaag taaggctaaa caatctccaa 110580
 catccttgcc aattaaaact ctatcatttc acagggcgca gtgcctcaca cctgtaatcc 110640
 cagcactttg ggaggccaag gcaggtggat caccggaggt ctggacttca agaccagcct 110700
 gaccaacatg gcgaaacccc gtctttacta aagacttggt ggtgggtgcc tgtaatccca 110760
 gctcctcagg aggctgagac aggagaatcg cttgaacctg ggaggcggag gttgcagtga 110820
 gcagagatca caccactgca ctccagcctg ggcgacagag tgagactcca tctcaaaaaa 110880
 acaaaacaaa caaacaaaca aaaactctgt atttcataca aagctatttc accaaaagct 110940
 gaaaacactt tgtaacctta tttatgcaaa acataaacca agatcaagag atccttatta 111000
 catagagaaa aaatgtgaca tatttcttag gaaagagagt agcttcttac ctgccagtgc 111060
 tagcttatgg gcttaaagga gatggttcaa agaatttctg gtaacagaaa gataatagga 111120
 gcttgaaata cccctgttga catcttgcga ataaacattg tgaaaaggtc tttgatctct 111180
 ttgtcgttaa gtcacttgga acatgctttt cttgtaaaag gttagttcca gtgtccaaaa 111240
 caaattttag ctcatctgat taccttctgc tgatgtaaat cccgtctagc atagcctgta 111300
 tcctaagtgg tccatcctac aaagttcctg ccgaagcctg actgggctgg cccacctgcc 111360
 cagtgatgag tgagtcatcc atatctacat ctcctgctca aagagaactc caccatccca 111420
 gatgtgagca gcctggaggt ggtgacatta tcaccgtgta acatacaatt ttgttttgcc 111480
 ttgatctcca ggcatgagga tgacgttcaa cacttcaagg tcatgcgaga caacaagggt 111540
 aattactttc tgtggactga gaagtttcca tccctaaata agctggtaga ctactacagg 111600
 acaaattcca tctccagaca gaagcagatc ttccttagag acagaacccg agaagaccag 111660
 gtatgctcca gatccagtcg accccaatct agagatttta ggcagcctga gttctcacat 111720
 gaaccaccag gaaaaatgca taggatgggt agatcctctg agtatactga aagacagagc 111780
 tcagagctct gaggtcagat ctcaacttaa cacttcctag tcgtgtgact ttggaaagtt 111840
 ctctgcgcct cagtttcctc atccataaag tagggacaat ggtaatatct acctcccaga 111900
 atggctgtga aggttggaga agataatgta tcccacgcct catgtcattc ctcatcacac 111960
 tgcgctcagc aagcatcagc tcttaccaca ggtgctgttt ttttgttatt catagacatt 112020
 gctacaccaa agttttcaac ctagctcaag agttgcccaa ggatgaagga gttgggggtg 112080
 ctacagacag ggacattagg gaacagccta gagttcagga gttaaatcag catgtggagt 112140
 tttatgatgg gattgggggt agggaggaca tgggaggaga aaactgcact tggaattatt 112200
 gctgttgcaa ctgtttgcaa tacagactat tgctttaaaa ggaaatgcgt cagacagacc 112260
 tggtatgaaa tcctgcttta atcgcttagc tacctgtatt acctagccaa gttaagaaac 112320
 catctgagta tcagttttct catctgtaga atggagagag caataaaacc tccctcactg 112380
 ggctgttgtg aggattaaat gacttaatac agctaagcac taccagagtc tggtccatat  112440
 taaacactaa gaacatgtta acttgcctcc cataagtaaa ttcacacatg cacacactca 112500
 cacacacaca cacacaccaa tttatgaact atttttcaaa ggaaataaca tggttataag 112560
 agacaggtat cataggaaga agcattcact agaatagctg aaatcctagg gacaggttat 112620
  ttgaaaagat attgagactg tgaaagcaat gtgtgctttg gggaagtcaa gaaaatcctc 112680
 ctttttcgag tccctagttg cttttaagcc tgagaagtta ctgccaaagg agaaaagaag 112740
 ttaccaccaa atgcacacag aagttcagaa aggaaaacaa aggctagcca agaccttgtg 112800
 aatcactcta accaggaaac ggacagaggt attaactcac taggatgggc attcagagaa 112860
 gcaatataaa attgcattaa atgggattaa atgagttgat atttgtaaag cgcttagaac 112920
 agtgcctggt atatgctgcc ctcagggtcc tacataattg tttgttaaat gaaactaaca 112980
 atacggtatt tctgatttgt aaggttgttg taacattagg gaaaaaggcc ttacttcttc 113040
 ccccacgtcc agcccggcgg caggcctggt tcccatggtg ttgcaagaat gttgctgttt 113100
 gggtctctat caccaggctg taaatgacag ttcaaaatca tgcaaagtca acagtggagc 113160
 ttatctggag ggtagattgt ccagtggtgt ggcaacatgt gataagaagg ggtggcattg 113220
 tatcagtaaa atggaatatt tcagcttgat tacacagaga aaaaacgagc gccctggaaa 113280
 tggactaaat ggctaccagg caaaaagtgt tagtctgtga accagagacc tgcactccta 113340
 aaactgggag gatctgagaa tgcagaggcc actttggaaa atgtgaaggt ctaaagcatc 113400
 aattatcttt tagctgcccc caccccacca gctatttctt ggagccagat gagcagggtc 113460
 tgggaacaac tgcccgaggg tagggtaggg ccagacgatc agagaggagg atgcatctgc 113520
 agcatctctg ttctttctcc cagggtcacc ggggcaacag cctggaccgg aggtcccagg 113580
 gaggcccaca cctcagtggg gctgtgggag aagaaatccg accttcgatg aaccggaagc 113640
 tgtcggatca ccccccgacc cttcccctgc agcagcacca gcaccagcca cagcctccgc 113700
 aatatgcccc agcgccccag cagctgcagc agcccccaca gcagcgatat ctgcagcacc 113760
  accatttcca ccaggtatct ggaaagaagg cagtgggcac agtacggtgg aaaggagaac 113820
 ctgcctcccc tccaggcctg gcccagcctc ttgagttctc agagagttca tgatgaagac 113880
 cctggacccc cccaaatggc agaaataggg aaactgttct tggcaaagac atctctatga 113940
 attaaatggc tcccacctga acacacacac acacacacac actgtctcac acacacacac 114000
 acacttaaac tcacacacac acacacttcc cctgaggacc cagtaaacaa ttgcttcatt 114060
 ttcctatcag cacaattcca aatctattca tgccccttag cccatctggc tgtcagatcc 114120
 acaagagaaa aaggcttaat acccacaaca gagccttgtt tattacttat ttatctccct 114180
 ccacccttgt tcccgatggg atttcaggcg gcttactgag atggacaata cggccagata 114240
 acatcattcc tgaattcctt agcagggcac acaaagtcct ttgtgagctg ccagaatcta 114300
 tttccccagc ctcgtccctg ctgcctccct gccaactccc cgtgcaaaca cacattccag 114360
 caacccccca cgctgcctta gttacccgaa tggtccattg cgtttcctct catgcctttg 114420
 tggcgtttta tatgctgatc tctctgcctg atgagcccct ccctgggcag tcctacccct 114480
 ctaagctgga gttcaagcat gacctcctct gtgaagcctt ccttgatttc ccgggcagat 114540
 acagacattt cttctctctg ctcacttacc acttaaatgt gcatggttcc ccctctaaat 114600
 ggaagctcca tgaagccaga gaccttctct ttccagctat atttcccttg tgtctgctac 114660
 tggaaacatg gtaggtgcct gataaatatt tcttgactga ataaataaaa cctgcctttg 114720
 ccttctttgc cttcagaatc taaggtgcct ttagacctta ggtcctcctc aacgtggagg 114780
 gtttattgtc attatcagta agtattcctg gaatataccg gctctgtgga tggcatctga 114840
 gcaaggcact gggggaaccg gtgggagatg tcctggcagt ggggtgacca gtcttctgtt 114900
 gtatgtttct aggaacgccg aggaggcagc cttgacataa atgatgggca ttgtggcacc 114960
 ggcttgggca gtgaaatgaa tgcggccctc atgcatcgga gacacacaga cccagtgcag 115020
 ctccaggcgg caggggtatg ggaactgtcc ttctctggga tccctgggga aaggccttgg 115080
 gacagaggtc aatggaggag atgaggcagg agagactcaa accacacaga tctggctggg 115140
 cacggtggct cacacctgta atcccaacac tttgggaggc caaggcaggt ggatcacctg 115200
 aggtcaggag ttcgagacca gcctggccaa catggtgaaa cctcacgtct actaaaaata 115260
 caaaaattag ccaggcatgg tggcagatgc cagtaatccc agctacttgg gaggctgagg 115320
 caggagaatt gcttgaaccc aggaggcaga ggttgcagtg agccgagatt gcgccatttt 115380
 actccatcct gggcaacaag agcgaaactc cgtctcaaaa aacaaaacaa aacaaaacaa 115440
 aaatgcacac acagatcaac gagaggtgat ggaatgtttg gggaggcctg gggctgagcc 115500
 agcaccgtcc agtctgttga tctcagtctg gtgccaggcc ttccctgttc tcatagttct 115560
 cagttctagt tctttatcat ctttatcata gtcctttacc attgccttta tcattgcatc 115620
 ttttttttgt tttttgagac agggtctcac tctgtctccc aggctcaagt gcagtggcac 115680
 aatcatggct cactgcagat tcaaactcct aggctcaagc gatcctcctg cctctgcttc 115740
 ccaagtagct aggtatatta tttgtagcga taagctcttg ctatattgcc caggctggtc 115800
 tggaactcct gggctcaagc aatcctccta cctcagcctc ccacagtgct gggattacag 115860
 gcatgagcca ccgtgcctgg cctgtgatcc atcttgactt gtgacttgat tgccctaaca 115920
 ccaagggctg ttgtttgggg catgttgccc ttctgtttgt cactcaagat aaaaatacca 115980
 cctattgatg tggagagagt ggttctcagg gagtctattg gggctttgga caataacatc 116040
 tgttggtaaa agtcctgggt ctccagagtg acgctggtgc gttctgggaa cttcttgctc 116100
 aggcctgtgc ataggtatct gatttaaatt gcagcagggt agccgggcat ggtggctcac 116160
 acctgtagtt ccagctactt gggaggccaa ggcaggagga cttcttgagg ccaagggttc 116220
 aaaaccagcc tgagcaacat agcaagaccc catctctaca aaaaaagttt ttttaagctg 116280
 cagaggggtc agccttcagg gaatgttgct ctcaaagact tggatgtggt gggaggagcc 116340
 agcagaccct cccctgcctg cccagcccac agctcagcag agcctcttct gtgcttcccc 116400
 caacagcgag tgcggtgggc ccgggcgctg tatgactttg aggccctgga ggatgacgag 116460
 ctggggttcc acagcgggga ggtggtggag gtcctggata gctccaaccc atcctggtgg 116520
 accggccgcc tgcacaacaa gctgggcctc ttccctgcca actacgtggc acccatgacc 116580
 cgataaactc ttcaggggac agaagctttt tgtctggagc tgcccacaag aaagagggca 116640
 aggaaaaaag gctggactcc atgactatat atacatacat ctatctacat ctgcctgtgt 116700
 acacacacaa ctttttatac tagtaattta ttggcaattg ggctggtaat tagttgatgc 116760
 aaaagggaac tcaggtggag aataatattg acacttgctt ttctgccccc ctcaggggtg 116820
 tgtggaaggc agtgggggag ttgggagggg ggcagggaaa tgaaatggag ttttgtcctg 116880
 gccttcagct gtcactgctt cctccttgtc ttgggaattt tcacggagaa cagctaagca 116940
 gagaccacac ctcggcactg gacacagaac aacagggtgg ggttgaactt ggtggggcac 117000
 gttctagctg acctgcaagc cccgctcacc tggagggctt gcagagcagc tctcctcctg 117060
 ttctccaagg ggtgggcact gttgcattag gaattaaggt gcagcccagt gctgcgggca 117120
 gccaagcgag tctgagcggg gatgtgaagg caggacgggg ttggagagac cctgcctgtg  117180
 caaggctggc ctcctagtca acacctagct gagacattca tctctgttca aattaatatt 117240
 ccttgggtct ttcaaatgaa tgtttcaatg tgaggagcga agtactggga aatcgaggga 117300
 ttttccacaa tccccaagca gcttactcag tggaacctct gtttccccag ctatgaagga 117360
 aatagcatcc tacattccgt aaagtgcttg aagaagctct agctgagaat gctgaatttt 117420
 acagtcattg ttttatggtt acaagggtat gtcttcaggg ctctgttcat tttccctctt 117480
 gattttctct tttgaagatg ccttgcccag tggcatggaa agaagcccac ttgatgatag 117540
 gagcctgact atgaattgat tgactaaaca tgaccccagg tggaagctgg ctttgacacc 117600
 agcttcctgt tcagtctgac cactgctgtc ctcctgctgc ccaagagttg cacctggagc 117660
 aaggaacccc accatggctg tcgctctcca tcccatcacg ctagaatcat gtgtccaagg 117720
 gctcactctg gaggtgcaca gcacaggtca gcctggccag gggcgaagga gacagtagag 117780
 aggaagctca gggccttagg ggaggccggg tgcaaacccg ttctgcacca agtgcactcg 117840
 gagtttgtgg gtatgggtgt gtacccctgc aggtgtgcac atgtgtgctt gcacgcacat 117900
 atttgtgcac tcctgtgtgt atacatgtgt gcttgtgtat gcatatgtgt gcattcctgc 117960
 atgtgtggac atgtgcgtgc atgcatctgt gtgtctgtgt gtgtgctgag acaggaaagg 118020
 gggtgaaagt gttggtgagg gagcctggaa gttttctctt ccccaacctc tcttgctcta 118080
 aggagggatg gggttggggg cagccgttat tgaaggtgat cggagaagaa agattttctg 118140
 actcagaagt gactgccagt gtagcacaag cagtgtccct tgtgactgtg attctacagt 118200
 tctctgatcc tcatgtttcc tttagaggaa agaggaaaaa aggaactctg tggtgggtat 118260
 tgggagggaa aagaaaatag cctggtggag gcaggaggga gtcgagtgtg agtaaggagc 118320
 acctgcagct tttggaagtg aaagcagaga gagggaaagg tagctaagac atccaggagg 118380
 atcaaggggc agcgtgagag gcacaggggg aggaaaggga gagggtgagt ggggccaggg 118440
 aagagaacgg tgtggagttg gtgggcagat ggtgcaggag gagggctggg cagtggggag 118500
  aggaagaatc agagcagaga aaccgctgct gcggaaggca gggagcaaag aagcataagg 118560
 aaaagaacag gagaaagaac aaaggcagag aagacctcct cagctatttt ggtgctaggt 118620
 aatgtgaaat gctgcagtaa ataaaagcca taagtaatgt ttgattttac agtatttaca 118680
 aaccatatgc tttaaacagc ccacaaactc catccagttg tctgatgatg tgggaggacc 118740
 agctctagtt agacggaggt atgtgattcg attctggtgg agactttgtg ccttgaaagg 118800
 cttctcagga aagcagtaat aaaacaaagt gtccttgttt ggccaggccg tgtctggtgt 118860
 ctgcgttgca tacccctcag gtagagagtg agaacgagac cagggggtga caggggtcat 118920
 cggcctgcag gagctgaccc cgtaggcagg cggtatgagc agagctttca gaacccctgg 118980
 agctcggtgt tctgttgtag caaaagctac tgaagagtat tttgtactga gatgccaaag 119040
 catctttccc ttgctcatca gcctccattc agaaggaagc gggaaagtca cccaaaccac 119100
 ctacaaggaa tgagggctct tagcggccag gtaaagagga caagaaccaa actgtccaca 119160
 ttatggaggg gagggggaaa gagagctcaa cccccctcag cctctggtgc tgccaggggg 119220
 agcccctccg catgtgtccc cacgggccct attttctacc tgacagcatt tcagcaccag 119280
 aggagggttg agccagctcc tctcaccagc cacagaacca gcagccaaca aacacattgt 119340
 ccccgagttt ggctgcaaca ctctatgtga cttgggaact tgaagcttcc agagaaaagc 119400
 caggtcctgt tggaccagtt gttgggtttt cctaaccact tgctgtgcct caccgcattt 119460
 caaatatctg gcacctgcca ctgcccaccc acttttagat ggccctaggg tgatctaacc 119520
 atggtgcttc tcaaaattta aagtgcctac gaattgcctg gggaccgtgt tgaaatgcag 119580
 cttccaactt ggtcctgaat ttctaacaag ctactgggtg ctgttgctag gtccacatgt 119640
 taaggagcaa aggcaaagaa cttagcagtg agcacaactc taattgggct cttcttctga 119700
 ggatattcgg ccattttttc ttcgctgcta acgaataggt cactttggct ttgggacaga 119760
 tgcaattcag aacggtcatt atgacgtcat tcatatttgg ctacccaggt gacttattat 119820
 tttagcatcc ttatctctag aattaaaaaa atgtaatgtg agaggaattc agatgaaatg 119880
 caaacaggaa tttcctataa taattactat ttcctaatag taattatttt aaacatcagc 119940
 agagattgca gaagttgtaa aagctttgtc aggaaatctt cagtcataaa attgactctg 120000
 gtcagatgtg gccctggttg aggcagggga ctgtgctccc agctaaccta aaacacaaca 120060
 gcccacactc gggacagatt agcatggcca aaatatttac tgtttgcctt gtctaagcca 120120
 acattttagc ccctctatac caaggcaagt gtgtgagaaa aaccttgatt gtctcaatgc 120180
 tttttaaaaa atgcctcctc agttcctcca ctttactcca tcaccttggc catgccacca 120240
 tcatctcttc ctttggcaac tgtcagcttt catacctttc tccctgcatt ctctcccgta 120300
 atctggtcct ccacacagat gccaaagcga tctttgtaaa aataaatccg atcacatcac 120360
 tccccttccc actggattta ggcttaagtc caaagtccta atgtggccct gtgaagtccg 120420
 gcccctgcct ccctcctcag cctcctcttc tgcctcccct gccccttgct tttatgctcc 120480
 tgccccactg gcctttcagc ctccaaatgg ccaaggattt gtccccaaac ctttcacact 120540
 tgccattctt gctacctgga ggcacatccc ctgctaaccc tgctaactct tgttcatctc 120600
 caggtctggg ttggtttttt gttttctgtt ttttgttttt tgtttttgtt tttgtttttg 120660
 tttttgtttt tgttttgaga tggggtctgg ctctgttgcc caggctggag tgcagtggca 120720
 cagtctcagc tcactgcagc ctctgcctcc caagttcaag tgattctccc acctcagcct 120780
 cccgagtagc tgggattaca gggtcatgtc accacacctg gctaattttt gcatttttgg 120840
 tagagacagg gtttcaccat gttggccagg gtggtcttga actcctgacc tcaggtgatc 120900
 cactcaccct ggcttcccaa agtgatggga atataggtgt gagccaccat gcctggccca 120960
 ggtctgggtt taaatgtcac ttccaaacag tcctcccctg ccctctaatc taaaataatc 121020
 cttcccctaa gatggtctta tgaatcctgt gcttttcctg aatagcacgt acacagatga 121080
 tggtgccaga ctgagctgta tggctattac agctcactgc agcctctgcc tcccaagttc 121140
 aagtgaactt ggagctgtaa gctccacgga gcaggggtca cctctgtttt gtaaaccatt 121200
 gtacacccag catctagcac tatgcaaggc acacagaggc tcagtaaata tttttctaat 121260
 gaaggaatga ttggacctgc ttcatctcat ctatttactc attttgtaac tcaactgtct 121320
 tgggcctaac agacctgtag atgcaaacaa ggtcatattt acaatgatgt ccaggttcca 121380
 gtagctttag ccactgtctt cggattctcc tccagttaac ttctgagagg ccaagagagg 121440
 gaggctgtta tctctcacgt gtttaggcac cagtatactc acgcttccta ctctggttcc 121500
 agtgttctgt tgccccacgc atcctctgct gacaatgcct tcccagatgc tgcggatcca 121560
 ctatgcacca catttatctg ctggtgaatt gacccaatcc ttcaggacac caaatctgcc 121620
 ctgcagtcca catgacaagg agattgggga agaggtagag gggagaatgg ccagcctgtg 121680
 cccaattctg agaggcactg cttggaccct ggctccctca gcatcttcca tgagcacagc 121740
 tggctctctt ctcagccgag ccctccctcc atcagacaga acaagggata ccaacccttc 121800
 cctccgtctc tctcttctca ctcttccctg ttgcctcttt ctccttgagc tcaaaagaag 121860
 gggaatgtac ctacatgcca tcgttagctc acagctaacc tgaaacacaa cagcccacac 121920
 tggggactga ttagcatggt caaaatattt gctgttttct cagtctaaag tcaacacttc 121980
 agcctgtcca taccaaggca agggtgtcct ctgcaccaca ccatttgtgc agtagatact 122040
 acctagaagc ctagtagctg tgcactcact tctattgttt taagttttgc tgtaattcat 122100
 tcattaagtc aacaaatatt tacaaagcac ctcttcaggg tcagacacaa tcagccatcg 122160
 ggtccttcac attctctcaa ctctgtccct tctctgcacc cattccacag ccactgcctt 122220
 acttcaaacc tctctcactt ctttccctga tgactgcaat agtctcagca ctcgtctccc 122280
 tgcctttctg gctggccccc tgtaatacag cctccaacgc agtcagggag atcttattcg 122340
 cagacaggct gatgatacca agctcctgct caaatctttg ggttctccat agtcttcagg 122400
 ctggagttta acctccttag cttcgcacta aaggcctttt gtgatctgcc tgctgccttg 122460
 ttcgttcagc cacatcttct acctctccag tcccaaacac tctttacttc agtcccttag 122520
 aactatctgt ggttcccaga atgaggcatg ttttctaaga cctctggtct cctacattct 122580
 gttctttttg cctggaatgc tttctcccac tgttttgtct agacaagggc tgtctattag 122640
 gactttctgt gatgagggaa aagctctgta tctgctccat ccaatgtggt agccactagc 122700
 cactagccac atgtggctat tgaatacttg aaatatgcct ggtataaatg actgaaattg 122760
 ccacatgtgg caaagagctg ccttataggg cagcgtgggt ccagacaact gttacttact 122820
 ttgaaatcat tagctcaggg ctccaggtct ccactgggaa accatcccaa tattatggtt 122880
 gatgtaagtg cccccgttcc cccaccccca cttatgttcc tgtagtaacc ttgttctccc 122940
 tctatcccaa tactcagaac accattgtca gtgattcact gatctgcctc ctctgctaga 123000
 ccaaatcttt tttaggtcaa agatatgcag tgcagtcaat aaatggttga tgcctagatg  123060
 cagtgacgtg ctggtaaaga tttaataatt ggctctctct aagaagaagc cctaacttgt 123120
 ggtatttgcc aattctatgg tgtaaacact cccaccatat gccaagagaa tgagaagaca 123180
 agtcacagac caggagaaaa tatgtacaga agacatatct gataaaggac tatgatacac 123240
  aaagaactct taaaactcaa caataggcag ggcacagtgg ctcacgcctg taatcccagc 123300
 actttgggag gccgaggcag gtggatcatg aggtcaggag tttgagacca gcctggccaa 123360
 gatggtgaaa tcccgtctct actaaaaata caaaaattag ccgggtttgg tggcgggcac 123420
 ctgtaatccc agctacttgg gaggctgatg caggaaaatt gtttgaaccc gggaggtgga 123480
 ggttgcagtg agccaagttc ctgccacttc gctctagcct gggcaacaga gcaagactcc 123540
 atctcaaaaa aagaaagaaa gaaagaaaga aagtaagaaa caaaaaaaac caacaacaac 123600
 aacaaaaaaa ctccacaatt agaagatgaa caacccaatt taaaaatggg caaaagacat 123660
 ggacagctca tggaagaaga tatagatggc aagtgaggag ataaaaagat gctcaatatc 123720
 atatgtcatt aggaaaatac aaattaaaac aatgaaatat caccacacac ctataagaat 123780
 gccccatatc tataatactg acaacaccat atgctggtga tgatgtgaaa caacaggaac 123840
 tctcattcat tgatggtggg aaggcaaaat ggtacagcta ctttggaaga gagttcgacg 123900
 gtttcttgca aaactaaact tacgctggtc ataggatcca gcattcacac tccttggtat 123960
 ttactgaaag gtgctgaaaa catccacaca aagacctgga catggatatt tatagtggct 124020
 ttattcataa ttgccaaaac ttagaagaaa ccaaaatgtc ctacaatagg tgaatgaata 124080
 aataaactgt ggtacctcca gacaatagaa tagtatttag aaagaaataa gctaccaagc 124140
 tatgaaagat gaaaaccctt aaatgcatat tattattatt attattatta ttattattat 124200
 tattaagatg gagtttcact ctgtcaccca ggctggagtg cagtggtgta atctcagctc 124260
 actgcaacct ccacctccct ggttcaagca aatctcctgc ctctgcctcc caagtagctg 124320
 ggattacagg cgcccgtcac cacgcttggc tgaatttttt tttttttttt agtagagacg 124380
 gggtttcacc atgttggcca gactggtttt gaactcctga cctaaggtga tctgcccacc 124440
 tcagcctccc aaagtgatgg tattacaggc atgcgatgct gcacccaacc cttaaatgca 124500
 tattactatg tgaaataagc caatatgaaa aggctacaca ctgtaccgtt tcaactacat 124560
 ggcatgctgg aaaaggaaaa actagagagg cggtaaaaag atcagtggtt ggaagggttg 124620
 agggtgggag gcatgaatac gcagagcccg gaggattttt agggcagtga aactcctctg 124680
 tgtgatgcca caacaataga cacatggcat gacacatttt tcaaaaccca taggatgcac 124740
 aacaggaaga gtgaacccta atgtaaacta cgcatttcgg gtgattatgg tgtgtcaatg 124800
 taggctcaac aattgtaaca aatatatcac tctgctggag gatgttgaca gtgagggagg 124860
 ctatgcgtgt gtggggacag ggggtatttg ggaactccct gtgtcttctg ttccattttg 124920
 ctgtgatcct aaaactgctg aaaaaaaaaa gtctacttaa aaaagaacaa ctcccaccat 124980
 ggcagatttc aggctaccaa catgacatca ctgaatccag agttgggaag agatgtacac 125040
 aattgttttt catgggcaga taggagccag ccccagcaca ccaccgcatg agtgagtgag 125100
 tgaatgagtg aatgaatgaa tgaatgaatg aatgaatgaa agaaatgtgc cagatgctgg 125160
 gaataccagg gacgccatca ggctctttag ggagaagtct attcagacct gcgagagctg 125220
 ggcatgcagc tgctagtcgg atttcaattc caactgagga gataaaggat cagggagtcc 125280
 catctttgat ttagtcagta aatcgaagat atgggacatt tgttttcttt gggtgcttta 125340
 cctttaatac caagacttgt caaggcatct ctattaagtg gcccactcag acaagtgcaa 125400
 agtgagtgag ctggaggcga aaaaaacaga ggcctgacca aaaggctcta gagcaacaag 125460
 aggctcatga tttcccatca caagaagtcc agagacaaga cagccattgg ctggcttaac 125520
 acaatggccc aacaatgcat cagtgatgtc tctgagcatc agtggtgtct cttctcagtg 125580
 gcttacagct ccagacatca catgcagacg tgacaatgtc taatggagaa ggggcacatt 125640
 ctctcccaat tctactcaat gagaaaccct ttccttcctg gaggtccttc agcggccatt 125700
 cacacagatc ccactggcaa gactggatcc catgctgttc ttacaccagc catttccaag 125760
 agaatgaggc caccataact ggcttaggcc aattggtagg acccttcagg aggcagaacc 125820
 tgggaaccta ggcagggctc tgcccacagg aagaagcagg tgagcgtgtg ggggtggcgg 125880
 atggttgtca aaacccaata tacagggaac attacaggaa gagtcactta ctttacaatc 125940
 atgtcatttc ataaacattt cttgacataa ttagggaaca agaggcagca tgaaggagca 126000
 cagcttccct gccattcccc ccgccacagt gagacgcctg caaggacaca gacacagcct 126060
 ttccatcagc cttcctctgt ggatccccca tccacactga gccagcaggt caatggggac 126120
 aggttccatg ctgttcagag aaaccagcac tgtacacagt ggggccctgc atccactgca 126180
 ggggtggacg cctcagccag cccaggactg tgccgtcatc cctgagactc actgatcctg 126240
 atgtgagact ctccccgaca ggggcttcca ggcatggctc tatgcagggt catttgtggc 126300
 cacactatga cgtgggcgat cccatttcta cacatctaaa ttccccaggg caggcagcat 126360
 gtggtatctc actccctcgg ctctaacctg gttatgggaa gttgctaggt aactgcttcc 126420
 cacactggag gaggcttagt taccatggaa agtccagatg ggtggggggg cacagaggaa 126480
 gggagcactg gctggggggt ctgcagctgg gattctgtcc ccactctctc ctgagcccct 126540
 ggacctaagg ggagtctctc aacccctctg ggcctcagtt tcctcctagt aaaatgaagg 126600
 aaaggctggg tcacttcttg ctctaaacca ctgatgcatg tggatggcat accctcagtg 126660
 agcactgatc ctcagacacc tcttcggcaa ggagtgactc aagatgggtg cagaaaagga 126720
 atgcattaag tttatgtctt agcctgggca acatagcaag actctgtctc tacaaaaaac 126780
 attttttttt tttttgagac agagtttcac tctgtcaccg aggctggagt acagtgacgt 126840
 gatctccact cgctgcaacc tccgcctccc gggttcaagc gattctcatg cctcagcctc 126900
 cctagtagct gggattacaa gcatgtgcca ccacacccag ctaatttttg tatttttagt 126960
 agagacaggt ttcaccatgt tggccaggct ggtctcgaac tcctgacctc aagtgatctg 127020
 cctgcctcag cctcccaaag tcctgagatt acaggcatga gccacagcgc ccggccctca 127080
 attttttttt tttaaattag ctaggtgtgg tacatacagg cacctgcctg tagtcccagc 127140
 tactccagac gcagaggtag taggatcact cgagctcagg agtttgagac tgcagtgagc 127200
 tatgattgtg ccaccacact cagcctgagt gacagagcaa gaccctatct taaaaaacaa 127260
 aaacaaaaca aaacaaaaca aaaggccagg cgtggtggct catgcctgta atcccagcac 127320
 tttgggaggc tgaggcaggc agatcatgag gtcaggaatt tgagaccagc ctgaccaaca 127380
 cggtgaaacc ccatctctac taaaaataca aaaattagct gggcgtggtg gcacacgcct 127440
 gtaatcccaa ctactcagga ggctgaggca ggagaatccc ttgaacctgg gaggcagagg 127500
 ttgcagtgaa ccgagattgc accactgcac tccagcctgg gcgacagacc gagactctgt 127560
 ctaaaaaaac aaaaacaaaa aagttttttc tttaaaaaaa tagagaaact agcaagcttg 127620
 tgtctctatt aggataaata aaagctatag gccaggcgca gtggctcaca cctgtaatcc 127680
 cagcactttg ggaggccgag gcgggtagat cccctgaggt caggagttca agaccagctt 127740
 ggccaacatg gtgaagtccc gtctctacta aaaatgcaaa aattggctgg gcatggtggc  127800
 tcatgcctat aatcccagca ctttgggagg ctgaggtagg tggatcacct gaggtcagga 127860
 gtttgagacc agcctggcca acatgatgaa acccgtctct actaaaaatg tgaaaattag 127920
 ctgggcatgg tggcgggcgc ctgtaatccc agctacttgg aaggctgagg caggagaatc 127980
  acttgaatcc aggagatgga ggttgcagtg agctgagatc acaccattgc actccagcct 128040
 ggtcaacgag agtgaaactt catcccaaaa caaaacaaaa caaagcaaaa attagccggg 128100
 catggtggtg ggcccctgta atcccagcta ccctggaggc tgaggtggga gaattgcttg 128160
 aacctgggag gtggaggctg caaggagtcg agatggcgcc actgcactcc agcctgggcg 128220
 acagagcaag accctgtcta aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa 128280
 aaaaaaaatt ggccgggcgc agtggctcac acctgtaatc ccagtacttt gggaggtcaa 128340
 ggcaggcgga tcacctaaag tcaggagttc aagaccagcc tgaccaagat ggtgaaaccc 128400
 tgtctctact aaaaatacaa aaattagcca ggcatggtgg ggggcacctg taatcccaac 128460
 tacttgggag gctgagacag gagaattgct tgaacctggg aggtggagat tgcagtgagc 128520
 cgagatcgtg ccactgcact ccagcctggg caacagagca agattgcacc tcaaaaaaaa 128580
 aaaaaaagtt atagagattc tcccttctgc taggagaaat ttcacttctg acatcaatat 128640
 tcacaagtcc tggggctccc taggtcctct tctgaaccga ggcttcctaa aaaaaaaact 128700
 taggatgcaa tgtgtgtccc taaaacaccc agcttgctaa agcatgatgt cctttcagac 128760
 agggtctccc agttcttggg ctctgctggt ccttctgccc cagatggagc catggcacag 128820
 gcccagccct ctctaggttg ctgggaccca tcctgactcc tccaatatgg gccactgcat 128880
 aagcctcttg ggtctgctat ttgttccttc tttcattctg agatccagcc ccaccttctt 128940
 cccttgcttc tgcaataaga tctctgccca ggcccagatg ctgggaccag tgcagtaccc 129000
 agctccccgt tcacctgcct tgttcatgcc aatcccattc ccagaatcca tatgacattt 129060
 ccaagcacta gctgccatcc tcctgtctac acgcccgaat ctccatgatg cagtggtggc 129120
  tccctctccc accatgcatg tcacccactc agcactctga tgaccttgtg ccggagcccc 129180
 tgctcctgct ggctgcacaa cacccccacc accatctgta cccacagtca caggaggccc 129240
 ctgtaatccc cgaagacagg ttggacccca tcccaccccc agaagctggt ctttactccc 129300
 acttccttct cggtctccac ctccagggtc cagttttaag ttttggccac tcctgatccc 129360
 tccccaccac catacaaaca tgacaaacag ggcaatgtct gagtgtggct aaggacgctg 129420
 cagtcatcat atcaggtaac attctccatc cccactcaac aactgagttt tctcctggct 129480
 gggagcagaa ggagaaattc acatctttta catatagagt gagcctctct agggtgtcag 129540
 ggtcagtggt ctctcagcta acagctttgc tctggggcat tcaagaacct tctggccctg 129600
 cagagaaaac cccacccttg agctgtacac cctgtccctc ccctcctttc taactattct 129660
 ctcttctctc ctccaggcaa tgtggagagg tggaaaagtc acaagctttg agtcagaaac 129720
 acgtgggctg cagtccagac tctgctactt acgctatcag cctggacaag tttcttgacc 129780
 actctgagct gatctagaga actggggata atagcactga gttgtcatga gaagtaaaca 129840
 aaattatagg aactacttgg taagaaccta gcaagtggga gagacatcat gactgctttc 129900
 ttcattcttt ttattcctat ggcccaggcc aagcaacagg gcatgaagag aagaaactca 129960
 gctgggcgtg ggggctcacg cctgtaatcc cagcactttg agaggctgag gcgggcagat 130020
 catgaggtca agagatcgag accatcctgg ccaatatgat gaaaccctgt ctctacaaaa 130080
 atacaaaaat tagctgggtg tggtggcgca cctgtattcc catctacttg ggagctggga 130140
 gagggagctc ccgcgtaggg agaatcactt gatcactgag gcaggagaat cacttgaacc 130200
 tgaaaggcgg aggttgcagt gagccgagat cgccccactg tattccagcc tgggcaacag 130260
 agtgagactc catctcagaa aaaaaaaaaa aaaaaaaaaa gagaagaaac ttggtccatt 130320
 cctaaggttc ctggccctcc caggagtctt gcccagcctc tacctcaccc ataactactt 130380
 tccatttttg gcagaaacag cctcttcttc acccctccct gccccacccc agtgggactt 130440
 gttgctgcaa cagcctcctt ccctttgaaa cttgcctgtc ctgtgttccg ccctccccgg 130500
 ggtaatctct ctgcacccat caaactgata acttgccaac acagcacatc aactttggga 130560
 gagctcccct ccctcacctc acccaccctc ctccagggta cacctgtcct gtgatggcca 130620
 cctgcaaggg acagagtgct gagggtgttg gccaagtaaa ggaataattt ttgaagggag 130680
 aatgccaggt taggcagggg tgtcagaggc atcccgggtc acttcctctg gtggctctcc 130740
 actgctttgc aaggcatccc acccagatca gtcactggct ttactagaat gcccttcccc 130800
 tgccaccccc agcttggggt tcaagctgcc tcttggaggt ggggctgcat ggaggcaaga 130860
 catctgggcc accctcaacc cctgcacctt gccctgcacc tgccctcgac ccctgcacct 130920
 ttctccttct tcggtaactg tgctcacata ggtccctcca cctccaccta ggggcctcct 130980
 tcctttctat ttacctctgt tcacatccta gccagccttc aaggccaggg aaaaggccac 131040
 ccccttcaca aagtcatctt tgattccacc ctcagcctag agcaagcagc cttgctgaac 131100
 cttcttctga cgggtgctct ctctgccagc cttgccctaa aagggtgagt gcactcaggt 131160
 cctgtgccct ggaatgtcca ggttccaggc cccaaggaca aggctgaact aacactaagg 131220
 aaataattct agcccaggcc tcttggttgg ggtcagagct gctttaaact ttgcctaaaa 131280
 atgtttctgg tgctgccagc cataaagcgg ggaggcactc ccttgagtca ggtgtgtctg 131340
 actcaaaagc actccgcctc tgtcatgtgg gtgaagttgt tcacccaagc agccctgcgc 131400
 tgcctgcaca gcctgccagg aacctctgct ccaagactct ctgttcctgt gtggctacct 131460
 agagaaagca agaaaagacc ccatgcctcc ccgaggcttc ctttctgaaa cttccctagt 131520
 ctcagaacct gagcagccct ctttctgtaa tgctaaatgt cactggagcc caccgcgggc 131580
 tctccctacc tcgggtccag cccatgctct tggtcaggtg catccatctc aagcatcatt 131640
 tttatcctgc cattccccag tttcccagcc ttccatggct cccagctgaa aacaaaatgc 131700
 aaactcagcc tggaattcac gcactcaaga gcatctgtga gacaacttgt atttctggct 131760
 ccttgtcatt ttcccatccc tgaaatacac atatatgtac atatttacac actggtacac 131820
 acatacacat acatgtactt acatacacac atgtacacac acacacacac acacacacac 131880
 acacacacac acacacacac acaccatgac ctaaacgagt cagttggttt agtctgcatt 131940
 taccttaagc actacattta ctcagtcact cactcactct tcatccactc aactctctca 132000
 gtaccaggtc tgttctagag ctggaacata actttcctgc ttccctacca tcagctacta 132060
 cctagaatat cctcccctgt cccttcaagc actttgggag gccaaggtag gtggatcacc 132120
 tgaggtcagg agttcgatac cagcctgacc aatatggtga aaccccatct ctactaaaag 132180
 tgcaaaaaat agccaggcgt ggtggcaggt gcctataatc ccagctactc aggaggctga 132240
 aacaggagaa tcacttaaac ctgggggatg gaggttgcag tgagccgaga tcatgccact 132300
 ttactccagt ctgcgtgaaa gagcgaaact ctgtctcaaa aaaaaaaaaa aaaaaaaaaa 132360
 aaagcattaa agaccagagg gtagaactca agctaatctg ccacggtcat ctctccagtg 132420
 accagctctt gctctggatc aatgcacatc aggaacacac cgtggggtag ttctaacaaa 132480
 caacccctgt gcggagagtc ttcaggcggg gagaagcgcc aaacccttag gcctcttcct  132540
 aggcagcctt tggattaaac cctctctctt cctgatgctg gtcctccatc cgcactggct 132600
 ggagaaaagg cctcctttgg actatgcctc ccgggaggac atggatgccg aaatccttct 132660
 tcatctttaa agataatcaa aaatgtctac cagagccagg catggtgact gaagcctgta 132720
 atcccagcta cttgggaggc ttaggtgaga tcacttgagg ccaagagttc aaggttgcag 132780
 tgagctatga ttgtgtcact gcactctagc ctgggcaaca gagcgaaatc ctgtctctaa 132840
 aaagaaaaaa aggtccactg tgtacaccct accacacata tgcattctct ctctctctgt 132900
 gtcacacaca cacacacaca cacacacaca cacacataca cagtcacact gggcaacaga 132960
 atggctgaaa agactcatgt tcaattaagt tgtctttggc atttgggttc ttatttctat 133020
 gttcctatgg tatttacggc aggggaagag aggaaaccct actaagtttt gagaaagaat 133080
 tcccaatccg tttgcagtaa agagggtgag ggggccggac gcggtggctc aggcctgtaa 133140
 tcccagcact ttgagaggcc aaggtgggcg aatcacgagg tcaagagatt gagaccatcc 133200
 tggacaacat ggtgaaaccc cgtctctact gaaaatacaa aaattagccg ggcttggtgg 133260
 tgggcgcctg taatcccagc aactcgggag gctgaggcag gagaatcgct tgaacccagc 133320
 aggcgaagat ccgagaagtg agccaagatc acgccactgc acttcagcct ggcgacagag 133380
 caagactccg tcttaaaaaa aaaaggcggg tgcagtggct cacgcctgta atcccagcac 133440
 tttgggaggc tgaggtgggc agatcacctg aggtcaggag tttgagacca gcctgaccaa 133500
 tatgatgaaa ccccatctct tctaaaaata caaaaattag cctggcgtgg tggcatgcct 133560
 gtaatcccag ctactcaaga ggctgaggca ggagactcgc ttgaacctgg gaggcaaagg 133620
 ttgcagtgag ctgagatggt gccactgcac tccagcctgg gggacaagag agaaactctg 133680
 tctcaaaaaa aaaaaaaaaa aaaagcgggt gacctcgggt gaaagcccag gggttagggc 133740
 ctaaggcctg ggaacaccct gatgaatgtg acagtcctgc catcaaggaa ctcacaactg 133800
 ctgggggaga cagaccatga gaacacagag cctggatgct cagacaggtc tagcgggaag 133860
  caaggaaagt ccctgcaccc ggacttagag gcccaggaga gactctacag agggagtgac 133920
 caccaggcta aagacaagag gagccagaag agtctcccgt gggctgggga gaaacacgtg 133980
 gtagcagcag aagcttgggg aggggaagaa aagtaggtct gaatcctaaa aggcctcgag 134040
 gcgcttgggc tgtagcctgc agggataggg acccttggca gggttttgtg cagggaaagg 134100
 acataatggt gtttaccttt tagaagagat ctaaggggag aatccggtta gggagcccag 134160
 ttaggaggct cttgcaaggc tcttgcaagg atgtccagga agggaggagt ggggagtggc 134220
 agcagggaag gagggagggg cagtgacgga accacaccac gtcaccccac atcacatcac 134280
 accctagccc agagaaagcc tcttctggtc tggtggccta agggaaagga aagagtcaaa 134340
 atgagcccct gtttcccatg ctggtgagat ggaggctggc tagtggaggg ctgggtcgtt 134400
 ttggacatgg taaacccagg aggaggggca tgcctggggg gcataggaga aggggctgac 134460
 aggtgccatt tgggacaagt tgtgttggag gtgcctgggg gatgtgtgac tggagatgac 134520
 cagcaggcag cctgatgaac tggcatggat tgaggagagg gttctggagt tgagctagag 134580
 tcatccaagc acagggaagc gaggttgccc acggatgggc gagatgtgaa aggcgggaag 134640
 gtcagggcag ggtcccgagg aacagcgcgt ttcagagatg gatgaaggag aatgagaagg 134700
 agtggcaggg aggcaaacaa acaaacaaaa aacaggaatc accaattcag agaaaacagt 134760
 gcaatggcag agtcttcagg ggactgggag cctctgtacc tccaaggctg gagaagcagc 134820
 aaagcccctg agtctggaag gtctgtgggg gcaggaactt gcctggtaca taattagtgc 134880
 tccataaaca gtcatttaat gaacagatga aagccgtagg tgagttccga cacaggtgag 134940
 agacctcggt gtatgcgtat tgtggagcag tcgagtggat cagacgggaa ggttgcttaa 135000
 gtcgttcagt cctaggatct ctgcctctcc tcccagtggg cctgggggaa ccccttcccc 135060
 ttattctctc tctcaccctc tctggccaac caagaatttt acagaggcat gagagagaga 135120
 gcccctgaag ttttgtagag atgctcatga cacagattgc tacagaggaa aaaagtcacc 135180
 cctggaaaac tcatctaaga atatatcatg aagtgggcta ttttgggact caaattacac 135240
 aagagggcct gggaagtgtg cagggatgaa cacagctaca attaatatta actagaaggt 135300
 gtcatgtctt tatcttgtga acacacagcc ctcagtgcct ggcgggtggg cgagaggaag 135360
 gtgaatccct cccgccatgt acccaggcag gagttgggtg gttttggggg agggtgtctg 135420
 ccggaggaag gaggagggag ccaggcaggg ttgcggggaa ttgctggagg aggcgccagt 135480
 tctcaggaag cctgaagtca ccttgggcaa ggtggcctcc gaagttggaa atgtaactac 135540
 gatcgggcct cacctagttc agggaaagtc cagactcagg accagagaga ccgggagagg 135600
 accaggggct ttcctagggt gtcatggcct catggagtgt ccctggaaaa gaagttactt 135660
 agcttaatct atagggcctg tgcctgaaag aaatcagttt ccactctcta aaaagagatt 135720
 tttttaaaaa aaatctcaat cacggccgga aacggtgggt caggcctgta atccagcact 135780
 ttaggaggcc gaggcaggcg gaccacctga ggtcaagagt tcgagactag cctggccaac 135840
 atagtgaaac cctgtctcta ctaaaaatac aaaaattagc taggcatggt ggtgcatgcc 135900
 tatagtccca gctactcggg aggctacggc aggagaattg cttgaactag ggaggcggag 135960
 gttgcagtga gccgagattg caccactgca ctccagcctg ggccacaaaa gtgaaactct 136020
 gtctcaaaaa aaaaaaaaaa tctcaatcac attgcacaga gtattttgct gggccggagg 136080
 gtggaaggcc tggggatcag gctatgtgga aatgcatccc agtatttcca gtcgccagtg 136140
 gatcatcttg aactggatgt ctcccctcca gaagcctcag cttattcatc tgtgacacct 136200
 cacaataatc cgtttcacgg agtacttcaa cagatttggg gaaaggggga tgggtcaaat 136260
 tagataagtg tacattaaaa ggcctccata gcctgcaacc tctctgtgag tggcatggta 136320
 tcacttatca acctgccttg taaagactgc tgtgagaatt tgactcccag ctaaactaag 136380
 agagtcacca gggcagccag ctatcatgtc tgattcctct gtgttattct cagaggcaag 136440
 cgtgttatct atctgtgtta ttatcagagt caagtgtgtt atctagtact gcttatctat 136500
 taactgcctc caactgttgg ttgaataagt aagtcattgg tacataaagg tgaatatcac 136560
 aaaacaagca caatatttca tattagttag atctaggaaa gaccttttcc aatgtgaact 136620
 gttactaaaa tattctgttc tgcttctaac cttctgtcca actgcaaatc acatcacata 136680
 atatttgtgg tctttgagag caaaaaccat gccttaatca ttctgtttca atgtgagctc 136740
 cgggtgggca aggacttggt tttgctcaga gcctgcactt ggaaacgggc cttgcgcttg 136800
 gtaagactcc atgagtattt ggtaaataaa caaatggttt ctaaccctta acacagagct 136860
 acgcattcag caaatgttgg ttggattaat tattaaacaa gggggatact ttttctttct 136920
 aatatctctt tctaacattc ccgactgagg cggcgtagca gaatggttag gtaggcgggc 136980
 tctggaatca gatggtctgg gtttgaattc tgcctattct acttactggc tgggtgacct 137040
 agagtagcta ctgaacctct ctgtgcttca ggtttctcac ttgtgaaatg aggataacat 137100
 tttttctcct ttttttttct gttgcccaga ctggagtgca atggtgcaat catagctcac 137160
 tgcagcctca aagtcctggg ctcaagtgat cctcctacct tggcctccgt aagcactggg 137220
 attacaggtg tgagccactc agctcagcta acaatttttc taataggatt acagggttca 137280
 tttaaagtgt acataaaata attagcacat agtaattgct acttttttgt gaccatatca 137340
 gtctcaacaa ccttcactga ctgcccttta accactggat agacctaaag tcgaattatc 137400
 cataatttgg ccccatatcc ccctctttcc agtcccatct tcccatactt taacactagc 137460
 tgccctttac tggctgctac ctgtgccaga cattcttcta agtggtctat atccattaac 137520
 ttgtttccct tctcaaataa cctagtaagg ttggacttca tttttaagag acagggtctc 137580
 actatgttgc ccaggctgaa ctcaaactcc tgggcttaag ggatcctctt gcctcagcct 137640
 cccatgtagc caggactact ggcccatcac tgcgcccagc tgaggtggga cttattgccc 137700
 atatttcact gatgacaaga caaaggccca gaaaataaaa ataactttcc tggggacaca 137760
 cagctaatat taggaaagct ggattcattc ccaggactct gtgatatgaa agttcatgct 137820
 gttatttacc atctctgata tccttgccat gcaaagtttg gtcagtggac cagcactcct 137880
 agcattacct gggggcttgc tagaaatgca gagtctcggg cctcacccca gacctactga 137940
 atcagaatct acattttaac aagccccctg gctgcacagg aaaattttgg aagcactatt 138000
 gtaaaccact ttctaccagg gatacacgag tactaattaa gtcaaagaag tgttctcgtt 138060
 taatccctac accaacgtgg gaggtcagga gagttaagca ttattatccc attttgcaga 138120
 tgaggagact aaggctctga aaggcatctt gaagtgactg agtccacata agcctgatgc 138180
 cagcataatg ttctgactaa actcagtttt aagtccctcc acctataatg tcttcattcc 138240
 ctctctccac cttgaattct tctcctcctt ttaggctcca cttgaaatcc cttcttgctg 138300
 gacaaagccc ttcttaccca gttcccactg ggcagattgc tccttccttc atattcccat 138360
 aagctccctc cacatacctt tctcttggct caaattcttt aagaaatgta cactgggtgc  138420
 aaactgtgta ccaggcacat ggtaggcatt gagtaaatgt ttgttgagcc catttgctcc 138480
 caaagcattt ctgactgtgt ttattaaaac actattgggc catgcctgta atcccagcac 138540
 tttgggaggc caaggtgagt ggatcacaag gtcaagagtt caagaccagc ctggccaaat 138600
  ggtgaaaccc taactctact aaaaatacaa aaattagccg ggcacggtgg caggtgcctg 138660
 taaccccagc tactcggagg ctgaggcagg agaatcgctt gaacccaggg ggcagaggtt 138720
 gcagtgagcc aagattgcac cacggcactg taacctggtc gacagagtga gactccgtct 138780
 caaacaaaac aaagtaaaac aaaacaaaat aaacaaaaaa agcccaaaga aaccactctc 138840
 attactccta tcctcttctg tgtttgtctg tctctcccac tgccctgagc tcctgtgtgt 138900
 ctccagacta ttgagtctgg catcttgtag ggcgtcaagt cgtaataaac taagtgctct 138960
 cccatctaag gacacaatct gtctatatgt acttaagagt ggagcattac caggagtgaa 139020
 gctttccagt tcccaagagg ggtaaaggac aagtgaggtg atggacacct tgctgctcac 139080
 cactcccaat ctttgggctg acacaggatg ccagaactga ttattgtaaa aaaaaaaata 139140
 ataataacaa taatgtgcag acatttgaaa atctaactct cattttttcc agagcatgaa 139200
 aggaaggcct agaaatggta agtgaccttt tcaaatcccc tggggtgaaa accaggtccc 139260
 caataacctg tcgtttcaca agaaaaggag aaagggtaaa ggcggccgtg atgtcagcga 139320
 aagacctcca agacagaaaa ccttgcagtc cccgtgctct gcctctttca cgggagacct 139380
 gggcaacgca cacgttgcta ggcctcaatt tcttcaactg taaaatgagg gggttggagg 139440
 agcttgaaaa gctccttcca gctctgagat gctgcgctat aaagtgagag aaatgtgaac 139500
 ctttagttgt tatgatctga aaatattttg aatgtggaga atcaaattgt agagcagtgc 139560
 atgaacaaca taatatgtta atgactaaga cgattgtatt taatccgatg ggaaacagca 139620
 gagctgctgc caccgctgct gtgtgtgtgc gtgtgtgtgg tgtgcacgca cgtgcggttt 139680
 ccttccttga gctcaaacat acattttgaa tcactaatat agtaatcatg tctctggcag 139740
 cctatcttgc ccaaacacac acggagagac accacacacc ctacttcaaa ttaaggtggg 139800
 ggcgggggga attccactgc tgctctttac atcatttctg tttggatagc tattttttaa 139860
 aagaaagttt tacagtgaag gtgttggact cccagcccag aagggctctg atctcagaac 139920
 tgggacgcaa gggtggggag ctcgagctct cattagcatt tcgcttttgc acaccccctg 139980
 cccgctcctc agccgtcaca atcccgtcct gcagcaggcc cccccaccaa caccggaccc 140040
 tcgacgggga aggggtcagc tcggcggccc cagaggccac tgggccagaa cacgtgctcc 140100
 ggactccacg tgcgcggaaa atgaactcgt acccgcgacg cggccggcgg gggcggatgg 140160
 cagcgagggc cggacagcga acctttaccc cgcggaggag tcggggccgg agcccgcacg 140220
 tgggtctgcg acggccccgc cccctggggg cgtcccctca gggactctag ccccggctgg 140280
 tgggccctgc aggcccgggc ccgaccgcgt ccgccaggcc gcccggaggt cccggcgagc 140340
 ccggcggagg cggcggcccc tccccgcccg acggccacgc ccgcgcggat tggccgctcc 140400
 ccgacggcgg ggcggggcgg gacgggccgg ggcagagctc gcggccaggt gaggcgcccc 140460
 gcccctcggc ggctccaggt gcggctgtgg gacctcggac cgcggcgggg ccggggccag 140520
 ggccggggcc ggggccgggg cgccatggcc gagtcccagc tgaactgcct ggacgaggcg 140580
 cacgtgaacg agaaggtgac cgaggcgcag gccgccttct actactgcga gcggcggcgg 140640
 gccgcgctgg aggcgctgct gggcggcggc gagcaggcct accgcgagcg gctcaaggag 140700
 gagcagctgc gggacttcct ctccagcccg gagcgccagg ccctgcgggc cgcctggagc 140760
 ccctacgagg acgccgtccc cgccgccaac gcccggggca agagcaaggc caaggccaag 140820
 gcccccgcgc cggcgccggc tgagtccggc gagtccctgg cctactggcc cgaccgttcc 140880
 gacaccgagg tgcctcctct ggacctgggc tggacggaca ctggtttcta ccgcggcgtg 140940
 agccgggtca cgctcttcac ccacccgccc aaggacgaga aggcgccgca cctcaagcag 141000
 gtggtcaggc agatgatcca acaggcccag aaggtaggcc cccgccttcg cccccacacc 141060
 gctgggacct cggccccagt cccctggacc gggccccacc tcccaggcag ggcccggggc 141120
 aggccgccct gagcaccctc tggaaaatgg gccccaaccc gcccctactt cctggggctg 141180
 cagtgaggcc tgtagagcga atggctggga acgtgtttgg caaattacaa ggtgctggac 141240
 agatgtcagc cgtcggtatt ccagcgttca gaggcactgg ctctgctctg tacttctgaa 141300
 acttccctgt ccagccttcc tccccaggga agactggggg ccgaggccct gtggttaaaa 141360
 tgcaccactc aaaggtcttg atgataacct acgtgctgcc cagaacatat cccgagccgc 141420
 tttctcatgt gatcgtcaaa acaacttcag ggagtgggtg gcggtgacct tcccggtccc 141480
 acctctgcca tgctgctcct tggaccaccc ctctcctccc atagtcaaag ctgagctggc 141540
 gccctcacag tcacagcctc tcctgggccg ggtactaggc cccagctgcc tggaatgaat 141600
 gggggacggg gtatattgag gacctactgt gtgcctggcc ctgtgctggg cgccttggca 141660
 cagcaggtca cctgactcgg cagctcagga aagggctcct acttagcata tgtgtcctgc 141720
 ttgagagttg gaaggagggg ctgtttccag ggtggctggt gaggccagtc cactgtggaa 141780
 caggtggaag actttaatct ttatgccttt gggtgggagt cctgggcagc ttccagatca 141840
 aatgtaggat gccccactac atttgaactt tcaataaaca acacataact ttttagtatc 141900
 agcttatccc aaacatgaca tgagacgtac tgatactgaa aaattcttcg ttgtgtatct 141960
 gaaattcaaa ttgaatggga acgttttgta cttttatttg ctaactctgg ctgccctaca 142020
 ctgagatttg ttaagaaaca gcagcagctt ttggtgccca attcagaata atacaacagg 142080
 agtggcttgg gttcaccact caaattccac tcagtgagtg aggttggagt cctggttccc 142140
 ctcgaggctg aagaggcctg aggagggaaa atagagctag aaagaccagt gctcaggctc 142200
 atcttcctgg aaggggtgat ttaggtagtt ggggtgatct agatagttgg ctacattggc 142260
 taccagaagg aagggttaac tttccactgc gcacatttct accctccctc tctataattc 142320
 ctccctgtct gactgagttt tctttgtata ttgtgttctg cagaagaaaa aggcaagatt 142380
 ggacacagaa gagggaaaaa ggatgtaggc ggcaatacag gctgcagctg gggttagggg 142440
 tcaagtctca tgatgtcata ctaacaaagc ctctatttat ttagcattta atatgtgcca 142500
 tccactgtgt taatgactca cctgcatttt ctcattagct tttcacaaca accgggtgaa 142560
 tatgtgtttt ccttattttt ggagaaaaag acatcaggat tcagaagttt cttgccagag 142620
 tttccatagc tagtaagtgg ctgagccagg acccaaactc caaagccctt gctcttaacc 142680
 actgtgctac actgccccag tgtctgaaat aatggtgcag tccgattaag caaggggttt 142740
 gaatgaagct agcctggtca caacctggag tgcaggtggt gtacccctgt tactagaagg 142800
 gggagactgg gcttctggcc actgaggcat ctagtcccat gtgggatgac aggactcttt 142860
 cctgcatagt gaggtatttt tgactcttta aatatttaac aacagaaact tttaacaatt 142920
 gtgaacccat ccaataagta caggtttaac cagtgatttc ctgagggctg actgtgtgcc 142980
 aggcactacc tagccatgaa gaagatacac ggtgtggctt tgccctccaa gagcttaaca 143040
 aatgctaggg ctctgctgga aagaaaagag tttttaaggc tgaatgtgcc taatctggga 143100
 aggcttcctg agggaggtga gttgcagaat tggaaaggga gagggtcaac tggaatgggc  143160
 actgtttcag taagagagct ttttgcttcg aaaaagcaag gaggtttgat tggcaggtaa 143220
 aaagagctgt cgtgggggga ggtgagtact gtgtggggcc tggtttgggg accctaaaac 143280
 tgggcccaag gcaggcaacc acccccaagg aagcaacagt gttggacact gtctgcgccc 143340
  acccaagtat caggacctcc gggtccccac ccttaatcac tgtcctgcct gtccgcacag 143400
 cctcttcttc ccgaagaccc tgagaagaag ttgggacaga gaggttgacc ctgtttcaca 143460
 ggtgaggaaa ctgaggcaca gagaaggaaa gagacttgcc cagaggtcac gtgggcagag 143520
 gtcacttggt tctagaaaaa cccagcttct gctctaggga ctgcaccttc tgatcactgc 143580
 ctgtccccca cccccacgcc agcctgtcca gctggcaggc agccttccct ggccattaac 143640
 ttagatcctt cctcctcccc tttcgccctg agggagggag tttcctttgt ttctagtgag 143700
 agtctggctg ctgtgaggcc aggtggggca gactgagatg gtttaca 143747
//

Δ.1. Απάντηση

Οι τέσσερεις περιοχές επανάληψης Alu

ID HS370M22_33; parent: HS370M22
AC Z82206;
FT repeat_region 1495..1797
FT /note="AluSp repeat: matches 1..303 of consensus"
>HS370M22_33
ggccgggcgcggtggctcaacgcctgtaatcccagcactttgggaggctgaggcgggcag
atcacctgaggtcgggagttcaagactagtctgaccaacatggagaaaccccgtctctac
taaaaatacaaaattagccgggtatggtggcatgtgcctgtaatcccagatactggggag
gctgaggcaggagaaccacttgaacctgggaggcagaggttgcggtgagccaagattgca
ccattgcactccagcctgggcaacaagagtgaaacttcatctcaaaaaaaaaaaaaaaaa
aaa

ID HS370M22_34; parent: HS370M22
AC Z82206;
FT repeat_region 2171..2375
FT /note="AluJo repeat: matches 100..302 of consensus"
FT /note="incomplete repeat"
>HS370M22_34
tagcaagatcttgtctcgaaaaaatattttttcaagtcagctgggtgtggcggtgtgtgc
ctgtagtcccagctagttggtaggctaagccaggaggattacttgagtccagtagttcaa
ggctgcagtgagtcattatcacaccactgcgctcctgccggggtgacagagcaagaccct
gtctcaaaaaaaaaaaaaaaagaaa

ID HS370M22_39; parent: HS370M22
AC Z82206;
FT repeat_region 6761..7062
FT  /note="AluSx repeat: matches 1..302 of consensus"
>HS370M22_39
ggctgggcacagtggctcacgcctataatcccagcactttcggaggccaaggcaggagga
tcacttgaggtcatgagttcgagaccagcctgggcaacatgctgaaaccctgtctctact
aaaaatacaaaaattagctgggcatggtgatgggtgcctgtaatcccagctactcaggag
gctgagtcaggagaattgcttgaacccaggagacagaggttgcagtgagctgagatagtg
ccactacactccagcctaggagacagagcaagattccgtctcaaaaataaataaataaat
aa

ID HS370M22_40; parent: HS370M22
AC Z82206;
FT repeat_region 7771..8069
FT /note="AluSc repeat: matches 1..299 of consensus"
>HS370M22_40
ggctgggtgcggtggctcatggctgtaatctcagcactttgggaggctgaagtgggcaga
tcacgaggtcaggaaatcaagaccatcctggccaatatggtgaaaccttgtctctactaa
aatacaaaaaactagctgggcatggtggcatgtgcctgtagtcccagctactcaggaagc
tgagacaggggaatcacttgaactcaagaggtagaggttgcagtgagctgagattgcacc
actgcactccagcttggcaagagagcgagactctgtctcaaaaaaaaaaaaaaaaagaa

Η πολλαπλή ευθυγράμμιση των τεσσάρων περιοχών επανάληψης Alu

CLUSTAL W (1.75) multiple sequence alignment
 
 
Seq1 GGCCGGGCGCGGTGGCTCAACGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGCAG
Seq4 GGCTGGGTGCGGTGGCTCATGGC-TGTAATCTCAGCACTTTGGGAGGCTGAAGTGGGCAG
Seq3 GGCTGGGCACAGTGGCTCA-CGCCTATAATCCCAGCACTTTCGGAGGCCAAGGCAGGAGG
Seq2 ------------------------------------------------------------
 
 
Seq1 ATCACCTGAGGTCGGGAGTTCAAGACTAGTCTGACCAACATGGAGAAACCCCGTCTCTAC
Seq4 ATCAC--GAGGTCAGGAAATCAAGACCATCCTGGCCAATATGGTGAAACCTTGTCTCTAC
Seq3 ATCACTTGAGGTCATGAGTTCGAGACCAGCCTGGGCAACATGCTGAAACCCTGTCTCTAC
Seq2 ----------------------------------------TAGCAAGATCTTGTCTCGAA
 * * * * ***** * 
 
Seq1 TAAAA---ATACAAAATTAGCCGGGTATGGTGGCATGTGCCTGTAATCCCAGATACTGGG
Seq4 TAAAAT--ACAAAAAACTAGCTGGGCATGGTGGCATGTGCCTGTAGTCCCAGCTACTCAG
Seq3 TAAAAA--TACAAAAATTAGCTGGGCATGGTGATGGGTGCCTGTAATCCCAGCTACTCAG
Seq2 AAAATATTTTTTCAAGTCAGCTGGGTGTGGCGGTGTGTGCCTGTAGTCCCAGCTAGTTGG
 *** ** *** *** *** * ********* ****** ** * *
 
Seq1  GAGGCTGAGGCAGGAGAACCACTTGAACCTGGGAGGCAGAGGTTGCGGTGAGCCAAGATT
Seq4 GAAGCTGAGACAGGGGAATCACTTGAACTCAAGAGGTAGAGGTTGCAGTGAGCTGAGATT
Seq3 GAGGCTGAGTCAGGAGAATTGCTTGAACCCAGGAGACAGAGGTTGCAGTGAGCTGAGATA
Seq2 TAGGCTAAGCCAGGAGGATTACTTGAGTCCAGTAGTTCAAGGCTGCAGTGAGTCATTATC
 * *** ** **** * * ***** ** *** *** ***** ** 
 
Seq1 GCACCATTGCACTCCAGCCTGGGCAACAAGAGTGAAACTTCATCTCAAAAAAAAAAAAAA
Seq4 GCACCACTGCACTCCAGCTTGG-CAAGA-GAGCGAGACTCTGTCTCAAAAAAAAAAAAAA
Seq3 GTGCCACTACACTCCAGCCTAGGAGACA-GAGCAAGATTCCGTCTCAAAAATAAATAAAT
Seq2 ACACCACTGCGCTCCTGCCGGGGTGACA-GAGCAAGACCCTGTCTCAAAAAAAAAAAAAA
 *** * * **** ** * * * *** * * ********* *** *** 
 
Seq1  AAAAAA
Seq4 AAAGAA
Seq3 AAATAA
Seq2 AAGAAA
 ** **

Δ.2.a Απάντηση

Η ακολουθία του γονιδίου Ζ82206 μεταξύ των βάσεων 20814...21617

 
ID HS370M22_2; parent: HS370M22
AC Z82206;
FT exon <20814..21617
FT /note="match: P47985"
FT /product="UQCRFS1"
>HS370M22_2
tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg
cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg
cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc
gtgggcctcaatgtccctgcttctgtttgttattcccacacagacgtcaaggtgcctgac
ttctctgaataccgccgccttgaagttttagatagtacgaagtcttcaagagaaagcacc
gaggctaggaaaggtttctcctatttggtaactggagtaactactgtgggtgtcgcatat
gctgccaagaatgccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttg
gccctggcgaaaatcgaaatcaagttatccgatattccagaaggcaagaacatggctttc
aaatggagaggcaaacccctgtttgtacgtcatagaacccagaaggaaattaagcaggaa
gctgcagttgaattatcacagttgagggacccacagcatgatctagatcgagtaaagaaa
cctgaatgggttatcctgataggtgtttgcactcatcttggttgtgtacccattgcaaat
gcaggagattttggtggttattactgcccttgccatgggtcacactatgatgcatctggc
aggatcagattgggtcctgctactctcaaccttgaagtccccacgtatgagttcaccagt

gacgatatggtgattgttggttag

Τα αποτελέσματα του BLAST για την παραπάνω ακολουθία:

 
      Score E
Sequences producing significant alignments: (bits) Value
 
emb|Z82206|HS370M22 Human DNA sequence from PAC 370M22 on c... 1594 0.0
ref|NM_006003.1|UQCRFS1| Homo sapiens ubiquinol-cytochrome ... 1544 0.0
gb|AC007786.1|AC007786 Homo sapiens chromosome 19, BAC 4185... 1164 0.0
gb|L32977|HUMUQCR02 Homo sapiens (clone f17252) ubiquinol c... 1164 0.0
gb|S58789|S58789 Rieske iron-sulfur [cattle, heart, mRNA, 1... 967 0.0
gb|M34336|BOVFESUP Bovine Rieske iron-sulfur protein mRNA, ... 807 0.0
gb|M24542|RATRIP Rat Rieske iron-sulfur protein mRNA, compl... 634 e-180
gb|L32917|HUMUQCR01 Homo sapiens (clone f17252) ubiquinol c... 383 e-104
emb|AL022104|SPBC16H5 S.pombe chromosome II cosmid c16H5  54 6e-05
gb|U40480|SPU40480 Schizosaccharomyces pombe Rieske iron-su...  54 6e-05
gb|U18530|SCE9871 Saccharomyces cerevisiae chromosome V cos...  42 0.22
gb|M23316|YSCRIP1 Yeast (S.cerevisiae; DC5) Rieske iron-sul...  42 0.22
emb|AL109848.1|SCI51 Streptomyces coelicolor cosmid I51   40 0.87
emb|AL117669.1|SCF12 Streptomyces coelicolor cosmid F12  38 3.4
emb|Y08879|MMSERO13 M.musculus gene encoding murine serotin...  38 3.4
gb|U77667|MMU77667 Mus musculus tyrosine kinase mRNA, compl...  38 3.4
gb|U04379|MMU04379 Mus musculus protein tyrosine kinase ZAP...  38 3.4
gb|L36064|PRULHP Prunus persica (clone pAB19) light harvest...  38 3.4
gb|L16813|TOBFESD Tobacco (clone 32.10) mitochondrial Riesk...  38 3.4
gb|L16811|TOBFESB Tobacco clone 8.8 mitochondrial Rieske ir...  38 3.4
 
 emb|Z82206|HS370M22 Human DNA sequence from PAC 370M22 on chromosome 22q12-qter. contains
 GRB2 ADAPTOR LIKE PROTEIN, UBIQUINOL-CYTOCHROME C
 REDUCTASE IRON-SULFUR SUBUNIT PRECURSOR (UQCRFS1) exon,
 ESTs, STS, CA repeat and CpG island
 Length = 143747
 
 Score = 1594 bits (804), Expect = 0.0
 Identities = 804/804 (100%)
 Strand = Plus / Plus
 
  
Query: 1 tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg 60
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 20814 tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg 20873
 
 
Query: 61 cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg 120
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 20874 cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg 20933
 
 
Query: 121 cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc 180
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 20934 cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc 20993
 
 
Query: 181 gtgggcctcaatgtccctgcttctgtttgttattcccacacagacgtcaaggtgcctgac 240
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 20994 gtgggcctcaatgtccctgcttctgtttgttattcccacacagacgtcaaggtgcctgac 21053
 
 
Query: 241 ttctctgaataccgccgccttgaagttttagatagtacgaagtcttcaagagaaagcacc 300
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21054 ttctctgaataccgccgccttgaagttttagatagtacgaagtcttcaagagaaagcacc 21113
 
  
Query: 301 gaggctaggaaaggtttctcctatttggtaactggagtaactactgtgggtgtcgcatat 360
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21114 gaggctaggaaaggtttctcctatttggtaactggagtaactactgtgggtgtcgcatat 21173
 
 
Query: 361 gctgccaagaatgccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttg 420
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21174 gctgccaagaatgccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttg 21233
 
 
Query: 421 gccctggcgaaaatcgaaatcaagttatccgatattccagaaggcaagaacatggctttc 480
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21234 gccctggcgaaaatcgaaatcaagttatccgatattccagaaggcaagaacatggctttc 21293
 
 
Query: 481 aaatggagaggcaaacccctgtttgtacgtcatagaacccagaaggaaattaagcaggaa 540
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21294 aaatggagaggcaaacccctgtttgtacgtcatagaacccagaaggaaattaagcaggaa 21353
 
 
Query: 541 gctgcagttgaattatcacagttgagggacccacagcatgatctagatcgagtaaagaaa 600
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21354 gctgcagttgaattatcacagttgagggacccacagcatgatctagatcgagtaaagaaa 21413
 
  
Query: 601 cctgaatgggttatcctgataggtgtttgcactcatcttggttgtgtacccattgcaaat 660
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21414 cctgaatgggttatcctgataggtgtttgcactcatcttggttgtgtacccattgcaaat 21473
 
 
Query: 661 gcaggagattttggtggttattactgcccttgccatgggtcacactatgatgcatctggc 720
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21474 gcaggagattttggtggttattactgcccttgccatgggtcacactatgatgcatctggc 21533
 
 
Query: 721 aggatcagattgggtcctgctactctcaaccttgaagtccccacgtatgagttcaccagt 780
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 21534 aggatcagattgggtcctgctactctcaaccttgaagtccccacgtatgagttcaccagt 21593
 
 
Query: 781 gacgatatggtgattgttggttag 804
 ||||||||||||||||||||||||
Sbjct: 21594 gacgatatggtgattgttggttag 21617
 
 
 ref|NM_006003.1|UQCRFS1| Homo sapiens ubiquinol-cytochrome c reductase, Rieske iron-sulfur
 polypeptide 1 (UQCRFS1), nuclear gene encoding
 mitochondrial protein, mRNA
 Length = 1203
 
 Score = 1544 bits (779), Expect = 0.0
 Identities = 797/803 (99%)
 Strand = Plus / Plus
 
 
Query: 1 tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg 60
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 112 tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg 171
 
  
Query: 61 cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg 120
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 172 cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg 231
 
 
Query: 121 cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc 180
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 232 cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc 291
 
 
Query: 181 gtgggcctcaatgtccctgcttctgtttgttattcccacacagacgtcaaggtgcctgac 240
 ||||||||||||||||||||||||||||||||||||||||||||| ||||||||||||||
Sbjct: 292 gtgggcctcaatgtccctgcttctgtttgttattcccacacagacatcaaggtgcctgac 351
 
 
Query: 241 ttctctgaataccgccgccttgaagttttagatagtacgaagtcttcaagagaaagcacc 300
 |||||||||||||||||||||||||||||||||||||||||||||||||||||||||| |
Sbjct: 352 ttctctgaataccgccgccttgaagttttagatagtacgaagtcttcaagagaaagcagc 411
 
 
Query: 301 gaggctaggaaaggtttctcctatttggtaactggagtaactactgtgggtgtcgcatat 360
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 412 gaggctaggaaaggtttctcctatttggtaactggagtaactactgtgggtgtcgcatat 471
 
 
Query: 361 gctgccaagaatgccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttg 420
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 472 gctgccaagaatgccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttg 531
 
  
Query: 421 gccctggcgaaaatcgaaatcaagttatccgatattccagaaggcaagaacatggctttc 480
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 532 gccctggcgaaaatcgaaatcaagttatccgatattccagaaggcaagaacatggctttc 591
 
  
Query: 481 aaatggagaggcaaacccctgtttgtacgtcatagaacccagaaggaaattaagcaggaa 540
 |||||||||||||||||||||||||| |||||||||||||||||||||||| ||||||||
Sbjct: 592 aaatggagaggcaaacccctgtttgtgcgtcatagaacccagaaggaaattgagcaggaa 651
 
 
Query: 541 gctgcagttgaattatcacagttgagggacccacagcatgatctagatcgagtaaagaaa 600
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 652 gctgcagttgaattatcacagttgagggacccacagcatgatctagatcgagtaaagaaa 711
 
 
Query: 601 cctgaatgggttatcctgataggtgtttgcactcatcttggttgtgtacccattgcaaat 660
 ||||||||||||||||||||||||||||||||||||||||| ||||||||||||||||||
Sbjct: 712 cctgaatgggttatcctgataggtgtttgcactcatcttggctgtgtacccattgcaaat 771
 
 
Query: 661 gcaggagattttggtggttattactgcccttgccatgggtcacactatgatgcatctggc 720
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 772 gcaggagattttggtggttattactgcccttgccatgggtcacactatgatgcatctggc 831
 
 
Query: 721 aggatcagattgggtcctgctactctcaaccttgaagtccccacgtatgagttcaccagt 780
 ||||||||||||||||||||| ||||||||||||||||||||||||||||||||||||||
Sbjct: 832 aggatcagattgggtcctgctcctctcaaccttgaagtccccacgtatgagttcaccagt 891
 
 
Query: 781 gacgatatggtgattgttggtta 803
 |||||||||||||||||||||||
Sbjct: 892 gacgatatggtgattgttggtta 914
 
 
 gb|AC007786.1|AC007786 Homo sapiens chromosome 19, BAC 41855 (CIT-B-32o4), complete sequence
 Length = 229061
 
 Score = 1164 bits (587), Expect = 0.0
 Identities = 605/611 (99%)
 Strand = Plus / Minus
 
 
Query: 193 gtccctgcttctgtttgttattcccacacagacgtcaaggtgcctgacttctctgaatac 252
 ||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||||
Sbjct: 108197 gtccctgcttctgtttgttattcccacacagacatcaaggtgcctgacttctctgaatac 108138
 
  
Query: 253 cgccgccttgaagttttagatagtacgaagtcttcaagagaaagcaccgaggctaggaaa 312
 |||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||
Sbjct: 108137 cgccgccttgaagttttagatagtacgaagtcttcaagagaaagcagcgaggctaggaaa 108078
 
 
Query: 313 ggtttctcctatttggtaactggagtaactactgtgggtgtcgcatatgctgccaagaat 372
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 108077 ggtttctcctatttggtaactggagtaactactgtgggtgtcgcatatgctgccaagaat 108018
 
 
Query: 373 gccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttggccctggcgaaa 432
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 108017 gccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttggccctggcgaaa 107958
 
 
Query: 433 atcgaaatcaagttatccgatattccagaaggcaagaacatggctttcaaatggagaggc 492
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 107957 atcgaaatcaagttatccgatattccagaaggcaagaacatggctttcaaatggagaggc 107898
 
  
Query: 493 aaacccctgtttgtacgtcatagaacccagaaggaaattaagcaggaagctgcagttgaa 552
 |||||||||||||| |||||||||||||||||||||||| ||||||||||||||||||||
Sbjct: 107897 aaacccctgtttgtgcgtcatagaacccagaaggaaattgagcaggaagctgcagttgaa 107838
 
  
Query: 553 ttatcacagttgagggacccacagcatgatctagatcgagtaaagaaacctgaatgggtt 612
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 107837 ttatcacagttgagggacccacagcatgatctagatcgagtaaagaaacctgaatgggtt 107778
 
 
Query: 613 atcctgataggtgtttgcactcatcttggttgtgtacccattgcaaatgcaggagatttt 672
 ||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||
Sbjct: 107777 atcctgataggtgtttgcactcatcttggctgtgtacccattgcaaatgcaggagatttt 107718
 
 
Query: 673 ggtggttattactgcccttgccatgggtcacactatgatgcatctggcaggatcagattg 732
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 107717 ggtggttattactgcccttgccatgggtcacactatgatgcatctggcaggatcagattg 107658
 
 
Query: 733 ggtcctgctactctcaaccttgaagtccccacgtatgagttcaccagtgacgatatggtg 792
 ||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 107657 ggtcctgctcctctcaaccttgaagtccccacgtatgagttcaccagtgacgatatggtg 107598
 
 
Query: 793 attgttggtta 803
 |||||||||||
Sbjct: 107597 attgttggtta 107587
 
 
 Score = 377 bits (190), Expect = e-102
 Identities = 190/190 (100%)
 Strand = Plus / Minus
 
 
Query: 4  ggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcggccc 63
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 113132 ggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcggccc 113073
 
  
Query: 64 ttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcggccc 123
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 113072 ttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcggccc 113013
 
 
Query: 124 ttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctccgtg 183
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 113012 ttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctccgtg 112953
 
 
Query: 184 ggcctcaatg 193
 ||||||||||
Sbjct: 112952 ggcctcaatg 112943
 
 
 gb|L32977|HUMUQCR02 Homo sapiens (clone f17252) ubiquinol cytochrome c reductase Rieske
 iron-sulphur protein (UQCRFS1) gene, exon 2
 Length = 1346
 
 Score = 1164 bits (587), Expect = 0.0
 Identities = 605/611 (99%)
 Strand = Plus / Plus
 
 
Query: 193 gtccctgcttctgtttgttattcccacacagacgtcaaggtgcctgacttctctgaatac 252
 ||||||||||||||||||||||||||||||||| ||||||||||||||||||||||||||
Sbjct: 342 gtccctgcttctgtttgttattcccacacagacatcaaggtgcctgacttctctgaatac 401
 
 
Query: 253 cgccgccttgaagttttagatagtacgaagtcttcaagagaaagcaccgaggctaggaaa 312
 |||||||||||||||||||||||||||||||||||||||||||||| |||||||||||||
Sbjct: 402 cgccgccttgaagttttagatagtacgaagtcttcaagagaaagcagcgaggctaggaaa 461
 
 
Query: 313 ggtttctcctatttggtaactggagtaactactgtgggtgtcgcatatgctgccaagaat 372
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 462 ggtttctcctatttggtaactggagtaactactgtgggtgtcgcatatgctgccaagaat 521
 
 
Query: 373 gccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttggccctggcgaaa 432
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 522 gccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttggccctggcgaaa 581
 
  
Query: 433 atcgaaatcaagttatccgatattccagaaggcaagaacatggctttcaaatggagaggc 492
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 582 atcgaaatcaagttatccgatattccagaaggcaagaacatggctttcaaatggagaggc 641
 
 
Query: 493 aaacccctgtttgtacgtcatagaacccagaaggaaattaagcaggaagctgcagttgaa 552
 |||||||||||||| |||||||||||||||||||||||| ||||||||||||||||||||
Sbjct: 642 aaacccctgtttgtgcgtcatagaacccagaaggaaattgagcaggaagctgcagttgaa 701
 
 
Query: 553 ttatcacagttgagggacccacagcatgatctagatcgagtaaagaaacctgaatgggtt 612
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 702 ttatcacagttgagggacccacagcatgatctagatcgagtaaagaaacctgaatgggtt 761
 
 
Query: 613 atcctgataggtgtttgcactcatcttggttgtgtacccattgcaaatgcaggagatttt 672
 ||||||||||||||||||||||||||||| ||||||||||||||||||||||||||||||
Sbjct: 762 atcctgataggtgtttgcactcatcttggctgtgtacccattgcaaatgcaggagatttt 821
 
 
Query: 673 ggtggttattactgcccttgccatgggtcacactatgatgcatctggcaggatcagattg 732
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 822 ggtggttattactgcccttgccatgggtcacactatgatgcatctggcaggatcagattg 881
 
 
Query: 733 ggtcctgctactctcaaccttgaagtccccacgtatgagttcaccagtgacgatatggtg 792
 ||||||||| ||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 882 ggtcctgctcctctcaaccttgaagtccccacgtatgagttcaccagtgacgatatggtg 941
 
 
Query: 793 attgttggtta 803
 |||||||||||
Sbjct: 942 attgttggtta 952
 
 
 gb|S58789|S58789 Rieske iron-sulfur [cattle, heart, mRNA, 1043 nt]
 Length = 1043
 
 Score = 967 bits (488), Expect = 0.0
 Identities = 725/804 (90%)
 Strand = Plus / Plus
 
 
Query: 1 tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg 60
 |||||||| |||||||||||||| ||||||||||||||||||||||||||||||||||||
Sbjct: 34 tcgggcccattcgcgcccgtcctatcggccacgtcccgcggggtggcgggcgcgctgcgg 93
 
 
Query: 61 cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg 120
 ||| |||| |||||| |||||||||||||| ||||| ||||||| ||||| ||||||| 
Sbjct: 94 cccctggtacaggccgcggtgcccgccacctcggagtcgcctgtgctggacttgaagcgc 153
 
 
Query: 121 cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc 180
 || |||| ||||||||||||| || |||||||||| | |||||||||||||||| |||
Sbjct: 154 tccgtcctgtgccgggagtcgctcagaggccaggccgcgggccggcctttggtcgcttcc 213
 
  
Query: 181 gtgggcctcaatgtccctgcttctgtttgttattcccacacagacgtcaaggtgcctgac 240
 ||| |||||||||||||||||||||| |||||||||| |||||| |||| |||||||||
Sbjct: 214 gtgagcctcaatgtccctgcttctgtccgttattcccatacagacatcaaagtgcctgac 273
 
  
Query: 241 ttctctgaataccgccgccttgaagttttagatagtacgaagtcttcaagagaaagcacc 300
 |||||||| || || |||| |||||| ||||||||||| |||||||||| ||| |||| 
Sbjct: 274 ttctctgactatcgtcgccctgaagtgttagatagtacaaagtcttcaaaagagagcagt 333
 
 
Query: 301 gaggctaggaaaggtttctcctatttggtaactggagtaactactgtgggtgtcgcatat 360
 |||||| |||||||||||||||||||||| |||| | ||||||||||||||| ||||||
Sbjct: 334 gaggctcggaaaggtttctcctatttggtgactgcaacaactactgtgggtgttgcatat 393
 
 
Query: 361 gctgccaagaatgccgtcacccagttcgtttccagcatgagtgcttctgctgatgtgttg 420
 ||||||||||||| |||| | ||||| ||||||||||||||||||||||| |||||||||
Sbjct: 394 gctgccaagaatgtcgtctctcagtttgtttccagcatgagtgcttctgccgatgtgttg 453
 
 
Query: 421 gccctggcgaaaatcgaaatcaagttatccgatattccagaaggcaagaacatggctttc 480
 ||| || ||||||| |||||||||||||||||||||||||| || |||||||||||||||
Sbjct: 454 gccatgtcgaaaattgaaatcaagttatccgatattccagaggggaagaacatggctttc 513
 
 
Query: 481 aaatggagaggcaaacccctgtttgtacgtcatagaacccagaaggaaattaagcaggaa 540
 ||||||||||||||||||||||| || || ||| ||||| ||||||||||| | ||||||
Sbjct: 514 aaatggagaggcaaacccctgttcgtgcgccatcgaaccaagaaggaaattgaccaggaa 573
 
  
Query: 541 gctgcagttgaattatcacagttgagggacccacagcatgatctagatcgagtaaagaaa 600
 |||||||||||| | || ||||||||||||||||||||||| |||| ||||||||||||
Sbjct: 574 gctgcagttgaagtgtcccagttgagggacccacagcatgacttagaacgagtaaagaaa 633
 
  
Query: 601 cctgaatgggttatcctgataggtgtttgcactcatcttggttgtgtacccattgcaaat 660
 ||||| ||||||||| ||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 634 cctgagtgggttatcttgataggtgtttgcactcatcttggttgtgtacccattgcaaat 693
 
 
Query: 661 gcaggagattttggtggttattactgcccttgccatgggtcacactatgatgcatctggc 720
 ||||||||||||||||||||||||||||||||||||||||||||||||||||| ||||||
Sbjct: 694 gcaggagattttggtggttattactgcccttgccatgggtcacactatgatgcgtctggc 753
 
 
Query: 721 aggatcagattgggtcctgctactctcaaccttgaagtccccacgtatgagttcaccagt 780
 |||||||| ||| ||||| |||||||||||||||| ||| | |||||||||||||| 
Sbjct: 754 aggatcaggaaggggcctgcacctctcaaccttgaagttccctcatatgagttcaccagc 813
 
 
Query: 781 gacgatatggtgattgttggttag 804
 || |||||||||||||||||||||
Sbjct: 814 gatgatatggtgattgttggttag 837
 
 
 gb|M34336|BOVFESUP Bovine Rieske iron-sulfur protein mRNA, complete cds.
 Length = 1112
 
 Score = 807 bits (407), Expect = 0.0
 Identities = 633/706 (89%), Gaps = 3/706 (0%)
 Strand = Plus / Plus
 
 
Query: 99 gcctgtgttggacctgaagcggcccttcctcagccgggagtcgctgagcggccaggccgt 158
 ||||||| ||||| ||||||| || |||| ||||||||||||| || |||||||||| 
Sbjct: 123 gcctgtgctggacttgaagcgctccgtcctgtgccgggagtcgctcagaggccaggccg- 181
 
 
Query: 159 gcgccggcctttggtcgcctccgtgggcctcaatgtccctgcttctgtttgttattccca 218
 || |||| ||||||||| |||||| |||||||||||||||||||||| ||||||||||
Sbjct: 182 -cggcggc-tttggtcgcttccgtgagcctcaatgtccctgcttctgtccgttattccca 239
 
 
Query: 219 cacagacgtcaaggtgcctgacttctctgaataccgccgccttgaagttttagatagtac 278
 |||||| |||| ||||||||||||||||| || || |||| |||||| |||||||||||
Sbjct: 240 tacagacatcaaagtgcctgacttctctgactatcgtcgccctgaagtgttagatagtac 299
 
  
Query: 279 gaagtcttcaagagaaagcaccgaggctaggaaaggtttctcctatttggtaactggagt 338
 |||||||||| ||| |||| |||||| |||||||||||||||||||||| |||| | 
Sbjct: 300 aaagtcttcaaaagagagcagtgaggctcggaaaggtttctcctatttggtgactgcaac 359
 
  
Query: 339 aactactgtgggtgtcgcatatgctgccaagaatgccgtcacccagttcgtttccagcat 398
 ||||||||||||||| ||||||||||||||||||| |||| | ||||| |||||||||||
Sbjct: 360 aactactgtgggtgttgcatatgctgccaagaatgtcgtctctcagtttgtttccagcat 419
 
 
Query: 399 gagtgcttctgctgatgtgttggccctggcgaaaatcgaaatcaagttatccgatattcc 458
 |||||||||||| |||||||||||| || ||||||| |||||||||||||||||||||||
Sbjct: 420 gagtgcttctgccgatgtgttggccatgtcgaaaattgaaatcaagttatccgatattcc 479
 
 
Query: 459 agaaggcaagaacatggctttcaaatggagaggcaaacccctgtttgtacgtcatagaac 518
 ||| || |||||||||||||||||||||||||||||||||||||| || || ||| ||||
Sbjct: 480 agaggggaagaacatggctttcaaatggagaggcaaacccctgttcgtgcgccatcgaac 539
 
 
Query: 519 ccagaaggaaattaagcaggaagctgcagttgaattatcacagttgagggacccacagca 578
  | ||||||||||| | |||||||||||||||||| | || ||||||||||||||||||||
Sbjct: 540 caagaaggaaattgaccaggaagctgcagttgaagtgtcccagttgagggacccacagca 599
 
 
Query: 579 tgatctagatcgagtaaagaaacctgaatgggttatcctgataggtgtttgcactcatct 638
 ||| |||| ||||||||||||||||| ||||||||| ||||||||||||||||||||||
Sbjct: 600 tgacttagaacgagtaaagaaacctgagtgggttatcttgataggtgtttgcactcatct 659
 
 
Query: 639 tggttgtgtacccattgcaaatgcaggagattttggtggttattactgcccttgccatgg 698
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 660 tggttgtgtacccattgcaaatgcaggagattttggtggttattactgcccttgccatgg 719
 
  
Query: 699 gtcacactatgatgcatctggcaggatcagattgggtcctgctactctcaaccttgaagt 758
 ||||||||||||||| |||||||| |||||| ||| ||||| ||||||||||||||||
Sbjct: 720 gtcacactatgatgcgtctggcagaatcagaaaggggcctgcacctctcaaccttgaagt 779
 
 
Query: 759 ccccacgtatgagttcaccagtgacgatatggtgattgttggttag 804
 ||| | |||||||||||||| || |||||||||||||||||||||
Sbjct: 780 tccctcatatgagttcaccagcgatgatatggtgattgttggttag 825
 
 
 Score = 79.8 bits (40), Expect = 1e-12
 Identities = 52/55 (94%), Gaps = 2/55 (3%)
 Strand = Plus / Plus
 
 
Query: 10 ttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcggccct 64
 |||||||||||||| ||||||||||||||||||||||| |||||||||||||||
Sbjct: 45 ttcgcgcccgtcctatcggccacgtcccgcggggtggc--gcgcgctgcggccct 97
 
 
 gb|M24542|RATRIP Rat Rieske iron-sulfur protein mRNA, complete cds.
 Length = 912
 
 Score = 634 bits (320), Expect = e-180
 Identities = 641/748 (85%)
 Strand = Plus / Plus
 
 
Query: 34 tcccgcggggtggcgggcgcgctgcggcccttggtgcaggccacggtgcccgccaccccg 93
 ||||||||||||||||| |||||||||||| || |||| | |||||||||||||| ||
Sbjct: 1 tcccgcggggtggcgggagcgctgcggcccctgctgcaaagcgcggtgcccgccacctcg 60
 
  
Query: 94 gagcagcctgtgttggacctgaagcggcccttcctcagccgggagtcgctgagcggccag 153
 || | || || ||||| ||||||| |||||||| |||| ||||||||||| ||||||
Sbjct: 61 gaaccaccggttctggacgtgaagcgacccttcctgtgccgtgagtcgctgagtggccag 120
 
  
Query: 154 gccgtgcgccggcctttggtcgcctccgtgggcctcaatgtccctgcttctgtttgttat 213
 |||| | ||| |||||||| ||| | |||||||| ||||| |||||||||||| |||||
Sbjct: 121 gccgcgacccgtcctttggtggccacagtgggcctgaatgttcctgcttctgttcgttat 180
 
 
Query: 214 tcccacacagacgtcaaggtgcctgacttctctgaataccgccgccttgaagttttagat 273
 |||||||||||| |||||||||| ||||||||||| || ||||| ||||||| |||||
Sbjct: 181 tcccacacagacatcaaggtgcccgacttctctgactatcgccgtgctgaagttctagat 240
 
 
Query: 274 agtacgaagtcttcaagagaaagcaccgaggctaggaaaggtttctcctatttggtaact 333
 || || |||||||| | ||| |||| |||||||| ||||| ||||| || |||||||||
Sbjct: 241 agcacaaagtcttctaaagagagcagtgaggctagaaaaggcttctcttacttggtaact 300
 
 
Query: 334 ggagtaactactgtgggtgtcgcatatgctgccaagaatgccgtcacccagttcgtttcc 393
 | | |||||||||||||| ||||| ||||| || ||||| ||| ||||||| ||||||
Sbjct: 301 gcaactactactgtgggtgttgcatacgctgcgaaaaatgcagtctcccagtttgtttcc 360
 
 
Query: 394 agcatgagtgcttctgctgatgtgttggccctggcgaaaatcgaaatcaagttatccgat 453
 ||||||||||||||||| ||||| ||||| || |||| ||||| |||||||| || |||
Sbjct: 361 agcatgagtgcttctgcggatgtactggccatgtcgaagatcgagatcaagttgtctgat 420
 
  
Query: 454 attccagaaggcaagaacatggctttcaaatggagaggcaaacccctgtttgtacgtcat 513
 |||||||| || |||||||||||||| ||||||||||||||||| |||||||| || |||
Sbjct: 421 attccagaggggaagaacatggcttttaaatggagaggcaaacctctgtttgtgcgccat 480
 
  
Query: 514 agaacccagaaggaaattaagcaggaagctgcagttgaattatcacagttgagggaccca 573
 |||||| ||||||| ||| | |||||||||||||||||| | || ||||| |||||||||
Sbjct: 481 agaaccaagaaggagattgaccaggaagctgcagttgaagtgtcccagttaagggaccca 540
 
 
Query: 574 cagcatgatctagatcgagtaaagaaacctgaatgggttatcctgataggtgtttgcact 633
 ||||||||| |||| || |||||||| |||||||||||||| ||||| ||||| || |||
Sbjct: 541 cagcatgatttagagcgtgtaaagaagcctgaatgggttattctgatcggtgtctgtact 600
 
 
Query: 634 catcttggttgtgtacccattgcaaatgcaggagattttggtggttattactgcccttgc 693
 |||||||||||||||||||||||||| ||||||||||||||||| || || ||||| |||
Sbjct: 601 catcttggttgtgtacccattgcaaacgcaggagattttggtggctactattgcccctgc 660
 
 
Query: 694 catgggtcacactatgatgcatctggcaggatcagattgggtcctgctactctcaacctt 753
  |||||||||||||||||||| |||||||||||||| ||| ||||| |||||||||| 
Sbjct: 661 catgggtcacactatgatgcttctggcaggatcaggaagggccctgcacctctcaacctg 720
 
 
Query: 754 gaagtccccacgtatgagttcaccagtg 781
 ||||| || || ||||||||||||||||
Sbjct: 721 gaagtacctacctatgagttcaccagtg 748
 
 
 gb|L32917|HUMUQCR01 Homo sapiens (clone f17252) ubiquinol cytochrome c reductase Rieske
 iron-sulphur protein (UQCRFS1) gene, exon 1
 Length = 382
 
 Score = 383 bits (193), Expect = e-104
 Identities = 193/193 (100%)
 Strand = Plus / Plus
 
 
Query: 1 tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg 60
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 170 tcgggcccgttcgcgcccgtcctgtcggccacgtcccgcggggtggcgggcgcgctgcgg 229
 
  
Query: 61 cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg 120
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 230 cccttggtgcaggccacggtgcccgccaccccggagcagcctgtgttggacctgaagcgg 289
 
  
Query: 121 cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc 180
 ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Sbjct: 290 cccttcctcagccgggagtcgctgagcggccaggccgtgcgccggcctttggtcgcctcc 349
 
 
Query: 181 gtgggcctcaatg 193
 |||||||||||||
Sbjct: 350 gtgggcctcaatg 362
 
 
 emb|AL022104|SPBC16H5 S.pombe chromosome II cosmid c16H5
 Length = 35660
 
 Score = 54.0 bits (27), Expect = 6e-05
 Identities = 36/39 (92%)
 Strand = Plus / Plus
 
 
Query: 617 tgataggtgtttgcactcatcttggttgtgtacccattg 655
 |||| ||||| || |||||||||||||||||||||||||
Sbjct: 15219 tgattggtgtctgtactcatcttggttgtgtacccattg 15257
 
 
 gb|U40480|SPU40480 Schizosaccharomyces pombe Rieske iron-sulfur protein (Rip1) mRNA,
 complete cds
 Length = 746
 
 Score = 54.0 bits (27), Expect = 6e-05
 Identities = 36/39 (92%)
 Strand = Plus / Plus
 
  
Query: 617 tgataggtgtttgcactcatcttggttgtgtacccattg 655
 |||| ||||| || |||||||||||||||||||||||||
Sbjct: 557 tgattggtgtctgtactcatcttggttgtgtacccattg 595
 
 
 gb|U18530|SCE9871 Saccharomyces cerevisiae chromosome V cosmids 9871, 8199, 9867, 9495
 and lambda clones 6693 and 5898
 Length = 62643
 
 Score = 42.1 bits (21), Expect = 0.22
 Identities = 39/45 (86%)
 Strand = Plus / Plus
 
 
Query: 667 gattttggtggttattactgcccttgccatgggtcacactatgat 711
 ||||||||||||| | ||| ||||||||||| ||||| ||||||
Sbjct: 18179 gattttggtggttggttctgtccttgccatggttcacattatgat 18223
 
 
 gb|M23316|YSCRIP1 Yeast (S.cerevisiae; DC5) Rieske iron-sulfur protein gene, complete
 cds. >gi|172427|gb|M24500|YSCRIP1A S.cerevisiae Rieske
 iron-sulfur protein (RIP1) gene, complete cds.
 Length = 1238
 
 Score = 42.1 bits (21), Expect = 0.22
 Identities = 39/45 (86%)
 Strand = Plus / Plus
 
  
Query: 667 gattttggtggttattactgcccttgccatgggtcacactatgat 711
 ||||||||||||| | ||| ||||||||||| ||||| ||||||
Sbjct: 836 gattttggtggttggttctgtccttgccatggttcacattatgat 880
 
 
 emb|AL109848.1|SCI51 Streptomyces coelicolor cosmid I51
 Length = 40745
 
 Score = 40.1 bits (20), Expect = 0.87
 Identities = 20/20 (100%)
 Strand = Plus / Plus
 
 
Query: 43 gtggcgggcgcgctgcggcc 62
 ||||||||||||||||||||
Sbjct: 5668 gtggcgggcgcgctgcggcc 5687
 
 
 emb|AL117669.1|SCF12 Streptomyces coelicolor cosmid F12
 Length = 24176
 
 Score = 38.2 bits (19), Expect = 3.4
 Identities = 25/27 (92%)
 Strand = Plus / Plus
 
 
Query: 39 cggggtggcgggcgcgctgcggccctt 65
 |||||| ||||||||||||| ||||||
Sbjct: 12339 cggggtcgcgggcgcgctgccgccctt 12365
 
 
 emb|Y08879|MMSERO13 M.musculus gene encoding murine serotin transporter, exon 13
 Length = 811
 
 Score = 38.2 bits (19), Expect = 3.4
 Identities = 19/19 (100%)
 Strand = Plus / Plus
 
 
Query: 193 gtccctgcttctgtttgtt 211
 |||||||||||||||||||
Sbjct: 230 gtccctgcttctgtttgtt 248
 
 
 gb|U77667|MMU77667 Mus musculus tyrosine kinase mRNA, complete cds
 Length = 1857
 
 Score = 38.2 bits (19), Expect = 3.4
 Identities = 19/19 (100%)
 Strand = Plus / Minus
 
 
Query: 392 ccagcatgagtgcttctgc 410
 |||||||||||||||||||
Sbjct: 1234 ccagcatgagtgcttctgc 1216
 
 
 gb|U04379|MMU04379 Mus musculus protein tyrosine kinase ZAP-70 mRNA, complete cds.
 Length = 2038
 
 Score = 38.2 bits (19), Expect = 3.4
 Identities = 19/19 (100%)
 Strand = Plus / Minus
 
 
Query: 392 ccagcatgagtgcttctgc 410
 |||||||||||||||||||
Sbjct: 1342 ccagcatgagtgcttctgc 1324
 
 
 gb|L36064|PRULHP Prunus persica (clone pAB19) light harvesting chlorophyll a/b binding
 protein (Lhcb-Pp1) gene, complete cds.
 Length = 1912
 
 Score = 38.2 bits (19), Expect = 3.4
 Identities = 19/19 (100%)
 Strand = Plus / Minus
 
 
Query: 429 gaaaatcgaaatcaagtta 447
 |||||||||||||||||||
Sbjct: 1736 gaaaatcgaaatcaagtta 1718
 
 
 gb|L16813|TOBFESD Tobacco (clone 32.10) mitochondrial Rieske iron-sulfur protein
 mRNA, complete cds.
 Length = 1121
 
 Score = 38.2 bits (19), Expect = 3.4
 Identities = 46/55 (83%)
 Strand = Plus / Plus
 
 
Query: 656 caaatgcaggagattttggtggttattactgcccttgccatgggtcacactatga 710
 ||||||| || ||||||||||||| | ||||| |||||||| || ||||||||
Sbjct: 758 caaatgctggtgattttggtggttggttttgcccatgccatggttcccactatga 812
 
 
 gb|L16811|TOBFESB Tobacco clone 8.8 mitochondrial Rieske iron-sulfur protein mRNA,
 complete cds.
 Length = 1202
 
 Score = 38.2 bits (19), Expect = 3.4
 Identities = 46/55 (83%)
 Strand = Plus / Plus
 
 
Query: 656 caaatgcaggagattttggtggttattactgcccttgccatgggtcacactatga 710
 ||||||| || ||||||||||||| | ||||| |||||||| || ||||||||
Sbjct: 774 caaatgctggtgattttggtggttggttttgcccatgccatggctcccactatga 828
 
 
 Database: Non-redundant GenBank+EMBL+DDBJ+PDB sequences
 Posted date: Oct 21, 1999 5:27 PM
 Number of letters in database: 1,348,281,623
 Number of sequences in database: 485,194
 
Lambda K H
 1.37 0.711 1.31 
 
Gapped
Lambda K H
 1.37 0.711 1.31 
 
 
Matrix: blastn matrix:1 -3
Gap Penalties: Existence: 5, Extension: 2
Number of Hits to DB: 490040
Number of Sequences: 485194
Number of extensions: 490040
Number of successful extensions: 39632
Number of sequences better than 10.0: 21
length of query: 804
length of database: 1,348,281,623
effective HSP length: 20
effective length of query: 784
effective length of database: 1,338,577,743
effective search space: 1049444950512
effective search space used: 1049444950512
T: 0
A: 0
X1: 6 (11.9 bits)
X2: 25 (49.6 bits)
S1: 12 (24.3 bits)
S2: 19 (38.2 bits)

Η ακολουθία με το υψηλότερο ποσοστό ομοιότητας σύμφωνα με το BLAST είναι:

ref|NM_006003.1|UQCRFS1| Homo sapiens ubiquinol-cytochrome ... 1544 0.0

LOCUS UQCRFS1 1203 bp mRNA PRI 14-SEP-1999
DEFINITION Homo sapiens ubiquinol-cytochrome c reductase, Rieske iron-sulfur
 polypeptide 1 (UQCRFS1), nuclear gene encoding mitochondrial
  protein, mRNA.
ACCESSION NM_006003
NID g5174742
VERSION NM_006003.1 GI:5174742
KEYWORDS .
SOURCE human.
 ORGANISM Homo sapiens
 Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia;
 Eutheria; Primates; Catarrhini; Hominidae; Homo.
REFERENCE 1 (sites)
 AUTHORS Nishikimi,M., Hosokawa,Y., Toda,H., Suzuki,H. and Ozawa,T.
 TITLE The primary structure of human Rieske iron-sulfur protein of
 mitochondrial cytochrome bc1 complex deduced from cDNA analysis
 JOURNAL Biochem. Int. 20 (1), 155-160 (1990)
 MEDLINE 90226406
REFERENCE 2 (bases 1 to 1203)
 AUTHORS Duncan AM, Anderson L, Duff C, Ozawa T, Suzuki H, Worton R and
 Rozen R.
 TITLE Assignment of the gene (UQCRFS1) for the Rieske iron-sulfur protein
 subunit of the mitochondrial cytochrome bc1 complex to the 22q13
 and 19q12-q13.1 regions of the human genome
 JOURNAL Genomics 21 (1), 281-283 (1994)
 MEDLINE 94375033
REFERENCE 3 (bases 1 to 1203)
 AUTHORS Pennacchio,L.A., Bergmann,A., Fukushima,A., Okubo,K., Salemi,A. and
 Lennon,G.G.
 TITLE Structure, sequence and location of the UQCRFS1 gene for the human
 Rieske Fe-S protein
 JOURNAL Gene 155 (2), 207-211 (1995)
 MEDLINE 95237611
COMMENT REFSEQ: This reference sequence was derived from L32977.1.
 PROVISIONAL RefSeq: This is a provisional reference sequence record
 that has not yet been subject to human review. The final curated
 reference sequence record may be somewhat different from this one.
FEATURES Location/Qualifiers
 source 1..1203
 /organism="Homo sapiens"
 /db_xref="taxon:9606"
 /chromosome="19"
 /map="19q12-q13.1"
 /tissue_lib="LL19NC01"
 gene 1..1203
 /gene="UQCRFS1"
 /note="RIS1"
  /db_xref="LocusID:7386"
 /db_xref="MIM:191327"
 CDS 91..915
 /gene="UQCRFS1"
 /EC_number="1.10.2.2"
 /codon_start=1
 /db_xref="LocusID:7386"
 /db_xref="MIM:191327"
 /label=UQCRFS1_CDS
 /product="ubiquinol-cytochrome c reductase, Rieske
 iron-sulfur polypeptide 1"
 /protein_id="NP_005994.1"
  /db_xref="PID:g5174743"
 /db_xref="GI:5174743"
 /translation="MLSVAARSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLD
  LKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKS
 SRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIP
 EGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCT
  HLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG"
BASE COUNT 274 a 288 c 318 g 323 t
ORIGIN 
 1 gtcgtcacgc gtcccgcgcc tcctcgcgcc tgcaccgtgg ttggaaggtc gtcccctgtg
 61 accggttggg cggttggagc ggctgtcgcc atgttgtcgg tagcagcccg ctcgggcccg
 121 ttcgcgcccg tcctgtcggc cacgtcccgc ggggtggcgg gcgcgctgcg gcccttggtg
 181 caggccacgg tgcccgccac cccggagcag cctgtgttgg acctgaagcg gcccttcctc
 241 agccgggagt cgctgagcgg ccaggccgtg cgccggcctt tggtcgcctc cgtgggcctc
 301 aatgtccctg cttctgtttg ttattcccac acagacatca aggtgcctga cttctctgaa
 361 taccgccgcc ttgaagtttt agatagtacg aagtcttcaa gagaaagcag cgaggctagg
 421 aaaggtttct cctatttggt aactggagta actactgtgg gtgtcgcata tgctgccaag
 481 aatgccgtca cccagttcgt ttccagcatg agtgcttctg ctgatgtgtt ggccctggcg
 541 aaaatcgaaa tcaagttatc cgatattcca gaaggcaaga acatggcttt caaatggaga
 601 ggcaaacccc tgtttgtgcg tcatagaacc cagaaggaaa ttgagcagga agctgcagtt
 661 gaattatcac agttgaggga cccacagcat gatctagatc gagtaaagaa acctgaatgg
 721 gttatcctga taggtgtttg cactcatctt ggctgtgtac ccattgcaaa tgcaggagat
 781 tttggtggtt attactgccc ttgccatggg tcacactatg atgcatctgg caggatcaga
 841 ttgggtcctg ctcctctcaa ccttgaagtc cccacgtatg agttcaccag tgacgatatg
 901 gtgattgttg gttaagagac ttggactcaa gtcataggct tctttcagtc tttatgtcac
 961 ctcaggagac ttatttgaga ggaagccttc tgtacttgaa gttgatttga aatatgtaag
 1021 aattgatgat gtatttgcaa acattaatgt gaaataaatt gaatttaatg ttgaatactt
 1081 tcaggcattc acttaataaa gacactgtta agcactgtta tgctcagtca tacacgcgaa
 1141 aggtacaatg tcttttagct aattctaatt aaaaattaca gactggtgta caagatactt
 1201 gtg
//
 

Starting to align, please wait for results ...

CLUSTAL W (1.75) multiple sequence alignment
 
 
UQCRFS1 GTCGTCACGCGTCCCGCGCCTCCTCGCGCCTGCACCGTGGTTGGAAGGTCGTCCCCTGTG
Z82206  ------------------------------------------------------------
 
 
UQCRFS1 ACCGGTTGGGCGGTTGGAGCGGCTGTCGCCATGTTGTCGGTAGCAGCCCGCTCGGGCCCG
Z82206 ---------------------------------------------------TCGGGCCCG
 *********
 
UQCRFS1 TTCGCGCCCGTCCTGTCGGCCACGTCCCGCGGGGTGGCGGGCGCGCTGCGGCCCTTGGTG
Z82206 TTCGCGCCCGTCCTGTCGGCCACGTCCCGCGGGGTGGCGGGCGCGCTGCGGCCCTTGGTG
 ************************************************************
 
UQCRFS1 CAGGCCACGGTGCCCGCCACCCCGGAGCAGCCTGTGTTGGACCTGAAGCGGCCCTTCCTC
Z82206 CAGGCCACGGTGCCCGCCACCCCGGAGCAGCCTGTGTTGGACCTGAAGCGGCCCTTCCTC
  ************************************************************
 
UQCRFS1 AGCCGGGAGTCGCTGAGCGGCCAGGCCGTGCGCCGGCCTTTGGTCGCCTCCGTGGGCCTC
Z82206 AGCCGGGAGTCGCTGAGCGGCCAGGCCGTGCGCCGGCCTTTGGTCGCCTCCGTGGGCCTC
 ************************************************************
 
UQCRFS1 AATGTCCCTGCTTCTGTTTGTTATTCCCACACAGACATCAAGGTGCCTGACTTCTCTGAA
Z82206 AATGTCCCTGCTTCTGTTTGTTATTCCCACACAGACGTCAAGGTGCCTGACTTCTCTGAA
 ************************************ ***********************
 
UQCRFS1 TACCGCCGCCTTGAAGTTTTAGATAGTACGAAGTCTTCAAGAGAAAGCAGCGAGGCTAGG
Z82206 TACCGCCGCCTTGAAGTTTTAGATAGTACGAAGTCTTCAAGAGAAAGCACCGAGGCTAGG
 ************************************************* **********
 
UQCRFS1 AAAGGTTTCTCCTATTTGGTAACTGGAGTAACTACTGTGGGTGTCGCATATGCTGCCAAG
Z82206 AAAGGTTTCTCCTATTTGGTAACTGGAGTAACTACTGTGGGTGTCGCATATGCTGCCAAG
 ************************************************************
 
UQCRFS1 AATGCCGTCACCCAGTTCGTTTCCAGCATGAGTGCTTCTGCTGATGTGTTGGCCCTGGCG
Z82206 AATGCCGTCACCCAGTTCGTTTCCAGCATGAGTGCTTCTGCTGATGTGTTGGCCCTGGCG
 ************************************************************
 
UQCRFS1 AAAATCGAAATCAAGTTATCCGATATTCCAGAAGGCAAGAACATGGCTTTCAAATGGAGA
Z82206 AAAATCGAAATCAAGTTATCCGATATTCCAGAAGGCAAGAACATGGCTTTCAAATGGAGA
 ************************************************************
 
UQCRFS1 GGCAAACCCCTGTTTGTGCGTCATAGAACCCAGAAGGAAATTGAGCAGGAAGCTGCAGTT
Z82206 GGCAAACCCCTGTTTGTACGTCATAGAACCCAGAAGGAAATTAAGCAGGAAGCTGCAGTT
 ***************** ************************ *****************
 
UQCRFS1 GAATTATCACAGTTGAGGGACCCACAGCATGATCTAGATCGAGTAAAGAAACCTGAATGG
Z82206 GAATTATCACAGTTGAGGGACCCACAGCATGATCTAGATCGAGTAAAGAAACCTGAATGG
 ************************************************************
 
UQCRFS1 GTTATCCTGATAGGTGTTTGCACTCATCTTGGCTGTGTACCCATTGCAAATGCAGGAGAT
Z82206 GTTATCCTGATAGGTGTTTGCACTCATCTTGGTTGTGTACCCATTGCAAATGCAGGAGAT
 ******************************** ***************************
 
UQCRFS1 TTTGGTGGTTATTACTGCCCTTGCCATGGGTCACACTATGATGCATCTGGCAGGATCAGA
Z82206 TTTGGTGGTTATTACTGCCCTTGCCATGGGTCACACTATGATGCATCTGGCAGGATCAGA
 ************************************************************
 
UQCRFS1 TTGGGTCCTGCTCCTCTCAACCTTGAAGTCCCCACGTATGAGTTCACCAGTGACGATATG
Z82206 TTGGGTCCTGCTACTCTCAACCTTGAAGTCCCCACGTATGAGTTCACCAGTGACGATATG
  ************ ***********************************************
 
UQCRFS1 GTGATTGTTGGTTAAGAGACTTGGACTCAAGTCATAGGCTTCTTTCAGTCTTTATGTCAC
Z82206 GTGATTGTTGGTTAG---------------------------------------------
 **************  
 
UQCRFS1 CTCAGGAGACTTATTTGAGAGGAAGCCTTCTGTACTTGAAGTTGATTTGAAATATGTAAG
Z82206 ------------------------------------------------------------
  
 
UQCRFS1 AATTGATGATGTATTTGCAAACATTAATGTGAAATAAATTGAATTTAATGTTGAATACTT
Z82206 ------------------------------------------------------------
 
 
UQCRFS1 TCAGGCATTCACTTAATAAAGACACTGTTAAGCACTGTTATGCTCAGTCATACACGCGAA
Z82206 ------------------------------------------------------------
 
 
UQCRFS1 AGGTACAATGTCTTTTAGCTAATTCTAATTAAAAATTACAGACTGGTGTACAAGATACTT
Z82206 ------------------------------------------------------------
 
 
UQCRFS1 GTG
Z82206 ---
  

Homo sapiens ubiquinol-cytochrome 

LOCUS UQCRFS1 1203 bp mRNA PRI 14-SEP-1999
DEFINITION Homo sapiens ubiquinol-cytochrome c reductase, Rieske iron-sulfur
 polypeptide 1 (UQCRFS1), nuclear gene encoding mitochondrial
 protein, mRNA.
/translation="MLSVAARSGPFAPVLSATSRGVAGALRPLVQATVPATPEQPVLD
 LKRPFLSRESLSGQAVRRPLVASVGLNVPASVCYSHTDIKVPDFSEYRRLEVLDSTKS
 SRESSEARKGFSYLVTGVTTVGVAYAAKNAVTQFVSSMSASADVLALAKIEIKLSDIP
 EGKNMAFKWRGKPLFVRHRTQKEIEQEAAVELSQLRDPQHDLDRVKKPEWVILIGVCT
 HLGCVPIANAGDFGGYYCPCHGSHYDASGRIRLGPAPLNLEVPTYEFTSDDMVIVG"
 

Δ.2.b Δομή εξονίων - ιντρονίων.

Η ακολουθία DNA με κωδικό J00271

ID HSMET2 standard; DNA; HUM; 1703 BP.
XX
AC J00271;
XX
SV J00271.1
XX
DT 29-JUL-1991 (Rel. 28, Created)
DT 02-JUL-1999 (Rel. 60, Last updated, Version 6)
XX
DE Human metallothionein-II gene (mt-II) and flanks.
XX
KW metallothionein.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria;
OC Primates; Catarrhini; Hominidae; Homo.
XX
RN [1]
RP 1-1703, 1-1703
RX MEDLINE; 83036944.
RA Karin M., Richards R.I.;
RT "Human metallothionein genes--primary structure of the metallothionein-II
RT gene and a related processed gene";
RL Nature 299(5886):797-802(1982).
XX
RN [2]
RP 781-865, 1167-1232, 1436-1656
RX MEDLINE; 82247198.
RA Karin M., Richards R.I.;
RT "Human metallothionein genes: molecular cloning and sequence analysis of
RT the mRNA";
RL Nucleic Acids Res. 10(10):3165-3173(1982).
XX
DR GDB; 120199; MT2A.
DR SWISS-PROT; P02795; MT2_HUMAN.
DR TRANSFAC; R01030; HS$MT2A_01.
DR TRANSFAC; R01039; HS$MT2A_10.
XX
CC On Mar 31, 1994 this sequence version replaced gi:187524.
CC Metallothioneins are heavy metal binding proteins with high
CC cysteine content. Mt-I seems to be a mixture of several different
CC species. Mt-II seems to be a unique protein belonging to a family
CC consisting of about eleven members which are about 80% homologous,
CC one of which is a pseudogene. See . See also .
XX
FH Key Location/Qualifiers
FH
FT source 1..1703
FT /db_xref="taxon:9606"
FT /organism="Homo sapiens"
FT exon 766..865
FT /note="metallothionein II old gene name 'MT2'"
FT /number=1
FT old_sequence 831..833
FT /citation=[1]
FT gene join(838..865,1167..1232,1436..1527)
FT /gene="MT2A"
FT /map="16q13"
FT CDS join(838..865,1167..1232,1436..1527)
FT /codon_start=1
FT  /db_xref="SWISS-PROT:P02795"
FT /gene="MT2A"
FT /product="metallothionein II"
FT  /protein_id="AAA59583.1"
FT /translation="MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCA
FT QGCICKGASDKCSCCA"
FT intron 866..1166
FT /note="mt-II intron 1"
FT exon 1167..1232
FT /note="metallothionein II"
FT /gene="MT2A"
FT old_sequence 1189
FT /citation=[2]
FT /gene="MT2A"
FT old_sequence 1219
FT /citation=[2]
FT /gene="MT2A"
FT old_sequence 1222
FT /citation=[2]
FT /gene="MT2A"
FT intron 1233..1435
FT /note="mt-II intron 2"
FT exon 1436..>1527
FT  /note="metallothionein II"
FT /gene="MT2A"
FT old_sequence 1479
FT /citation=[2]
FT  /gene="MT2A"
FT old_sequence 1633
FT /citation=[2]
XX
SQ Sequence 1703 BP; 323 A; 528 C; 422 G; 430 T; 0 other;
  aagcttgtgg cttcttctcc ttactcttcc tccttggtgt ctctatgtta gagggccgtt 60
 agcatctgct ggggcctggt cgcattcacc ctgctctgcc actcactggc tgtgtgactc 120
 tggacaaatt aacttctctg gacctggcag tttctcctct ctacaatgag aatactggag 180
 agtccttatc ttatgggttg ctacagaatt aagtgacatc tcacacacaa cacacttcct 240
 acagtccctg ttacacgcta aaagtactca actagcttcg gatacgtcat cagcaaccac 300
 cccacgggtt actgtgatgc tgcacaatta ttaagccctg gctgctacag agttgtaacc 360
 tgtctgcact tccaaccggc gccgcaagca gcattcccag tcccgctttc acccgcgcgc 420
 taacggctca ggttcgagta caggacagga gggaggggag ctgtgcacac ggcggaggcg 480
 cacggcgtgg gcacccagca cccggtacac tgtgtcctcc cgctgcaccc agccccttca 540
 gcccgaggcg tccccgaggc gcaagtgggc cgccttcagg gaactgaccg cccgcggccc 600
 gtgtgcagag ccgggtgcgc ccggcccagt gcgcgcggcc gggtgtttcg cttggagccg 660
 caagtgactt ctagcgcggg gcgtgtgcag gcacggccgg ggcggggctt ttgcactcgt 720
 cccggctctt tctagctata aacactgctt gccgcgctgc actccaccac gcctcctcca 780
 agtcccagcg aacccgcgtg caacctgtcc cgactctagc cgcctcttca gcacgccatg 840
 gatcccaact gctcctgcgc cgccggtaag aggctgggga tgcccagtgt agactgtagc 900
 gctagagaag caatttctga cccctctttc tttctctggt cactcaattt caggcacagg 960
 agttgctctt cccaaagagt tttggtatct ttctctccat tctaggttat tcggagcccc 1020
 ctttttaccg ttaaggagat ctgagttaat ggcttgctca agttcccagg aatcggttgt 1080
 ggactgagga actcggcccc gggtcttagt acgcgtccct tgttcaggta tccagggagt 1140
 tctcacctct gtcttttctc cttcaggtga ctcctgcacc tgcgccggct cctgcaaatg 1200
 caaagagtgc aaatgcacct cctgcaagaa aagtaagtgg gatcctctct ttcctctacc 1260
 ccttccctgt cctccagcct gtcccctctc caccatcctc aggggaatta aagcagtctg 1320
 gggatgcccc attgcgcgga aattgttgcc tcctcagtga tcttatcagg gagagcagga 1380
 atccttattc ccggtgtcgc tagtactcat ctctgcgcct cctgtctgcc cccaggctgc 1440
 tgctcctgct gccctgtggg ctgtgccaag tgtgcccagg gctgcatctg caaaggggcg 1500
 tcggacaagt gcagctgctg cgcctgatgc tgggacagcc ccgctcccag atgtaaagaa 1560
 cgcgacttcc acaaacctgg attttttatg tacaaccctg accgtgaccg tttgctatat 1620
 tcctttttct ataaaataat gtgaatgata ataaaacagc tttgacttga ttctgtctct 1680
 ggttttcttt atatgcctta aaa  1703
//

Η ακολουθία mRNA με κωδικό V00594

ID HSTHIO standard; RNA; HUM; 372 BP.
XX
AC V00594;
XX
SV V00594.1
XX
DT 03-NOV-1982 (Rel. 02, Created)
DT 10-APR-1994 (Rel. 39, Last updated, Version 6)
XX
DE Human mRNA for metallothionein from cadmium-treated cells.
XX
KW complementary DNA; metallothionein.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria;
OC Primates; Catarrhini; Hominidae; Homo.
XX
RN [1]
RP 1-372
RX MEDLINE; 82247198.
RA Karin M., Richards R.I.;
RT "Human metallothionein genes: molecular cloning and sequence analysis of
RT the mRNA";
RL Nucleic Acids Res. 10:3165-3173(1982).
XX
DR SWISS-PROT; P02795; MT2_HUMAN.
XX
FH Key Location/Qualifiers
FH
FT source 1..372
FT /db_xref="taxon:9606"
FT /organism="Homo sapiens"
FT mRNA <1..>372
FT /note="messenger RNA"
FT CDS 58..243
FT /db_xref="SWISS-PROT:P02795"
FT /note="reading frame metallothionein"
FT /protein_id="CAA23841.1"
FT /translation="MDPNCSCAAGDSCTCAGSCKCKECKCTSCKKSCCSCCPVGCAKCA
FT  QGCICKGASDKCSCCA"
XX
SQ Sequence 372 BP; 84 A; 114 C; 90 G; 84 T; 0 other;
 agtcccagcg aacccgcgtg caacctgtcc cgactctagc cgcctcttca gcacgccatg 60
 gatcccaact gctcctgcgc cgccggtgac tcctgcacct gcgccggttc ctgcaaatgc 120
 aaagagtgca aatgcacttc gtgcaagaaa agctgctgct cctgctgccc tgtgggctgt 180
 gccaagtgtg cccaaggctg catctgcaaa ggggcgtcgg acaagtgcag ctgctgcgcc 240
 tgatgctggg acagccccgc tcccagatgt aaagaacgcg acttccacaa acctggattt 300
 tttatgtaca accctgaccg tgaccgtttg ctatattcct ttttctatga aataatgtga 360
 atgataataa aa 372
//

Η ευθυγράμμιση των δύο ακολουθιών J00271 και V00594

Starting to align, please wait for results ...

CLUSTAL W (1.75) multiple sequence alignment
 
 
V00594 ------------------------------------------------------------
J00271 AAGCTTGTGGCTTCTTCTCCTTACTCTTCCTCCTTGGTGTCTCTATGTTAGAGGGCCGTT
 
 
V00594 ------------------------------------------------------------
J00271 AGCATCTGCTGGGGCCTGGTCGCATTCACCCTGCTCTGCCACTCACTGGCTGTGTGACTC
  
 
V00594 ------------------------------------------------------------
J00271 TGGACAAATTAACTTCTCTGGACCTGGCAGTTTCTCCTCTCTACAATGAGAATACTGGAG
  
 
V00594 ------------------------------------------------------------
J00271 AGTCCTTATCTTATGGGTTGCTACAGAATTAAGTGACATCTCACACACAACACACTTCCT
  
 
V00594 ------------------------------------------------------------
J00271 ACAGTCCCTGTTACACGCTAAAAGTACTCAACTAGCTTCGGATACGTCATCAGCAACCAC
 
 
V00594  ------------------------------------------------------------
J00271 CCCACGGGTTACTGTGATGCTGCACAATTATTAAGCCCTGGCTGCTACAGAGTTGTAACC
 
 
V00594 ------------------------------------------------------------
J00271 TGTCTGCACTTCCAACCGGCGCCGCAAGCAGCATTCCCAGTCCCGCTTTCACCCGCGCGC
 
 
V00594 ------------------------------------------------------------
J00271 TAACGGCTCAGGTTCGAGTACAGGACAGGAGGGAGGGGAGCTGTGCACACGGCGGAGGCG
 
 
V00594 ------------------------------------------------------------
J00271 CACGGCGTGGGCACCCAGCACCCGGTACACTGTGTCCTCCCGCTGCACCCAGCCCCTTCA
 
 
V00594 ------------------------------------------------------------
J00271 GCCCGAGGCGTCCCCGAGGCGCAAGTGGGCCGCCTTCAGGGAACTGACCGCCCGCGGCCC
 
 
V00594 ------------------------------------------------------------
J00271 GTGTGCAGAGCCGGGTGCGCCCGGCCCAGTGCGCGCGGCCGGGTGTTTCGCTTGGAGCCG
 
 
V00594 ------------------------------------------------------------
J00271 CAAGTGACTTCTAGCGCGGGGCGTGTGCAGGCACGGCCGGGGCGGGGCTTTTGCACTCGT
 
 
V00594 ------------------------------------------------------------
J00271 CCCGGCTCTTTCTAGCTATAAACACTGCTTGCCGCGCTGCACTCCACCACGCCTCCTCCA
  
 
V00594 ------------------------------------------------------------
J00271 AGTCCCAGCGAACCCGCGTGCAACCTGTCCCGACTCTAGCCGCCTCTTCAGCACGCCATG
  
 
V00594 ------------------------------------------------------------
J00271 GATCCCAACTGCTCCTGCGCCGCCGGTAAGAGGCTGGGGATGCCCAGTGTAGACTGTAGC
  
 
V00594 ------------------------------------------------------------
J00271 GCTAGAGAAGCAATTTCTGACCCCTCTTTCTTTCTCTGGTCACTCAATTTCAGGCACAGG
 
 
V00594  ------------------------------------------------------------
J00271 AGTTGCTCTTCCCAAAGAGTTTTGGTATCTTTCTCTCCATTCTAGGTTATTCGGAGCCCC
 
 
V00594 ------------------------------------------------------------
J00271 CTTTTTACCGTTAAGGAGATCTGAGTTAATGGCTTGCTCAAGTTCCCAGGAATCGGTTGT
 
 
V00594 ------------------------------------------------------------
J00271 GGACTGAGGAACTCGGCCCCGGGTCTTAGTACGCGTCCCTTGTTCAGGTATCCAGGGAGT
 
 
V00594 ------------------------------------------------------------
J00271  TCTCACCTCTGTCTTTTCTCCTTCAGGTGACTCCTGCACCTGCGCCGGCTCCTGCAAATG
 
 
V00594 ------------------------------------------------------AGTCCC
J00271 CAAAGAGTGCAAATGCACCTCCTGCAAGAAAAGTAAGTGGGATCCTCTCTTTCCTCTACC
 * **
 
V00594 AGCGAACCCGCGTGCAACCTGTCCCGACTCTAGCCGCCTC--------TTCAGCACGCCA
J00271 CCTTCCCTGTCCTCCAGCCTGTCCCCTCTCCACCATCCTCAGGGGAATTAAAGCAGTCTG
 * * * ** ******** *** * * **** * **** * 
 
V00594 TGGAT-CCCAACTGCTCC--------TGCGCCGCCGGTGA-CTCCTGCACCTGCGCCGG-
J00271 GGGATGCCCCATTGCGCGGAAATTGTTGCCTCCTCAGTGATCTTATCAGGGAGAGCAGGA
  **** *** * *** * *** * * **** ** * * ** ** 
 
V00594 ----TTCCTGCAAATGCAAAGAGTGCAAAT----GCACTTCGTGCAAGAA---AAGCTGC
J00271 ATCCTTATTCCCGGTGTCGCTAGTACTCATCTCTGCGCCTCCTGTCTGCCCCCAGGCTGC
 ** * *  ** *** * ** ** * ** ** * * *****
 
V00594 TGCTCCTGCTGCCCTGTGGGCTGTGCCAAGTGTGCCCAAGGCTGCATCTGCAAAGGGGCG
J00271 TGCTCCTGCTGCCCTGTGGGCTGTGCCAAGTGTGCCCAGGGCTGCATCTGCAAAGGGGCG
 ************************************** *********************
 
V00594 TCGGACAAGTGCAGCTGCTGCGCCTGATGCTGGGACAGCCCCGCTCCCAGATGTAAAGAA
J00271 TCGGACAAGTGCAGCTGCTGCGCCTGATGCTGGGACAGCCCCGCTCCCAGATGTAAAGAA
 ************************************************************
 
V00594 CGCGACTTCCACAAACCTGGATTTTTTATGTACAACCCTGACCGTGACCGTTTGCTATAT
J00271 CGCGACTTCCACAAACCTGGATTTTTTATGTACAACCCTGACCGTGACCGTTTGCTATAT
 ************************************************************
 
V00594 TCCTTTTTCTATGAAATAATGTGAATGATAATAAAA------------------------
J00271 TCCTTTTTCTATAAAATAATGTGAATGATAATAAAACAGCTTTGACTTGATTCTGTCTCT
 ************ *********************** 
 
V00594 -----------------------
J00271  GGTTTTCTTTATATGCCTTAAAA
 

3. Ψευδογονίδια.

H ακολουθία DNA του γονιδίου της beta tubulin.

ID HSTUBB2 standard; DNA; HUM; 3284 BP.
XX
AC X02344;
XX
SV X02344.1
XX
DT 28-JAN-1986 (Rel. 08, Created)
DT 16-NOV-1998 (Rel. 57, Last updated, Version 4)
XX
DE Homo sapiens beta 2 gene
XX
KW beta 2 gene; beta-tubulin; tubulin.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria;
OC Primates; Catarrhini; Hominidae; Homo.
XX
RN [1]
RP 1-3284
RX MEDLINE; 85210890.
RA Lewis S.A., Gilmartin M.E., Hall J.L., Cowan N.J.;
RT "Three expressed sequences within the human Beta-Tubulin multigene family
RT each define a distinct Isotype";
RL J. Mol. Biol. 182:11-20(1985).
XX
DR EPD; 14031; Hs b'-tubulin b'2.
DR GDB; 119622; TUBB.
DR SWISS-PROT; P05217; TBB2_HUMAN.
XX
CC Data kindly reviewed (06-MAR-1986) by N.J. Cowan
XX
FH Key  Location/Qualifiers
FH
FT source 1..3284
FT /db_xref="taxon:9606"
FT /organism="Homo sapiens"
FT TATA_signal 643..648
FT  /gene="beta 2"
FT misc_RNA 676..676
FT /note="cap-site"
FT CDS join(748..804,1108..1216,1295..1405,1880..2940)
FT /db_xref="SWISS-PROT:P05217"
FT /gene="beta 2"
FT /product="beta-tubulin"
FT /protein_id="CAA26203.1"
FT /translation="MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLE
FT RINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKG
FT HYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRI
FT MNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTY
FT  GDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQY
FT RALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSY
FT FVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYT
FT GEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA"
FT exon 676..804
FT /number=1
FT /gene="beta 2"
FT intron 805..1107
FT /number=1
FT /gene="beta 2"
FT exon 1108..1216
FT /number=2
FT /gene="beta 2"
FT intron 1217..1294
FT /number=2
FT /gene="beta 2"
FT exon 1295..1405
FT /number=3
FT /gene="beta 2"
FT intron 1406..1879
FT /number=3
FT  /gene="beta 2"
FT exon 1880..2940
FT /number=4
FT /gene="beta 2"
FT 3'UTR 2938..3071
FT /gene="beta 2"
FT polyA_signal 3072..3077
FT /note="putative"
FT /gene="beta 2"
XX
SQ Sequence 3284 BP; 589 A; 1040 C; 1064 G; 591 T; 0 other;
 gagcccgtat gtcttcctgc ctttaaggca tcgcagcctc ctcgcctgga ggccccgggg 60
 ctcgctccgt cggaccccgc tccagaaccc gcccagcgcg caggataccg tgtcccggcg 120
 cgcaaggcca gagaggggcg caactctgga cgtggggccg ccaccgagcc tgcccttccc 180
 ggctcccgaa aggccccggg ctcagagcca agactgcgct tgcccgaggc tgtcgggccc  240
 gccctccctc gcgcccccag cgcagctgcc cgccgcccga ccggaagccc gcactccgcc 300
 tcgccccacc ccgtccgcgc gccggccgcg gcactgcggc ggttaccagg acgctgaagc 360
 agcgcagcca atagcgccac gctggcggcg tgctcccggc agccagccaa tgagacggca 420
 aatcaatcat ttgaaacacc caatggacgg agcactgcgg cgccaggagg gggattgtga 480
 tagggagata ggaggctgcg gctgaccaat aaagaccaaa ctggcttaaa aaggcggacc 540
 ttaggcagct tgattgacgg gggcaaggcc aatcaaacga gggagcttgc cagcctcgtt 600
 ctggcagccc attccgagac tagcggaggc gggcagggag ggtatataag cgttggcgga 660
 cggtcggttg tagcactctg cgcgcccgct cttctgctgc tgtttgtcta cttcctcctc 720
 ttccccgccg ccgccgccgc cgccatcatg agggaaatcg tgcacttgca ggccgggcag 780
 tgcggcaacc aaatcggcgc caaggtaagt tgccggggcg ctggggccag gcgggcctag 840
 ccgggcggtg tgggcgggcg gccggggaag atggcggcag cagcggccgg gcggcgcccc 900
 gcattgcggc cgccgggccc cctccgcggg gaattggccg agccgggcga ccgaagcccc 960
 caggcaaccc gcggccaggg cagcgcgggg cggggggagg ggcggggagg gccggctgcc 1020
 gcgcccgtcc ggggcggggc tgcctccctg cgcaccggcc gcggtgactc agccccgccc 1080
 gcccgggccc gcccgcgtcc cttgtagttt tgggaggtga tcagcgatga gcacggcatc 1140
 gaccccacgg gcacctacca cggggacagc gacctgcagc tggaacgcat caacgtgtac 1200
 tacaatgagg ccaccggtga ggccccggcc ccttccccga ccgcctcggg gaccccgcgg 1260
 cccctgcctt gctgacgccc tcccgtcccc gcaggcggca agtacgtgcc ccgcgccgtg 1320
 ctcgtggatc tggagcccgg caccatggac tccgtgcggt cggggccctt cgggcagatc  1380
 ttccggccgg acaacttcgt tttcggtgag ccgtggctgg ggactgggcg gcggctcaaa 1440
 ggtcaagggg ctgctccaag ggcaccgccg tgggaactgc gcagcggggc ccctggaagc 1500
 ctcctcttct ctgagccact caatccctgt agtaaatcgg gctttgggag caaggctcca 1560
  ggcgtgtctg ccgaggcgag gagcgccaca cacgtaatct ccctgcaggg agctgagctg 1620
 gggcagtggc tgttcctctg tccttgggaa ttggcagtgg cccccccggg gaggggtttg 1680
 ttaagctgtc aggtttggcc cctgacttaa ttcgtagcag ggcaggctgc cgtcttttgg 1740
 ctttgaaggg tccgtttgct ctacctccag ggtgaattct gtggtcagct cacaccatgt 1800
 cactcggctt ttttcgcatg gcggtgacca gtagtgctgt ctacctggct gacaaatgat 1860
 tagctgtgtt ctctcacagg tcagagtggt gctgggaaca actgggccaa ggggcactac 1920
 acagaaggcg cggagctggt ggactcggtg ctggatgttg tgagaaagga ggctgagagc 1980
 tgtgactgcc tgcagggttt ccagctgacc cactccctgg gtggggggac tgggtctggg 2040
 atgggtaccc tcctcatcag caagatccgg gaggagtacc cagacaggat catgaacacg 2100
 tttagtgtgg tgccttcgcc caaagtgtca gacacagtgg tggagcccta caacgccacc 2160
 ctctcagtcc accagctcgt agaaaacaca gacgagacct actgcattga taacgaagct 2220
 ctctacgaca tttgcttcag aaccctaaag ctgaccacgc ccacctatgg tgacctgaac 2280
 cacctggtgt ctgctaccat gagtggggtc accacctgcc tgcgcttccc aggccagctc 2340
 aatgctgacc tgcggaagct ggctgtgaac atggtcccgt ttccccggct gcacttcttc 2400
 atgcccggct ttgccccact gaccagccgg ggcagccagc agtaccgggc gctgaccgtg 2460
 cccgagctca cccagcagat gtttgatgcc aagaacatga tggctgcctg cgacccccgc 2520
 catggccgct acctgacggt tgccgccgtg ttcaggggcc ggatgtccat gaaggaggtg 2580
 gatgagcaaa tgcttaatgt ccaaaacaaa aacagcagct attttgttga gtggatcccc 2640
 aacaatgtga aaacggctgt ctgtgacatc ccacctcggg ggctaaaaat gtccgccacc 2700
 ttcattggca acagcacggc catccaggag ctgttcaagc gcatctccga gcagttcacg 2760
 gccatgttcc ggcgcaaggc cttcctgcac tggtacacgg gcgagggcat ggacgagatg 2820
 gagttcaccg aggccgagag caacatgaat gacctggtgt ccgagtacca gcagtaccag 2880
 gatgccacag ccgaggagga gggcgagttc gaggaggagg ctgaggagga ggtggcctag 2940
 agccttcagt cactggggaa agcagggaag cagtgtgaac tctttattca ctcccagcct 3000
 gtcctgtggc ctgtcccact gtgtgcactt gctgttttcc ctgtccacat ccatgctgta 3060
 cagacaccac cattaaagct tattctaagt gtgtggtttc gctttgccca ttccttccag 3120
 taggccctcc gggtgctgtt gccgaatgtc agggcgtagt tgtcctgcat ggctgcgggg 3180
 agccaggctg cagctgagct ggggcttatg tgcccaggac cagcatgggc tggacaccca 3240
 ggcttcagag aagtgtgggg ctgccctggg ccctgggtat ctgc 3284
//

H ακολουθία DNA του γονιδίου της beta tubulin σε μορφή FASTA

>HSTUBB2
gagcccgtatgtcttcctgcctttaaggcatcgcagcctcctcgcctggaggccccgggg
ctcgctccgtcggaccccgctccagaacccgcccagcgcgcaggataccgtgtcccggcg
cgcaaggccagagaggggcgcaactctggacgtggggccgccaccgagcctgcccttccc
ggctcccgaaaggccccgggctcagagccaagactgcgcttgcccgaggctgtcgggccc
gccctccctcgcgcccccagcgcagctgcccgccgcccgaccggaagcccgcactccgcc
tcgccccaccccgtccgcgcgccggccgcggcactgcggcggttaccaggacgctgaagc
agcgcagccaatagcgccacgctggcggcgtgctcccggcagccagccaatgagacggca
aatcaatcatttgaaacacccaatggacggagcactgcggcgccaggagggggattgtga
tagggagataggaggctgcggctgaccaataaagaccaaactggcttaaaaaggcggacc
ttaggcagcttgattgacgggggcaaggccaatcaaacgagggagcttgccagcctcgtt
ctggcagcccattccgagactagcggaggcgggcagggagggtatataagcgttggcgga
cggtcggttgtagcactctgcgcgcccgctcttctgctgctgtttgtctacttcctcctc
ttccccgccgccgccgccgccgccatcatgagggaaatcgtgcacttgcaggccgggcag
tgcggcaaccaaatcggcgccaaggtaagttgccggggcgctggggccaggcgggcctag
ccgggcggtgtgggcgggcggccggggaagatggcggcagcagcggccgggcggcgcccc
gcattgcggccgccgggccccctccgcggggaattggccgagccgggcgaccgaagcccc
caggcaacccgcggccagggcagcgcggggcggggggaggggcggggagggccggctgcc
gcgcccgtccggggcggggctgcctccctgcgcaccggccgcggtgactcagccccgccc
gcccgggcccgcccgcgtcccttgtagttttgggaggtgatcagcgatgagcacggcatc
gaccccacgggcacctaccacggggacagcgacctgcagctggaacgcatcaacgtgtac
tacaatgaggccaccggtgaggccccggccccttccccgaccgcctcggggaccccgcgg
cccctgccttgctgacgccctcccgtccccgcaggcggcaagtacgtgccccgcgccgtg
ctcgtggatctggagcccggcaccatggactccgtgcggtcggggcccttcgggcagatc
ttccggccggacaacttcgttttcggtgagccgtggctggggactgggcggcggctcaaa
ggtcaaggggctgctccaagggcaccgccgtgggaactgcgcagcggggcccctggaagc
ctcctcttctctgagccactcaatccctgtagtaaatcgggctttgggagcaaggctcca
ggcgtgtctgccgaggcgaggagcgccacacacgtaatctccctgcagggagctgagctg
gggcagtggctgttcctctgtccttgggaattggcagtggcccccccggggaggggtttg
ttaagctgtcaggtttggcccctgacttaattcgtagcagggcaggctgccgtcttttgg
ctttgaagggtccgtttgctctacctccagggtgaattctgtggtcagctcacaccatgt
cactcggcttttttcgcatggcggtgaccagtagtgctgtctacctggctgacaaatgat
tagctgtgttctctcacaggtcagagtggtgctgggaacaactgggccaaggggcactac
acagaaggcgcggagctggtggactcggtgctggatgttgtgagaaaggaggctgagagc
tgtgactgcctgcagggtttccagctgacccactccctgggtggggggactgggtctggg
atgggtaccctcctcatcagcaagatccgggaggagtacccagacaggatcatgaacacg
tttagtgtggtgccttcgcccaaagtgtcagacacagtggtggagccctacaacgccacc
ctctcagtccaccagctcgtagaaaacacagacgagacctactgcattgataacgaagct
ctctacgacatttgcttcagaaccctaaagctgaccacgcccacctatggtgacctgaac
cacctggtgtctgctaccatgagtggggtcaccacctgcctgcgcttcccaggccagctc
aatgctgacctgcggaagctggctgtgaacatggtcccgtttccccggctgcacttcttc
atgcccggctttgccccactgaccagccggggcagccagcagtaccgggcgctgaccgtg
cccgagctcacccagcagatgtttgatgccaagaacatgatggctgcctgcgacccccgc
catggccgctacctgacggttgccgccgtgttcaggggccggatgtccatgaaggaggtg
gatgagcaaatgcttaatgtccaaaacaaaaacagcagctattttgttgagtggatcccc
aacaatgtgaaaacggctgtctgtgacatcccacctcgggggctaaaaatgtccgccacc
ttcattggcaacagcacggccatccaggagctgttcaagcgcatctccgagcagttcacg
gccatgttccggcgcaaggccttcctgcactggtacacgggcgagggcatggacgagatg
gagttcaccgaggccgagagcaacatgaatgacctggtgtccgagtaccagcagtaccag
gatgccacagccgaggaggagggcgagttcgaggaggaggctgaggaggaggtggcctag
agccttcagtcactggggaaagcagggaagcagtgtgaactctttattcactcccagcct
gtcctgtggcctgtcccactgtgtgcacttgctgttttccctgtccacatccatgctgta
cagacaccaccattaaagcttattctaagtgtgtggtttcgctttgcccattccttccag
taggccctccgggtgctgttgccgaatgtcagggcgtagttgtcctgcatggctgcgggg
agccaggctgcagctgagctggggcttatgtgcccaggaccagcatgggctggacaccca
ggcttcagagaagtgtggggctgccctgggccctgggtatctgc
 
 

H πρωτεϊνική ακολουθία που προκύπτει από την μετάφραση του DNA

db_xref="SWISS-PROT:P05217" /gene="beta 2" /product="beta-tubulin" /protein_id="CAA26203.1"
>HU beta tub DNA
MREIVHLQAGQCGNQIGAKFWEVISDEHGIDPTGTYHGDSDLQLERINVYYNEATGGKYVPRAVLVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKEAESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVVPSPKVSDTVVEPYNATLSVHQLVENTDETYCIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDAKNMMAACDPRHGRYLTVAAVFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATAEEEGEFEEEAEEEVA

H ακολουθία mRNA του γονιδίου της beta tubulin.

ID HSBT278 standard; RNA; HUM; 1594 BP.
XX
AC X79535;
XX
SV X79535.1
XX
DT 03-JUN-1994 (Rel. 39, Created)
DT 03-JUN-1994 (Rel. 39, Last updated, Version 1)
XX
DE H.sapiens mRNA for beta tubulin, clone nuk_278
XX
KW beta tubulin.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria;
OC Primates; Catarrhini; Hominidae; Homo.
XX
RN [2]
RP 1-1594
RA Leffers H.;
RT ;
RL Submitted (01-JUN-1994) to the EMBL/GenBank/DDBJ databases.
RL H. Leffers, Inst. of Medical Research Biochemistry & Danish Centre for
RL Human Genome Research, Ole Worms Alle 170, Aarhus Univ., 8000 Aarhus C,
RL DENMARK
XX
RN [3]
RA Leffers H., Wiemann S., Ansorge W.;
RT "Cloning and vaccinia virus expression of a cDNA containing the complete
RT coding seqeunce of human beta tubulin mRNA";
RL Unpublished.
XX
DR SPTREMBL; Q13885; Q13885.
XX
FH Key Location/Qualifiers
FH
FT source 1..1594
FT /db_xref="taxon:9606"
FT /organism="Homo sapiens"
FT /tissue_type="skin"
FT /cell_type="keratinocytes"
FT /cell_line="non fractionated non cultures normal
FT keratinocytes"
FT /clone_lib="lambda ZapII"
FT /clone="nuk_278"
FT CDS 64..1401
FT /db_xref="SPTREMBL:Q13885"
FT /product="beta tubulin"
FT  /protein_id="CAA56071.1"
FT /translation="MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLE
FT RINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKG
FT HYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRI
FT MNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTY
FT GDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQY
FT RALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSY
FT FVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYT
FT GEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA"
FT polyA_signal 1576..1581
XX
SQ Sequence 1594 BP; 357 A; 485 C; 462 G; 290 T; 0 other;
 gcccgccggt ccacgccgcg caccgctccg agggccagcg ccacccgctc cgcagccggc 60
 accatgcgcg agatcgtgca catccaggcg ggccagtgcg gcaaccagat cggcgccaag 120
 ttttgggagg tcatcagcga tgagcatggg atcgacccca caggcagtta ccatggagac 180
 agtgacttgc agctggagag aatcaacgtg tactacaatg aggctgctgg taacaaatat 240
 gtacctcggg ccatcctggt ggatctggag cctggcacca tggactctgt caggtctgga 300
 cccttcggcc agatcttcag accagacaac ttcgtgttcg gccagagtgg agccgggaat 360
 aactgggcca agggccacta cacagaggga gccgagctgg tcgactcggt cctggatgtg 420
 gtgaggaagg agtcagagag ctgtgactgt ctccagggct tccagctgac ccactctctg 480
 gggggcggca cggggtccgg gatgggcacc ctgctcatca gcaagatccg ggaagagtac 540
 ccagaccgca tcatgaacac cttcagcgtc atgccctcac ccaaggtgtc agacacggtg 600
 gtggagccct acaacgccac cctctcggtc caccagctgg tggaaaacac agatgaaacc 660
 tactccattg ataacgaggc cctgtatgac atctgcttcc gcaccctgaa gctgaccacc 720
 cccacctacg gggacctcaa ccacctggtg tcggccacca tgagcggggt caccacctgc 780
 ctgcgcttcc cgggccagct gaacgcagac ctgcgcaagc tggcggtgaa catggtgccc 840
 ttccctcgcc tgcacttctt catgcccggc ttcgcgcccc tgaccagccg gggcagccag  900
 cagtaccggg cgctcacggt gcccgagctc acccagcaga tgttcgactc caagaacatg 960
 atggccgcct gcgacccgcg ccacggccgc tacctgacgg tggctgccat cttccggggc 1020
 cgcatgtcca tgaaggaggt ggacgagcag atgctcaacg tgcagaacaa gaacagcagc 1080
 tacttcgtgg agtggatccc caacaacgtg aagacggccg tgtgcgacat cccgccccgc 1140
 ggcctgaaga tgtcggccac cttcatcggc aacagcacgg ccatccagga gctgttcaag 1200
 cgcatctccg agcagttcac ggccatgttc cggcgcaagg ccttcctgca ctggtacacg 1260
 ggcgagggca tggacgagat ggagttcacc gaggccgaga gcaacatgaa cgacctggtg 1320
 tccgagtacc agcagtacca ggacgccacg gccgacgaac aaggggagtt cgaggaggag 1380
 gagggcgagg acgaggctta aaaacttctc agatcaatcg tgcatcctta gtgaacttct 1440
 gttgtcctca agcatggtct ttctacttgt aaactatggt gctcagtttt gcctctgtta 1500
 gaaattcaca ctgttgatgt aatgatgtgg aactcctcta aaaattacag tattgtctgt 1560
 gaaggtatct atactaataa aaaagcatgt gtag 1594
//

H ακολουθία mRNA του γονιδίου της beta tubulin σε μορφή FASTA

>HUTUBMRNA

gcccgccggtccacgccgcgcaccgctccgagggccagcgccacccgctccgcagccggcaccatgcgcg

agatcgtgcacatccaggcg ggccagtgcg gcaaccagat cggcgccaagttttgggaggtcatcag

cgatgagcatgggatcgaccccacaggcagttaccatggagacagtgacttgcagctggagagaatcaac

gtgtactacaatgaggctgctggtaacaaatatgtacctcgggccatcctggtggatctggagcctggca

ccatggactctgtcaggtctggacccttcggccagatcttcagaccagacaacttcgtgttcggccagag

tgg agccgggaataactgggccaagggccactacacagagggagccgagctggtcgactcggtcctgga

tgtggtgaggaaggagtcagagagctgtgactgtctccagggcttccagctgacccactctctggggggc

ggcacggggtccgggatgggcaccctgctcatcagcaagatccgggaagagtacccagaccgcatcatga

acaccttcagcgtcatgccctcacccaaggtgtcagacacggtggtggagccctacaacgccaccctctc

ggtccaccagctggtggaaaacacagatgaaacctactccattgataacgaggccctgtatgacatctgc

ttccgcaccctgaagctgaccacccccacctacggggacctcaaccacctggtgtcggccaccatgagcg

gggtcaccacctgcctgcgcttcccgggccagctgaacgcagacctgcgcaagctggcggtgaacatggt

gcccttccctcgcctgcacttcttcatgcccggcttcgcgcccctgaccagccggggcagccagcagtac

cgggcgctcacggtgcccgagctcacccagcagatgttcgactccaagaacatgatggccgcctgcgacc

cgcgccacggccgctacctgacggtggctgccatcttccggggccgcatgtccatgaaggaggtggacga

gcagatgctcaacgtgcagaacaagaacagcagctacttcgtggagtggatccccaacaacgtgaagacg

gccgtgtgcgacatcccgccccgcggcctgaagatgtcggccaccttcatcggcaacagcacggccatcc

aggagctgttcaagcgcatctccgagcagttcacggccatgttccggcgcaaggccttcctgcactggta

cacgggcgagggcatggacgagatggagttcaccgaggccgagagcaacatgaacgacctggtgtccgag

taccagcagtaccaggacgccacggccgacgaacaaggggagttcgaggaggaggagggcgaggacgagg

cttaaaaacttctcagatcaatcgtgcatccttagtgaacttctgttgtcctcaagcatggtctttctac

ttgtaaactatggtgctcagttttgcctctgttagaaattcacactgttgatgtaatgatgtggaactcc

tctaaaaattacagtattgtctgtgaaggtatctatactaataaaaaagcatgtgtag

H πρωτεϊνική ακολουθία που προκύπτει από την μετάφραση του mRNA

/db_xref="SPTREMBL:Q13885" /product="beta tubulin"
/protein_id="CAA56071.1"
>HU beta_tub mRNA
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEPGTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLGGGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDICFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQYRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVKTAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVSEYQQYQDATADEQGEFEEEEGEDEA

H ακολουθία DNA του ψευδογονιδίου της beta tubulin.

ID HSTBB21P standard; DNA; HUM; 1781 BP.
XX
AC K00841;
XX
SV K00841.1
XX
DT 13-JUN-1985 (Rel. 06, Created)
DT 02-JUL-1999 (Rel. 60, Last updated, Version 5)
XX
DE human beta-tubulin pseudogene, clone 21-beta.
XX
KW beta-tubulin; beta-tubulin pseudogene; pseudogene; reverse transcription;
KW tubulin.
XX
OS Homo sapiens (human)
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria;
OC Primates; Catarrhini; Hominidae; Homo.
XX
RN [1]
RP 1-1781
RX MEDLINE; 83232883.
RA Lee M.G.-S., Lewis S.A., Wilde C.D., Cowan N.J.;
RT "evolutionary history of a multigene family: an expressed human
RT beta-tubulin gene and three processed pseudogenes";
RL Cell 33:477-487(1983).
XX
CC [1] reports two other pseudogenes and a functional beta-tubulin
CC gene. all three pseudogenes reported in [1] lack the intron
CC sequences present in the functional gene. because of this and the
CC poly-a tracts present in the 3' regions, [1] suggests that the
CC three pseudogenes were generated by reverse transcription of mrna
CC into the germline dna. 21-beta is quite similar to another
CC pseudogene (46-beta) reported in an earlier paper. [1] argues that
CC the two the mrnas apparently transcribed from the functional gene
CC differ only in the lengths of their 3' cds flanks, and that 21-beta
CC and 14-beta were derived from the 1.8 kb mrna and 7-beta from the
CC 2.6 kb mrna. the estimated time of integration for 21-beta is 4.4
CC million years ago [1].
XX
FH Key Location/Qualifiers
FH
FT source 1..1781
FT /db_xref="taxon:9606"
FT /organism="Homo sapiens"
FT CDS 204..1537
FT /codon_start=1
FT /note="pseudo-beta-tubulin cds"
FT /pseudo
XX
SQ Sequence 1781 BP; 423 A; 505 C; 446 G; 407 T; 0 other;
 ccaggctggt agcatatgcc tgtaagtccc ggctactcaa gaagctgagg tgtcgagaaa 60
 cttcctaccg cccgttcgca cctcgctact ccagcatcta gggcatattc aaccttccag 120
 cctcgacctg cagagaaaaa aaaattactt attttcttgc cccgtacata ccttgaagtg 180
 agcaaaaaaa ttaaatttta accatgaggg aaatcgtgca catccaggct ggtcagcgtg 240
 gcaaccagat cggtgccaag ttctgggagg tcatcagtga tgagcatggc atcgacccca 300
 ccggcaccta ccacggggac agcgacctgc agctggaccg catctccgtg tactacagtg 360
 aagccactca tggcaaatat gttcctcgtg ccatactggt ggatctagag cctgggacca 420
 tggactctgt tcgctcaggt ccttttggcc agatctttag accagacaac tttgtatttg 480
 gtcagtctgg cgcaggtaac aactgggcca aaggccacta cacagagggc gccgagctgg 540
 ttgattctgt cctggatgtg gtacggaagg agccagagag ctgtgactgc ctgcagggct 600
 tccagctcac ccactcactg ggtgggcgca caggctctgg aatgggcact ctccttatca 660
 gcaagatccg agaagaatac cctgatcgca tcatgaatac cttcagtgtg gtgccttcac 720
 ccaaagtgtc tgacaccgtg atcgagtcct acaatgctac cctgtccgtc catcagttgg 780
 tagagaacac tgatgagacc tattgcattg acaacgaggc cctctatgat atctgcttcc 840
 gcactctgag ggtgaccaca cccacctatg gggatctcaa cctcctcgtg taagacacca 900
 tggagtgtgt caccacctgc ctccgcttcc ctggccagct caatgctgac ctccgcaagt 960
 tggcagttaa catggtcccc ttcccacgtc tccatttctt catgcctgct ttgcccctct 1020
 caccagccat ggaagccagc agtatcaaga gctcacagtg ccggacctca cccagcaggt 1080
 cttcgatgcc aagagcatga tggctgcctc tgtccccggc cacggccgat acctcaccgt 1140
 ggctgctgac ttccgtggtc ggatgtccat gaaggaggtc gatgagcaga tgtttaacgt 1200
 gcagaacaag aacagcagct actttgtgga atggatcccc aacaatatca agacagctgt 1260
 ctgtgacatc ccacctcgtg gcctcaagat ggcagtcacc ttcatcggca gtagcacggc 1320
 catccaggag ctcttcaagc acatctcgga gcagttcact gccatgttcc gccggaaggc 1380
 cttcctccac tggtacacag gcgagggcat ggacgagatg gagttcaccg aggctgacag 1440
 caacatgaac gacctcgtct ctgattatca gcagtaccag gatgccaccg cagaagagga 1500
 ggaggatttg ggtgaggagg ccgaaaagga ggcctaaaga gagcccccaa tcaacctcga 1560
 ggcttctcag ttcccttagc cgtcttgact caactgcccg tttcctctcc ctcagaattt 1620
 gtgtttgctg cctctatctt gttttttgtt ttttcttctg gggagggtct agaacatgcc 1680
 tggcacatag taggcactca ataaatactt gtttgttgga aaaaaaaaaa aaaaaaggct 1740
 gaggtgtcag gatcccttga gcctgggagg tcaggctgca g 1781
//

H ακολουθία DNA του ψευδογονιδίου της beta tubulin σε μορφή FASTA.

>PSEUDO_betatub

ccaggctggtagcatatgcctgtaagtcccggctactcaagaagctgaggtgtcgagaaa

cttcctaccgcccgttcgcacctcgctactccagcatctagggcatattcaaccttccag

cctcgacctgcagagaaaaaaaaattacttattttcttgccccgtacataccttgaagtg

agcaaaaaaattaaattttaaccatgagggaaatcgtgcacatccaggctggtcagcgtg

gcaaccagatcggtgccaagttctgggaggtcatcagtgatgagcatggcatcgacccca

ccggcacctaccacggggacagcgacctgcagctggaccgcatctccgtgtactacagtg

aagccactcatggcaaatatgttcctcgtgccatactggtggatctagagcctgggacca

tggactctgttcgctcaggtccttttggccagatctttagaccagacaactttgtatttg

gtcagtctggcgcaggtaacaactgggccaaaggccactacacagagggcgccgagctgg

ttgattctgtcctggatgtggtacggaaggagccagagagctgtgactgcctgcagggct

tccagctcacccactcactgggtgggcgcacaggctctggaatgggcactctccttatca

gcaagatccgagaagaataccctgatcgcatcatgaataccttcagtgtggtgccttcac

ccaaagtgtctgacaccgtgatcgagtcctacaatgctaccctgtccgtccatcagttgg

tagagaacactgatgagacctattgcattgacaacgaggccctctatgatatctgcttcc

gcactctgagggtgaccacacccacctatggggatctcaacctcctcgtgtaagacacca

tggagtgtgtcaccacctgcctccgcttccctggccagctcaatgctgacctccgcaagt

tggcagttaacatggtccccttcccacgtctccatttcttcatgcctgctttgcccctct

caccagccatggaagccagcagtatcaagagctcacagtgccggacctcacccagcaggt

cttcgatgccaagagcatgatggctgcctctgtccccggccacggccgatacctcaccgt

ggctgctgacttccgtggtcggatgtccatgaaggaggtcgatgagcagatgtttaacgt

gcagaacaagaacagcagctactttgtggaatggatccccaacaatatcaagacagctgt

ctgtgacatcccacctcgtggcctcaagatggcagtcaccttcatcggcagtagcacggc

catccaggagctcttcaagcacatctcggagcagttcactgccatgttccgccggaaggc

cttcctccactggtacacaggcgagggcatggacgagatggagttcaccgaggctgacag

caacatgaacgacctcgtctctgattatcagcagtaccaggatgccaccgcagaagagga

ggaggatttgggtgaggaggccgaaaaggaggcctaaagagagcccccaatcaacctcga

ggcttctcagttcccttagccgtcttgactcaactgcccgtttcctctccctcagaattt

gtgtttgctgcctctatcttgttttttgttttttcttctggggagggtctagaacatgcc

tggcacatagtaggcactcaataaatacttgtttgttggaaaaaaaaaaaaaaaaaggct

gaggtgtcaggatcccttgagcctgggaggtcaggctgcag