Development of new methodologies for the preparation of amine derivatives of naphthoquinones and hydroquinones.
Synthesis of Dephostatin (inhibitor of tyrosine kinase).
Development of a new methodology for the efficient synthesis of both o- and p- naphthoquinones from juglone derivatives.

(Project: Quinones)

Development of new methodologies for the efficient asymmetric total synthesis of Alkannin and Shikonin (natural products with anticancer, anti-inflammatory and wound healing activity; major active ingredients of the commercial preparation of 'HELIXDERM').
Study on the activity of naphthoquinone-type Alkannin analogues, as topoisomerase I inhibitors.

(Project: Alkannin)

Development of new general synthetic methodologies for the construction of chiral gamma- and delta- lactones.
Asymmetric total synthesis of Muricatacin (natural product with anticancer activity).
Asymmetric total synthesis of (5R, 6S)-6-acetoxy-hexadecanolide (mosquito oviposition pheromone).

(Project: Pheromones)

Asymmetric total synthesis of Combretastatin D-1 and D-2 (natural products with anticancer activity). Study on the potentional inhibition of tubulin polymerization by diarylethers (analogues of Combretastatins).

(Project: Tubulin)

Studies aimed at the enrichment in Baccatin III (precursor of the anticancer drug Taxol®) of Taxus baccata extracts.

(Project: Taxol)

Development of a general methodology for the total asymmetric synthesis of all the members of the Bastadin class of antibiotics (natural products that regulate the activity of intercellular Ca++ ion channels).

(Project: Bastadins)

Synthesis of anthracene derivatives with application in microlithography.

(Project: Microlithography)

Biomimetic total synthesis of Bisorbicillinoids and Trichodimerol (BMS-182123).

(Project: Bisorbicillinoids)

Design, synthesis and development of bioactive derivatives of pharmacophoric scaffolds. Formal synthesis of Prosophylline.

(Project: Combinatorial Chemistry)

New anti-MRSA & VRSA antibiotics: Biomimetic formal synthesis of Abyssomicin C.

(Project: Abyssomicin C)

Stereostuctural determination by a synthetic and NMR-based approach of oxazinins isolated from Adriatic mussels.

(Project: Oxazinins)

Solid-phase supported total synthesis of (-)-Phenylhistine and (-)-Aurantiamine. Synthesis of a diverse dehydro-2,5-diketoppiperazine library.

(Project: Phenylhistine)

Novel stereocontrolled approach to syn and -anti-oxepene-cyclogeranyl trans fused polycyclic systems. Asymmetric total synthesis of (-)-Aplysistatin, (+)-Palisadin B, (+)-12-Hydroxy-Palisadin B and the AB ring system of Adociasulfate-2 and Toxicol A.

(Project: Aplysistatin)

Synthesis of the bicyclic carbon skeleton of Hyperforin and related PPA's.

(Project: Hyperforin)

A short and convenient chemical route to optically pure 2-methyl chromanmethanols. Total asymmetric synthesis of beta-, gamma-, and delta-tocotrienols.

(Project: Tocotrienols)